Clinical trials: Gastroesophageal Reflux
Gastroesophageal Reflux Disease
An Observational Clinical Feasibility Study of the Magnetic Esophageal Sphincter
Magnetic Esophageal Sphincter implant is intended to reinforce Esophageal Sphincter function in the treatment of Gastroesophageal Reflux Disease (GERD)
- Trial name
- NCT01058070
- Testing
- Torax Medical, Inc. LINX Reflux Management System
- Where
- 5 sites in United States, Italy and 1 more
- Volunteers
- 44 people
- Sponsor
- Torax Medical Incorporated
Laryngopharyngeal Reflux, Chronic Rhinosinusitis (Diagnosis)
Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis
The hypothesis of this study is that a gastroesophageal reflux recommended treatment with proton pump inhibitor (dose and duration) compared to placebo significantly reduces both the signs and symptoms of laryngopharyngeal reflux…
- Trial name
- NCT03086070
- Testing
- Omeprazole 20mg
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Srebrnjak
Gastroesophageal Reflux Disease
A Study to Evaluate the Improvement Effect on Subjective Symptom of FEXUCLUE Tab
This observation study is a large-scale, prospective, and multi-organ observation study to observe the improvement effect of the self-evaluation results (PRO) of erosive gastroesophageal reflux disease at least 4 to 8 weeks after…
- Trial name
- NCT05660122
- Testing
- Fexuprazan Hydrochloride
- Where
- South Korea
- Volunteers
- 2,852 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Gastroesophageal Reflux
Natural History of Gastroesophageal Reflux (GER) in Children and Adolescents
The goal of this project is to determine the long-term health outcome of children diagnosed with gastroesophageal reflux (GER). We are inviting subjects that were previously followed in the Pediatric GI programs at Massachusetts…
- Trial name
- NCT00181805
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastroesophageal Reflux
Targeting Hypervigilance and Autonomic Arousal: the Psycho-physiologic Model of Gastroesophageal Reflux Disease (GERD)
GERD affects roughly 20% of the U.S. population and the direct and indirect costs of GERD are substantial, totaling close to 50 billion dollars per year.
- Trial name
- NCT04960566
- Testing
- Cognitive Behavioral Therapy
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Northwestern University
Mitral Valve (MV) Regurgitation
HighLife Clarity Treatment of Severe Mitral Regurgitation
The purpose of the study is to evaluate the safety and effectiveness of the HighLife transcatheter trans-septal mitral valve replacement (TSMVR) system in NYHA Class ≥ II-IV patients with moderate-to-severe or severe mitral…
- Trial name
- HIGHFIVE (NCT06683729)
- Testing
- Trans-septal (TS) Mitral Valve Replacement (TSMVR) Valve system
- Volunteers
- 240 people
- Sponsor
- HighLife SAS
Gastroesophageal Reflux
Serial Exhaled Breath pH Monitoring
This study will seek to determine the amount of acids a person with a chronic cough that is suspected to be related to acid reflux breathes out after coughing.
- Trial name
- NCT00330603
- Testing
- Serial exhaled breath collections
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- University of Virginia
Hiatal Hernia With Gastroesophageal Reflux Disease, Gastroesophageal Reflux
Complications, Outcomes and Revisions Following Hiatal Hernia Repair With MIROMESH
Investigator will identify a consecutive cohort of patients who have undergone a hiatal hernia repair and are at least 6 months post index procedure.
- Conditions
- Hiatal Hernia With Gastroesophageal Reflux Disease, Gastroesophageal Reflux, GERD
- Trial name
- NCT03735862
- Testing
- Hepatic derived surgical matrix
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Miromatrix Medical Inc.
Dyspepsia, Malabsorption Syndrome
Evaluation of Topical Lidocaine Spray as Adjuvant to Upper Gastrointestinal Endoscopy in Children
There is some controversy in the medical literature regarding the effectiveness of topical lidocaine in children as an adjuvant drug to upper gastrointestinal endoscopy.
- Conditions
- Dyspepsia, Malabsorption Syndrome, Gastroesophageal Reflux Disease, Abdominal Pain
- Trial name
- NCT00521703
- Testing
- Lidocaine, Tannic acid
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Hospital Infantil Cândido Fontoura
Vesicoureteral Reflux
Study of Endoscopic Versus Open Surgery for Urinary Reflux
This study seeks to compare outcomes after anti-reflux surgery (ARS) for correction of low-grade vesicoureteral reflux (VUR). It is a randomized controlled open-label trial of conventional open anti-reflux technique versus…
- Trial name
- STRETCH (NCT00830479)
- Testing
- Anti-reflux surgery, Endoscopic injection
- Where
- United States
- Sponsor
- Boston Children's Hospital
Inferior Nasal Turbinate Hypertrophy, Extraesophageal Reflux
Effect of Extraesophageal Reflux on Inferior Nasal Turbinates Hypertrophy
The study examines the severity of extraesophageal reflux using oropharyngeal pH monitoring in patients with varying degrees of lower turbinates hypertrophy.
