Clinical trials: Gastro-Intestinal Tolerance, open to volunteers
Critical Illness, Surgery
Diluted and Undiluted Enteral Nutrition
Adult patients after elective major abdominal surgeries who are planned to be admitted to the Intensive Care Unit (ICU) can be included in the trial. Each patient will be fed via the gastrointestinal tract.
- Conditions
- Critical Illness, Surgery, Enteral Feeding Intolerance, Gastro-Intestinal Disorder
- Trial name
- NCT06516835
- Testing
- Enteral fluid, Intravenous fluid
- Where
- 5 sites in Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lublin
Food Allergy, Eosinophilic Esophagitis
Molecular Basis of Food Allergy
The Study examines the molecular basis of food allergy. It explores the interaction between T cells, InKT cells, basophils and cytokines in the development of food allergy.
- Trial name
- NCT01832324
- Where
- United States
- Volunteers
- 5,300 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Critical Illness, Enteral Nutrition
Optimizing Enteral Nutrition Regimen for Critically Ill Patients
Clinical Trial The goal of this clinical trial is to learn whether different enteral feeding cycles (18-hour, 20-hour, or standard 24-hour continuous feeding) improve outcomes for critically ill ICU patients who need tube…
- Conditions
- Critical Illness, Enteral Nutrition, Ventilator Associated Pneumonia, Hyperglycemia
- Trial name
- NCT07270939
- Testing
- 20-Hour Cycled Enteral Nutrition with a 4-Hour Fasting Window, 18-Hour Cycled Enteral Nutrition with a 6-Hour Fasting Window
- Volunteers
- 150 people
- Sponsor
- Hamad Medical Corporation
Crohn Disease (CD)
Tolerance of Local Administration of Cryopreserved Autologous Stromal Vascular Fraction Combined With Micrograft for the Treatment of Refractory Ano-perineal Fistulas in Crohn's Disease
The ADICROHN-3 study is a prospective, multicenter, open-label cohort study. Its design is supported by the following elements: The results of the ADICROHN pilot study (EudraCT No.
- Trial name
- ADICROHN3 (NCT07629245)
- Testing
- injection of thawed SVF
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Neurogenic Bowel, Spinal Cord Injuries (SCI)
Transcutaneous Spinal Cord Stimulation for Bowel Management in Individuals with Motor Complete Spinal Cord Injury
The primary goals of this pilot trial are to understand the feasibility and safety of thoracolumbar transcutaneous spinal cord stimulation for neurogenic bowel management in individuals with new onset, traumatic, cervicothoracic…
- Trial name
- NCT06801431
- Testing
- Transcutaneous spinal cord stimulation
- Volunteers
- 5 people
- Sponsor
- Nova Scotia Health Authority
Milk Intolerance, Milk Hypersensitivity
Goat vs. Cow Milk Digestive Tolerance
The objective of this study is to assess to what extent goat's milk is better tolerated than cow's milk among individuals who report being intolerant to cow's milk, and, if so, to understand the underlying factors.
- Conditions
- Milk Intolerance, Milk Hypersensitivity, Cow Milk Protein Sensitivity
- Trial name
- DIGIGOAT (NCT07239856)
- Testing
- Cow milk, Goat Milk
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Cerebral Palsy (CP), Oncology
Acceptability and Tolerance Study of Bolus Tube Feed With Food Blends
This is a prospective acceptability study to evaluate the gastrointestinal tolerance and compliance of a bolus tube feed over a 28 -day period for up to 50 participants.
- Trial name
- Blends (NCT07341464)
- Testing
- Tube feed
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Société des Produits Nestlé (SPN)
Colon Cancer Adenocarcinoma
A Phase Ib/II Study to Evaluate HLX43 Combined With HLX07 or Serplulimab in Patients With Advanced or Metastatic Colorectal Cancer
This study is a phase Ib/II study to evaluate the efficacy, safety and tolerance of HLX43 combined with HLX07 or Serplulimab in patients with advanced or metastatic colorectal cancer failed or intolerance to standard first-line…
- Trial name
- NCT07358585
- Testing
- HLX43 dose 1 + HLX07, HLX43 dose 2 + HLX07, HLX43 dose 3 + Serplulimab
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Shanghai Henlius Biotech
Breast Cancer, Lung Cancer (Non-Small Cell)
Effectiveness of a Multimodal Outpatient Supervised Physical Activity Program to Improve Tolerance and Efficacy of Chemotherapy in Adults With Breast, Lung and Colon Cancer
This clinical study evaluates whether a supervised, multimodal therapeutic exercise program started before chemotherapy and continued during treatment can improve treatment outcomes in patients aged 35 to 65 years with breast…
- Conditions
- Breast Cancer, Lung Cancer (Non-Small Cell), Colorectal Cancer, Physical Activity
- Trial name
- PREDU (NCT07502963)
- Testing
- PREDU Exercise Program, Recommendation Exercise Program
- Where
- 3 sites in Spain
- Volunteers
- 70 people
- Sponsor
- University of Vic - Central University of Catalonia
Lower Gastrointestinal Disorder, Tolerance
A Pilot Study of Commercially Available Bowel Preparation Regimens Packaged and Ingested Via Vegan Capsules
The goal of this clinical trial is to learn whether bowel preparation powders used before colonoscopy can be taken as capsules instead of being mixed and drunk as a liquid.
- Trial name
- CLEAR-CAP (NCT07700277)
- Testing
- Sodium picosulfate, magnesium oxide, and citric acid capsules, Polyethylene glycol 3350 with electrolytes capsules
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute