Clinical trials: Gastric Neoplasms
Gastric Cancer Stage I
Laparoscopic Gastric Function Preserving Surgery Combined With Resection of the Anterior Lymphatic Drainage Area
Nowadays, while pursuing the eradication of tumor, how to maximize the preservation of normal anatomy and physiological functions of the stomach, reduce the surgical trauma caused by excessive debridement, and improve the quality…
- Trial name
- NCT05160753
- Testing
- Laparoscopic gastric function preserving surgery combined with resection of the anterior lymphatic drainage area
- Where
- China
- Volunteers
- 580 people
- Sponsor
- Affiliated Hospital of Nantong University
Colorectal Cancer Not MSI-H or MMR-deficient, GIST
A Phase I/II Study of Regorafenib Plus Avelumab in Solid Tumors
Assessment of the efficacy and safety of Regorafenib and Avelumab in patients with advanced or metastatic solid tumors (ten cohorts), once the Recommanded Phase II Dose (RP2D) has been determined (phase I trial).
- Conditions
- Colorectal Cancer Not MSI-H or MMR-deficient, GIST, Oesophageal or Gastric Carcinoma, Biliary Tract Cancer
- Trial name
- REGOMUNE (NCT03475953)
- Testing
- Phase 1 : Regorafenib, Phase 1 : Avelumab, Phase 2 : Regorafenib
- Where
- 7 sites in France
- Volunteers
- 747 people
- Sponsor
- Institut Bergonié
Gastric Cancer
Antiangiogenic Factors in Gastric Cancer
Endogenous antiangiogenic factors are related with gastric cancer progression.
- Trial name
- NCT00735566
- Where
- South Korea
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Gastrointestinal Neoplasms, Abnormality of Enteric Nervous System Morphology
Endoscopic Vital Nerve Staining in Gastrointestinal Diseases
In this study, methylene blue (MB) was used as vital nerve staining agent. During gastroenteroscopy, mucosal nerve staining was achieved by endoscopic submucosal injection of MB solution.
- Trial name
- NCT05232357
- Testing
- Sodium thiosulfate and Methylene blue solution
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Metastatic Gastric Cancer
Fruquintinib Combined With Toripalimab and SOX Regimen in the First-line Treatment of Advanced Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
This is a prospective, open-label, multicenter, single arm phase Ⅰb/Ⅱ clinical study aims to explore the efficacy and safety of fruquintinib combined with toripalimab and SOX regimen in the first-line treatment of unresectable…
- Trial name
- NCT05024812
- Testing
- fruquintinib＋toripalimab + SOX
- Where
- China
- Volunteers
- 64 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Gastric Cancer (GC), Double-tract Reconstruction
Comparison of Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer
This study includes patients diagnosed with proximal gastric cancer (Siewert type II/III, cT1-3N0-1M0) across six tertiary hospitals, who underwent either double-tract reconstruction (DTR) or tubular gastric anastomosis (TGA).
- Conditions
- Gastric Cancer (GC), Double-tract Reconstruction, Tubular Gastric Anastomosis
- Trial name
- NCT07635836
- Testing
- Double-tract reconstruction
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Qilu Hospital of Shandong University
Gastric Adenocarcinoma, Esophageal Adenocarcinoma
Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas
The initial intent of the study was to be a multi-center single-arm open-label Simon's two-stage Phase II clinical trial of first-line mFOLFOX6 + trastuzumab + avelumab in metastatic HER2-amplified gastric and esophageal…
- Conditions
- Gastric Adenocarcinoma, Esophageal Adenocarcinoma, Metastasis, HER-2 Gene Amplification
- Trial name
- NCT03783936
- Testing
- Oxaliplatin, Leucovorin, 5 fluorouracil
- Where
- 7 sites in United States
- Volunteers
- 18 people
- Sponsor
- Ashwin Somasundaram
Stomach Neoplasms, Neoplasm Metastasis
Gastric Cancer Liver Metastasis Cohort of China
This multi-institutional retrospective cohort study aimed to describe and analyze the overall clinical characteristics, therapeutic status and prognosis pattern of gastric cancer liver metastasis (GCLM) in China.
