Clinical trials: Gastroesophageal Reflux
Gastro-Esophageal Reflux Disease With Ulceration
The 90% Effective Sedation Dose Of Midazolam
There are no clear conclusive clinical reports defining the adequate effective dose of midazolam in patients undergoing day-case esophageal-gastro-duodenoscopy (EGD).
- Trial name
- NCT03813043
- Testing
- Midazolam injection
- Volunteers
- 40 people
- Sponsor
- King Fahad Specialist Hospital Dammam
Vesico-Ureteral Reflux
A Prospective Study Comparing the Success Rate of Injection of (DefluxR) Versus (VantrisR) for VUR in Children
Vesicoureteral reflux (VUR) is the most common urologic diagnosis in neonates estimated at 1% of newborns, and 30-45% of the children who present with urinary tract infection (1).
- Trial name
- NCT02271035
- Testing
- Deflux, Vantris
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Functional Gastrointestinal Disorders, Gastroesophageal Reflux
Prevalence and Natural History of Functional Gastrointestinal Disorders Among At-risk Infants.
The goal of this observational study is to learn about the prevalence and characteristics of functional gastrointestinal disorders (FGID) in at risk infants (former preterm infants and those with birth asphyxia) during the first…
- Conditions
- Functional Gastrointestinal Disorders, Gastroesophageal Reflux, Constipation - Functional, Diarrhea
- Trial name
- FUSID (NCT06031025)
- Testing
- Questionnaire, clinical examination
- Where
- Italy
- Volunteers
- 71 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Non-erosive Reflux Disease, Barrett's Esophagus
The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients
Gastroesophageal reflux disease(GERD) mainly related to the reflux of stomach content induced by the dysfunction of lower esophageal sphincter.
- Trial name
- NCT02149914
- Testing
- Ryodoraku, ANSWatch, UGI endoscopy
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taichung Tzu Chi Hospital
Reflux
Prospective Randomized Trial Evaluating the Utility of Esophageal Stitches During Laparoscopic Fundoplication
This is a prospective trial of the utility of esophageal stitches during fundoplication. The hypothesis is that recurrence rate may be different with or without the esophageal stitches.
- Trial name
- NCT01509352
- Testing
- esophageal stitches during fundoplication, no esophageal stitches placed during fundoplication
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Children's Mercy Hospital Kansas City
Gastroesophageal Reflux
Natural History of Gastroesophageal Reflux (GER) in Children < 12 Years of Age
The goal of this project is to determine the long-term health outcome of children diagnosed with gastroesophageal reflux (GER). We are inviting subjects that were previously followed in the Pediatric GI programs at Massachusetts…
- Trial name
- NCT01048840
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastroesophageal Reflux Disease
Factors Influencing the Human Gut Microbiome Profile in Multi-ethnic Groups of the Singapore Community (FAMES)
The objectives of this study are to examine the effects of ethnicity, gender, and proton pump inhibitor (PPI, omeprazole), on the human gut microbiome.
- Trial name
- FAMES (NCT02893709)
- Testing
- Omeprazole
- Where
- Singapore
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Changi General Hospital
Gastroesophageal Reflux
Determination of the Minimal Clinically Important Difference After Treatment With Pantoprazole in Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-340)
Gastroesophageal reflux disease (GERD) is a medical condition affecting the stomach and esophagus. GERD occurs when the lower esophageal sphincter does not close properly and stomach contents leaks back (refluxes) into the…
- Trial name
- NCT00246909
- Testing
- Pantoprazole
- Where
- 51 sites in United States
- Volunteers
- 600 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease, Morbid Obesity
Gastroesophageal Reflux Disease (GERD) Before and After Gastric Bypass
The hypothesis of this study was that gastric bypass (GBP) ameliorates gastroesophageal reflux disease (GERD) in morbidly obese patients.
- Trial name
- NCT00951093
- Testing
- Gastric bypass
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Clinica Gastrobese
GERD
Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
This study is a randomised, double-blind, parallel-group and placebo controlled study comparing the efficacy of esomeprazole 40 mg orally qd vs. placebo and esomeprazole 20 mg orally qd vs.
- Trial name
- NCT00241540
- Testing
- Esomeprazole
- Where
- 119 sites in United States, Belgium and 4 more
- Volunteers
- 808 people
- Sponsor
- AstraZeneca
Dyspepsia, Gastroesophageal Reflux
BRAVO Study for Functional Dyspepsia
Background: Functional dyspepsia is one of the commonest digestive disorders. The pathophysiology of functional dyspepsia is uncertain.
- Trial name
- BD (NCT01349413)
- Testing
- Esomeprazole 20mg
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- Chinese University of Hong Kong
Gastroesophageal Reflux Disease
Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
This study is designed to evaluate the efficacy and tolerability of ilaprazole relative to that of esomeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.
- Trial name
- NCT02860624
- Testing
- 10 mg ilaprazole, 40mg esomeprazole
- Volunteers
- 550 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Gastroesophageal Reflux Disease
Prevalence of Gastroesophageal Reflux Disease in Primary Care Patients With Upper Gastrointestinal Symptoms
The purpose of this study is to provide data on the gastroesophageal reflux disease (GERD) prevalence as percentage of patients with upper gastrointestinal (GI) symptoms that are identified with GERD using the Gerd-Q…
- Trial name
- NCT01020890
- Where
- 12 sites in Bulgaria
- Volunteers
- 2,210 people
- Sponsor
- AstraZeneca
Heartburn
Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With Heartburn
Remote un-controlled trial to evaluate the tolerability of MHS-1031 and separately the tolerability of the formulated placebo in subjects with heartburn.
- Trial name
- NCT05363618
- Testing
- Panosyl-isomaltooligosaccharides (PIMO) 1g (1.4 ml)
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Microbiome Health Sciences
Esophageal Motility Disorders
Effect of Azithromycin on Oesophageal Hypomotility
Patients with difficulty in swallowing (dysphagia) or with reflux disease are frequently found to suffer from oesophageal hypomotility (weak contractions).
- Trial name
- NCT01448993
- Testing
- Azithromycin
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- JAFAR JAFARI
Laryngopharyngeal Reflux
Laryngopharyngeal Reflux and Proton Pump Inhibitor (PPI) Treatment
This study proposes to investigate prospectively, the presence of molecular markers for inflammation in laryngopharyngeal reflux (LPR) patients and to study the effect of a proton pump inhibitor (Aciphex) on these molecular…
- Trial name
- NCT00204698
- Testing
- Aciphex
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Utah
Peptic Ulcer, Gastroesophageal Reflux
S-CEI of Nexium in Paediatric Patients
To capture safety and efficacy when Nexium are administered to pediatric patients in clinical practice after launch
- Trial name
- NCT03562026
- Where
- 31 sites in Japan
- Volunteers
- 240 people
- Sponsor
- AstraZeneca
Peptic Ulcer, Dyspepsia
HEP-FYN 12-Years Follow-up
Aims: 1. Evaluate the long-term effect of screening and eradication of Helicobacter Pylori on the prevalence of dyspepsia, and, as secondary outcomes, to assess the effect on dyspepsia related health-care consumption and quality…
- Conditions
- Peptic Ulcer, Dyspepsia, Reflux
- Trial name
- NCT02001727
- Testing
- 13C-Urea breath test for Helicobacter Pylori, Questionaire
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Reflux, Esophagitis
The Effect of Nexium on Transmucosal Esophageal Leak
In a related study, the investigators have found evidence that patients with Barrett's esophagus have a leak for oral sucrose to leave their upper gastrointestinal tract, enter the blood, and be filtered into urine.
- Conditions
- Reflux, Esophagitis, Barrett's Esophagus
- Trial name
- NCT00216788
- Testing
- Esomeprazole (Nexium) 40 mg/day
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Main Line Health
Non-Erosive Gastro-Esophageal Reflux Disease, Gastroesophageal Reflux Disease (GERD)
Evaluation of the Clinical Course of NERD and Assessment of the Esophageal Mucosa Resistance
GERD is characterized by a high prevalence (about 13.3%) and is associated with a deterioration in the quality of life, as well as an increased risk of esophageal adenocarcinoma and a rise in the number of refractory cases.
- Trial name
- NCT07174882
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
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