Clinical trials: Gastric Symptoms
Gastroparesis
Ultrasound Assessment of Gastric Contents in Fasted Patient Undergoing Cholecystectomy
Investigators assess the gastric contents by ultrasonography in fasted patients undergoing cholecystectomy.
- Trial name
- NCT03259841
- Testing
- Ultrasound assessment of gastric contet
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- SMG-SNU Boramae Medical Center
Spinal Bupivacaine/Morphine in Laparoscopic Surgery
Spinal Bupivacaine/Morphine in Laparoscopic Gastro-intestinal Surgery
The objective of this study is to determine if a single spinal shot of morphine can decrease post-operative opioid-use, and thereby decrease opioid side-effects and lead to a quicker recovery after surgery.
- Trial name
- Salmon (NCT02284282)
- Testing
- Spinal injection bupivacaine/morphine, subcutaneum injection lidocaine
- Where
- Netherlands
- Volunteers
- 56 people
- Sponsor
- Maasstad Hospital
Critical Illness, Surgery
Gastric US in ICU Patient
This is a case series study using gastric ultrasound in critically ill patients to quantify gastric residual volumes to compare the efficacy of different NPO protocols.
- Conditions
- Critical Illness, Surgery, Aspiration Pneumonia
- Trial name
- NCT05526105
- Testing
- Gastric Ultrasound
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chronic Use of Acid Suppressive Medication, GORD
On-Demand Use of Pantoprazole: Determinants for Chronic Use of Acid Suppressive Medication
The purpose of this study is to investigate several aspects of chronic use of acid suppressing medication: dependence on maintenance therapy, the possibilities for on-demand use, and predictors (patient characteristics) for daily…
- Conditions
- Chronic Use of Acid Suppressive Medication, GORD, GERD, Reflux
- Trial name
- NCT00161096
- Testing
- pantoprazole 20 mg (drug)
- Volunteers
- 276 people
- Sponsor
- UMC Utrecht
Bariatric Surgery, Weight Loss
The Banded Mini Gastric Bypass Trial: A Prospective Randomized Controlled Trial
Rationale: Investigate if there is a significant weight reduction expressed in total body weight loss percentage (%TBWL) in patients 5 years after surgery, whom underwent a mini gastric bypass (MGB-OAGB) with addition of the…
- Conditions
- Bariatric Surgery, Weight Loss, Comorbidities and Coexisting Conditions
- Trial name
- RiMini (NCT05472922)
- Testing
- Placement of MiniMizer Gastric Ring, Normal MGB-OAGB
- Where
- Netherlands
- Volunteers
- 210 people
- Sponsor
- Marc van Det
Morbid Obesity
Comparison of Gastric Bypass and Sleeve Gastrectomy in Metabolic and Cardiovascular Indices
Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery.
- Trial name
- NCT03851874
- Testing
- Bariatric surgery
- Volunteers
- 28 people
- Sponsor
- National and Kapodistrian University of Athens
Gastro-Intestinal Disorder
Effect of Palatable Lidocaine Gel on Gag Reflex for Patients Undergoing Upper Gastrointestinal Endoscopy
The development of upper gastrointestinal endoscopy (UGIE) has greatly expanded the diagnostic and therapeutic capabilities of gastroenterologists.
- Trial name
- NCT04213833
- Testing
- Propofol Injection [Diprivan], Dexmedetomidine [Precedex], Palatable Lidocaine Topical Gel
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Zagazig University
Esophageal Cancer, Gastric Cancer
Use of Cetuximab for Unresectable or Metastatic Esophageal and Gastric Cancer
Purpose: There remains a great need for novel therapeutic agents and treatment strategies for advanced esophagogastric cancer. Preclinical and clinical studies have demonstrated increased EGFR expression in a significant…
- Conditions
- Esophageal Cancer, Gastric Cancer, Neoplasm Metastasis
- Trial name
- NCT00130689
- Testing
- Cetuximab
- Where
- 4 sites in United States
- Volunteers
- 43 people
- Sponsor
- Dana-Farber Cancer Institute
Obesity
Endostapler Gastric Bypass Study
The goal of this prospective, post-market study is to evaluate safety and efficacy of the AEON™ Endostapler when used in laparoscopic Roux-en-Y gastric bypass surgery.
- Trial name
- NCT04712526
- Testing
- AEON Endostapler
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Lexington Medical Inc.
Gastroparesis, Diabetic Gastroparesis
Gastroparesis Registry 2
To expand a registry of patients for the study of the epidemiology, etiology, and degree of morbidity associated with gastroparesis.
- Conditions
- Gastroparesis, Diabetic Gastroparesis, Idiopathic Gastroparesis
- Trial name
- GpR2 (NCT01696747)
- Where
- 6 sites in United States
- Volunteers
- 506 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Gastroparesis
A Study to Assess the Effect of Repeat Doses of GSK962040 on the Pharmacokinetics of L-DOPA in Subjects With Parkinson's Disease Exhibiting Delayed Gastric Emptying
Gastric emptying is the end-result of a complex and carefully regulated series of events which follow the ingestion of a meal, each of which is dependent on the other and subject to neurohormonal control.
