Clinical trials: Gastric Diseases
Gastric Cancer, Benign Gastric Tumor
Body Composition After Laparoscopic Gastrectomy for Gastric Cancer
Nutritional status including changes of body composition is one of the most important clinical determinants of outcome after gastrectomy for gastric cancer.
- Trial name
- NCT02541461
- Testing
- Laparoscopic gastrectomy
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Hanyang University Seoul Hospital
Obesity, Bariatric Surgery
Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol
Obesity affects more than 1 in 3 adults in the U.S. It is commonly associated with reduced quality of life and complications such as metabolic syndrome, heart disease, high blood pressure and sleep disorders.
- Conditions
- Obesity, Bariatric Surgery, Roux-en Y Gastric Bypass
- Trial name
- NCT04049786
- Testing
- Digestive biopsy, Carvedilol 25mg, Serial blood sampling for PK analysis
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Natalia Valadares de Moraes
Carcinoma, Hepatocellular, Gastric/Gastroesophageal Junction Cancer
A Study to Investigate Sitravatinib as Monotherapy and in Combination With Tislelizumab in Participants With Unresectable Locally Advanced or Metastatic Hepatocellular Carcinoma or Gastric/Gastroesophageal Junction Cancer
The purpose of this study was to evaluate the safety, tolerability, pharmacokinetics and preliminary antitumor activity of sitravatinib as monotherapy and in combination with tislelizumab in participants with unresectable locally…
- Trial name
- NCT03941873
- Testing
- Sitravatinib, Tislelizumab
- Where
- 18 sites in China
- Volunteers
- 111 people
- Sponsor
- BeiGene
Esophageal Cancer, Gastric Cancer
Chemoimmunotherapy Followed by Surgery for Oligometastatic Esophagogastric Cancer: (TORO Protocol)
Esophageal cancer and cancers of the gastroesophageal junction (GEJ) are among the most common malignancies worldwide. The outcome for these patients remains very poor.
- Conditions
- Esophageal Cancer, Gastric Cancer, Oligometastatic Disease
- Trial name
- TORO (NCT06668454)
- Testing
- Surgical resection followed by preoperative chemoimmunotherapy for oligometastatic esophagogastric cancer
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- University Health Network, Toronto
Advanced Solid Tumor, Gastric Cancer
First in Human Study of TORL-2-307-ADC in Participants With Advanced Cancer
This first-in-human study will evaluate the safety, tolerability, pharmacokinetics, and antitumor activity of TORL-2-307-ADC in patients with advanced cancer
- Conditions
- Advanced Solid Tumor, Gastric Cancer, Pancreas Cancer, Gastroesophageal Junction Adenocarcinoma
- Trial name
- NCT05156866
- Testing
- TORL-2-307-ADC
- Where
- 12 sites in United States, South Korea
- Volunteers
- 163 people
- Sponsor
- TORL Biotherapeutics, LLC
Gastroparesis, Gastroesophageal Reflux
Domperidone for Gastroparesis in Solid Organ Transplantation
The purpose of this study is to examine the clinical response to domperidone in solid organ transplant recipients with gastroparesis.
- Trial name
- NCT00552422
- Testing
- domperidone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- David J. Lederer, M.D.
Obesity
Effects of Intragastric Balloon Surgery and Sleeve Gastrectomy on Brain Function
This is a prospective, single-center, randomized, open-label, parallel-controlled clinical trial to compare the changes in brain function after intragastric balloon and sleeve gastrectomy.
- Trial name
- NCT05127213
- Testing
- Intragastric balloon system, Sleeve gastrectomy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Cancer
Detection of Peritoneal Metastasis of Gastric Cancer by Liquid Biopsy in Peripheral Blood: A Prospective Study
This study is a prospective, multi-omics, observational study aimed at detecting peritoneal metastasis of gastric cancer by combined assays for methylation of cell-free DNA (cfDNA) and other blood-based biomarkers.
- Trial name
- NCT05347524
- Testing
- Baseline blood draw and blood-based biomarkers analyses
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Shanghai Zhongshan Hospital
Morbid Obesity
Prospective Study of the Impact of Sleeve Gastrectomy on Gastro-esophageal Junction Function
Improved results for sleeve gastrectomy could be possible if more was known about the surgical / mechanical factors that affect outcome.
- Trial name
- FFSI (NCT01980420)
- Testing
- Laparoscopic sleeve gastrectomy
- Where
- France
- Volunteers
- 35 people
- Sponsor
- IHU Strasbourg
Gastroesophageal Reflux Disease
Symptom Assessment for GERD Patients Receiving H. Pylori Eradication
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies.
