Clinical trials: Gastric Diseases
Hypertrophic Pyloric Stenosis, Respiratory Complication
Gastric Tube in Pyloric Stenosis
Pyloric stenosis is a current condition in pediatric surgery. The medical management prior to surgery consists of ionic correction.
- Trial name
- SONPYL (NCT05068622)
- Where
- France
- Volunteers
- 87 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Gastric Cancer
As a Second-line Treatment for Metastatic Gastric Adenocarcinoma Patients, the Safety and Effective of Vactosertib Administration in Combination With Paclitaxel+Ramucirumab is Evaluated, and a Phase 2a Clinical Trial to Biomarkers
This clinical trial is to evaluate the efficacy and safety of subjects with metastatic gastric adenocarcinoma or adenocarcinoma of the gastroesophageal junction.
- Trial name
- NCT04656002
- Testing
- Vactosertib
- Volunteers
- 43 people
- Sponsor
- Samsung Medical Center
Gastric Cancer
Pilot Study for High Output Drainage Removal After Gastrectomy
*Objective: The study aims to evaluate whether there is a difference in intra-abdominal complication rates between patients discharged with or without a drainage tube following gastrectomy with high postoperative drainage…
- Trial name
- NCT06690112
- Testing
- Arm I (Drainage tube removal)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gangnam Severance Hospital
Mesenteric Ischemia, Permeability CT Technics
Dynamic Contrast Enhancement Computed Tomography Based Technic to Assess Gastro Intestinal Wall Perfusion : Feasibility Study
This feasibility study has therefore several aims: 1. construct a dedicated CT perfusion protocol for GIT wall perfusion; 2. used a two-compartment pharmacokinetic model which is more adapted that a unique compartment model; 3.
- Trial name
- PERFE-CT (NCT03367065)
- Testing
- Dynamic contrast enhanced computerised tomography
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Poitiers University Hospital
Diabetes, Gastric Content Aspiration
Effects of GLP-1 Agonists on Gastric Volume
This study will enroll patients ages 18 and over who have a diagnosis of diabetes, are undergoing an elective surgery under general anesthesia and 1) are taking a GLP-1 receptor agonist medication, or 2) not taking a GLP-1…
- Conditions
- Diabetes, Gastric Content Aspiration, Glucagon-like Peptide 1, GLP-1
- Trial name
- NCT05854979
- Testing
- Gastric Ultrasound
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Medical University of South Carolina
Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer
Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial
This study aims to evaluate the efficacy of vonoprazan combined with different antibiotics in dual therapy for Helicobacter pylori eradication treatment.
- Trial name
- NCT07068607
- Testing
- Vonoprazan, Tetracycline 500mg tid, Minocycline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yongquan Shi
Stomach Neoplasms
A Phase II Study of Oxaliplatin in Association With 5FU and Folinic Acid in the Treatment of Subjects With Non-Surgical or Advanced Metastatic Gastric Cancer
This phase II trial will evaluate, in first line advanced or metastatic gastric cancer, the efficacy and tolerance of another oxaliplatin, 5FU bolus combination already tested in advanced colorectal cancer
- Trial name
- NCT00611507
- Testing
- Oxaliplatin, 5-Fluorouracil
- Where
- Colombia
- Volunteers
- 21 people
- Sponsor
- Sanofi
Gastroesophageal Junction, Gastroesophageal Adenocarcinoma
Substudy 06C: A Study of Investigational Agents With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)
This is a phase 1/2, multicenter, open-label umbrella platform study that will evaluate the safety and tolerability of investigational agents with pembrolizumab and fluoropyrimidine chemotherapy for the first-line (1L) treatment…
- Conditions
- Gastroesophageal Junction, Gastroesophageal Adenocarcinoma, Esophageal Neoplasms, Esophageal Cancer
- Trial name
- NCT06469944
- Testing
- Pembrolizumab, Sacituzumab Tirumotecan (sac-TMT), Capecitabine
- Where
- 50 sites in United States, Brazil and 10 more
- Volunteers
- 160 people
- Sponsor
- Merck Sharp & Dohme LLC
Obesity, Obesity, Morbid
Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss
The Investigators propose suture plication placement at the distal gastric body drives a significant portion of weight loss in endoscopic sleeve and sutures only need to be placed in the distal gastric body.
- Conditions
- Obesity, Obesity, Morbid, Metabolic Disease, Weight, Body
- Trial name
- NCT06299644
- Testing
- Endoscopic Sleeve Gastroplasty - Belt and Suspenders, Endoscopic Sleeve Gastroplasty - Belt
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Stomach Ulcer
Healing Effects of Rebamipide and Omeprazole in Helicobacter Pylori-positive Gastric Ulcer After Eradication Therapy
The purpose of this study is to evaluate the ulcer healing efficacy of rebamipide in comparison with omeprazole in Helicobacter pylori-positive gastric ulcer after eradication therapy.
