Clinical trials: Gastric Symptoms
Gastroparesis
Study Evaluating the Effect of TC-6499 on Gastric Emptying Time in Diabetic Subjects With Gastroparesis
Gastroparesis, also referred to as delayed gastric emptying, is a debilitating, chronic disorder that slows or stops the passage of food from the stomach to the small intestine.
- Trial name
- NCT02187094
- Testing
- TC-6499
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- Targacept Inc.
Cancer
Aminocamptothecin in Treating Patients With Advanced Cancer of the Peritoneal Cavity
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of aminocamptothecin in treating patients with advanced…
- Trial name
- NCT00003548
- Testing
- aminocamptothecin colloidal dispersion
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Grade III Obesity, Type 2 Diabetes Mellitus
Metabolic Changes After Bariatric Surgery
Literature data clearly demonstrate that treatment of obese patients is very expensive, long and achieve weight loss may not be permanent, and regardless of whether the treatment dominated diet therapy, physical activity, or…
- Trial name
- NCT02893891
- Testing
- Laparoscopic sleeve gastrectomy, Laparoscopic gastric plication, Intragastric balloon
- Where
- 2 sites in Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Ostrava
Gastric Cancer
Systemic Oxidative Stress Score as a Predictor of Gastric Cancer Survival and Recurrence Risk
The Systemic Oxidative Stress Score (SOSS) , a comprehensive score reflecting the oxidative stress conditions in the microenvironment, can independently and effectively predict tumor burden and long-term prognosis in GC patients.
- Trial name
- NCT06337279
- Where
- China
- Volunteers
- 3,820 people
- Sponsor
- Fujian Medical University
Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer
Symptom Control With or Without Docetaxel in Treating Patients With Relapsed Esophageal Cancer or Stomach Cancer
RATIONALE: Analgesics, antiemetics, steroids, and radiation therapy are effective in helping to control symptoms caused by cancer.
- Conditions
- Adenocarcinoma of the Gastroesophageal Junction, Esophageal Cancer, Gastric Cancer, Nausea and Vomiting
- Trial name
- NCT00978549
- Testing
- docetaxel, steroid therapy, questionnaire administration
- Where
- 8 sites in United Kingdom
- Volunteers
- 320 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
PCOS, Semaglutide
The Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity
The purpose of the study is to explore the effects of GLP-1 receptor agonist (GLP-1 RA) semaglutide on modulation of taste sensitivity, tongue tissue transcriptome, modulation of neural response in central reward processing…
- Conditions
- PCOS, Semaglutide, Taste, Altered, Tongue Tissue Transcriptome
- Trial name
- NCT04263415
- Testing
- Semaglutide
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Obesity
Incretin Physiology and Beta-cell Function Before and After Weight-loss
To evaluate the impact of laparoscopic adjustable gastric banding (LAGB) on beta-cell function, insulin sensitivity, incretin function, postprandial secretion of incretin hormones (glucagon-like peptide-1 (GLP-1) and…
- Trial name
- NCT00625040
- Testing
- Oral glucose tolerance test (OGTT), isoglycemic iv. clamp, liquid meal test, gastric emptying rate
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Obesity, Metabolic Disease
Conventional Vs Tailored Limb Lengths in Laparoscopic Roux-en Y Gastric Bypass Surgery
The study aims to investigate whether tailoring limb lengths based on the 1/3rd and 2/3rd concept improves clinical outcomes in Laparoscopic Roux-en-Y Gastric Bypass (LRYGB) surgery compared to conventional limb lengths.
- Conditions
- Obesity, Metabolic Disease, Bariatric Surgery Candidate, Metabolic Surgery
- Trial name
- TAILO-R-YGB (NCT06756789)
- Testing
- Laparoscopic Roux-en Y Gastric bypass (RYGB)- Conventional approach, Laparoscopic Roux-en Y Gastric bypass (RYGB)- Tailored approach
- Where
- India
- Volunteers
- 40 people
- Sponsor
- GEM Hospital & Research Center
Diabetes Mellitus, Type 2, Insulin Resistance
Treatment of Type 2 Diabetes Mellitus by Duodenal Exclusion Associated With Omentectomy: Clinical and Hormonal Study
Based in a surgery technique studied in a non-obese diabetic mouse model by Rubino and Marescaux(2004), wich reversed diabetes in those animals, we have performed a previous study in human volunteers with type 2 diabetes and…
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Obesity
- Trial name
- NCT00566215
- Testing
- Duodenal exclusion plus omentectomy, Duodenal exclusion without omentectomy
- Where
- Brazil
- Volunteers
- 6 people
- Sponsor
- University of Campinas, Brazil
Morbid Obesity
Impact of Resected Gastric Volume on Postoperative Weight Loss After Laparoscopic Sleeve Gastrectomy for Morbid Obesity
Impact of resected gastric volume on postoperative weight loss after laparoscopic sleeve gastrectomy for morbid obesity. Observational study with a mathematical method to approximate the calculation of the resected gastric volume…
- Trial name
- NCT03938025
- Testing
- Gastric volume resected in sleeve gastrectomy
- Volunteers
- 92 people
- Sponsor
- University of Rome Tor Vergata
Peptic Ulcer Bleeding
Tegoprazan And Lansoprazole Effectiveness in Bleeding Peptic Ulcer Treatment
The goal of this clinical trial is to compare the effects of tegoprazan vs lansoprazole in healing bleeding peptic ulcers. It will also teach about the safety of both modalities.
