Clinical trials: Gastro-Intestinal Disorders
Eosinophilic Esophagitis
Open-Label Extension Study of Reslizumab in Pediatric Subjects With Eosinophilic Esophagitis
This study is an open-label study where all subjects will receive active drug, reslizumab. Subjects are able to enter this trial only through completion of study Res-05-0002 (NCT00538434).
- Trial name
- NCT00635089
- Testing
- reslizumab
- Where
- 36 sites in United States, Canada
- Volunteers
- 190 people
- Sponsor
- Ception Therapeutics
Colorectal Cancer, Colorectal Disorders
Reducing Colonoscopies in Patients Without Significant Bowel Disease
Investigating people with bowel symptoms uses a test that detects traces of blood in the stools, the FIT test. There are many possible reasons for positive tests. A few people have cancer.
- Conditions
- Colorectal Cancer, Colorectal Disorders, Colorectal Adenoma, Colorectal Polyp
- Trial name
- RECEDE (NCT04516785)
- Testing
- FIT and VOC
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,181 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Adrenal Cortical Cancer, Brain Cancer
Spectroscopy With Surface Coils and Decoupling
The purpose of this study is to obtain chemical information from part of your body without a biopsy. This is done using a technique called magnetic resonance spectroscopy (MRS) which is similar to magnetic resonance imaging (MRI)…
- Conditions
- Adrenal Cortical Cancer, Brain Cancer, Breast Cancer, CNS Cancer
- Trial name
- NCT00581815
- Testing
- Proton-decoupled 31P MRS at 1.5T, 1H Spectroscopy at 1.5T and 3T
- Where
- United States
- Volunteers
- 582 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Adenocarcinoma, Metastatic Cholangiocarcinoma
CD8+ T Cell Therapy and Pembrolizumab in Treating Patients With Metastatic Gastrointestinal Tumors
This phase I pilot trial studies the side effects of cluster of differentiation 8 (CD8)+ T cells in treating patients with gastrointestinal tumors that have spread to other places in the body.
- Conditions
- Colorectal Adenocarcinoma, Metastatic Cholangiocarcinoma, Metastatic Colorectal Carcinoma, Metastatic Digestive System Carcinoma
- Trial name
- NCT02757391
- Testing
- Adoptive Immunotherapy, Aldesleukin, Cyclophosphamide
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Gastric Ulcer
The Study Compare and Evaluate the Safety and PK Data of a Single Dose Administration of 'AD-115A' or 'AD-1151'
The study compare and evaluate the safety and pharmacokinetic characteristics of a single dose administration of 'AD-115A' or 'AD-1151' in healthy adults.
- Trial name
- NCT06902818
- Testing
- AD-115A, AD-1151
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Addpharma Inc.
Eosinophilic Esophagitis
A Study to Evaluate the Efficacy and Safety of CC-93538 in Adult and Adolescent Participants With Eosinophilic Esophagitis
Study CC-93538-EE-001 is a Phase 3, multicenter, multinational, randomized, double-blind, placebo-controlled induction and maintenance study to evaluate the efficacy and safety of CC- 93538 in adult and adolescent participants…
- Trial name
- NCT04753697
- Testing
- CC-93538
- Where
- 212 sites in United States, Argentina and 13 more
- Volunteers
- 430 people
- Sponsor
- Celgene
Dysphagia, Pneumonia
How Does Dysphagia Assessment in Acute Stroke Affect Pneumonia?
Stroke-associated pneumonia (SAP) is common in acute stroke. A significant risk factor is dysphagia. To identify dysphagia, patients are screened using a bedside tool and those suspected of dysphagia then have a specialist Speech…
- Conditions
- Dysphagia, Pneumonia, Acute Stroke
- Trial name
- NCT04779710
- Testing
- Staff Survey
- Where
- United Kingdom
- Volunteers
- 113 people
- Sponsor
- Manchester Metropolitan University
Clostridium Difficile Infection
Effect of Acid Suppression Medication on Pediatric Microbiome
The colonic microbiome is essential in health and disease, and is highly dynamic during the first several years of life. Proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs) are widely used in children, but…
- Trial name
- NCT02016820
- Testing
- Omeprazole (suspension), Lifestyle Modification
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Columbia University
Lung Cancer, Gastro-intestinal Cancer
A Phase I Study of Adagrasib and Durvalumab for Treatment of Advanced Non-small Cell Lung Cancers and Gastro-intestinal Cancers Harboring KRAS G12C Mutations
To find a recommended dose of the combination of adagrasib and durvalumab that can be given to patients with cancers that have a KRAS G12C mutation.
- Trial name
- NCT05848843
- Testing
- Durvalumab, Adagrasib
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Neoplasms, Solid Tumor
Methylation Profile Test (Methylscape) in Body Fluids for Multi-Cancer Detection and Monitoring in Colombia
DNA methylation changes occur early and broadly during carcinogenesis. Methylscape is a rapid assay that detects global DNA methylation patterns in body fluids (blood, urine, and saliva) and may detect a cancer signal and predict…
- Conditions
- Neoplasms, Solid Tumor, Breast Neoplasms, Lung Neoplasms
- Trial name
- METHYLSCAPE-CO (NCT07741435)
- Testing
- Methylscape DNA methylation assay
- Where
- Colombia
- Volunteers
- 3,250 people, healthy volunteers welcome
- Sponsor
- Centro de Tratamiento e Investigación sobre Cáncer, Luis Carlos Sarmiento Angulo
Infant Nutrition Disorders, Gastrointestinal Dysfunction
Management of Infant Digestive Disorders and Quality of Life
The objective of the study is to measure the evolution of the quality of life in infants between 0 and 5 months old, not breastfed and suffering from regurgitation or colic.
- Trial name
- NCT04462640
- Testing
- Management of Infant Digestive Disorders and Quality of Life
- Where
- France
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Non-erosive Gastroesophageal Reflux Disease
Phase 3 Study of JP-1366: Efficacy and Safety of JP-1366 in Patients With Non-erosive Gastroesophageal Reflux Disease
This study aims to evaluate the efficacy and safety of JP-1366 in Patients with NERD
- Trial name
- NCT07160790
- Volunteers
- 321 people
- Sponsor
- Onconic Therapeutics Inc.
Gastroesophageal Reflux
Study on the Tolerance and Efficacy of a New Anti Regurgitation Formula
The aim of this study is to evaluate the efficacy of a new thickened formula on regurgitation.
- Trial name
- SONAR (NCT02425423)
- Testing
- New thickened formula
- Where
- 3 sites in Belgium, France
- Volunteers
- 100 people
- Sponsor
- United Pharmaceuticals
Fecal Incontinence with Fecal Urgency, Urine Incontinence
Idiopathic Normal Pressure Hydrocephalus: Focus on Imaging and Clinical Symptoms.
LiNPH is a prospective single center clinical and radiological study.
- Conditions
- Fecal Incontinence with Fecal Urgency, Urine Incontinence, Diffusion Tensor Imaging, Leukoencephalopathies
- Trial name
- LiNPH (NCT04808076)
- Testing
- Shunt surgery
- Where
- Sweden
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Swallowing Disorders, Dysphagia
Development and Validation of the SWADOC Tool
Background: After a period of coma, patients with severe brain injury may present disorders of consciousness (DOC). A wide proportion of these patients also suffer from severe dysphagia.
- Conditions
- Swallowing Disorders, Dysphagia, Disorders of Consciousness, Assessment Tool
- Trial name
- NCT04706689
- Testing
- SWADOC tool, FOTT-SAS
- Where
- 8 sites in Belgium, France
- Volunteers
- 104 people
- Sponsor
- University of Liege
Gastric Cancer, Colo-rectal Cancer
Tislelizumab Plus Anlotinib for Immunotherapy Resistant Gastrointestinal Cancer
Immunotherapy acquired resistance was observed in clinical practice. The investigators intended to add anlotinib to PD-1 inhibitors, hoping reverse the resistance.
- Trial name
- NCT04777162
- Testing
- Tislelizumab, Anlotinib
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University
Type 2 Diabetes Mellitus, Celiac Disease
Fiber-enriched Buckwheat Pasta and Glucose Variability in Patients With Type 1 Diabetes and Celiac Disease
The intervention was preceded by a 1-week run-in period during which participants underwent continuous glucose monitoring (CGM) and filled in a 7-day dietary record to optimize basal infusion rate and insulin-to-glycemic load…
- Trial name
- NCT03380988
- Testing
- Acute test meal with fiber-enriched buckwheat pasta, Acute test meal with corn pasta
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Federico II University
Gastroparesis, Diabetes Mellitus
Effects of Sitagliptin on Gastric Emptying in Healthy Subjects
The purpose of this study is to determine the effects of the drug, sitagliptin, on the rate at which the stomach empties, and the release of gut hormones and blood glucose concentrations, after a mashed potato meal in healthy…
- Trial name
- NCT00501657
- Testing
- Sitagliptin
- Where
- Australia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Adelaide Hospital
GERD, Barrett Esophagus
The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample With 3-Dimensional Computer-Assisted Analysis) vs. 4-Quadrant Forceps Biopsy
Patients scheduled to undergo routine upper endoscopy for foregut or esophageal symptoms or undergoing surveillance for Barrett's esophagus with no dysplasia or low-grade dysplasia are candidates for participation, but patients…
- Conditions
- GERD, Barrett Esophagus, Low Grade Esophageal Glandular Dysplasia, Esophageal Diseases
- Trial name
- NCT03859557
- Where
- United States
- Volunteers
- 1,032 people
- Sponsor
- CDx Diagnostics
Cancer, Colon Cancer
Emergence of Chemotherapy Related Hyperglycemia in nOn-diabetic Patients
To assess chemotherapy related hyperglycemia in non-diabetic patients, the investigators will assess the incidence of hyperglycemia and analyze co-medications and risk factors.
- Conditions
- Cancer, Colon Cancer, Breast Cancer, Malignant Lymphoma
- Trial name
- ECHO (NCT03062072)
- Testing
- Chemotherapy
- Where
- 2 sites in South Korea
- Volunteers
- 300 people
- Sponsor
- National Cancer Center, Korea
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