Clinical trials: Gastroesophageal Reflux
Gastroesophageal Reflux, Sleeve Gastrectomy
The Use of EndoFlip as a Clinical Tool for the Prediction of Postoperative GERD After Sleeve Gastrectomy
This study aims to determine if preoperative EndoFlip measurement can effectively predict postoperative GERD-related quality of life and lower esophageal acid exposure.
- Conditions
- Gastroesophageal Reflux, Sleeve Gastrectomy, Bariatric Surgery Complication
- Trial name
- NCT05690022
- Testing
- sleeve gastrectomy
- Volunteers
- 100 people
- Sponsor
- Laval University
Varicose Veins, Venous Insufficiency
The Party Balloon Assisted Valsalva in Diagnosis of Superficial Venous Valvular Reflux of Lower Limb
This study was designed to compare the party balloon assisted Valsalva with the conventional Valsava for exhibiting the reverse venous flow in superficial venous valvular incompetence duplex examination.
- Trial name
- NCT02051439
- Testing
- Valsava
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Cough, GERD
The Utility of Nexium in Chronic Cough and Reflux Disease
The purpose of this research study is to investigate different doses of proton pump inhibitors in reducing cough symptoms felt to be associated with Gastroesophageal reflux disease (GERD).
- Trial name
- NCT00287339
- Testing
- Esomeprazole
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Gastrointestinal Health
Viome Nutritional Programs to Improve Clinical Outcomes for Gastrointestinal Conditions
US residents who have gastrointestinal issues sign the informed consent form and are screened and enrolled for this study. Participants who are enrolled complete a survey upon enrollment and are randomized into one of three arms.
- Trial name
- NCT05465629
- Testing
- VIOME Precision Nutrition Program, VIOME-designed condition-based supplements
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Viome
Laryngopharyngeal Reflux
Comparison of Voice Therapy and Antireflex Therapy in LPR
This study will be a prospective, randomized, unblinded but controlled trial. Patients presenting to the Otolaryngology clinic who are diagnosed with laryngopharyngeal reflux disorder related dysphonia and meet inclusion criteria…
- Trial name
- NCT02530879
- Testing
- Omeprazole, Lansoprazole, Esomeprazole, Rantidine, Voice therapy, Combination of anti-reflux medication and voice therapy
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Temple University
Chronic Renal Failure, Haemodialysis, Haemodiafiltration, Haemofiltration
Catheter Dysfunction Rate in Patients Undergoing Kidney Replacement Therapy. Evaluation of the Safety and Efficacy of Anti-reflux Valves Without Heparin Lock Solution
Catheter dysfunction and infections are the most common complications observed among patients with dialysis catheters for long-term dialysis ( CDLD ) .
- Conditions
- Chronic Renal Failure, Haemodialysis, Haemodiafiltration, Haemofiltration, Kidney Replacement Therapy, Catheter Infection, Catheter Dysfunction, Catheter Related Bloodstream Infections
- Trial name
- DUKE (NCT06259266)
- Testing
- Anti-reflux valve for dialysis catheter
- Where
- France
- Sponsor
- University Hospital, Clermont-Ferrand
Laryngo-pharyngeal Reflux
Effect of Topical Anesthesia on the Phonation Process During High-Speed Digital Imaging Laryngoscopy in Patients With Laryngopharyngeal Reflux
The goal of this clinical trial is to learn if topical anesthesia (lidocaine spray) affects the phonation process during High-Speed Digital Imaging (HSDI) laryngoscopy in adults with laryngopharyngeal reflux (LPR).
- Trial name
- NCT07696429
- Testing
- Lidocaine 10% Spray
- Where
- Croatia
- Volunteers
- 70 people
- Sponsor
- Mario Bilić
Gastroesophageal Reflux Disease
Mass Balance Study of [14C]X842 in Healthy Adult Male Subjects
This study is a single-site, single-dose, non-randomized, open-label study to assess the absorption, metabolism, and excretion profile of [14C]X842 in healthy adult male subjects.
- Trial name
- NCT07107672
- Testing
- [14C]X842
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Lung Transplant, GERD
The Effect of the Reflux Band™ Upper Esophageal Sphincter (UES) Assist Device on Reflux for Lung Transplant Recipients
A prospective, open label, study designed to assess the affect of the Reflux Band® UES Assist Device (Reflux Band) on reflux in patients that have undergone lung transplantation.
- Trial name
- Reflux Band (NCT03886961)
- Testing
- Reflux Band
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Varicose Veins of Lower Limb
Effect of Vitis Vinifera Seed Extract on Venous Reflux Time in Varicose Vein
The number of patients with lower extremity varicose veins has been increasing due to an aging population, with treatments divided into conservative and invasive methods.
- Trial name
- VICTORY (NCT05851183)
- Testing
- Vitis Vinifera seed extract medication plus therapeutic lifestyle change, Therapeutic lifestyle change only
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Yonsei University
Achalasia
POEM-F for Achalasia International Study
Per-oral endoscopic myotomy (POEM) has emerged as the endoscopic treatment of choice for achalasia, offering comparable symptom relief with laparoscopic Heller's cardiomyotomy.
- Trial name
- NCT06042127
- Testing
- POEM-F, Conventional POEM
- Where
- 7 sites in United States, China and 2 more
- Volunteers
- 81 people
- Sponsor
- Chinese University of Hong Kong
Reflux Esophagitis
The Efficacy and Safety of DWP14012 in Chinese Patients With Reflux Esophagitis
To evaluate the efficacy, safety, and cost-effectiveness of DWP14012 40 mg compared to esomeprazole magnesium enteric-coated tablets for the treatment of reflux esophagitis.
- Trial name
- NCT05813561
- Testing
- DWP14012
- Where
- China
- Volunteers
- 332 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Laryngomalacia
Assessing the Role of Proton Pump Inhibitors in Reducing Aspiration Incidence in Pediatric Laryngomalacia Cases
Laryngomalacia is the most common congenital laryngeal anomaly in children and is frequently associated with aspiration. This randomized controlled study aims to assess the role of proton pump inhibitor (PPI) therapy in reducing…
- Trial name
- NCT07750379
- Testing
- PPI, vitamin D, feeding instruction
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Minia University
Gastro-esophageal Reflux
Evaluation of Esomeprazole in Treating Gastro-esophageal Reflux Disease (GERD) in Head and Neck Cancer Patients Exposed to Radiation Therapy
The purpose of this research study is to measure acid reflux into the throat both before and after medical treatment in people who have had radiation therapy to their head and neck for the treatment of cancer.
- Trial name
- NCT00222079
- Testing
- Esomeprazole (Nexium)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Douglas Trask
Laryngopharyngeal Reflux
Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction
Laryngopharyngeal Reflux (LPR) is a common condition that causes symptoms like chronic cough, throat clearing, hoarseness, and trouble swallowing.
- Trial name
- FLUTTER (NCT04383262)
- Testing
- Fosamprenavir Calcium
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Medical College of Wisconsin
Obesity, Obesity, Abdominal
Laparoscopic Clip-Gastroplasty With The Use Of Bariclip
Sleeve gastrectomy, the most commonly performed bariatric surgery procedure, carries limitations both short-term including postoperative complications such as hemorrhage and gastric fistula and long-term such as weight regain and…
- Conditions
- Obesity, Obesity, Abdominal, Surgery
- Trial name
- B-Clamp (NCT05557084)
- Testing
- laparoscopic vertical clip gastroplasty (LVCG) with Bariclip.
- Where
- 2 sites in Italy
- Volunteers
- 50 people
- Sponsor
- University of Rome Tor Vergata
Gastroesophageal Reflux
Efficacy of Pantoprazole in Patients Older Than 18 Years Who Have Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-339)
Gastroesophageal reflux disease (GERD) is a medical condition affecting the stomach and esophagus. GERD occurs when the lower esophageal sphincter does not close properly and stomach contents leaks back (refluxes) into the…
- Trial name
- NCT00163306
- Testing
- Pantoprazole
- Where
- 79 sites in Austria, Germany and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Takeda
Gastroesophageal Reflux
Medical Treatment for Gastroesophageal Reflux Disease (GERD) in Preterm Infants
Study Question: In premature infants with apnea and/or bradycardia attributed to gastroesophageal reflux disease (GERD), does treatment with medications (acid blockers and motility agents), compared to placebo, reduce the…
- Trial name
- NCT00131248
- Testing
- Metaclopramide, Ranitidine
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- The University of Texas Health Science Center, Houston
Paraesophageal Hernia
Short Esophagus in Type II-IV Hiatus Hernia
Background: The existence, diagnosis and treatment of short esophagus is one of the controversies of the past which has recently re-emerged.
- Trial name
- SEHH (NCT01587859)
- Testing
- laparoscopic surgery
- Where
- 2 sites in Italy
- Volunteers
- 34 people
- Sponsor
- University of Bologna
Hernia, Hiatal, GERD (Gastroesophageal Reflux Disease)
TLSA Versus TBSA Surgical Approach for Hiatal Hernia With Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD), characterized by pathological reflux of gastric contents, affects 10%-20% of the global population with Western predominance and escalating incidence over recent decades.
- Trial name
- NCT07252115
- Testing
- Laparoscopic total left-sided surgical approach, Laparoscopic traditional bilateral approach
- Where
- 2 sites in China
- Volunteers
- 143 people
- Sponsor
- Beijing Friendship Hospital
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