Clinical trials: Gastro-Intestinal Disorders
Oropharyngeal Dysphagia, Swallowing Disorder
Effects of 6-month of Treatment With TRPV1 and TRPA1 Agonists in Older Patients With OD
In recent years, the investigators have characterized the impairments in pharyngeal sensory function associated with swallowing disorders in older patients with oropharyngeal dysphagia (OD).
- Trial name
- NCT05958173
- Testing
- Capsaicin, Piperine
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital de Mataró
Gastroesophageal Reflux Disease
Prevalence of Gastroesophageal Reflux Disease in Peritoneal Dialysis and Hemodialysis Patients
The purpose of this study is to determine the prevalence of GERD among chronic kidney disease with peritoneal dialysis and hemodialysis in Korea.
- Trial name
- NCT01634672
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Song Kyung Ho
Neoplasms, Nerve Tissue, Neurofibromatosis 1
Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in People With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST)
Background: Gastrointestinal stromal tumors (GIST) can cause serious medical problems. The only known treatment is surgery. But completely removing a GIST tumor with surgery is often not possible.
- Conditions
- Neoplasms, Nerve Tissue, Neurofibromatosis 1, Heredodegenerative Disorders, Nervous System, Peripheral Nervous System Diseases
- Trial name
- NCT03109301
- Testing
- Selumetinib (AZD6244 hyd sulfate) 50mg/dose, Selumetinib (AZD6244 hyd sulfate) 25mg/m2
- Sponsor
- National Cancer Institute (NCI)
Gastric Ulcer
Study to Evaluate the Safety and Efficacy of CJ-12420 in Patients With Gastric Ulcer
To demonstrate non-inferiority of CJ-12420 to lansoprazole 30 mg capsule in terms of therapeutic efficacy, and to confirm safety of CJ-12420, after once daily oral administration of CJ-12420 50 mg, 100 mg or Lansoprazole 30 mg…
- Trial name
- NCT02761512
- Testing
- CJ-12420 50 mg QD, CJ-12420 100 mg QD, Lansoprazole 30 mg QD
- Where
- 2 sites in South Korea
- Volunteers
- 306 people
- Sponsor
- HK inno.N Corporation
Early Gastric Cancer
Screening for Early Gastric Cancer in Shaanxi Province
This study collect the relevant data of local residents over 20 years old in 11 regions of Shaanxi Province, The basic information of the subjects was collected by filling in the questionnaire, and serum helicobacter pylori…
- Trial name
- NCT05291728
- Where
- China
- Volunteers
- 12,500,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Healthy Volunteers
Single-dose and Multiple-dose X842 Phase 1 Study
The purpose of this study is to evaluate the safety and tolerability of X842 after administration of single and multiple doses in healthy subjects
- Trial name
- NCT04293965
- Testing
- Single ascending dose of X842, Multiple ascending dose of X842, Food Effect
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Scleroderma, Dysphagia
Functional Luminal Imaging Probe (FLIP) Topography Use in Patients With Scleroderma and Trouble Swallowing
FLIP topography has been FDA cleared to evaluate a variety of esophageal conditions, but has never been evaluated in patients with scleroderma.
- Conditions
- Scleroderma, Dysphagia, GERD - Gastro-Esophageal Reflux Disease
- Trial name
- NCT03270722
- Testing
- FLIP topography, Upper Endoscopy
- Where
- United States
- Sponsor
- Stanford University
Gastric Cancer, Esophageal Adenocarcinoma
Cabozantinib Plus Durvalumab With or Without Tremelimumab in Patients With Gastroesophageal Cancer and Other Gastrointestinal Malignancies
The investigators propose to evaluate the safety of drug combinations in patients with advanced gastroesophageal cancer and other gastrointestinal (GI) malignancies.
- Conditions
- Gastric Cancer, Esophageal Adenocarcinoma, Hepatocellular Carcinoma, Colorectal Cancer
- Trial name
- CAMILLA (NCT03539822)
- Testing
- Cabozantinib, Durvalumab, Tremelimumab
- Where
- 2 sites in United States
- Volunteers
- 117 people
- Sponsor
- Anwaar Saeed
Breast Cancer
Effects of a Mindful Self-Compassion Intervention on Psychological Adjustment in Breast Cancer Survivors
This clinical trial will test a Mindful Self-Compassion (MSC) group program after breast cancer treatment. MSC teaches people to notice difficult feelings and respond to themselves with kindness.
- Trial name
- NCT07911631
- Testing
- Mindful Self-Compassion, Usual care
- Where
- 2 sites in Taiwan
- Volunteers
- 80 people
- Sponsor
- Chung Yuan Christian University
Helicobacter Pylori, Atrophic Gastritis
Helicobacter Pylori, Atrophic Gastritis and Intestinal Metaplasia Registry and Prospective Study
Since much is unknown about factors that lead to progression of the pre-neoplastic lesions and cancer. In addition, there is ongoing debate on the optimal surveillance intervals and techniques.
