Clinical trials: Gastric Symptoms
Obese Adults
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity
This study will assess whether a single subcutaneous dose of tirzepatide 7.5 mg , compared with saline placebo, increases total esophageal acid exposure time during a 96-hour wireless pH recording beginning about 48 hours after…
- Trial name
- NCT07893457
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastric Cancer
Hematological Dynamic Scores for Predicting Survival and Treatment Response for Advanced Gastric Cancer After Neoadjuvant Therapy
HMDLS, based on hematological markers, could effectively distinguish the long-term efficacy of AGC patients after NAT. The predictive performance of nomogram-HMDLS was better than ypTNM stage, achieving better prognostic…
- Trial name
- NCT06573307
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Chang-Ming Huang, Prof.
Functional Dyspepsia, Gastro Esophageal Reflux
Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting
The purpose of this prospective cohort study is to compare upper GI symptoms and endoscopy findings in Canada with Japan and Iran, and correlate this with the upper GI microbiome.
- Conditions
- Functional Dyspepsia, Gastro Esophageal Reflux, Peptic Ulcer, Normal Control
- Trial name
- NCT03868267
- Where
- 3 sites in Canada, Iran and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Hamilton Health Sciences Corporation
Morbid Obesity
Laparoscopic Gastric Plication Operation for Patients With Severe or Morbid Obesity
The purpose of this study is to collect data prospectively on the safety and efficacy of the Laparoscopic Gastric Plication operation for patients with Severe or Morbid Obesity.
- Trial name
- NCT01207609
- Testing
- Laparoscopic Gastric Plication
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- Ponce, Jaime, M.D.
Constipation
Colonic Transit Time Validation Study
The protocol described herein is designed to provide clinical evidence of the substantial equivalence of SmartPill GI Monitoring System (SP) to the Sitzmarks (Konsyl Pharmaceuticals, Easton, MD) radio-opaque markers (ROM).
- Trial name
- CTT (NCT00857363)
- Where
- 13 sites in United States, United Kingdom
- Volunteers
- 210 people
- Sponsor
- The SmartPill Corporation
Obesity
Laparascopic Sleeve Gastrectomy vs. Endoscopic Gastric Plication in Obesity
The project will describe the efficacy and safety of laparoscopic sleeve gastrectomy and endoscopic gastric plication procedures as compared to conservative therapy and clarify the mechanisms of action of these treatments.
- Trial name
- SLAVIA (NCT05259644)
- Testing
- laparoscopic sleeve gastrectomy, conservative treatment of obesity, endoscopic gastric plication
- Where
- Czechia
- Volunteers
- 75 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Gastroesophageal Varices, Liver Cirrhosis
Gastric Variceal Ligation Versus Gastric Variceal Obturation for Secondary Prophylaxis of Gastric Varices
The investigators establish a randomized controlled clinical trial, comparing the efficacy and prognosis of GVL and GVO in secondary prevention of GVs, especially in patients with portosystemic shunting, and exploring the…
- Trial name
- NCT03729921
- Testing
- gastric variceal ligation, gastric variceal obturation
- Volunteers
- 166 people
- Sponsor
- Shanghai Zhongshan Hospital
Therapeutic Endoscopic Ultrasound, Advanced Endoscopy
Therapeutic Endoscopic Ultrasound for Gastrointestinal Disorders: A Multicenter Registry Study
The purpose of this retrospective chart-review registry study is to evaluate the safety profile, efficacy profile and cost-effectiveness of the various therapeutic endoscopic ultrasound (EUS) procedures (for benign and malignant…
- Conditions
- Therapeutic Endoscopic Ultrasound, Advanced Endoscopy, Therapeutic Endoscopy, Interventional Endoscopy
- Trial name
- TEUS Registry (NCT05051358)
- Testing
- Therapeutic Endoscopic Ultrasound
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University
Ulcer, Gastric, Obesity, Morbid
The Use of Indocyanine Green to Visualize Blood Flow to the Gastrojejunostomy During Bariatric Surgery.
This is an interventional pilot study aimed to evaluate the use of NIF imaging as an intraoperative aid to assess the anastomotic blood flow to the gastric pouch and gastrojejunostomy during Roux-en-Y gastric bypass surgery and…
- Trial name
- NCT06002906
- Testing
- Indocyanine green, Stryker 1688 AIM system
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University Health Network, Toronto
Gastro-entero-pancreatic Carcinoma, Esophageal Neuroendocrine Carcinoma
Octreotide LAR as Maintenance Treatment for Patients With NEC
This is phase II study on the efficacy of octreotide lar as maintenance treatment after first-line chemotherapy for patients with unresectable or metastatic gastro-entero-pancreatic or esophageal neuroendocrine carcinomas.