- Trial name
- NCT00272467
- Testing
- Rebamipide, Omeprazole
- Where
- 7 sites in China, South Korea
- Volunteers
- 132 people
- Sponsor
- Korea Otsuka International Asia Arab
Lung Cancer, Stomach Cancer
A First-in-human Study of 3H-10000 in Patients With Unresectable or Metastatic Solid Tumors
The study is being conducted to evaluate the safety, tolerability, efficacy, pharmacokinetics, and pharmacodynamics of 3H-10000 in the treatment of unresectable or metastatic solid tumors .
- Trial name
- NCT07354711
- Testing
- 3H-10000
- Where
- China
- Volunteers
- 170 people
- Sponsor
- 3H Pharmaceuticals Co., Ltd.
Gastric Varix
The Validation and Efficacy of Varix Trainer as a Training Device Esophagogastroduodenoscopy (a Multicenter Study)
The goal of this exploratory validation study is to compare levels of expertise (or non-expertise) between GI fellows and experts with the varix trainer.
- Trial name
- NCT05614999
- Testing
- Endoscopy training curriculum
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Gastric Cancer
Phase 1/2 Study of S-1 and Cisplatin in Advanced Gastric Cancer
The purpose of the phase 1 portion of the study is to determine the safe dose of S-1 and cisplatin that can be administered in gastric cancer patients.
- Trial name
- NCT00072787
- Testing
- S-1, cisplatin
- Where
- 11 sites in United States
- Volunteers
- 41 people
- Sponsor
- Taiho Oncology, Inc.
Gastric Cancer
Telatinib in Combination With Capecitabine/ Oxaliplatin in 1st Line Gastric or GEJ Cancer
The purpose of the trial is to compare the combination regimen of Telatinib and Capecitabine and Oxaliplatin vs. Capecitabine and Oxaplatin to explore superiority of the Telatinib combination in terms of progression-free survival…
- Trial name
- NCT03817411
- Testing
- Telatinib, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Taizhou EOC Pharma Co., Ltd.
Gastroparesis
Gastric Electrical Stimulation (GES) and Pyloroplasty for the Treatment of Gastroparesis
Gastroparesis (GP) is describing a condition when stomach does not empty as fast as it should. This fact creates the situation, when food stays in the stomach for a long time and it causes symptoms of nausea, vomiting, loss of…
- Trial name
- GES+PP (NCT03123809)
- Testing
- Gastric Electrical Stimulation (GES) System
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Metabolic Syndrome, Gastric Cancer
A Metabolomics-based Study to Explore the Mechanism of Remission of Metabolic Syndrome After Radical Gastrectomy
1. Analysis of preoperative and postoperative metabolite changes: Through metabolomics technology, the changes of preoperative and postoperative metabolites in patients with gastric cancer complicated with metabolic syndrome were…
- Trial name
- Metabolomics (NCT06707714)
- Testing
- hypertension, diabetes, fatty liver
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Dong Peng
Gastric Cancer
Biomarker Study of PDR001 in Combination With MCS110 in Gastric Cancer
<Background> 1. Current status of treatment options in advanced gastric cancer. The cytotoxic chemotherapy, usually fluoropyrimidine + platinum combination regimen is current standard of care.
- Trial name
- NCT03694977
- Testing
- MCS110/PDR001 combination
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Morbid Obesity
Semaglutide Given Before and After Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass for Recurrent Weight Gain
Recurrent weight gain affects 15% to 40% of patients after metabolic and bariatric surgery (MBS). SG is the most performed operation worldwide, and long-term regain after SG is well documented.
- Trial name
- NCT07859163
- Testing
- Semaglutide weekly injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Obesity, Morbid, Obesity and Overweight
Identification of Pre-surgical Phenotypic Indicators Predictive of Quality of Life Trajectories in Obese Patients Following Bariatric Surgery
This study aims to identify pre-operative phenotypic determinants predictive of quality of life trajectories in post-bariatric surgery patients.
- Conditions
- Obesity, Morbid, Obesity and Overweight, Bariatric Surgery, Bariatric Surgery Patients
- Trial name
- PHENOBEQOL73 (NCT06951893)
- Testing
- Hospital Anxiety and Depression Scale, Dutch Eating Behaviour Questionnary, Impact of Weight on Quality Of Life
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Colorectal Cancer, Pancreatic Adenocarcinoma
Circulating Tumor DNA Exposure in Peripheral Blood
This is a prospective, multi-center, blinded feasibility study. The objective of this study is to test the feasibility of the detection of tumor DNA of a variety of tumors in peripheral blood using a novel process for the…
- Conditions
- Colorectal Cancer, Pancreatic Adenocarcinoma, Gastric Cancer, Hepatocellular Carcinoma
- Trial name
- NCT03517332
- Where
- 6 sites in United States, Switzerland
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Quantgene Inc.
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