Clinical trials: Gastroesophageal Reflux
Pulmonary Aspiration of Gastric Contents
Prophylaxis for Aspiration of Gastric Contents.
Effect of orally administered two equal and consecutive doses of proton pump inhibitors, omeprazole, lansoprazole, esomeprazole , rabeprazole and pantoprazole and Histamine 2 receptor antagonists cimetidine…
- Trial name
- NCT02703896
- Testing
- Drug either PPIS or H2RA and prokinetics, orogastric intubation
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- King Saud University
Cough
Esophageal Motility in Reflux Induced Cough
To determine whether contraction abnormalities in the esophagus plays a role in gastroesophageal reflux induced cough, and thus cough severity in patients with chronic cough.
- Trial name
- NCT02492126
- Testing
- Citric Acid
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Mayo Clinic
Asthma
Lansoprazole to Treat Children With Asthma
Many individuals with asthma also experience gastroesophageal reflux disease (GERD), a condition in which excess stomach acid flows backwards into the esophagus.
- Trial name
- SARCA (NCT00442013)
- Testing
- Lansoprazole
- Where
- 20 sites in United States
- Volunteers
- 306 people
- Sponsor
- Johns Hopkins University
Barrett's Esophagus, Gastroesophageal Reflux Disease
Reflux-Induced Oxidative Stress in Barrett's Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition
The purpose of this study is to elucidate mechanisms whereby oxidative stress induced by acute reflux esophagitis: 1) activates p38 to regulate proteins that control the G1/S cell cycle checkpoint, and 2) activates HIFs (hypoxia…
- Trial name
- NCT02579460
- Testing
- Cessation of Acid Suppressing Medications
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dallas VA Medical Center
Non-Erosive Gastro-Esophageal Reflux Disease, Gastroesophageal Reflux Disease (GERD)
Evaluation of the Clinical Course of NERD and Assessment of the Esophageal Mucosa Resistance
GERD is characterized by a high prevalence (about 13.3%) and is associated with a deterioration in the quality of life, as well as an increased risk of esophageal adenocarcinoma and a rise in the number of refractory cases.
- Trial name
- NCT07174882
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Non-Erosive Gastroesophageal Reflux Disease (NERD)
Mirgeal® Gel as Add-on Therapy to Esomeprazole in Adults With Non-Erosive Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a common condition that can cause symptoms including heartburn, acid regurgitation, sour taste and other upper gastrointestinal complaints.
- Trial name
- NCT07790549
- Testing
- Esomeprazole 20mg, Mirgeal® Gel (manufacturer: PharmExtracta S.p.A.)
- Where
- 2 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Early Gastric Cancer, Adenocarcinoma of the Stomach
SPADE Clinical Trial.
Purpose: This multicenter, prospective, single-arm phase 2 clinical trial aims to evaluate the safety, feasibility, and clinical outcomes of the SPADE operation (Spade-Shaped Anastomosis) in patients undergoing laparoscopic or…
- Conditions
- Early Gastric Cancer, Adenocarcinoma of the Stomach, Proximal Gastric Cancer, SPADE Operation
- Trial name
- SPADE (NCT07892183)
- Testing
- Spade-Shaped Anastomosis after Laparoscopic or Robotic Proximal Gastrectomy Using Double Suture Anchoring between the Posterior Wall of the Esophagus and the Anterior Wall of the Stomac
- Where
- South Korea
- Volunteers
- 159 people
- Sponsor
- National Cancer Center, Korea
Gastroesophageal Reflux, GERD
Influence of Central Obesity on the Esophageal Epithelial Barrier
This study is being done to help understand why some people with an increased amount of central obesity, without gastroesophageal reflux, develop changes to the lining of their esophagus that can potentially lead to esophageal…
- Trial name
- NCT02776982
- Testing
- Confocal endomicroscopy, Mucosal impedance, Research biopsies
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Dyspepsia, GERD
Famotidine and Antacids for Treatment of Dyspepsia
The aim of this study is to compare intravenous famotidine, an H2 receptor antagonist, and Maalox/ Mylanta, an oral antacid, in treatment of dyspepsia in the emergency department.
- Conditions
- Dyspepsia, GERD, Acid Reflux
- Trial name
- NCT06241183
- Testing
- Intravenous Famotidine, Oral Maalox/ Mylanta
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Stony Brook University
Laryngopharyngeal Reflux, Chronic Rhinosinusitis (Diagnosis)
Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic Rhinosinusitis
The hypothesis of this study is that a gastroesophageal reflux recommended treatment with proton pump inhibitor (dose and duration) compared to placebo significantly reduces both the signs and symptoms of laryngopharyngeal reflux…
- Trial name
- NCT03086070
- Testing
- Omeprazole 20mg
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Srebrnjak
Gastroesophageal Reflux Disease (GERD)
Anthropometry in Gastroesophageal Reflux Disease and Esophageal Injury
Is waist to hip ratio (WHR), waist circumference (WC), (as markers of visceral adiposity) associated with an increase in acidic and non acidic reflux as well as systemic inflammation involving esophageal mucosa, thereby…
- Trial name
- NCT01570842
- Testing
- Anthropometric measurements, Tissue samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
Gastro Esophageal Reflux Disease
Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance
Study Hypothesis: This study is designed as an integral part of the development of new or improved features or components of the Bravo® pH Monitoring System and may serve verification and validation purposes The study population…
- Trial name
- NCT01503476
- Testing
- Bravo® pH Monitoring System
- Where
- Israel
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Non-erosive Gastroesophageal Reflux Disease
Efficacy of TAK-438 Compared to Placebo in the Treatment of Non-Erosive Gastroesophageal Reflux Disease
The purpose of this study is to investigate the superiority of efficacy of TAK-438, once daily (QD), to placebo in patients with non-erosive gastroesophageal reflux disease.
- Trial name
- NCT01474369
- Testing
- TAK-438
- Where
- 52 sites in Japan
- Volunteers
- 827 people
- Sponsor
- Takeda
Gastroesophageal Reflux
Long Term Incidence and Effect of de Novo GERD After Laparoscopic Sleeve Gastrectomy in Chinese Population
To evaluate the long-term incidence and effects of gastroesophageal reflux disease in the Chinese population after laparoscopic sleeve gastrectomy.
- Trial name
- NCT04237857
- Testing
- Laparoscopic sleeve gastrectomy
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Feeding Tube
Self-Propelled Versus Standard Percutaneous Endoscopic Gastrojejunostomy(PEG-J); RCT
Our main hypothesis is that self-propelled Percutaneous Endoscopic Gastrojejunostomy tube (PEG-J) that has a balloon on it's tip is associated with lower J-tube retrograde migration rate, and lower rates of short- and long-term…
- Trial name
- NCT01892267
- Testing
- PEG-J placement
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Reflux Disease
AZD3355 Dose-escalation Study in Healthy Males
The aim is to establish the maximal tolerated dose of AZD3355 for the selection of doses in the up-coming studies. This will be done by comparing single and repeated doses of AZD3355 to placebo ("inactive substance").
- Trial name
- NCT00757419
- Testing
- AZD3355
- Where
- Sweden
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hiatal Hernia, Paraesophageal, Hiatal Hernia Large
Laparoscopic Nissen Versus Toupet Fundoplication for Hiatal Hernia.
This randomized controlled trial compares laparoscopic Nissen fundoplication and laparoscopic Toupet fundoplication in patients undergoing surgical treatment for hiatal hernia associated with gastroesophageal reflux disease.
- Conditions
- Hiatal Hernia, Paraesophageal, Hiatal Hernia Large, Hiatal Hernia With Gastroesophageal Reflux Disease
- Trial name
- NCT07718828
- Testing
- Laparoscopic Nissen Fundoplication, Laparoscopic Toupet Fundoplication
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Sofia Med Hospital
GERD (Gastroesophageal Reflux Disease), NERD
New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)
The goal of this randomized, double-blind, single-center clinical trial RELEIF is to learn if medical devices work to decrease symptoms of gastroesophageal reflux disease (GERD) in adults' patients.
- Conditions
- GERD (Gastroesophageal Reflux Disease), NERD, Heartburn, Regurgitation, Gastric
- Trial name
- RELIEF (NCT07624383)
- Testing
- Esophageal barrier medical device
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Cellmedis
Gastroesophageal Reflux Disease, Hiatal Hernia
Long-term Outcome of Laparoscopic Hiatal Hernia Repair With or Without Alloderm Mesh at a University Hospital
To study the long term outcome of Laparoscopic Hiatal Hernia Repair with human acellular dermal matrix Alloderm (LifeCell, Branchburg, NJ) mesh.
- Conditions
- Gastroesophageal Reflux Disease, Hiatal Hernia, Paraesophageal Hernia
- Trial name
- NCT01776827
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Nebraska
Gastroesophageal Reflux Disease (GERD)
A Study to Determine the Effectiveness of Endoscopic Full-Thickness Plication for the Treatment of GERD
The aim of this study was to determine the effectiveness of endoscopic full-thickness plication (Plicator; NDO Surgical, Inc., Mansfield, MA) for the treatment of GERD in comparison to a sham procedure.
- Trial name
- NCT00575822
- Testing
- NDO Full-thickness Plicator
- Where
- 15 sites in United States, Belgium and 1 more
- Volunteers
- 159 people
- Sponsor
- NDO Surgical, Inc.
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