Clinical trials: Gastro-Intestinal Tolerance
Dysphagia
Acceptability and Tolerance Study of a Thickener
This is a prospective, acceptability study to evaluate the gastrointestinal tolerance and compliance of a thickener for the management of reflux, GORD and dysphagia
- Trial name
- NCT05026476
- Testing
- Resource Thicken up Junior
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Société des Produits Nestlé (SPN)
Gastrointestinal Tolerance
Tolerance of Infants Fed a Hydrolysate Formula
This is a prospective, randomized, multicenter study to assess the tolerance of infant formulas.
- Trial name
- NCT03628183
- Testing
- Hydrolysate Infant Formula 1, Hydrolysate Infant Formula 2
- Where
- 5 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Celiac Disease
Safety Study of Larazotide Acetate to Treat Celiac Disease.
To demonstrate the safety, pharmacokinetics and efficacy of larazotide acetate in patients with controlled celiac disease on a gluten-free diet following a gluten challenge.
- Trial name
- NCT00386165
- Testing
- larazotide acetate
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- 9 Meters Biopharma, Inc.
Child Nutrition Disorders
Acceptability, Gastro Intestinal Tolerance Compliance of a Paediatric Tube-feed Formula Derived From Food for Children
This is an acceptability study to evaluate the gastrointestinal tolerance and compliance over a seven-day period, of pediatric formula for the dietary management of participants with short bowel syndrome; intractable…
- Trial name
- NCT03718195
- Testing
- Pediatric Formula
- Where
- 3 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Société des Produits Nestlé (SPN)
Formula Milk, Infants
Infant Formula Study With Pre- And Postbiotics
This prospective, single-arm study evaluates the gastrointestinal tolerance, safety, and growth, quality of life and gut microbiome development of healthy term infants fed a commercially available palm oil free infant formula…
- Trial name
- NCT07734532
- Testing
- Infant Formula
- Where
- Ireland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nutricia UK Ltd
Celiac Disease
Assessment of Immune Activation and Tolerance in Celiac Disease During Gluten Challenge
The primary purpose of this study is to characterize changes in gluten-specific T cells and pathology in the small intestine with specific focus on biomarkers likely to change with therapeutic celiac disease (CeD) treatment.
- Trial name
- NCT03409796
- Testing
- Gluten
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Takeda
Gastro-Intestinal Tolerance
Term Infants Fed a Partially Hydrolyzed Whey Protein-Based Formula
To assess the effects of partially hydrolyzed whey protein-based infant formula with oligosaccharides on symptoms of formula intolerance in healthy, term infants.
- Trial name
- NCT04934397
- Testing
- Study Infant Formula
- Where
- 14 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Gastrointestinal, Tolerance
Gastrointestinal Tolerance of Erythritol-containing Beverages in Young Children
Purpose of this study: assess the maximum tolerated bolus dose of erythritol, delivered in a clear beverage, compared with placebo (saccharose) in 4-6 year old children.
- Trial name
- NCT02016703
- Testing
- Erythritol drink
- Where
- 3 sites in France
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Cargill
Cryptosporidiosis, HIV Infections
Open-Label "Compassionate" Use Study of Spiramycin for the Treatment of Diarrhea Due to Chronic Cryptosporidiosis in Immunocompromised Patients
This protocol provides for the availability of spiramycin under compassionate-use conditions for the treatment of chronic diarrhea due to cryptosporidium in patients with a compromised immune system, thus deriving additional…
- Trial name
- NCT00002062
- Testing
- Spiramycin
- Where
- United States
- Sponsor
- Rhone-Poulenc Rorer
Gastrointestinal Tolerance
Tolerance of Healthy Infants Fed Infant Formulas
The primary objective of this study is to assess the comparative gastrointestinal tolerance of normal term infants to two experimental milk-based powdered formulas compared with a standard milk-based powdered formula.
- Trial name
- NCT02401217
- Testing
- Phase 1- Arm 1 Infant Formula, Phase 2- Arm 2 Infant Formula, Phase 2- Arm 3 Infant Formula
- Where
- 6 sites in United States
- Volunteers
- 126 people
- Sponsor
- Abbott Nutrition
Gastrointestinal Tolerance
A Study Assessing the Tolerable Upper Intake Level and Safety of Sugars From Fiber
The purpose of this study is to determine the upper tolerable limit of Sugars from Fiber
- Trial name
- NCT05051202
- Testing
- Sugars from Fiber, Resistant Maltodextrin
- Where
- Ireland
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Cambridge Glycoscience
Growth
Evaluation of Safety, Growth, Tolerance and Effects on the Intestinal Fora of a New Milk for Healthy Infants
The purpose of the study is to assess growth and tolerance in new born and infant fed an experimental infant formula with reduced total protein concentration, enriched in alpha-lactalbumin and containing a symbiotic.
- Trial name
- Pétunia (NCT00920166)
- Testing
- Pétunia 1, Regular formula
- Where
- 4 sites in France
- Volunteers
- 97 people
- Sponsor
- Sodilac
Gastrointestinal Tolerance of Dietary Fiber
Fiber Tolerance Study
Research shows that many people do not get enough dietary fiber through their normal diet. As a result, some nutrients are not properly absorbed into the bloodstream. The immune system however does need these nutrients.
- Trial name
- Gitomix (NCT06115057)
- Testing
- Fiber
- Where
- Netherlands
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Population With Self-perceived Gastro-intestinal Sensitivity to Fibers
Tolerance Profile of Soluble Fibers in Individuals With Self-perceived GI Sensitivity to Fibers (Tarine)
The purpose of this study is to determine the optimal dose of soluble fibers that induces tolerable gastrointestinal symptoms.
- Trial name
- Tarine (NCT06877013)
- Testing
- Fiber's mix (among 4 doses)
- Where
- France
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Healthy
Safety of Larazotide Acetate in Healthy Volunteers
To demonstrate the safety, tolerance and pharmacokinetics of multiple, oral doses of larazotide acetate.
- Trial name
- NCT00386490
- Testing
- larazotide acetate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- 9 Meters Biopharma, Inc.
Gastrointestinal Tolerance
Evaluation of Infants Fed an Extensively Hydrolyzed Hypo Allergenic Infant Formula
The purpose of this study is to evaluate the growth and compliance of an intended use population of infants receiving an extensively hydrolyzed infant formula.
- Trial name
- NCT03597113
- Where
- 46 sites in Turkey (Türkiye)
- Volunteers
- 320 people
- Sponsor
- Abbott Nutrition
Gastro-Intestinal Tolerance
Gastrointestinal Tolerance of a Nutritional Supplement in Adult Patients With or at Risk of Malnutrition
The purpose of this study is to evaluate the GI tolerance, palatability and compliance to a high protein energy-dense oral nutrition supplement in adult patients with or at risk of malnutrition.
- Trial name
- NCT04259437
- Testing
- High Protein, Energy Dense Nutritional Supplement
- Where
- 3 sites in United Kingdom
- Volunteers
- 46 people
- Sponsor
- Abbott Nutrition
Colon Cancer Adenocarcinoma
A Phase Ib/II Study to Evaluate HLX43 Combined With HLX07 or Serplulimab in Patients With Advanced or Metastatic Colorectal Cancer
This study is a phase Ib/II study to evaluate the efficacy, safety and tolerance of HLX43 combined with HLX07 or Serplulimab in patients with advanced or metastatic colorectal cancer failed or intolerance to standard first-line…
- Trial name
- NCT07358585
- Testing
- HLX43 dose 1 + HLX07, HLX43 dose 2 + HLX07, HLX43 dose 3 + Serplulimab
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Shanghai Henlius Biotech
Gastrointestinal Tolerance
TolerUp Enteral Feeding Protocol
This prospective, observational, multi-center study will follow children with cerebral palsy who decided to switch to an enteral product that contains partially hydrolyzed protein and medium chain triglycerides as a result of…
- Trial name
- NCT03648255
- Where
- 19 sites in Turkey (Türkiye)
- Volunteers
- 133 people
- Sponsor
- Abbott Nutrition
Gastrointestinal Tolerance
The Effects of Soluble Corn Fiber on Gastrointestinal Tolerance and Fecal Microbiome in Healthy Children
The purpose of this study is to compare the effects of PROMITOR® Soluble Corn Fiber versus inulin on GI symptoms (tolerance), stool consistency (laxation) and fecal microbiome at levels that could contribute to closing the fiber…
- Trial name
- NCT05213494
- Testing
- Inulin, soluble corn fiber
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Tate & Lyle