Clinical trials: Gastric Symptoms
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Gastroparesis, Diabetes Mellitus
Safety and Efficacy of IV Infusion of Investigational Agent (TZP-101) in Patients With Severe Diabetic Gastroparesis
The purpose of this study is to determine whether TZP-101 is effective in the treatment of symptomatic gastroparesis due to diabetes.
- Trial name
- NCT00612014
- Testing
- 5% dextrose in water, TZP-101
- Where
- 12 sites in United States, Denmark and 4 more
- Volunteers
- 78 people
- Sponsor
- Tranzyme, Inc.
Gastric Cancer (GC), Gastric Cancer (Diagnosis)
The Application of Extracellular Vesicle Detection in Gastric Juice Based on Metamaterial Sensing in the Diagnosis of Gastric Cancer and Related Diseases
After obtaining informed consent from the patients, all the medical history and treatment records of the patients who underwent gastroscopy since the onset of the disease, as well as gastric fluid samples, including laboratory…
- Trial name
- NCT07332104
- Testing
- In vitro surface plasmon resonance detection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Beijing Friendship Hospital
Triple-Negative Breast Cancer (TNBC), Gastric Cancer (GC)
A Study of MDSY-1240, a STAT3 Degrader, for the Treatment of Hematologic Malignancies and Advanced Solid Tumors
This clinical trial is evaluating a drug called MDSY-2140 in participants with hematologic malignancies and advanced solid tumors.
- Conditions
- Triple-Negative Breast Cancer (TNBC), Gastric Cancer (GC), Gastric Cancer Adenocarcinoma Metastatic, Ovarian Cancer Metastatic
- Trial name
- NCT07899632
- Testing
- MDSY-1240
- Volunteers
- 75 people
- Sponsor
- Medsyn Biopharma, LLC
Gastric or Gastro-esophageal Junction (GEJ) or Esophageal Adenocarcinoma (EAC)
NT-I7 in Combination With Nivolumab in Advanced Gastric, Gastro-Esophageal Junction or Esophageal Adenocarcinoma
The main purposes of the dose escalation part of this study is to determine the following in participants with gastric or gastro-esophageal junction (GEJ) or esophageal adenocarcinoma (EAC): Safety and tolerability of NT-I7 in…
- Trial name
- NCT04594811
- Testing
- NT-I7, Nivolumab
- Where
- 6 sites in United States, Poland
- Volunteers
- 10 people
- Sponsor
- NeoImmuneTech
Gastric Cancer
The Relationship Between Microsatellite Instability and Efficacy of Fluorouracil Based Adjuvant Chemotherapy in Gastric Cancer After Operation
The relationship between Microsatellite instability and efficacy of fluorouracil based adjuvant chemotherapy in gastric cancer after operation.
- Trial name
- NCT03485196
- Testing
- Microsatellite instability
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Affiliated Hospital of Qinghai University
Severe Obesity
Comorbidity After Gastric Bypass
To evaluate effect on comorbid disease and weight loss in the long-term (>five years) after Roux-en-Y gastric bypass (RYGB) surgery for severe obesity.
- Trial name
- NCT02710786
- Testing
- Gastric bypass
- Where
- Sweden
- Volunteers
- 25,000 people
- Sponsor
- Uppsala University
Stomach Neoplasms
Study of Continuous or Intermittent S-1 Combined With Oxaliplatin in Recurrent or Metastatic Gastric Carcinoma
Randomized phase II study designed to evaluate the efficacy and safety of continuous S-1 plus oxaliplatin versus intermittent S-1 plus oxaliplatin as first-line therapy in patients with recurrent and/or metastastic gastric…
- Trial name
- NCT00515190
- Testing
- S-1,oxaliplatin
- Where
- South Korea
- Volunteers
- 198 people
- Sponsor
- National Cancer Center, Korea
Diabetes Mellitus, Diabetes Mellitus Complications
Phase 2 Study to Evaluate Safety & Efficacy of RM-131 Administered to Patients With Diabetic Gastroparesis
The purpose of this study is to evaluate the effects of RM-131 on gastric emptying, gastroparesis symptoms, and the safety and tolerability of RM-131 compared to placebo in patients with Type 1 and Type 2 diabetes mellitus and…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus Complications, Gastroparesis
- Trial name
- NCT01571297
- Testing
- RM-131
- Where
- 30 sites in United States
- Volunteers
- 204 people
- Sponsor
- Motus Therapeutics, Inc.
Obesity, Body Weight
Endoscopic Suturing for Primary Obesity Treatment
Gastric restriction is an important principle of both roux-en-Y gastric bypass and laparoscopic adjustable gastric banding. The FDA cleared OverStitch Endoscopic Suturing System (Apollo Endosurgery, Austin, TX) offers the…
- Conditions
- Obesity, Body Weight, Overweight
- Trial name
- PROMISE (NCT01662024)
- Testing
- Endoscopic gastric restrictive procedure
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Aspiration of Gastric Contents
A Multicentre Preoperative Fasting Audit
The new European Society of Anaesthesiology and Intensive Care (ESAIC) preoperative fasting guideline recommends a one hour minimum fasting time for clear fluids.
- Trial name
- EUROFAST (NCT05519969)
- Where
- Sweden
- Volunteers
- 307,162 people
- Sponsor
- Uppsala University
Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
Metabolic Surgery for Atrial Fibrillation Elimination
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030.
- Trial name
- METSAFE (NCT07027969)
- Testing
- Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ali Aminian
Obesity, Morbid
Effectiveness Gastric Balloon in Obese Adolescents
Assess the effectiveness of utilization of endoscopically placed intra-gastric balloon in obese and morbid obese adolescents combined with behavioral support for weight loss and health optimization.
- Trial name
- NCT04209842
- Testing
- gastric balloon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Morbid Obesity
Long-term Adverse Effects After Bariatric Surgery on Bone Density
The goal of this trial is to examine long-term effects of laparoscopic gastric bypass (LRYGB) and sleeve gastrectomy (LSG) on bone mineral density, fracture risk, and body composition ≥ 5 years post-surgery.
- Trial name
- FUB-A (NCT03410459)
- Testing
- DEXA (= Dual-energy x-ray absorptiometry)
- Where
- Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Gastrointestinal Stromal Tumors
WB-DWI for Early Prediction of Therapy Response in Patients With Advanced Metastatic GIST Treated With Regorafenib
The purpose of this study is to evaluate WB DWI as early predictor of response to treatment with regorafenib or placebo in patients with advanced metastatic GIST.
- Trial name
- NCT01265979
- Testing
- Whole body diffusion MRI
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Diabetes Mellitus Typ 2 and Obesity
Mechanisms Behind Antidiabetic Effects by Gastric By-pass
The aim of the study is to develop new strategies in treatment of continuous increasing number of patients with type 2 diabetes by understanding how bariatric surgery cures or improves this condition.
- Trial name
- NCT01708096
- Testing
- Modifast, Normal diet
- Where
- 2 sites in Sweden
- Volunteers
- 15 people
- Sponsor
- Karolinska Institutet
Obesity, Morbid Obesity
Study of Weight Loss Using Gastric Stimulation in Obese Patients
The purpose of this study is to test the effect of an implanted device that stimulates the stomach to help obese patients lose weight.
- Trial name
- SHAPE (NCT00200083)
- Testing
- Transcend II Model 8848
- Where
- 8 sites in United States
- Volunteers
- 190 people
- Sponsor
- MedtronicNeuro
Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IVA Gastric Cancer AJCC v8
PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer
This phase I trial studies the side effects of pressurized intraperitoneal aerosol chemotherapy (PIPAC) in treating patients with ovarian, uterine, appendiceal, stomach (gastric), or colorectal cancer that has spread to the…
- Conditions
- Clinical Stage IV Gastric Cancer AJCC v8, Clinical Stage IVA Gastric Cancer AJCC v8, Clinical Stage IVB Gastric Cancer AJCC v8, Malignant Uterine Neoplasm
- Trial name
- NCT04329494
- Testing
- Biopsy, Cisplatin, Doxorubicin
- Where
- 3 sites in United States
- Volunteers
- 49 people
- Sponsor
- City of Hope Medical Center
Cap-assisted Endoscopy, Upper Gastro Intestinal Bleeding
Is Cap Assisted Endoscopy Useful in Acute Upper Gastrointestinal Bleeding ?
High digestive bleeding (HDH) is a medical emergency associated with high morbidity and mortality rates and significant healthcare costs. Upper endoscopy can locate the bleeding and treat it.
- Conditions
- Cap-assisted Endoscopy, Upper Gastro Intestinal Bleeding, Endoscopy
- Trial name
- CAP (NCT07268365)
- Testing
- upper endoscopy, CAP
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Morbid Obesity
Bariatric Procedures and Changes in Incretins and Gastric Emptying
The study evaluates the gastric emptying by scintigraphy in patients that had bariatric surgery (RYGB of gastric sleeve) comparing patients with successful and unsuccessful weight loss and in patients before and after the…
- Trial name
- BIG (NCT02539641)
- Testing
- Gastric emptying scintigraphy, Determination of gut hormones
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- Rijnstate Hospital
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