Clinical trials: Gastroesophageal Reflux
Gastroesophageal Reflux Disease
Phase IV Study of the Impact of Dietary Fibers on Symptoms and Esophageal Motility in Patients With Non-erosive GERD
Gastroesophageal reflux disease (GERD) is a chronic condition, which may significantly decrease patients' quality of life due to the typical symptoms - heartburn and regurgitation.
- Trial name
- OGIG-130-1 (NCT01882088)
- Testing
- Mucofalk
- Where
- Russia
- Volunteers
- 36 people
- Sponsor
- Russian Academy of Medical Sciences
Gastroesophageal Reflux
The Influence of Hypnotic Medications on Sleep Arousal and Its Effect on Gastroesophageal Reflux
This is a continuation of a study that has already been completed in the division of gastroenterology (GI) looking at the effects of sleep medication zolpidem (Ambien) on subjects with Gastroesophageal reflux disease (GERD).
- Trial name
- NCT00462137
- Testing
- Sleep Studies
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Thomas Jefferson University
Non-erosive Gastroesophageal Reflux Disease
Phase 3 Study of TAK-438 10 mg in the Treatment of Non-Erosive Gastroesophageal Reflux Disease (NERD)
The purpose of this study was to evaluate the efficacy and safety of oral TAK-438 10 mg once-daily in the treatment of non-erosive gastroesophageal reflux disease (NERD).
- Trial name
- NCT02954848
- Testing
- TAK-438 10 mg
- Where
- 30 sites in Japan
- Volunteers
- 484 people
- Sponsor
- Takeda
Morbid Obesity, Gastroesophageal Reflux
MGB/OAGB and LSG Effects on Lower Esophageal Sphincter (LES) Function
Background While several articles have reported about the effects of laparoscopic sleeve gastrectomy (LSG) on the lower esophageal sphincter (LES), to date, just one paper has discussed this issue with regard the Mini/One…
- Conditions
- Morbid Obesity, Gastroesophageal Reflux, Bariatric Surgery Candidate
- Trial name
- NCT02987673
- Testing
- MGB/OAGB, LSG
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Mario Musella MD
Barrett's Esophagus, Gastroesophageal Reflux Disease
PillCam® ESO 2 in Esophageal Pathologies
Study Hypothesis: PillCam™ ESO-2 will demonstrate equivalent accuracy parameters as compared to blinded esophagogastroduodenoscopy (EGD) in detecting suspected Barrett's esophagus, detecting and grading esophagitis.
- Trial name
- MA-76 (NCT00885469)
- Where
- 10 sites in United States
- Volunteers
- 101 people
- Sponsor
- Medtronic - MITG
Gastro Esophageal Reflux Disease
Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance
Study Hypothesis: This study is designed as an integral part of the development of new or improved features or components of the Bravo® pH Monitoring System and may serve verification and validation purposes The study population…
- Trial name
- NCT01503476
- Testing
- Bravo® pH Monitoring System
- Where
- Israel
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Gastro Esophageal Reflux Disease
Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance (Encore)
Study Hypothesis: This study is designed as an integral part of the development of new or improved features or components of the Bravo® pH Monitoring System and may serve verification and validation purposes.
- Trial name
- NCT01788085
- Testing
- Bravo pH monitoring procedure
- Where
- Israel
- Sponsor
- Medtronic - MITG
Barrett's Esophagus, GERD
Cytosponge Adequacy Study Evaluation II
This study will assess the Minimally Invasive Esophageal Cytology Collection System in Patients with Barrett's Esophagus or GERD Symptoms.
- Trial name
- CASEII (NCT02395471)
- Testing
- Cytosponge™ Cell Collection Device
- Where
- 5 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Aortic Valve Disorder, Aortic Valve Insufficiency
Clinical Trial of the Edwards Aortic Bioprosthesis, Model 11000
The purpose of this observational trial is to gather further clinical data to confirm the safety and performance of the Edwards Pericardial Aortic Bioprosthesis, Model 11000 in this trial population.
- Conditions
- Aortic Valve Disorder, Aortic Valve Insufficiency, Aortic Valve Stenosis, Heart Failure
- Trial name
- NCT01651052
- Testing
- Heart Valve Surgery
- Where
- 2 sites in Poland
- Volunteers
- 133 people
- Sponsor
- Edwards Lifesciences
Gastroesophageal Reflux
Gastroesophageal Reflux Disease Among College Students
Background: Gastroesophageal reflux disease (GERD) is a worldwide prevalent gastrointestinal disorder which has negative impacts on quality of life, health and economy.
- Trial name
- NCT04034017
- Testing
- no intervention
- Where
- Saudi Arabia
- Volunteers
- 2,878 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Cough
Validation of Peptest™ for the Detection of Reflux in Cough
Chronic cough is a common presenting problem which has a significant impact on quality of life. Gastro-oesophageal reflux (GOR) is a common cause of chronic cough and reflux of stomach contents into the airways has been…
- Trial name
- NCT03851393
- Testing
- Induction of cough with inhaled citric acid, Peptest™ analysis of saliva pepsin, Peptest™
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Barrett's Esophagus, Radiofrequency Ablation
Radiofrequency Ablation in Patients With Barrett's Esophagus
The aim of this study is to establish a nationwide registry to collect data regarding the treatment of Barrett's Esophagus (BE) with radiofrequency ablation.
- Conditions
- Barrett's Esophagus, Radiofrequency Ablation, Gastroesophageal Reflux Disease
- Trial name
- RABE (NCT02793479)
- Where
- Austria
- Volunteers
- 500 people
- Sponsor
- Matthias Paireder
Heartburn, Gastroesophageal Reflux Disease
Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese Patients
The purpose of this study is to determine the efficacy and safety of dexlansoprazole compared to placebo in relief of daytime and nighttime heartburn over 4 weeks in Chinese participants with symptomatic non-erosive…
- Trial name
- NCT02873689
- Testing
- Dexlansoprazole
- Where
- 25 sites in China
- Volunteers
- 217 people
- Sponsor
- Takeda
Quality of Life, Dysphagia
Lower Esophageal Sphincter (LES) Stimulation in Patients With Ineffective Esophageal Motility
The aim of this study is to evaluate gastroesophageal reflux disease - health related quality of life (GERD-HRQL) after electrical stimulation of the lower esophageal sphincter (LES) in patients with gastroesophageal reflux…
- Conditions
- Quality of Life, Dysphagia, Electrical Stimulation of the Lower Esophageal Sphincter, Gastro Esophageal Reflux
- Trial name
- DYSMOSTIM (NCT03476265)
- Testing
- Electrical Stimulation of the Lower Esophageal Sphincter
- Where
- Austria
- Volunteers
- 17 people
- Sponsor
- Austrian Society Of Surgical Oncology
Esophageal Disease
Treatment Response of High-dose and Standard-dose Rabeprazole for Extra-esophageal Reflux.
This is a single-center, randomized, open-label clinical study to assess the treatment response of high-dose rabeprazole compared with standard-dose rabeprazole in patients with extra-esophageal manifestations of gastroesophageal…
- Trial name
- NCT04001400
- Testing
- Rabeprazole 20mg bid, Rabeprazole 20mg qd
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Hospital
Esophageal Disease
Efficacy of DA-5204 on Gastroesophageal Reflux Disease
This is a single-center, randomized, double-blind, placebo-controlled clinical Study to evaluate the efficacy of DA-5204 and proton pump inhibitor combination therapy compared with proton pump inhibitor alone therapy in patients…
- Trial name
- NCT03998969
- Testing
- Pantoprazole, DA-5204
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Hospital
Non-Erosive Gastroesophageal Reflux Disease
Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Non Erosive Reflux Disease
The purpose of this study is to demonstrate the superiority of efficacy of DWP14012, once daily (QD), compared to placebo in patients with non-erosive reflux disease at Week 4.
- Trial name
- NCT03811080
- Testing
- DWP14012 A mg, DWP14012 B mg
- Where
- South Korea
- Volunteers
- 327 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Gastroesophageal Reflux Disease
Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease
BACKGROUND: Gastroesophageal reflux disease is a very frequent clinical condition and nocturnal symptoms are a cause of quality of life impairment, poor sleep quality and absenteeism.
- Trial name
- IBELGA (NCT02706938)
- Testing
- Head of bed elevation, Standard treatment
- Where
- Colombia
- Volunteers
- 65 people
- Sponsor
- Universidad Nacional de Colombia
Gastroesophageal Reflux Disease, Globus Pharyngeus
Manual Therapy Effects on Upper and Lower Esophageal Sphincter Pressures
The aim of this study is to test the influence of manual cervical traction and chest stabilization maneuvers on pressures in upper and lower esophageal sphincters.
- Trial name
- NCT03871426
- Testing
- manual therapy
- Where
- Czechia
- Volunteers
- 54 people
- Sponsor
- University Hospital, Motol
Gastro Esophageal Reflux
Bitter Tastants and Reflux
Recently the relationship between intragastric pressure (IGP) and reflux events after a meal was investigated, both in gastro-esophageal reflux disease (GERD) patients and in healthy volunteers.
- Trial name
- NCT03777787
- Testing
- Denatonium Benzoate, Water
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven