Clinical trials: GastroIntestinal Bleeding, open to volunteers
Melena, Gastrointestinal Bleeding
A Study to Evaluate the Performance of a Wireless Optical Sensor Capsule in Detection of UGIB
Upper gastrointestinal bleeding (UGIB) is a common and potentially lethal medical emergency, which requires hospitalization and healthcare resources.
- Conditions
- Melena, Gastrointestinal Bleeding, Hematemesis
- Trial name
- Hemopill-Pro (NCT06715293)
- Testing
- Hemopill, OGD
- Where
- Hong Kong
- Volunteers
- 193 people
- Sponsor
- Chinese University of Hong Kong
Coronary Artery Disease, Percutaneous Coronary Intervention
Potassium-Competitive Acid Blocker Versus pROton-Pump Inhibitor for GastroproTECTion Strategies In Patients at High Gastro-Intestinal Bleeding Risk Receiving Antithrombotic Therapy
The primary aim of this study is to evaluate the efficacy and safety of novel P-CAB (tegoprazan 50 mg once daily) as compared with standard PPI (rabeprazole 20 mg once daily) for protection of GI events in patients with known…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Myocardial Infarction
- Trial name
- PROTECT-HBR (NCT04416581)
- Testing
- PPI, P-CAB 50
- Where
- 45 sites in South Korea
- Volunteers
- 3,320 people
- Sponsor
- Duk-Woo Park, MD
GastroIntestinal Bleeding
Validation of CAGIB Score for In-hospital Mortality of Cirrhotic Patients With Acute Gastrointestinal Bleeding
Acute gastrointestinal bleeding is potentially lethal in liver cirrhosis. Accurate assessment of prognosis is critical in a timely fashion.
- Trial name
- NCT04662918
- Where
- 23 sites in United States, Brazil and 6 more
- Volunteers
- 3,000 people
- Sponsor
- Xingshun Qi
Hemorrhoid, Hemorrhoid Bleeding
Bleeding Reduction in Grade II-III Haemorrhoids Through Embolization Treatment
BRIGHT is a Europe-wide study that will follow up to 250 adults with bleeding symptoms from haemmorhoids (Grade II-III categories).
- Trial name
- BRIGHT (NCT07264413)
- Testing
- Haemorrhoid artery embolizsation (HAE)
- Volunteers
- 250 people
- Sponsor
- Cardiovascular and Interventional Radiological Society of Europe
GIT - Gastrointestinal Tract Hemorrhage
Endoscopic Findings in Patients With Upper GIT Bleeding
This study aims to identify the causes of upper gastrointestinal bleeding through comprehensive evaluation via upper endoscopy in Assiut University Hospital and contribute valuable insights into effective management strategies.
- Trial name
- NCT06886880
- Testing
- endoscope
- Volunteers
- 100 people
- Sponsor
- Assiut University
Bleeding, Aortic Rupture
Life-saving Treatment With Dry-plasma for Massive Bleeding in an Pre-hospital Setting
The overall goal of this clinical trial is to study how prehospital transfused dry plasma affect outcomes in terms of mortality as well as complications and coagulation status of patients in or about to develop bleeding shock.
- Conditions
- Bleeding, Aortic Rupture, Gastrointestinal Hemorrhage, Obstetric Bleeding
- Trial name
- NCT07012863
- Testing
- Dry plasma
- Volunteers
- 650 people
- Sponsor
- Vastra Gotaland Region
Hemorrhoid, Hemorrhoid Bleeding
Trial of Latex vs Non-latex Hemorrhoid Banding
This study will involve the recruitment of adult patients with hemorrhoids for whom rubber band ligation is the recommended treatment. Patients will be randomized to receive banding with a latex band or non-latex band.
- Trial name
- NO-Tex (NCT06625138)
- Testing
- Latex Band, Non-Latex Band
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Huntington Memorial Hospital
Autoimmune Diseases, Lupus Erythematosus, Systemic
Comparative Autoantibody and Immunologic Cell Marker Study
The purpose of this study is to compare immune phenotype, function, and specificity of B lymphocytes from different developmental stages in autoimmune patients to B cells from infectious disease patients and healthy controls.
- Conditions
- Autoimmune Diseases, Lupus Erythematosus, Systemic, Communicable Diseases
- Trial name
- NCT02422875
- Where
- 3 sites in United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Emory University
Portal Hypertension, Gastric Varices Bleeding
Preemptive TIPS for Gastric Variceal Bleeding in Patients With Cirrhosis
The prevalence of gastric varices is approximately 20%. It is important to note that gastric varices tend to bleed more severely, have a higher morbidity and mortality rate, and have a 35% to 90% risk of rebleeding after the…
- Conditions
- Portal Hypertension, Gastric Varices Bleeding, Portosystemic Shunt
- Trial name
- NCT06122792
- Testing
- preemptive TIPS, standard second prophylaxis
- Volunteers
- 144 people
- Sponsor
- West China Hospital
GI Bleeding
High Dose Oral Omeprazole in High Risk UGIB
Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding.
- Trial name
- NCT04394663
- Testing
- High-dose oral omeprazole, Standard IV PPI
- Where
- 2 sites in Thailand
- Volunteers
- 128 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Acute Upper Gastrointestinal Bleeding, Capsule Endoscopes
Detachable String Magnetically Controlled Capsule Endoscopy for Patients with AUGIB
Use CE for pre-examination of patients with AUGIB symptoms in emergency centers may reduce the need for emergency electronic gastroscopy and have certain advantages in clinical work.
- Trial name
- NCT06725056
- Testing
- DS-MCE and EGD examinations
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Preterm Birth Complication, Neonatal Morbidity and Mortality
Delayed Versus Immediate Cord Clamping in Preterm Birth
The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth.
- Conditions
- Preterm Birth Complication, Neonatal Morbidity and Mortality, Cord Clamping, Delayed Cord Clamping
- Trial name
- PREM-CORD (NCT07699666)
- Testing
- Delayed Umbilical Cord Clamping, Immediate Umbilical Cord Clamping
- Where
- Tunisia
- Volunteers
- 200 people
- Sponsor
- Faculty of Medicine of Tunis
Hepatocellular Carcinoma (HCC), Esophageal Varices
Endoscopic Variceal Ligation vs Carvedilol for the Prevention of First Esophageal Variceal Bleeding in Patients With HCC
The goal of this clinical trial is to evaluate whether endoscopic variceal ligation (EVL) or carvedilol is more effective at preventing the first esophageal variceal bleeding (EVB) in patients with hepatocellular carcinoma (HCC).
- Trial name
- P-HCC-CVL (NCT06594744)
- Testing
- Endoscopic variceal ligation, Carvedilol
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Ischemic Stroke, Transient Ischemic Attack
Zastaprazan for the prEvention of Upper GI Bleeding in Ischemic Stroke
The goal of this clinical trial is to learn if zastaprazan can help prevent upper gastrointestinal bleeding in adults who have recently had a transient ischemic attack (TIA) or ischemic stroke and are taking antiplatelet or…
- Trial name
- NCT07730840
- Testing
- Zastaprazan
- Where
- 15 sites in South Korea
- Volunteers
- 984 people
- Sponsor
- Asan Medical Center
Massive Transfusion, Trauma
Australian and New Zealand Massive Transfusion Registry
Severe and un-stopped blood loss can occur for a number of different reasons including after a serious injury, delivery of a baby and following other medical and surgical emergencies.
- Conditions
- Massive Transfusion, Trauma, Cardiothoracic Surgery, Gastrointestinal Bleeding
- Trial name
- ANZ-MTR (NCT02863250)
- Where
- Australia
- Volunteers
- 50,000 people
- Sponsor
- Monash University
Rectal Cancer
Hypofractionated Palliative Radiotherapy in Patients With Advanced Non-operable Rectal Cancer
Many patients with rectal cancer were not candidates for surgical resection because advanced age, comorbidities, or multiple synchronous metastases.
- Trial name
- NCT03853733
- Testing
- rectal cancer radiotherapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Consorci Sanitari de Terrassa
Ischemic Stroke, Ischemic Stroke, Acute
Tegoprazan for Prevention of Gastrointestinal Complication in Ischemic Stroke Patients on Antiplatelet Therapy (TegoStroke)
Patients with ischemic stroke commonly receive antiplatelet therapy, frequently starting as dual antiplatelet therapy, which is associated with an increased risk of gastrointestinal complications.
- Conditions
- Ischemic Stroke, Ischemic Stroke, Acute, Transient Ischemic Attack (TIA), Cerebrovascular Disease
- Trial name
- TegoStroke (NCT07687706)
- Testing
- Tegoprazan 50 mg
- Where
- 24 sites in South Korea
- Volunteers
- 1,524 people
- Sponsor
- Hanyang University Guri Hospital
GI Bleeding
Hematological Disorders in Patients With GI Angiodysplasia
The aim of this study will be to assess the association between GIT angiodysplasia with any hematological disorders as von Willebrand factor and Prognostic value of von Willebrand factor on patient's outcomes as risk of…
- Trial name
- NCT07183995
- Volunteers
- 55 people
- Sponsor
- Assiut University
Portal Hypertension
Austrian Registry on Transjugular Intrahepatic Portosystemic Shunts
Patients with TIPS will be recruited in this prospective registry study. The clinical course will be documented and biomarkers for prediction of complicatiosn will be assessed.
- Trial name
- AUTIPS (NCT03409263)
- Testing
- Observational study
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Thomas Reiberger
Hemorrhoid
The Efficacy of Aescin in Combination With Micronized Purified Flavonoid Fraction (MPFF) in the Control of Bleeding and Prevent Recurrence of Acute Internal Hemorrhoids, A Randomized Controlled Trial, A Pilot Study
Hemorrhoidal disease, characterized by symptomatic enlargement and distal displacement of anal cushions, has been a subject of recognition and management for centuries.
- Trial name
- NCT06748014
- Testing
- Aescin in Horse Chestnut, MPFF
- Where
- Thailand
- Volunteers
- 120 people
- Sponsor
- Chiang Mai University