Clinical trials: Gastro-Intestinal Disorders
Ulcerative Colitis
Phosphatidylcholine (LT-02) vs. Placebo vs. Mesalamine for Maintenance of Remission in Ulcerative Colitis (PROTECT-2)
The purpose of this study is to prove the superiority of a 48-weeks treatment with 3.2 g/day delayed-release phosphatidylcholine (LT-02) versus placebo for the maintenance of remission in patients with ulcerative colitis (UC)
- Trial name
- PROTECT-2 (NCT02280629)
- Testing
- LT-02, Mesalamine
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Dr. Falk Pharma GmbH
GERD
Sopran - Omeprazole Treatment Versus Surgery
The purpose of this study is to study gastritis, GI symptoms during long term omeprazole treatment
- Trial name
- NCT00256737
- Testing
- Omeprazole
- Where
- 13 sites in Denmark, Finland and 2 more
- Volunteers
- 219 people
- Sponsor
- AstraZeneca
Head and Neck Neoplasm, Gastrostomy
Endoscopic Direct-PEG Placement in Patients Unable to Undergo Pull-PEG Procedure
Placement of a feeding tube through a gastrostomy can be performed endoscopically or radiologically. While percutaneous endoscopic gastrostomy (PEG) tube placement is most frequently performed using a "pull" technique, this…
- Conditions
- Head and Neck Neoplasm, Gastrostomy, Esophageal Stenosis and Obstruction
- Trial name
- PEG (NCT04151030)
- Testing
- PEG placement
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Kansas City Veteran Affairs Medical Center
Advanced Solid Tumors
Study of Continuous OSI-906 Dosing
Multicenter, open-label, phase 1, cohort dose escalation study to determine the Maximum Tolerated Dose (MTD) on both Once Daily (QD) and Twice Daily (BID) schedules.
- Trial name
- NCT00514007
- Testing
- OSI-906
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 95 people
- Sponsor
- Astellas Pharma Inc
Functional Abdominal Pain, Irritable Bowel Syndrome
Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain
IND application was submitted to FDA on November 17th.
- Conditions
- Functional Abdominal Pain, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- FAP (NCT01269671)
- Testing
- Melatonin, Peppermint Oil (mentharil), and Simethicone, Sugar pill
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Cancer, Neoplasms
A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
This study will investigate OC-001 as monotherapy, and in combination with, Avelumab, in various cancer types
- Conditions
- Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer
- Trial name
- NCT04260802
- Testing
- OC-001, Drug: OC-001 in Combination with Avelumab
- Where
- 5 sites in Canada
- Volunteers
- 73 people
- Sponsor
- Ocellaris Pharma, Inc.
Spinal Cord Injuries, Constipation
Pharmacokinetics of Neostigmine and Glycopyrrolate
A group of 6 able-bodied healthy volunteers will receive Neostigmine (NEO) and Glycopyrrolate (GLY) intravenously and via 2 methods of Iontophoresis (ION): one-patch and two-patch administration, with subsequent blood draws over…
- Conditions
- Spinal Cord Injuries, Constipation, Fecal Incontinence, Neurogenic Bowel
- Trial name
- NCT04027972
- Testing
- Combination of Neostigmine and Glycopyrrolate, I-Box by Dynatronics
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Bladder Cancer, Breast Cancer
Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)
This clinical trial studies the effect of four different intervention components "tools" on body weight, nutrition, and physical activity in cancer survivors.
- Conditions
- Bladder Cancer, Breast Cancer, Colon Cancer, Endometrial Cancer
- Trial name
- TTBF (NCT05056077)
- Testing
- Counseling, Educational Intervention, Health Education
- Where
- United States
- Volunteers
- 353 people
- Sponsor
- University of California, San Francisco
Metastatic Solid Tumor, Advanced Solid Tumor
A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.
- Trial name
- NCT06657144
- Testing
- CHS-114, Toripalimab, 5 Fluorouracil
- Where
- 30 sites in United States, Taiwan
- Volunteers
- 154 people
- Sponsor
- Coherus Oncology, Inc.
Inflammatory Bowel Diseases, Crohn Disease
Prevalence and Factors Associated With Sleep Disorders in Inflammatory Bowel Disease
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC), are an inflammatory disease that can affect the entire digestive tract from the mouth to the anus for CD and the entire colon and…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Sleep Disorder
- Trial name
- SOMMICI (NCT06439641)
- Testing
- Ulcerative colitis Disease Activity Index
- Where
- France
- Volunteers
- 300 people
- Sponsor
- CHU de Reims
Peptic Ulcers, Upper Gastrointestinal Bleeding
High Versus Standard Dose of Proton Pump Inhibitors (PPIs) in Peptic Ulcer Bleeding
High intravenous dosage of Proton Pump Inhibitors is not better than standard dosage in bleeding peptic ulcers successfully treated by endoscopic therapy
- Trial name
- NCT00374101
- Testing
- omeprazole, pantoprazole
- Where
- 10 sites in Italy
- Volunteers
- 450 people
- Sponsor
- Casa Sollievo della Sofferenza IRCCS
Mesenteric Ischemia, Permeability CT Technics
Dynamic Contrast Enhancement Computed Tomography Based Technic to Assess Gastro Intestinal Wall Perfusion : Feasibility Study
This feasibility study has therefore several aims: 1. construct a dedicated CT perfusion protocol for GIT wall perfusion; 2. used a two-compartment pharmacokinetic model which is more adapted that a unique compartment model; 3.
- Trial name
- PERFE-CT (NCT03367065)
- Testing
- Dynamic contrast enhanced computerised tomography
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Poitiers University Hospital
Hand and Foot Syndrome, Erythrodysesthesia Syndrome
Possible Protective Effect of Celecoxib Against Capecitabine Induced Hand and Foot Syndrome in Patients With Colorectal Cancer
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of malignancy-related mortality. Capecitabine has been approved for the treatment of colorectal cancer as first-line therapy.
- Conditions
- Hand and Foot Syndrome, Erythrodysesthesia Syndrome, HFS, Colorectal Cancer
- Trial name
- HFS (NCT05327751)
- Testing
- Celecoxib 200mg, Capecitabine-based chemotherapy
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Colonic Neoplasms
Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer
Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.
- Trial name
- NCT00516230
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Oesophageal Tumour, Gastric Tumours
DESI - Düsseldorfer ESD Study
Safety and effectiveness of endoscopic submucosal dissection
- Conditions
- Oesophageal Tumour, Gastric Tumours, Duodenal Tumours, Colon Tumours
- Trial name
- NCT06993402
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Torsten Beyna
Autism Spectrum Disorder, Autism in Children
Abdominal Transcutaneous Electrical Acupoint Stimulation on Children With Autism Spectrum Disorder
The goal of this clinical trial is to learn if abdominal transcutaneous electrical acupoint stimulation (abdominal TEAS) works to treat autism spectrum disorder (ASD) in children.
- Trial name
- TEAS/ASD (NCT06763237)
- Testing
- abdominal transcutaneous electrical acupoint stimulation (abdominal TEAS)
- Where
- 2 sites in China
- Volunteers
- 42 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Sore Throat, Dysphagia
Laryngeal Mask Airway (LMA) Protector for Minimally Invasive Thyroidectomy
The patients will be allocated to 2 groups: the LMA group and the endotracheal tube (ET) group. Airway management will be done with the LMA Protector for the patients of the LMA group and with the classic endotracheal tube for…
- Conditions
- Sore Throat, Dysphagia, Postoperative Pain
- Trial name
- NCT03098667
- Testing
- LMA Protector, Endotracheal tube
- Where
- Greece
- Volunteers
- 79 people
- Sponsor
- 424 General Military Hospital
Velopharyngeal Insufficiency, Head and Neck Cancer
Velopharyngeal Dysfunction in Head & Neck Cancer Patients, Pilot Study
Some head and neck cancer survivors develop velopharyngeal dysfunction (VPD), a problem with closure between the soft palate and throat that can cause nasal-sounding speech, food or liquid leaking into the nose, difficulty…
- Conditions
- Velopharyngeal Insufficiency, Head and Neck Cancer, Survivorship, Dysphagia
- Trial name
- NCT07264036
- Testing
- Pharyngeal Wall Augmentation Injection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanessa Torrecillas
Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation
Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair
CABA-MiTRA-AFNET12 is a non-commercial, parallel-group, prospective, randomised, open, blinded endpoint assessment (PROBE), multi-centre, therapy strategy trial.
- Trial name
- NCT07380932
- Testing
- Usual Care, Pulmonary Vein Isolation
- Where
- 4 sites in Germany
- Volunteers
- 956 people
- Sponsor
- Atrial Fibrillation Network
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