- Trial name
- RECORD (NCT04574245)
- Testing
- Gastrectomy; Hepatectomy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Chinese PLA General Hospital
Gastroesophageal Adenocarcinoma
A Study of Novel Agents or Combinations as Perioperative Treatment in Participants With Locally Advanced Resectable Gastroesophageal Adenocarcinoma
GEMINI-PeriOp GC study will assess the safety, tolerability, pharmacokinetics (PK) and preliminary anti-tumor activity of novel agents or novel combinations as perioperative treatment in participants with locally advanced…
- Trial name
- NCT07069712
- Testing
- Sonesitatug Vedotin, Rilvegostomig, Trastuzumab Deruxtecan (T-DXd)
- Where
- 70 sites in United States, Canada and 9 more
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Colorectal Cancer, Liver Cancer
Acupuncture for Oxaliplatin-induced Peripheral Neuropathy in Gastro-intestinal Cancer Patients
ACUPOX is a multicenter, open label, 2-cohort based phase II clinical study evaluating the interest of a standardized protocol of verum acupuncture in treatment of Oxaliplatin-induced peripheral neuropathy in patients with…
- Conditions
- Colorectal Cancer, Liver Cancer, Gastric Cancer, Pancreas Cancer
- Trial name
- ACUPOX (NCT05850130)
- Testing
- Acupuncture intervention, No acupuncture
- Where
- 15 sites in France
- Volunteers
- 182 people
- Sponsor
- GERCOR - Multidisciplinary Oncology Cooperative Group
Survival
Perioperative Chemotherapy Combined With HIPEC for High-risk Advanced Gastric Cancer
The investigators intend to conduct a randomized controlled study to find if combining HIPEC (hyperthermic intraperitoneal perfusion chemotherapy) with post-neoadjuvant chemotherapy D2 resection could improve survival for…
- Trial name
- HIPEC (NCT02960061)
- Testing
- Neoadjuvant chemotherapy, D2 radical resection, Hyperthermic intraperitoneal perfusion chemotherapy
- Where
- China
- Volunteers
- 640 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Gastric Low-grade MALT Lymphoma With Helicobacter Pylori Positive
Prognostic Study of Gastric MALT Lymphoma After Eradication of Helicobacter Pylori
To survey the grade of gastric MALT lymphoma after eradication of Helicobacter pylori
- Trial name
- NCT01264822
- Testing
- Rabeprazole Sodium
- Where
- 42 sites in Japan
- Volunteers
- 108 people
- Sponsor
- Eisai Co., Ltd.
Solid Tumour, Haematological Malignancy
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
This clinical trial is looking at a drug called capmatinib. Capmatinib is approved as standard of care treatment for adult patients with certain types of lung cancer.
- Conditions
- Solid Tumour, Haematological Malignancy, Malignant Neoplasm, Neoplasms by Histologic Type
- Trial name
- DETERMINE (NCT06988475)
- Testing
- Capmatinib
- Where
- 17 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cancer Research UK
Locally Advanced or Metastatic Solid Tumors, Colorectal Cancer
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
This is an open-label, multi-center, phase I study to evaluate the safety, tolerability, efficacy, and pharmacokinetics of MRG007 (ARR-217) in patients with unresectable locally advanced or metastatic solid tumors.
- Conditions
- Locally Advanced or Metastatic Solid Tumors, Colorectal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT07066657
- Testing
- MRG007, MRG007 and Bevacizumab
- Where
- 21 sites in United States, China
- Volunteers
- 572 people
- Sponsor
- ArriVent BioPharma, Inc.
Helicobacter Infections, Stomach Neoplasms
Helicobacter Pylori Eradication to Prevent Gastric Cancer
Gastric cancer is the fourth most common type of cancer and the second leading cause of cancer-related death in the world. In China, more than 390,000 new patients are diagnosed with gastric cancer and more than 300,000 patients…
- Trial name
- NCT01133951
- Testing
- OAC triple therapy
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Jie-Jun Wang
Stomach Neoplasms, Pain
A Phase IV Randomized Trial of Maxigesic® Versus Standard Analgesia After Radical Gastrectomy
Background: Radical gastrectomy causes moderate-to-severe pain during the first 48 hours after surgery. Opioids are effective but carry adverse effects and risks of prolonged use, so ERAS-based care recommends multimodal…
- Conditions
- Stomach Neoplasms, Pain, Postoperative
- Trial name
- NCT07687394
- Testing
- Acetaminophen (Newaminophen Premix), Maxigesic IV (acetaminophen/ibuprofen)
- Volunteers
- 160 people
- Sponsor
- Yonsei University
Colorectal Cancer, Esophageal Cancer
Nutritional Status and Nutrient Supply in Hospitalised Surgical Patients
Prospective single arm, single center observational study to assess the nutritional status and the nutrient supply during hospitalization for elective gastrointestinal surgery.
- Conditions
- Colorectal Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT03787537
- Where
- Germany
- Volunteers
- 128 people
- Sponsor
- Charite University, Berlin, Germany
Recurrent Malignant Solid Neoplasm, Stage IV Breast Cancer
Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites
The study designed is to evaluate the safety of Canady Helios™ Cold Plasma Scalpel (CHCPS) in patients with solid tumors with carcinomatosis scheduled to undergo surgical resection for cytoreduction.
- Conditions
- Recurrent Malignant Solid Neoplasm, Stage IV Breast Cancer, Stage IV Prostate Cancer, Stage IV Pancreatic Cancer
- Trial name
- NCT04267575
- Testing
- Canady Helios Cold Plasma Scalpel
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jerome Canady, M.D.
Gastric Cancer
Nab-paclitaxel Combined With Cadonilimab (AK104) for the Second-line Treatment of Advanced Gastric Cancer
Currently, standard treatment options for gastric cancer failed to first-line treatment include monotherapy with paclitaxel/irinotecan/docetaxel/albumin paclitaxel, or paclitaxel combined with ramucirumab.
- Trial name
- NCT06349967
- Testing
- Nab-paclitaxel Combined With Cadonilimab (AK104)
- Volunteers
- 59 people
- Sponsor
- West China Hospital
Pancreatic Cancer, Gastric Cancer
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
Background: A new cancer therapy involves taking white blood cells from a person, growing them in the lab, genetically modifying them, then giving them back to the person.
- Conditions
- Pancreatic Cancer, Gastric Cancer, Gastrointestinal Cancer, Colon Cancer
- Trial name
- NCT03190941
- Testing
- Cyclophosphamide, Fludarabine, Anti-KRAS G12V mTCR PBL
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- National Cancer Institute (NCI)