Clinical trials: Gastric Symptoms
Gastroesophageal Reflux Disease, Hiatal Hernia
Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication
Laparoscopic fundoplication is the standard operation for gastroesophageal reflux disease (GERD) that does not respond adequately to medication, and it relieves reflux symptoms in most patients who are carefully selected for it.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Esophagitis, Peptic, Barrett Esophagus
- Trial name
- NCT07809620
- Testing
- Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication
- Where
- Egypt
- Volunteers
- 470 people
- Sponsor
- Minia University
Gastric Emptying, Gastroparesis
Gastric Emptying Recovery After GLP-1 RA Cessation
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) can delay gastric emptying and may increase residual gastric contents before general anesthesia.
- Conditions
- Gastric Emptying, Gastroparesis, Preoperative Care
- Trial name
- NCT07360262
- Testing
- Preoperative gastric ultrasound
- Where
- 2 sites in South Korea
- Volunteers
- 186 people
- Sponsor
- Wonkwang University Hospital
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma
Camrelizumab in Combination With Apatinib in Refractory and Relapsed DLBCL
This study will evaluate the efficacy and safety of camrelizumab in combination with apatinib in in patients with relapsed or refractory diffuse large B cell lymphoma failed from second line chemotherapy.
- Conditions
- Diffuse Large B Cell Lymphoma, High-grade B-cell Lymphoma, Follicular Lymphoma Grade IIIb, Transformed Lymphoma
- Trial name
- NCT04476459
- Testing
- Camrelizumab, Apatinib
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Huiqiang Huang
Obesity
PRebiotic to IMprovE Calcium Absorption
Gastric bypass surgery is a highly effective treatment for obesity, but it has negative effects on skeletal health, due in part to a dramatic decline in intestinal calcium absorption capacity.
- Trial name
- PRIME (NCT03272542)
- Testing
- Prebiotic: soluble corn fiber
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- San Francisco Veterans Affairs Medical Center
Obesity
MGB/OAGB Versus RYGB After Failed Sleeve
Sleeve Gastrectomy is the most performed bariatric procedure worldwide. But a growing number of data documents that some patients have to be surgical revised due to weight regain or gastro-esophageal reflux disease.
- Trial name
- NCT03526783
- Testing
- Roux en Y gastric bypass, Mini/One anastomosis gastric bypass
- Where
- Germany
- Volunteers
- 55 people
- Sponsor
- Sana Klinikum Offenbach
Non-Erosive Gastro-Esophageal Reflux Disease, Heartburn
A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo for Relief of Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease (NERD)
The primary objectives of this study are to assess the efficacy of vonoprazan (10 mg and 20 mg once daily [QD]) compared to placebo (QD) in relief of heartburn over 4 weeks in participants with NERD.
- Trial name
- NCT05195528
- Testing
- Vonoprazan
- Where
- 108 sites in United States
- Volunteers
- 776 people
- Sponsor
- Phathom Pharmaceuticals, Inc.
Morbid Obesity
Cost-Effectiveness and Outcome of Robot-assisted Vs Laparoscopic Roux-en-Y Gastric Bypass
The objective of this randomized controlled trial is to compare perioperative outcomes between laparoscopic and robotic approaches in patients with severe obesity who are candidates for RYGB.
- Trial name
- LvRRYGB (NCT07153419)
- Testing
- Laparoscopic and robotic (DaVinci) RYGB
- Where
- Italy
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity
Weight Loss Following Gastric Bypass or Sleeve Surgery
The overall aim is to study the multiple factors determining the variation of weight loss after Roux-en-Y Gastric Bypass (RYGB) and Sleeve surgery.
- Trial name
- NCT02070081
- Testing
- Roux-en-Y gastric bypass surgery or sleeve surgery
- Where
- Denmark
- Volunteers
- 55 people
- Sponsor
- University of Copenhagen
Diabetes, Gastric Content Aspiration
Effects of GLP-1 Agonists on Gastric Volume
This study will enroll patients ages 18 and over who have a diagnosis of diabetes, are undergoing an elective surgery under general anesthesia and 1) are taking a GLP-1 receptor agonist medication, or 2) not taking a GLP-1…
- Conditions
- Diabetes, Gastric Content Aspiration, Glucagon-like Peptide 1, GLP-1
- Trial name
- NCT05854979
- Testing
- Gastric Ultrasound
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Medical University of South Carolina
Gastritis, Indigestion, Helicobacter Pylori Infection, Gastric Cancer, Peptic Ulcer
Efficacy Comparison of Vonoprazan Combined With Different Antibiotics in Dual Therapy for Helicobacter Pylori Eradication: A Prospective, Randomized Controlled Clinical Trial
This study aims to evaluate the efficacy of vonoprazan combined with different antibiotics in dual therapy for Helicobacter pylori eradication treatment.
- Trial name
- NCT07068607
- Testing
- Vonoprazan, Tetracycline 500mg tid, Minocycline
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yongquan Shi
Obesity, Obesity, Morbid
Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss
The Investigators propose suture plication placement at the distal gastric body drives a significant portion of weight loss in endoscopic sleeve and sutures only need to be placed in the distal gastric body.
- Conditions
- Obesity, Obesity, Morbid, Metabolic Disease, Weight, Body
- Trial name
- NCT06299644
- Testing
- Endoscopic Sleeve Gastroplasty - Belt and Suspenders, Endoscopic Sleeve Gastroplasty - Belt
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Brigham and Women's Hospital
Gastroparesis
Gastric Electrical Stimulation (GES) and Pyloroplasty for the Treatment of Gastroparesis
Gastroparesis (GP) is describing a condition when stomach does not empty as fast as it should. This fact creates the situation, when food stays in the stomach for a long time and it causes symptoms of nausea, vomiting, loss of…
- Trial name
- GES+PP (NCT03123809)
- Testing
- Gastric Electrical Stimulation (GES) System
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Morbid Obesity
Semaglutide Given Before and After Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass for Recurrent Weight Gain
Recurrent weight gain affects 15% to 40% of patients after metabolic and bariatric surgery (MBS). SG is the most performed operation worldwide, and long-term regain after SG is well documented.
- Trial name
- NCT07859163
- Testing
- Semaglutide weekly injection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- General Committee of Teaching Hospitals and Institutes, Egypt
Obesity, Morbid, Obesity and Overweight
Identification of Pre-surgical Phenotypic Indicators Predictive of Quality of Life Trajectories in Obese Patients Following Bariatric Surgery
This study aims to identify pre-operative phenotypic determinants predictive of quality of life trajectories in post-bariatric surgery patients.
- Conditions
- Obesity, Morbid, Obesity and Overweight, Bariatric Surgery, Bariatric Surgery Patients
- Trial name
- PHENOBEQOL73 (NCT06951893)
- Testing
- Hospital Anxiety and Depression Scale, Dutch Eating Behaviour Questionnary, Impact of Weight on Quality Of Life
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Diabetes Mellitus
Effect of 10mg Domperidone on Gastric Emptying of a High-fat Meal and Appetite Sensations in Healthy Adults
The purpose of this study is to determine whether domperidone was sufficient to accelerate gastric emptying of a high-fat solid meal and reduce satiety responses in a healthy adult population.
- Trial name
- NCT01347814
- Testing
- Domperidone 10mg
- Where
- Ireland
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Obesity, Over Weight
Endoscopic Suturing of the Gastric Pylorus to Delay Gastric Emptying and Treat Obesity
The purpose of this study is to demonstrate the efficacy and safety of endoscopic suturing of the gastric pylorus to delay gastric emptying and treat obesity.
- Trial name
- NCT02191501
- Testing
- Pyloric restriction
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Northwell Health
Digestive System Disorder, Dyspepsia
Domperidone in Treating Patients With Gastrointestinal Disorders
This phase III trial studies how well domperidone works in treating patients with gastrointestinal disorders. Domperidone may help control chronic gastrointestinal disorders and their symptoms, such as pain, bloating, and nausea…
- Conditions
- Digestive System Disorder, Dyspepsia, Esophagitis, Gastroesophageal Reflux Disease
- Trial name
- NCT01696734
- Testing
- Domperidone, Questionnaire Administration
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- M.D. Anderson Cancer Center
Lung Neoplasms, Pancreatic Neoplasms
Diagnosis of Multiple Cancer and Monitoring of Minimal Residual Tumors After Treatment Using Blood and High-Sensitivity Genetic Analysis Techniques
This is a combined prospective and retrospective observational study aiming to validate a highly sensitive and specific blood-based method for the early diagnosis and post-treatment monitoring of multiple cancers.
- Conditions
- Lung Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Esophageal Neoplasms
- Trial name
- NCT07035587
- Testing
- Serial Blood Sampling for Molecular Profiling, One-Time Blood Sampling for Molecular Profiling
- Where
- South Korea
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Incretin Action, Obesity
Oxyntomodulin, Mechanisms of Action in Relation to Appetite, Food Intake, Gastric Emptying and Energy Expenditure.
Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism.
- Trial name
- NCT01232244
- Testing
- GLP-1 infusion, Glucagon infusion, Oxyntomodulin infusion
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen