Clinical trials: Gastro-Intestinal Disorders
Breast Cancer, Gastric Cancer
Biological Therapy in Treating Patients With Advanced Cancer
RATIONALE: A person's white blood cells mixed with tumor proteins may make the body build an immune response to kill tumor cells.
- Conditions
- Breast Cancer, Gastric Cancer, Ovarian Cancer
- Trial name
- NCT00005956
- Testing
- HER-2/neu intracellular domain protein, therapeutic autologous dendritic cells
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Duke University
Peptic Ulcer, Gastritis
Residual Gastric Volume After the Ingestion of a Beverage Containing Carbohydrates Plus Whey Protein
Carbohydrate enriched-drinks has been used as preoperative treatment up to two hours before anesthesia. These drinks are safe and are not associated to bronchial aspiration during anesthesia.
- Trial name
- NCT01828645
- Testing
- Carbohydrate plus whey protein enriched drink
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of Mato Grosso
Stomach Ulcer
Is Rebamipide Effective on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection?
Treatment strategy of post endoscopic submucosal dissection (ESD) ulcer is not yet conclusive. Rebamipide is a mucosal protective agent widely used in East Asia and has good effect on quality of ulcer healing (QOUH).
- Trial name
- NCT01167101
- Testing
- Rebamipide, pantoprazole
- Where
- South Korea
- Volunteers
- 290 people
- Sponsor
- Kangdong Sacred Heart Hospital
NSAID Associated Gastric Ulcers
Prevention of Gastric Ulcers
Nonsteroidal anti-inflammatory drugs (NSAIDS) are often associated with gastric ulcers. This study looks at the prevention of these gastric ulcers with one of the three following treatment groups for up to 8 weeks: esomeprazole…
- Trial name
- NCT00629512
- Testing
- Esomeprazole
- Volunteers
- 504 people
- Sponsor
- AstraZeneca
Cervical Pain, Posterior, Swallowing Difficulties
Tongue Pressure in Middle-Aged and Elderly Individuals With Chronic Cervical Pain
The goal of the cross-sectional study is to explore the impact of neck pain on tongue pressure in the middle-aged and elderly population and analyze the effects of different cranio-cervical positioning on tongue pressure…
- Conditions
- Cervical Pain, Posterior, Swallowing Difficulties, Swallowing Disorders
- Trial name
- NCT07021586
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Yang Ming Chiao Tung University
Colorectal Cancer, Locally Advanced
QUILT-3.026: AMG 655 in Combination With AMG 479 in Advanced, Refractory Solid Tumors
This is a multi-center, 2-part phase 1b/2 study of AMG 655 in combination with AMG 479 to be conducted in the United States and Spain.
- Conditions
- Colorectal Cancer, Locally Advanced, Metastatic Cancer, Non-Small Cell Lung Cancer
- Trial name
- NCT00819169
- Testing
- AMG 479, AMG 655
- Volunteers
- 89 people
- Sponsor
- NantCell, Inc.
Gastroparesis, Gastroesophageal Reflux Disease
Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis
The purpose of this study is to compare the blood drug levels of two prescribed medications, immediate-release omeprazole 40 mg powder and delayed-release omeprazole 40 mg capsule to determine which drug is better absorbed in…
- Trial name
- NCT00492622
- Testing
- Immediate-release omeprazole, Delayed-release omeprazole
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Louisville
GERD
Endomina Suturing Device as a Treatment of GERD.
Gastroesophageal Reflux Disease (GERD) is a common problem affecting 10-20% of the population in the Western World. Surgical therapy is able to restore the EGJ barrier function against reflux of the gastric content, decreases…
- Trial name
- NCT03999502
- Testing
- Endomina
- Where
- Belgium
- Volunteers
- 15 people
- Sponsor
- Erasme University Hospital
Gastric Cancer, Invasive Breast Cancer
CONFIRM: Magnetic Resonance Guided Radiation Therapy
This research is being done to determine the safety and feasibility of using a type of radiation guided by magnetic resonance imaging (MRI) and chemotherapy to treat patients with gastric and breast cancer.
- Conditions
- Gastric Cancer, Invasive Breast Cancer, in Situ Breast Cancer, Mantle Cell Lymphoma
- Trial name
- CONFIRM (NCT04368702)
- Testing
- Viewray MRIdian® Linac
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Brigham and Women's Hospital
Hereditary Cancer Syndrome
Cell-free DNA in Hereditary And High-Risk Malignancies 1
The goal of this study is to develop an effective, sensitive blood test that can detect early tumours in patients with known or suspected hereditary cancer syndromes (HCS).
- Trial name
- CHARM1 (NCT04261972)
- Testing
- Next generation sequencing (NGS)
- Where
- 7 sites in Canada
- Volunteers
- 1,416 people
- Sponsor
- University Health Network, Toronto
Cerebral Small Vessel Diseases, Dysphagia
Effect of Multifunctional Nutrition Tube on Cerebral Small Vessel Disease Patients
Nasogastric tube feeding (NGT) has been widely used in cerebral small vessel disease (CSVD) patients with dysphagia but has a significant risk of complications.