- Trial name
- TALENT (NCT06894992)
- Testing
- Tegoprazan, Lansoprazole
- Where
- 2 sites in Indonesia
- Volunteers
- 162 people
- Sponsor
- Mario Steffanus
Esophagectomy
Prediction of Anastomotic Leak/Stricture After Esophagectomy With Gastric Pull-up by Venous Blood Gas
Esophageal resection becomes a routine surgical procedure in many medical centers. Usually reconstruction after esophagectomy is achieved by gastric pull-up with cervical or intrathoracic anastomosis.
- Trial name
- NCT02546687
- Testing
- Venous blood sampling
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Anal Cancer, Anxiety Disorder
Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer Either in a Clinical Trial or as Standard Off-Trial Therapy
RATIONALE: Gathering information from patients who received treatment for metastatic cancer while participating in a phase II or phase III randomized clinical trial and from patients receiving standard treatment off-trial may…
- Conditions
- Anal Cancer, Anxiety Disorder, Breast Cancer, Depression
- Trial name
- NCT00896467
- Testing
- questionnaire administration, psychosocial assessment and care, quality-of-life assessment
- Where
- 2 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Oscar Lambret
Obesity
Impact of the Residual Gastric Volume in Laparoscopic Sleeve Gastrectomy's Failure
Obesity is a worldwide health problematic whose incidence is increasing especially in developed countries. The surgical management of this illness consists in different techniques such as Laparoscopic Sleeve Gastrectomy but this…
- Trial name
- GASTROMANCH (NCT01539967)
- Testing
- Laparoscopic Sleeve Gastrectomy
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Gastric Cancer
Escorting Octogenarian for Gastric Cancer Surgery
An objective analysis of postoperative complications is vital to escort octogenarian for gastric cancer surgery. Investigator carefully collected clinical data prospectively to pave way for standard management in high risk…
- Trial name
- NCT03639792
- Testing
- gastric cancer surgery
- Where
- China
- Volunteers
- 61 people
- Sponsor
- Ruijin Hospital
Breast Cancer, Melanoma
Non-Invasive Artificial Intelligence-Based Platform MonIToring Program (NIP IT!)
Patients who have undergone curative treatment may be at risk of relapse. This study will collect, annotate, and sequence biospecimens (blood, stool, and tissue) from patients across different tumor types to detect molecular…
- Conditions
- Breast Cancer, Melanoma, Gastrointestinal Neuroendocrine Tumor
- Trial name
- NIP IT! (NCT05196087)
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University Health Network, Toronto
Stomach Cancer, Pancreatobiliary Cancer
Effects of Red Ginseng on Gastrointestinal Symptoms and Microbiota After Surgery for Gastrointestinal Cancer
After surgery for gastrointestinal cancer (stomach cancer, pancreaticobiliary cancer, colorectal cancer), many patients experiences various symptoms such as weight loss, diarrhea, constipation and excessive gas due to structural…
- Conditions
- Stomach Cancer, Pancreatobiliary Cancer, Colorectal Cancer
- Trial name
- NCT06561516
- Testing
- Arm I (Red ginseng)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Gangnam Severance Hospital
Gastric Cancer (GC), Peritoneal Metastases From Gastric Cancer
Retlirafusp Alfa Plus SOX and Intraperitoneal Nab-Paclitaxel for Advanced Gastric/GEJ Cancer With Malignant Ascites
To evaluate the efficacy and safety of retlirafusp alfa in combination with SOX chemotherapy and intraperitoneal nab-paclitaxel as first-line treatment for advanced gastric/gastroesophageal junction (GC/GEJ) adenocarcinoma with…
- Conditions
- Gastric Cancer (GC), Peritoneal Metastases From Gastric Cancer, Ascites, Malignant
- Trial name
- NCT07855757
- Testing
- Retlirafusp Alfa + SOX + Intraperitoneal Nab-Paclitaxel
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Zhejiang Cancer Hospital
Post-Operative Pain
Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injection for Post-operative Pain Following Gastrectomy
VVZ-149 is a novel analgesic drug candidate that shows a potential analgesic activity inhibiting GlyT2 and 5HT2A simultaneously.
- Trial name
- NCT02522598
- Testing
- VVZ-149 injections
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Vivozon, Inc.
Gastric Cancer, Neoplasm Metastasis
A Study of 5-FU Versus MTX+5-FU in Gastric Cancer With Peritoneal Metastasis
To develop effective chemotherapy regimen against gastric cancer with peritoneal metastasis
- Trial name
- NCT00149201
- Testing
- 5-FU continuous infusion, MTX + 5-FU sequential therapy
- Where
- 34 sites in Japan
- Volunteers
- 160 people
- Sponsor
- Japan Clinical Oncology Group
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