- Conditions
- Helicobacter Pylori, Atrophic Gastritis, Intestinal Metaplasia
- Trial name
- NCT05053945
- Testing
- Esophagogastroduodenoscopy
- Where
- 2 sites in Hong Kong
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Chronic Idiopathic Constipation
A Exploratory Study of KWA-0711 in Patients With Chronic Idiopathic Constipation (CIC)
The purpose of this study is to evaluate the efficacy and safety of KWA-0711 in Chronic Idiopathic Constipation (CIC) patients.
- Trial name
- NCT01600001
- Testing
- KWA-0711
- Where
- Japan
- Volunteers
- 75 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Breast Cancer, Cardiovascular Complications
Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid Tumor
RATIONALE: Studying samples of blood and urine in the laboratory from patients with cancer receiving bevacizumab may help doctors learn more about changes that occur in DNA and identify biomarkers related to high blood pressure.
- Conditions
- Breast Cancer, Cardiovascular Complications, Colorectal Cancer, Fallopian Tube Cancer
- Trial name
- NCT01096381
- Testing
- laboratory biomarker analysis, questionnaire administration
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Eosinophilic Esophagitis
EDN and Eosinophilic Esophagitis
Eosinophilic esophagitis is a recent and emerging chronic disease, secondary to eosinophilic infiltration of the esophageal mucosa leading to esophageal dysfunction.
- Trial name
- OesEDN (NCT06387030)
- Testing
- Blood sampling, Esophageal biopsies, Unstimulated saliva sampling
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Eosinophilic Esophagitis
Mometasone-furoate for Treatment of Eosinophilic Esophagitis - a Randomized Placebo Controlled Study.
Background: Eosinophilic esophagitis ( EoE ) is a disease entity which has been properly recognized only within the past two decades.(1) A prevalence of nearly 1% means that almost 20,000 people in the Region of Western Sweden…
- Trial name
- NCT02113267
- Testing
- Mometasone furoate
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Mogens Bove
Colorectal Cancer, Bladder Cancer
Feasibility Testing of Patient Reported Outcomes - Informed Symptom Management System (PRISMS)
This is a proof-of-concept pilot randomized clinical trial to test the feasibility of the innovative Patient-Reported Outcomes-Informed Symptom Management System (PRISMS) to enhance personalized supportive care for cancer…
- Conditions
- Colorectal Cancer, Bladder Cancer, Ovarian Cancer, Cervical Cancer
- Trial name
- PRISMS (NCT04492007)
- Testing
- Patient-Reported Outcomes-Informed Symptom Management System (PRISMS)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Esophageal Achalasia
Short Versus Long Submucosal Tunneling in Per-oral Endoscopic Myotomy (POEM) for Type II Achalasia.
this study is prospective , randomized and interventional ,will be performed on 50 patients to compare the clinical utility , safety profile and postoperative recovery metrics between short and long per-oral endoscopic myotomy …
- Trial name
- NCT07686471
- Testing
- per-oral endoscopic myotomy
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Dysphagia
Anterior Cervical Discectomy and Fusion (ACDF) - Behavioral Intervention
This study will prospectively recruit and enroll patients undergoing primary Anterior Cervical Discectomy and Fusion (ACDF) surgeries at NYU Langone.
- Trial name
- NCT06520579
- Testing
- Proactive pharyngeal-laryngeal Exercise Program, Premier Protein Clear ® High Protein, Hydration Counseling
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- NYU Langone Health
Motility Disorders
Pilot of AbStats /AEGIS System for Detecting Motility Abnormalities
When compared to existing analyses: manometry, Smart Pill and lactulose breath testing, external Acoustic Esophago-Gastro-Intestinal Surveillance (AEGIS) may identify unique audible patterns characteristic of features of…
- Trial name
- AEGIS (NCT02233270)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cedars-Sinai Medical Center
Deglutition Disorders
Effect Of Piperine In Patients With Oropharyngeal Dysphagia
Piperine acts on the oropharyngeal TRPV1, increasing sensory input and the release of substance P. These actions may accelerate the oropharyngeal swallow response, improving the swallowing of dysphagic patients.
- Trial name
- FIS 2009_2 (NCT01383694)
- Testing
- Piperine
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Hospital de Mataró
Gastrectomy, Oesophagectomy
Metabolic Consequences of Gastrointestinal Surgery
Surgery on the gastrointestinal (GI) tract results in profound changes to the metabolic profile. This is well described, including the rapid resolution of diabetes seen after bariatric surgery.
- Conditions
- Gastrectomy, Oesophagectomy, Dumping Syndrome, Hypoglycaemia
- Trial name
- MaS (NCT02836353)
- Testing
- Somatostatin, Rifaximin
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
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