- Trial name
- NCT06265857
- Testing
- Intermittent Oro-esophageal Tube Feeding, Nasogastric Tube Feeding, comprehensive rehabilitation therapy
- Where
- Thailand
- Volunteers
- 88 people
- Sponsor
- Zeng Changhao
Colorectal Cancer, Familial Adenomatous Polyposis
DNA Adductomics for Colorectal Cancer Investigation
This project seeks to identify DNA-adducts in colon tissue from different groups of patients with CRC scheduled for complete or partial colon resections. Other patients scheduled for resection of the colon serve as controls.
- Conditions
- Colorectal Cancer, Familial Adenomatous Polyposis, Hereditary Non-polyposis Colon Cancer, Lynch Syndrome
- Trial name
- adductomics (NCT04865601)
- Testing
- resectomy of the colon
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hepatitis C, Deglutition Disorders
Bioequivalence Study of Crushed Elbasvir/Grazoprevir Compared to the Whole Tablet
Elbasvir/grazoprevir (Zepatier®) is a once-daily tablet for the treatment of chronic hepatitis C virus (HCV) GT1a, 1b or 4 infection containing the NS5A inhibitor elbasvir (ELB) 50 mg and the NS3/4A protease inhibitor grazoprevir…
- Trial name
- CRUSADE-2 (NCT03817619)
- Testing
- Zepatier whole tablet, Zepatier crushed tablet
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Iron Deficiency Anemia
Capsule Endoscopy vs Standard of Care for Obscure Intestinal Bleeding
The role of capsule endoscopy (CE) in patients with obscure / occult gastrointestinal (GI) bleeding remains unclear. This pragmatic randomized controlled trial is designed to determine the diagnostic yield and clinical outcomes…
- Trial name
- NCT00694954
- Testing
- Diagnostic Test - Given Imaging Pillcam, Diagnostics
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University of Calgary
GERD
Evaluation of Safety and Effectiveness of the RefluxStop Device in the Management of GERD
Prospective, open-label, multi-centre, single arm treatment only trial to evaluate the safety and effectiveness of RefluxStop for the treatment of GERD.
- Trial name
- NCT02759094
- Testing
- Treatment with RefluxStop
- Where
- 4 sites in Hungary, Serbia
- Volunteers
- 50 people
- Sponsor
- Implantica CE Reflux Ltd.
Gastroesophageal Disease
To Determine if Sleep Deprivation Results in Increased Esophageal Acid Exposure
The purpose of this study is to determine if sleep deprivation results in increased esophageal acid exposure in healthy controls and gastroesophageal reflux disease (GERD) patients.
- Trial name
- IRUSESOM0428 (NCT01093339)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Southern Arizona VA Health Care System
Emotions, Rumination
Neural Predictors of Social Emotion Regulation Training
The purpose of this study is to investigate the basic psychological and neural mechanisms underlying the social regulation of emotion - that is, how one person's actions can impact, or regulate - the emotions of another person …
- Trial name
- NCT03487081
- Testing
- Social regulation, Self regulation
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Columbia University
Li Fraumeni Syndrome, Lynch Syndrome
Inherited Cancer Early Diagnosis (ICED) Study
ICED is a prospective sample collection research study, aiming to develop or validate a blood/urine biomarker which could potentially detect cancers early in individuals at high risk of developing cancers, due to certain germline…
- Conditions
- Li Fraumeni Syndrome, Lynch Syndrome, Hereditary Diffuse Gastric Cancer, Cowden Syndrome
- Trial name
- ICED (NCT06163365)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Gastroesophageal Reflux Disease
Diagnostic Value of Flexible Spectral Imaging Color Enhancement (FICE) Plus Probe-based Confocal Laser Endomicroscopy (pCLE) for Minimal Change Esophageal Reflux Disease (MERD) Diagnosis
Gastroesophageal reflux disease (GERD) patients without obvious mucosal break by endoscopy were examined by FICE, followed by confocal. Validity scores for MERD diagnosis were analyzed.
- Trial name
- NCT02336100
- Testing
- Endoscopy (FICE and pCLE)
- Where
- Thailand
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- King Chulalongkorn Memorial Hospital
Non Small Cell Lung Cancer, Breast Cancer
Analysis of PD-L1, TMB, MSI and ctDNA Dynamics to Predict and Monitor Response to Immunotherapy in Metastatic Cancer.
This is an observational clinical trial, aiming to investigate whether the ctDNA dynamics could predict early response to ICIs in patients with advanced-stage cancer.
- Conditions
- Non Small Cell Lung Cancer, Breast Cancer, Colorectal Cancer, Gastric Cancer
- Trial name
- PTC-IMPACT (NCT06227728)
- Where
- 2 sites in Vietnam
- Volunteers
- 50 people
- Sponsor
- Gene Solutions
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