Clinical trials: Gastroesophageal Reflux
Gastro-esophageal Reflux Disease
Outcomes for Patients With Gastro-Esophageal Reflux Disease
Gastro-esophageal reflux disease (GERD), the most common cause of erosive esophagitis (EE), remains highly prevalent worldwide. GERD poses substantial burden on both patients and society.
- Trial name
- NCT03824548
- Testing
- this is non-intervention study, there is no intervention drug or device in this study.
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- Tianjin Happy Life Technology Co., Ltd.
Varicocele
Reflux Flow Volume Impact on Semen Parameters Pre and Post Varicocelectomy
Evaluation of the impact of reflux flow volume and other ultrasonographic diagnostic parameters of varicocele on semen parameters before and 3 months varicocelectomy
- Trial name
- NCT07263009
- Volunteers
- 100 people
- Sponsor
- Assiut University
Gastroesophageal Reflux, Regurgitation
Prospective, Comparative, Randomized, Controlled Trial on the Efficacy of the Treatment of Gastroesophageal Reflux Infant With Magnesium Alginate
The results on the efficacy of the formulations based on alginic acid are controversial. Corvaglia et al demonstrated a significant reduction in reflux episodes in preterm infants by evaluation with pH-impedance analysis.
- Conditions
- Gastroesophageal Reflux, Regurgitation, Vomiting, Chronic Cough
- Trial name
- NCT01858584
- Testing
- Gastrotuss, thickened milk
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Federico II University
Gastroesophageal Reflux Disease
Treatment of Gastroesophageal Reflux Disease in 12-16 Year Old Patients With Rabeprazole
The primary objective of this study is to collect safety information on rabeprazole 10 mg and 20 mg in the treatment of gastroesophageal reflux disease (GERD) in children aged 12 to 16 years.
- Trial name
- NCT00132496
- Testing
- rabeprazole sodium
- Where
- 25 sites in United States
- Volunteers
- 111 people
- Sponsor
- Eisai Inc.
Esophagitis, Reflux Esophagitis
The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis
The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on the production of inflammatory cytokines that lead to reflux esophagitis.
- Conditions
- Esophagitis, Reflux Esophagitis, Gastroesophageal Reflux Disease
- Trial name
- NCT01733810
- Testing
- Cessation of Acid Suppressing Medications
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Dallas VA Medical Center
Non-Erosive Gastroesophageal Reflux Disease
Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Non Erosive Reflux Disease
The purpose of this study is to demonstrate the superiority of efficacy of DWP14012, once daily (QD), compared to placebo in patients with non-erosive reflux disease at Week 4.
- Trial name
- NCT03811080
- Testing
- DWP14012 A mg, DWP14012 B mg
- Where
- South Korea
- Volunteers
- 327 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
GERD, Reflux
Role of ARMA in Selective Subset of Refractory GERD Patients.
To study the role of a novel endoscopic treatment technique (ARMA) in GERD patients who doesn't respond to PPI therapy (Proton Pump Inhibitor).
- Conditions
- GERD, Reflux, Reflux Esophagitis
- Trial name
- NCT05899491
- Testing
- ARMA, UGI Endoscopy
- Where
- India
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
GASTROINTESTINAL NEOPLASMS
Longitudinal Study on the Evolution Trend and Influencing Factors of Postoperative Reflux of Esophageal Cancer Based on PEPTEST Technique
The goal of this observational study intends to explore the evolution trend and related factors of postoperative reflux of esophageal cancer based on PEPTEST detection, in order to identify postoperative reflux The main question…
- Trial name
- NCT06509022
- Testing
- PEPTEST test
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Pregnancy, Respiratory Aspiration of Gastric Contents
Gastric Emptying Following an Oral Carbohydrate Load in Women Admitted for Elective Cesarean Delivery
Because of the risk of pulmonary aspiration, patients are asked to comply with the fasting guidelines when they are scheduled for an elective cesarean section.
- Trial name
- NCT03593980
- Testing
- Cranberry juice
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Gastroesophageal Reflux Disease, Heartburn
Investigate the Effect of Different Doses of Lesogaberan (AZD3355) as add-on to PPI in GERD Patients With Partial Response to PPI
This study is being carried out to see whether AZD3355 is an effective treatment as an add-on to PPI therapy in patients with Gastroesophageal Reflux Disease (GERD) with a partial response to PPI and to compare this with Proton…
- Conditions
- Gastroesophageal Reflux Disease, Heartburn, Regurgitation
- Trial name
- NCT01005251
- Testing
- lesogaberan (AZD3355)
- Where
- United States
- Volunteers
- 661 people
- Sponsor
- AstraZeneca
Esophageal Reflux
Rabeprazole in Subjects With Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to determine the production of mucin in GERD/RE subjects before and after 8 weeks of treatment with rabeprazole.
- Trial name
- NCT00222170
- Testing
- Rabeprazole
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Kansas
Varicose Veins, Venous Reflux
Comparison of Zero- and Two-centimeter Distance From Sapheno-femoral Junction in Laser Ablation of Varicose Vein
EVLA is used in in treating refluxing veins, commonly the GSV. The tip of catheter is usually placed 2-2.5 cm distal to the sapheno-femoral junction.
- Conditions
- Varicose Veins, Venous Reflux, Venous Insufficiency, Venous Leg Ulcer
- Trial name
- NCT05707169
- Testing
- Saphenous Ablation, Endogenous Laser Ablation (EVLA), mixture of 20 mL 2% lidocaine, 1: 200,000 adrenaline and 20 mL 0.5% levobupivacaine in 1 L of 0.9% saline
- Where
- Egypt
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Reflux Esophagitis
The Phase III Clinical Trial of X842 Capsules for Reflux Esophagitis
To evaluate the efficacy and safety of X842 Capsules 50 mg compared to Lansoprazole Enteric Capsules for the treatment of reflux esophagitis, and to characterize the population pharmacokinetics of X842 capsules in this patient…
- Trial name
- X842 (NCT07079540)
- Testing
- X842, Lansoprazole
- Where
- 53 sites in China
- Volunteers
- 380 people
- Sponsor
- Jiangsu Sinorda Biomedicine Co., Ltd
Gastro-oesophageal Reflux
A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg
The primary objective of this study is to compare, the number of patients with heartburn and regurgitation symptom resolution after treatment with either rabeprazole 20 mg, esomeprazole 20 mg or esomeprazole 40 mg.
- Trial name
- NCT00464308
- Testing
- Esomeprazole, Rabeprazole
- Where
- 25 sites in Australia
- Volunteers
- 1,392 people
- Sponsor
- Janssen-Cilag Pty Ltd
Aortic Regurgitation
HLT® Meridian® TAVR Valve System Early Feasibility Study for Aortic Regurgitation
To evaluate the safety and performance of The Meridian® TAVR Valve in patients with severe aortic regurgitation who present at high risk for aortic valve replacement surgery.
- Trial name
- RIVAL - AR EFS (NCT05409378)
- Testing
- The HLT® Meridian® TAVR Valve (Meridian® with TriVentTM Anticalcification Treatment Valve and Pathfinder® Delivery System)
- Where
- 3 sites in United States
- Sponsor
- HLT Inc.
Anesthesia, Gastric Ultrasound
Gastric Emptying Time in Traumatic Injuries
The investigators plan to do serial sonographic examinations of the gastric antrum (quantity, quality) to estimate the gastric emptying time and dependant factors after traumatic injurys.
- Conditions
- Anesthesia, Gastric Ultrasound, Sonography, Point of Care Ultrasound (POCUS)
- Trial name
- NCT06643325
- Testing
- Gastric ultrasound
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Kantonsspital Winterthur KSW
Gastroesophageal Reflux, Obesity
A Study to Reduce the Reflux After a Sleeve Gastrectomy in Obese Patients
This is a monocentric randomized controlled prospective study. A total of 122 patients will be recruited and randomized 1: 1 in the experimental group - Laparoscopic Sleeve Gastrectomy and Diaphragmatic Pillar Closure - or in the…
- Trial name
- NCT04287972
- Testing
- DPC, LSG
- Where
- Switzerland
- Sponsor
- Fabio Garofalo
Vesicoureteral Reflux 3
Study of Gut Microbiota Diversity in Children Aged 1-3 Years on Prolonged Antibiotic Prophylaxis for Grade 3 or Higher Vesicoureteral Reflux Compared With 2 Age-matched Control Groups
Urinary tract infections are very common in pediatrics. Urinary antibiotic prophylaxis is commonly used in children with malformative uropathies.
- Trial name
- PROPHYBIOTA (NCT05319067)
- Testing
- Stool sampling
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Gastroesophageal Reflux
An Efficacy and Safety Study of XP19986 in Subjects With Symptomatic GERD
To evaluate efficacy and safety of treatment with XP19986 Sustained Release (SR) Tablet compared to placebo in subjects with symptomatic GERD
- Trial name
- NCT00557401
- Testing
- XP19986 SR3, 20 mg QD, XP19986 SR3, 40 mg QD, XP19986 SR3, 60 mg QD
- Where
- United States
- Volunteers
- 156 people
- Sponsor
- XenoPort, Inc.
Bile Duct Stricture
Intraintestinal Extended Biliary Stents Preventing Duodenobiliary Reflux in Patients With Biliary Stricture
Metal or plastic biliary stents placement under Endoscopic Retrograde Cholangiopancreatography(ERCP) is a well-established treatment for patients with benign biliary obstruction to relieve jaundice, a palliative treatment for…
- Trial name
- NCT04550819
- Testing
- intraintestinal extended biliary stents, ordinary plastic biliary stents
- Where
- China
- Volunteers
- 724 people
- Sponsor
- Peking University Third Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.