- Trial name
- NCT01602549
- Testing
- GSK962040 (25 mg tablet)
- Where
- 11 sites in Australia, Germany and 2 more
- Volunteers
- 58 people
- Sponsor
- GlaxoSmithKline
Obesity, Gallstones
Obeticholic Acid in Bariatric and Gallstone Disease
By binding to the nuclear receptor FXR, bile acids not only regulate their own turn-over but presumably also pivotal steps in cholesterol, triglyceride and glucose metabolism as shown in laboratory animals.
- Trial name
- OCABSGS (NCT01625026)
- Testing
- Obeticholic acid
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Advanced Gastric Carcinoma
Prospective Study on Double-Stapling End-to-End Gastroduodenostomy Billroth-I Anastomosis in Laparoscopy-Assisted Surgery for Locally Advanced Distal Gastric Cancers
The purpose of this study is to explore the clinical application value of Double-Stapling End-to-End Gastroduodenostomy Billroth-I Anastomosis in Laparoscopy-Assisted Surgery for Locally Advanced Distal Gastric Cancers.
- Trial name
- NCT05545293
- Where
- China
- Volunteers
- 100 people
- Sponsor
- West China Hospital
Gastroparesis, Diabetic Gastroparesis
Daily Tadalafil and Gastric Emptying Time in Diabetic Gastroparesis
The investigators hypothesize that in adult patients with diabetic gastroparesis with Type 1 diabetes (HbA1c ≤ 10.5%), daily tadalafil use will significantly improve gastric emptying compared to baseline as measured by gastric…
- Conditions
- Gastroparesis, Diabetic Gastroparesis, Nausea, Vomiting
- Trial name
- NCT01326117
- Testing
- tadalafil
- Where
- United States
- Sponsor
- Mark Feinglos
Metastatic or Recurrent Gastric Adenocarcinoma
Envafolimab Combined With Chemotherapy in Metastatic or Recurrent Gastric Adenocarcinoma
The objective is to investigate the efficacy and safety of Envafolimab combined with chemotherapy in the treatment of metastatic or recurrent gastric adenocarcinoma.
- Trial name
- NCT05237349
- Testing
- Envafolimab, Oxaliplatin, S1
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Liangjun Zhu M.M.
Jaundice, Obstructive
Endoscopic Access Loop With Bilio-enteric Anastomosis: A Prospective Randomized Comparison Between Gastric and Subcutaneous Accesses
Roux-en-Y hepaticojejunostomy is the standard procedure used by most hepatobiliary surgeons for biliary reconstruction following iatrogenic bile duct injury, benign and malignant CBD strictures, choledochal cysts and biliary…
- Trial name
- NCT03252379
- Testing
- hepaticojejunostomy, modified hepaticojejunostomy with subcutaneous access loop, modified hepaticojejunostomy with gastric access loop
- Volunteers
- 30 people
- Sponsor
- Assiut University
Stomach Cancer
Effect of Mosapride Citrate on Gastrointestinal Motility After Laparoscopic Gastrectomy
"Mosapride citrate is a 5-hydroxytryptamine 4 receptor agonist, and is widely used as an agent to increase intestinal motility. Mosapride citrate has been demonstrated in in vitro and in vivo studies to increase both gastric and…
- Trial name
- NCT04493125
- Testing
- Mosapride citrate
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Gangnam Severance Hospital
Obesity, Severe Obesity
Prospective Study of an Explainable AI Tool to Support Biliopancreatic Limb Selection in One-Anastomosis Gastric Bypass
This prospective observational cohort study will develop and externally validate a human-supervised, explainable artificial-intelligence decision-support model for analysing factors associated with biliopancreatic limb length…
- Conditions
- Obesity, Severe Obesity, Metabolic Disease
- Trial name
- JI-AI-OAGB (NCT07818317)
- Testing
- One-anastomosis gastric bypass with observed biliopancreatic limb length
- Where
- Kazakhstan
- Volunteers
- 120 people
- Sponsor
- The Society of Bariatric and Metabolic Surgeons of Kazakhstan
Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma
First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors
A multicenter, single-arm, first-in-human study to investigate the safety, pharmacokinetics, and preliminary antitumor activity of PLX-61639 in participants with locally advanced or metastatic, relapsed/refractory…
- Conditions
- Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Gastric Squamous Cell Carcinoma, Gastroesophageal Junction (GEJ) Adenocarcinoma
- Trial name
- NCT07284186
- Testing
- PLX-61639
- Where
- 10 sites in United States
- Volunteers
- 155 people
- Sponsor
- Plexium, Inc.
Esophageal Cancer, Nutrition Disorders
Gastrointestinal Nutrient Transit and Enteroendocrine Function After Upper Gastrointestinal Surgery
The incidence of oesophagogastric cancer has increased by 400% since the 1970s in Ireland and the United Kingdom. In addition, refinement of perioperative management and the now widespread use of multimodal protocols for patients…
- Conditions
- Esophageal Cancer, Nutrition Disorders, Appetite Disorders, Dumping Syndrome
- Trial name
- EndoGut (NCT03734627)
- Testing
- Octreotide Acetate, Saline Solution, Paracetamol
- Where
- 2 sites in Ireland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
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