Clinical trials: Gastroesophageal Hernia
Paraesophageal Hernia
Fundoplication in Laparoscopic PEH Repair Based on FLIP
Prospective randomized controlled trial to identify a sub-set of patients that do not benefit from the routine addition, and added morbidity, of a fundoplication during laparoscopic paraesophageal hernia repair.
- Trial name
- PEHFLIP (NCT05807763)
- Testing
- Laparoscopic paraesophageal hernia repair without fundoplication
- Where
- 2 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- The Foundation for Surgical Innovation and Education
Hernia, Hiatal
Laparoscopic Repair of Giant Hiatal Hernias With Nitinol-framed Lightweight Polytetrafluoroethylene Mesh
This study is prospective randomized trial enrolling at least 50 participants which compares efficacy and safety of two alternative methods of laparoscopic hiatal repair for giant (i.e.
- Trial name
- GIANT (NCT01780285)
- Testing
- Nitinol-framed lightweight PTFE mesh for hiatal repair, Partially absorbable lightweight mesh for hiatal repair
- Where
- Ukraine
- Volunteers
- 50 people
- Sponsor
- Odessa National Medical University
Hiatal Hernia, Paraesophageal Hernia
Study of Paraesophageal Hernia Repair With Small Intestine Submucosa
In 2006 this research group reported their initial findings of a multi-center prospective trial comparing primary repair and primary repair buttressed with a biologic mesh made from porcine small intestinal submucosa (SIS).
- Trial name
- PEH (NCT00786084)
- Where
- 4 sites in United States
- Volunteers
- 108 people
- Sponsor
- University of Washington
GERD, Hiatal Hernia
Antireflux Surgery Without Preoperative Esophageal Manometry
The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia.
- Conditions
- GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia
- Trial name
- NOMA (NCT07659080)
- Testing
- Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry
- Where
- 2 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McMaster University
Gastroesophageal Reflux Disease, Hiatal Hernia
Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital
To study the long term outcome of Laparoscopic Hiatal Hernia Repair with human acellular dermal matrix Alloderm (LifeCell, Branchburg, NJ) mesh.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Paraesophageal Hernia
- Trial name
- NCT01776827
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Nebraska
Reflux Esophagitis, Hiatal Hernia
Immunologic Factors in Reflux Esophagitis and Barrett's Esophagus
By using combination of the expression of COX-2 and NOS and immunologic reaction in the esophagus with manometry of LES and cruel diaphragm and 24 hr esophageal pH monitoring to investigate the mechanisms and to make a new and…
- Trial name
- NCT00155805
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taiwan University Hospital
Paraesophageal Hernia, Hiatal Hernia Large
Anterior Gastropexy vs. No Anterior Gastropexy for Paraesophageal Hernia Repair
This study evaluates the effect of anterior gastropexy (one or more sutures fixing the stomach to the inner abdominal wall) on improving durability of paraesophageal hernia repair.
- Trial name
- NCT04007952
- Testing
- Anterior Gastropexy
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Clayton Petro
Hiatal Hernia
Impact of Biosynthetic Mesh on Paraesophageal Hernia Repair
The aim of this study is to find out if using a certain kind of mesh can reduce the chances of hiatal hernias coming back after anti-reflux surgery.
- Trial name
- NCT06444347
- Testing
- Biosynthetic Mesh, Hiatal Hernia Repair
- Where
- 6 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Gastroesophageal Reflux
Antireflux Efficacy of Hiatal Hernia Repairs in Sleeve Gastrectomy Patients
Gastroesophageal reflux (GR) occurrence or persistence following a sleeve gastrectomy (SG) can be correlated to several factors but it is clear that one of the key factors is a persistent hiatal hernia or laxity of the esophageal…
- Trial name
- NCT04433507
- Testing
- Sleeve gastrectomy, Hiatal Hernia repair
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Paraesophageal Hernia
Effect of Hernia Sac Excision on Crural Tension in Paraesophageal Hernia Repair
Paraesophageal hernia can cause significant clinical symptoms, including reflux, chest pain, nausea, regurgitation, and even life threatening conditions such as bowel obstruction, and gastric volvulus.
- Trial name
- NCT07197619
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Corewell Health West
Paraesophageal Hernia
Short Esophagus in Type II-IV Hiatus Hernia
Background: The existence, diagnosis and treatment of short esophagus is one of the controversies of the past which has recently re-emerged.
- Trial name
- SEHH (NCT01587859)
- Testing
- laparoscopic surgery
- Where
- 2 sites in Italy
- Volunteers
- 34 people
- Sponsor
- University of Bologna
Paraesophageal Hernia, Hiatal Hernia
Sutures Versus Polyglactin Mesh in Hiatal Hernia Repair
Paraesophageal hernia causes pain, heartburn, regurgitation, anemia and in extreme, life-threatening strangulation. For symptomatic patients, laparoscopic surgery is offered which includes hiatal defect closure and antireflux…
- Conditions
- Paraesophageal Hernia, Hiatal Hernia, Hiatal Hernia, Paraesophageal, Recurrence
- Trial name
- NCT05201508
- Testing
- Polyglactin mesh, Sutures only
- Where
- Finland
- Volunteers
- 110 people
- Sponsor
- Oulu University Hospital
Gastroesophageal Reflux Disease, Hiatal Hernia
Transoral Incisionless Fundoplication (TIF) Versus Sham for Treatment of Gastroesophageal Reflux Disease (GERD)
The study objective is to evaluate the relative merits, safety and effectiveness of transoral incisionless fundoplication (TIF) in proton pump inhibitor (PPI) dependent GERD patients compared with sham procedure.
- Trial name
- NCT01110811
- Testing
- Transoral Incisionless Fundoplication (TIF)
- Where
- 4 sites in Belgium, France and 1 more
- Volunteers
- 60 people
- Sponsor
- EndoGastric Solutions
Body Weight, Post-Op Complication
Development of Machine Learning Models for the Prediction of BMI and Complications After Bariatric Surgery (CABS-Study)
This Study aims to develop machine learning models with the ability to predict patients' BMI and complications after Bariatric Surgery (CABS-Score).
- Conditions
- Body Weight, Post-Op Complication, Anastomosis, Leaking, Hiatal Hernia
- Trial name
- NCT05710913
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- Dr. Med Anas Taha
Hiatal Hernia Large, Reflux, Gastroesophageal
Platelet Rich Plasma in Hiatal Hernia Repair
Rationale: Gastroesophageal reflux disease (GERD) is a common disease caused by a dysfunctional lower esophageal sphincter and an abnormal esophageal hiatus or hiatal hernia.
- Trial name
- PPR-HHR (NCT05023174)
- Testing
- Hiatal Hernia Repair with Platelet Rich Plasma, Hiatal Hernia Repair without Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Southern California
Gastroesophageal Reflux
Manual Therapy and Gastroesophageal Reflux Disease in Patients With Hiatal Hernia
Introduction: Gastroesophageal reflux disease (GERD) is highly prevalent in our society. The association between GERD and hiatal hernia has been shown to be etiologically critical in the onset or worsening of these patients'…
- Trial name
- NCT05283447
- Testing
- Osteopathic Medicine, Control
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Escoles Universitaries Gimbernat
Hernia, Hiatal, GERD (Gastroesophageal Reflux Disease)
TLSA Versus TBSA Surgical Approach for Hiatal Hernia With Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD), characterized by pathological reflux of gastric contents, affects 10%-20% of the global population with Western predominance and escalating incidence over recent decades.
- Trial name
- NCT07252115
- Testing
- Laparoscopic total left-sided surgical approach, Laparoscopic traditional bilateral approach
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Beijing Friendship Hospital
Achalasia, Paraesophageal Hernia
Minimally Invasive Surgery of the Gastro-esophageal Junction
This study will assess short and long term outcomes of individuals undergoing minimally invasive surgery of the gastro-esophageal junction (MISGEJ).
- Conditions
- Achalasia, Paraesophageal Hernia, GERD, Epiphrenic Diverticula
- Trial name
- MISGEJ (NCT01799967)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Ottawa Hospital Research Institute
Hiatal Hernia, GERD
Laparoscopic Total Left-sided Surgical Approach Versus Traditional Bilateral Surgical Approach for Hiatal Hernia
Background: In China, guidelines for the treatment of hiatal hernia (HH) are lacking. Furthermore, efficacy and safety assessments of surgical approaches for HH and for the protection of the vagus nerve and organ function are…
- Trial name
- NCT06828627
- Testing
- TLSA, TBSA
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Beijing Friendship Hospital
Gastro Esophageal Reflux
Antireflux Ablation Therapy (ARAT) for Gastroesophageal Reflux Treatment
Gastroesophageal Reflux Disease (GERD) is defined as the rise of gastric or gastroduodenal contents above the esophagogastric junction (EGJ), generating symptoms and/or esophageal lesions.
- Trial name
- ARAT (NCT03548298)
- Testing
- ARAT
- Where
- Mexico
- Volunteers
- 95 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico