Clinical trials: Gastro-Intestinal Disorders
Bowel Dysfunction, Helicobacter Pylori Infection
The Clinical Evaluation of Probiotics Product in Patients With Various Functional Bowel Disorders and Helicobacter Pylori Infection
People nowadays tend to have irregular diet and routine due to the stress at work. This condition may cause intestinal microflora imbalance, and in the long term may lead to constipation, diarrhea, gastroenteritis, gastric ulcer…
- Trial name
- NCT04319991
- Testing
- Probiotics product
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Fooyin University
Gastroparesis
Transcutaneous Electroacupuncture for Gastrointestinal Motility Disorders
Gastrointestinal (GI) dysmotility is common in GI motility disorders, such as functional dyspepsia (FD) gastroparesis and chronic constipation.
- Trial name
- TEA (NCT04349891)
- Testing
- Transcutaneous Electroacupuncture
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Idiopathic Parkinson's Disease
Change in Gastrointestinal Complaints After Switch From Oral Parkinson's Disease Treatment to Neupro® Transdermal Patch
The study intends to collect data on gastrointestinal symptoms (swallowing disorders, heartburn, feeling of fullness, nausea, vomiting, abdominal pain, diarrhea) and on patient satisfaction under everyday practice conditions…
- Trial name
- NON-GI (NCT01159691)
- Where
- 21 sites in Germany
- Volunteers
- 76 people
- Sponsor
- UCB Pharma GmbH
Other Gastrointestinal Disorders, Cramp, Abdominal
The Influence of Different Mood States and Emotions on the Physiologic, Metabolic, and Perceptual Responses to Feeding Before Exercise
Many athletes anecdotally report modifying their nutritional intake before competition in order to avoid gut problems, but no studies have evaluated whether emotional state impacts tolerance to pre-exercise feeding.
- Trial name
- NCT05217589
- Testing
- Funny/Amusing Video Clips, Horror/Scary Video Clips, Thrilling/Suspenseful Video Clips
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Old Dominion University
Colorectal Neoplasms, Aged
Effect of Transversus Abdominis Plane Block Combined With Dexmedetomidine Infusion on the Prognosis in Elderly Patients Undergoing Abdominal Surgery
To compare the prognosis of elderly patients undergoing radical resection of colorectal cancer treated with general anesthesia and general anesthesia combined with transversus abdominis plane block and continuous infusion of…
- Trial name
- NCT04516174
- Testing
- Transversus abdominis plane block using ropivacaine, Dexmedetomidine, Transversus abdominis plane block using saline
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing Tiantan Hospital
Eosinophilic Esophagitis
Comparison of Histology From a Mesh Sponge and Traditional Esophageal Biopsies in Children and Adolescents With EoE
The aim of the present study is determining the accuracy, safety and tolerance of the CytospongeTM (expandable sponge within a gelatin capsule attached to a string) relative to traditional upper endoscopy and esophageal biopsies…
- Trial name
- NCT05342168
- Testing
- Using a swallowed expanding sponge (Cytosponge TM) to obtain sampling of the esophageal musosa
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- The Hospital for Sick Children
Peritoneal Surface Malignancy, Postoperative Adhesion
SurgiPerito Trial: High-Purity Type-I Collagen for Peritoneal Reconstruction After Cytoreductive Surgery
This dual-centre, randomized controlled trial evaluates the safety and efficacy of high-purity Type-I collagen-based biomaterial, as a peritoneal substitute following peritonectomy in patients undergoing cytoreductive surgery…
- Conditions
- Peritoneal Surface Malignancy, Postoperative Adhesion, Bowel Obstruction, Wound Complications
- Trial name
- NCT07241091
- Testing
- High-Purity Type-I Collagen Scaffold, Standard Peritonectomy Closure
- Where
- 2 sites in India
- Volunteers
- 60 people
- Sponsor
- Adichunchanagiri Institute of Medical Sciences, B G Nagara
Esophageal Achalasia
POEM vs. Pneumatic Dilation for Esophageal Achalasia
The purpose of this study is to determine the efficacy and safety of peroral endoscopic myotomy (POEM) compared with pneumatic dilation in the treatment of esophageal achalasia.
- Trial name
- NCT01768091
- Testing
- POEM, Pneumatic dilation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Cholestasis
Low Dose Fat for the Prevention of Liver Disease in Babies With Gastrointestinal Disorders
Neonates with congenital/acquired gastrointestinal disorders are at high risk for Parenteral Nutrition Associated Cholestasis (PNAC).
- Trial name
- NCT01373918
- Testing
- Intralipid
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of California, Los Angeles
Confusion Postoperative, Delirium
Preoperative Prognostic Nutritional Index and Postoperative Delirium in Gastrointestinal Cancer Surgery
Aim: We aimed to show the relationship between preoperative prognostic nutritional index and postoperative delirium in patients who had undergone gastrointestinal cancer surgery.
- Conditions
- Confusion Postoperative, Delirium, Gastrointestinal Cancer, Nutritional Deficiency
- Trial name
- NCT06603129
- Testing
- prognostic nutritional index
- Where
- Turkey (Türkiye)
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Colorectal Cancer
Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia
The purpose of this study is to find out whether adding insulin after current colorectal cancer surgery promotes making and keeping proteins in the body, and to find out whether or not this effect can be further increased by…
- Trial name
- NCT02032953
- Testing
- Travasol (amino acid injection), Insulin
- Where
- Canada
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Morbid Obesity
Bioavailability of Paracetamol, Amoxicillin and Talinolol Before, Immediately and One Year After Gastric Bypass Operation
The purpose of this study is to evaluate pharmacokinetics of paracetamol, amoxicillin and talinolol in morbid adipose subjects before as well as shortly after and about one year after proximal Roux-en-Y Gastric Bypass (RYGB) and…
- Trial name
- NCT02514941
- Testing
- paracetamol, amoxicillin, talinolol
- Where
- 2 sites in Germany
- Volunteers
- 12 people
- Sponsor
- University Medicine Greifswald
Head and Neck Cancer, Dysphagia
QUantitative Assessment of Swallowing After Radiation (QUASAR)
To use novel methods for quantitative analysis of VFSS (videofluoroscopic swallow study, also known as modified barium swallow) to study and compare dysphagia in patients treated for head and neck carcinoma with concurrent…
- Conditions
- Head and Neck Cancer, Dysphagia, Oropharyngeal Dysphagia, Oropharynx Cancer
- Trial name
- QUASAR (NCT04359199)
- Testing
- Radiation Therapy, Cetuximab, Chemotherapy
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Loren Mell, MD
Stroke, Swallowing Disorder
The Effects of Neuromuscular Electrical Stimulation on Swallowing Functions in Stroke Patients With Dysphagia
In our study, our aim is to evaluate the effect of neuromuscular electrical stimulation added to traditional dysphagia therapy in stroke patients with dysphagia, on functional oral intake status, dysphagia-related symptoms…
- Conditions
- Stroke, Swallowing Disorder, Dysphagia, Stroke, Complication
- Trial name
- NCT04421937
- Testing
- Procedure: Traditional Dysphagia Therapy (TDT), Procedure: Neuromuscular Electrical Stimulation with TDT
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istanbul University
Domestic Violence
Brief Yoga and Mindfulness for Women Who Have Experienced Domestic Violence
This study aimed to examine the effectiveness of a brief yoga- and mindfulness-based psychoeducation program and its working mechanisms in improving psychological health parameters (depression, anxiety, and stress) among women…
- Trial name
- NCT06061029
- Testing
- Brief Yoga- and Mindfulness-Based Psychoeducation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Istanbul Aydın University
Acid Aspiration Syndrome
Detection of Silent Aspiration Events Utilizing pH/Impedance Probes in Hospitalized Patients
Monitoring and quantification of reflux events in high risk critically ill inpatients and lower risk general medical/surgical inpatients, with comparison to relevant clinical variables.
- Trial name
- NCT02720029
- Testing
- pH/impedance monitor
- Sponsor
- Vanderbilt University
Stoma Ileostomy, Stoma Colostomy
The Effect of Education on Self-Efficacy and Adaptation to Stoma of Individuals With Stoma
The aim of this study is to determine the effect of stoma care training given at home via videoconferencing after discharge on the self-efficacy and compliance with stoma of individuals with stoma.
- Conditions
- Stoma Ileostomy, Stoma Colostomy, Self Efficacy, Adjustment
- Trial name
- NCT05531331
- Testing
- At home education via video conferencing
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ankara University
Stage IV Gastric Carcinoma, Stage IV Nasopharyngeal Carcinoma
PD-1 Knockout EBV-CTLs for Advanced Stage Epstein-Barr Virus (EBV) Associated Malignancies
This study will evaluate the safety of PD-1 knockout EBV-CTL cells in treating EBV (Epstein-Barr virus) positive advanced stage malignancies. Blood samples will also be collected for research purposes.
- Conditions
- Stage IV Gastric Carcinoma, Stage IV Nasopharyngeal Carcinoma, T-Cell Lymphoma Stage IV, Stage IV Adult Hodgkin Lymphoma
- Trial name
- NCT03044743
- Testing
- Fludarabine, Cyclophosphamide, Interleukin-2
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Yang Yang
Gastroesophageal Reflux
Efficacy of Dexlansoprazole MR on Heartburn Control in Participants Previously Receiving Twice Daily Proton Pump Inhibitor Therapy
The purpose of this study is to determine if patients with well-controlled heartburn symptoms on twice-daily proton pump inhibitor therapy remain well-controlled after stepping down to once-daily (QD) dexlansoprazole modified…
- Trial name
- NCT00847808
- Testing
- Dexlansoprazole MR QD
- Where
- 52 sites in United States
- Volunteers
- 178 people
- Sponsor
- Takeda
Head and Neck Cancer, Ovarian Cancer
Deciphering Mechanisms Underlying Cancer Immunogenicity
This trial is a translational, open-label, multicentric, prospective cohort study of 1100 patients aiming to describe the PD-1 (programmed death) expression in T cells (T lymphocytes) in different solid tumors.
- Conditions
- Head and Neck Cancer, Ovarian Cancer, Cervical Cancer, Cervical Intraepithelial Neoplasia 3
- Trial name
- DECIDE (NCT03958240)
- Testing
- Blood samples, tumor biopsy specimens and ascites samples will be collected.
- Where
- 3 sites in France
- Volunteers
- 1,100 people
- Sponsor
- Institut Claudius Regaud
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