- Trial name
- NCT04581174
- Testing
- 24-hour monitoring of oropharyngeal pH by Restech, RYAN scores upright and supine, and pH values <5.5 will be evaluated
- Where
- 3 sites in Czechia, Slovakia
- Volunteers
- 160 people
- Sponsor
- University Hospital Ostrava
Gastroesophageal Reflux Disease
Determinants of Efficacy of EsophyX Treatment in Gastro-Esophageal Reflux Disease
EsophyX is a promising endoscopic treatment for gastro-esophageal reflux disease. It is not known whether there are some pre- or per-operative anatomic or pathophysiological findings which may influence outcome.
- Trial name
- NCT00498082
- Where
- Belgium
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Gastro Esophageal Reflux
The Effect of Positional Therapy on Symptoms of Gastroesophageal Reflux Disease: A Prospective Pilot Study
Gastroesophageal reflux disease related symptoms are reported by 10-20% of the adult population and of those 50-75% report symptoms during sleep time.
- Trial name
- NCT04500288
- Testing
- LEFT Device
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Gastroesophageal Reflux Disease
Anti-reflux Mucosal Ablation Therapy Randomized Sham Control Trial for Gastroesophageal Reflux Disease
The goal of this randomized clinical trial is to investigate the efficacy and safety of antireflux mucosal ablation (ARMA) for patients with refractory gastroesophageal reflux disease (GERD).
- Trial name
- NCT06106100
- Testing
- Antireflux mucosal ablation
- Volunteers
- 68 people
- Sponsor
- Far Eastern Memorial Hospital
GERD
Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal Patients
The purpose of this study is to assess the difference between esomeprazole and placebo in the treatment of signs and symptoms as observed by 8-hour video and cardiorespiratory monitoring in neonatal patients.
- Trial name
- NCT00427635
- Testing
- Esomeprazole
- Where
- 3 sites in Australia, Germany and 1 more
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease, Erosive Esophagitis
Safety and Efficacy of Dexlansoprazole Delayed-Release Capsules for Healing of Erosive Esophagitis and Maintenance of Healed Erosive Esophagitis and Relief of Heartburn in Adolescents
The purpose of this study is to assess the safety and effectiveness of treatment with once daily oral administration of dexlansoprazole delayed-release capsules in adolescents with erosive esophagitis (EE) and for maintenance of…
- Trial name
- NCT01642615
- Testing
- Dexlansoprazole
- Where
- 60 sites in United States, Belgium and 6 more
- Volunteers
- 63 people
- Sponsor
- Takeda
Non-erosive Gastroesophageal Reflux Disease
Phase 3 Study of TAK-438 10 mg in the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)
The purpose of this study was to evaluate the efficacy and safety of oral TAK-438 10 mg once-daily in the treatment of non-erosive gastroesophageal reflux disease (NERD).
- Trial name
- NCT02954848
- Testing
- TAK-438 10 mg
- Where
- 30 sites in Japan
- Volunteers
- 484 people
- Sponsor
- Takeda
Insomnia, GERD
Sleep Disorders and Gastroesophageal Reflux Disease (GERD)
This study will investigate Gastroesophageal Reflux Disease (GERD)as a cause of sleep disturbance. Patients with GERD may experience all or some of the following symptoms: stomach acid or partially digested food re-entering the…
- Trial name
- NCT00287391
- Testing
- Rabeprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
GERD
Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM
Peroral Endoscopic Myotomy (POEM) is a well-established treatment for achalasia; however, it is frequently associated with gastroesophageal reflux disease (GERD), with many patients developing LA grade B or higher esophagitis.
- Trial name
- NCT06955520
- Testing
- Vonoprazan, Esomeprazole 40mg
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Asian Institute of Gastroenterology, India
Varicose Veins
Endovenous Radiofrequency Versus Laser Ablation for the Treatment of Great Saphenous Vein Reflux
our aim is to compare early outcomes following EVL 1320 nm and segmental RF in a randomized study.
- Trial name
- NCT02080013
- Testing
- radiofrequency
- Volunteers
- 5 people
- Sponsor
- Ain Shams University
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