- Trial name
- NCT01249482
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Adiposity
Study on the Performance of Symmcora® Mid-term Suture Versus Novosyn® Suture in Patients Undergoing Robotic Assisted Gastric Bypass Surgery
The study is designed as a prospective, mono-centric, randomized, patient blinded comparison of unidirectional barbed suture (Symmcora® mid term, UBS) vs. a conventional suture (Novosyn®, CS).
- Trial name
- BARGASTRO (NCT05433688)
- Testing
- Robotic assisted gastric bypass surgery
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Aesculap AG
Colorectal Cancer, Esophageal Cancer
LMB-9 Immunotoxin in Treating Patients With Advanced Pancreatic, Esophageal, Stomach, Colon, or Rectal Cancer
RATIONALE: LMB-9 immunotoxin can locate tumor cells and kill them without harming normal cells. This may be an effective treatment for advanced pancreatic, esophageal, stomach, colon or rectal cancer.
- Conditions
- Colorectal Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT00010270
- Testing
- LMB-9 immunotoxin
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University Hospital Freiburg
Gastroparesis
Autonomic and Enteric Profiling
Autonomic, inflammatory, enteric, electrophysiologic and hormonal.
- Trial name
- NCT03178370
- Testing
- Gastric Electrical Stimulation
- Volunteers
- 43 people
- Sponsor
- University of Louisville
Obesity, Weight Gain
Endoscopic Argon Plasma Coagulation Vs. Control For Weight Regain After Gastric Surgery
Bariatric surgery procedures have consistently been demonstrated to reduce long-term co-morbidities and mortality. Despite its benefits, weight regain is common, usually initiating around two years after the initial procedure…
- Trial name
- NCT03055754
- Testing
- Argon randomized arm, Control arm
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Kaiser Clinic and Hospital
Gastric Cancer, Esophagogastric Junction Adenocarcinoma
Efficacy and Safety of Anti-PD-1, Thymalfasin, and SOX in Neoadjuvant Treatment of cStage III Gastric/Gastroesophageal Junction Adenocarcinoma
This Phase II clinical study is a prospective, open-label, single-arm trial designed to evaluate the efficacy and safety of combining anti-PD-1 therapy (Serplulimab) with thymalfasin and the SOX chemotherapy regimen as a…
- Trial name
- NCT06461910
- Testing
- Serplulimab, thymalfasin, Oxaliplatin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zekuan Xu
Solid Tumor, NSCLC
Afuresertib +Sintilimab+Chemotherapy in Patients With Selected Solid Tumors That Resistance to Prior Anti-PD-1/PD-L1
This is a multicenter, open-label, dose-escalation and efficacy/safety Phase I/II study to assess RP2D, safety, tolerability and anti-tumor activity of Sintilimab + afuresertib + nab-paclitaxel or docetaxel administered as a…
- Conditions
- Solid Tumor, NSCLC, Cervical Cancer, Endometrial Cancer
- Trial name
- NCT05383482
- Testing
- Afuresertib, Nab paclitaxel, Docetaxel
- Where
- 5 sites in China
- Volunteers
- 22 people
- Sponsor
- Laekna Limited
GastroEsophageal Cancer, Incurable Disease
The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach (RADICES)
The survival of patients with incurable gastroesophageal cancer can extend over a year with anticancer therapy. However, the number of patients with deteriorating quality of life in this patient group steadily decreases over time…
- Trial name
- RADICES (NCT06138223)
- Testing
- Exercise intervention, Nutrition intervention
- Where
- 22 sites in Netherlands
- Volunteers
- 196 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Esophageal Varices, Bleeding
Self-expandable Esophageal Stent Versus Balloon Tamponade in Refractory Esophageal Variceal Bleeding.
In the last years, important advances have been done in the treatment and prevention of esophageal variceal bleeding. Experts agree that the combination of pharmacological and endoscopic therapy should be the first line therapy…
- Conditions
- Esophageal Varices, Bleeding, Cirrhosis
- Trial name
- NCT01242280
- Testing
- Stent, Tamponade
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Hospital Clinic of Barcelona
Gastric Cancers, Air Pollution
The Effect of Environmental Factors on Gastric Cancer Based on Macrogenome
The objectives of this study were to clarify how environmental factors such as air pollution affect the occurrence and development of gastric cancer; to identify patient-specific macrogenomic markers of gastric cancer; and to…
- Trial name
- NCT06854146
- Testing
- gastric cancer, healthy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dong Peng
Gastric Cancer, Nutrition Disorders
Functional Jejunal Interposition Improve Nutritional Status After Total Gastrectomy
The purpose of this study is to find out whether the nutritional status of patients undergoing Functional Jejunal Interposition is better than those with Roux-en-Y After Total Gastrectomy for Gastric Cancer.
- Trial name
- FJINS (NCT01996059)
- Testing
- Functional Jejunal Interposition, Roux-en-Y
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Sun Yat-sen University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.