- Trial name
- NCT02409849
- Testing
- Octreotide lar
- Where
- China
- Volunteers
- 92 people
- Sponsor
- Peking University
Gastric Cancer Adenocarcinoma Metastatic, Lymph Node Metastasis
AI-Based Prediction of Lymph Node Metastasis in Gastric Cancer Using Preoperative Multimodal Data
This study aims to develop and validate an artificial intelligence (AI) system that can predict whether lymph node metastasis has occurred in patients with gastric cancer before surgery.
- Conditions
- Gastric Cancer Adenocarcinoma Metastatic, Lymph Node Metastasis, Artificial Intelligence (AI) in Diagnosis
- Trial name
- NCT06957678
- Testing
- Artificial Intelligence-Based Predictive Model for Lymph Node Metastasis
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Qun Zhao
Obesity, Morbid, Diabetes Mellitus, Type 2
Different Limb Lengths in Gastric Bypass Surgery
Obesity and type 2 diabetes mellitus (T2DM) are reaching epidemic proportions in the developed world. In morbidly obese patients only surgical treatment (bariatric operations) leads to a sustained weight loss and relief of…
- Conditions
- Obesity, Morbid, Diabetes Mellitus, Type 2, Hypertension, Dyslipidemias
- Trial name
- SLIM (NCT04219787)
- Testing
- Long BPL LRYGB, Short BPL LRYGB
- Where
- Switzerland
- Volunteers
- 800 people
- Sponsor
- Clarunis - Universitäres Bauchzentrum Basel
Gastro Intestinal Bleeding
The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper GI Bleeding
This study is conducted to evaluate the effectivity of hypertonic dextrose spray as an endoscopic topical hemostatic agent, compared to conventional agent (adrenaline injection, followed by hemoclip or thermocoagulation), in…
- Trial name
- NCT04979273
- Testing
- Dextrose 40 % in Water, Adrenaline 1 Mg/mL Solution for Injection, argon plasma coagulation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Esophageal Cancer, Gastric Cancer
Selinexor in Combination With Irinotecan in Adenocarcinoma of Stomach and Distal Esophagus
The main purpose of this study is to see whether the combination of selinexor (KPT-330) and irinotecan can help people with esophageal or stomach cancer.
- Trial name
- NCT02283359
- Testing
- Selinexor, Irinotecan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Obesity, Diabetes
Surgical Intervention for Morbidly Obese Adolescents
The purpose is to study whether the positive effects from obesity surgery in adults also can be achieved when adolescent subjects are operated.
- Conditions
- Obesity, Diabetes, Hypertension
- Trial name
- NCT00289705
- Testing
- Surgery
- Where
- 4 sites in Sweden
- Volunteers
- 80 people
- Sponsor
- Göteborg University
Laparoscopic Gastric Bypass, Obesity
Ketamine vs Hydromorphone
This study will help to determine if investigators can minimize narcotic use in laparoscopic gastric bypass patients while maintaining adequate pain control.
- Conditions
- Laparoscopic Gastric Bypass, Obesity, Pain, Postoperative
- Trial name
- NCT03001843
- Testing
- Ketamine, Narcotics, pain scale
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Florida
Esophageal Neoplasms, Constriction
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures.
- Conditions
- Esophageal Neoplasms, Constriction, Anastomotic Leak, Ischemia
- Trial name
- NCT02937389
- Testing
- Patients after esophagectomy
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Nagasaki University
Locally Advanced and Recurrent/Metastatic Gastric Cancer
Paclitaxel-HDFL for Locally Advanced and Recurrent/Metastatic Gastric Cancers
The purpose of this study is to evaluate the efficacy,response rate,time to treatment failure,overall survival,toxicities of Paclitaxel-HDFL regimen in locally advanced/inoperable and recurrent/metastatic gastric cancers.
- Trial name
- NCT00154726
- Testing
- Paclitaxel-HDFL
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Obesity
Comparison of Two Surgical Techniques for Treatment of Type III Obesity (BMI 40-50 kg/m2): Single Anastomosis Duodenoileal Bypass With Sleeve Gastrectomy and Roux-en-Y Gastric Bypass.
Roux-en-Y gastric bypass (RY-GBP) is one of the surgical techniques most widely used for the treatment of obesity. Long series of operated patients published in the literature have demonstrated its safety and efficacy.
- Trial name
- BYPSADIS (NCT06789965)
- Testing
- SADI-S, RY-GBP
- Where
- Spain
- Volunteers
- 450 people
- Sponsor
- Hospital Clinic of Barcelona
Morbid Obesity
An Evaluation of the Outcomes of Bariatric Surgery - a Cohort Study
A prospective bariatric database was carried out in the Department of Digestive and Endocrine Surgery at the University Hospital of Strasbourg, France, starting in January 1996.
- Trial name
- ChirBar (NCT02811900)
- Testing
- Roux en Y gastric bypass, Sleeve gastrectomy, Gastric banding
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- IHU Strasbourg
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