Clinical trials: Gastroesophageal Reflux
GERD, Gastro Esophageal Reflux
Endoscopic Resection in Gastro-Esophageal Reflux Disease
Currently patients with gastroesophageal reflux disease (GERD) are treated with proton pump inhibitors (PPIs). This long-term PPI treatment would likely increase the risk of pulmonary and digestive infections and would not…
- Trial name
- RESECT-RGO (NCT03357809)
- Testing
- Endoscopic mucosal resection
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Gastroesophageal Reflux Disease
The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease
Gastro-Esophageal Reflux Disease was defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications.
- Trial name
- NCT00915616
- Testing
- Melatonin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mansoura University
Hiatal Hernia Large, Reflux, Gastroesophageal
Platelet Rich Plasma in Hiatal Hernia Repair
Rationale: Gastroesophageal reflux disease (GERD) is a common disease caused by a dysfunctional lower esophageal sphincter and an abnormal esophageal hiatus or hiatal hernia.
- Trial name
- PPR-HHR (NCT05023174)
- Testing
- Hiatal Hernia Repair with Platelet Rich Plasma, Hiatal Hernia Repair without Platelet Rich Plasma
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Southern California
Gastroesophageal Reflux Disease, Erosive Esophagitis
Sensory Evaluation of Dexlansoprazole Delayed-Release Orally Disintegrating Tablets
The purpose of this study is to measure the in-vivo disintegration time of a single dexlansoprazole delayed-release orally disintegrating (OD) tablet.
- Conditions
- Gastroesophageal Reflux Disease, Erosive Esophagitis, Heartburn
- Trial name
- NCT02096458
- Testing
- Dexlansoprazole
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Takeda
GERD, Non-erosive Reflux Disease
Comorbid Esophageal Disorders in IBS Patients
assess the incidence of the entire spectrum of esophageal disorders and possible theories for overlap in IBS patients using different diagnostic modalities.
- Conditions
- GERD, Non-erosive Reflux Disease, Functional Esophageal Disorders, Irritable Bowel Syndrome
- Trial name
- NCT04759378
- Testing
- Upper endoscopy, esophageal manometry, 24-hour pH monitoring
- Volunteers
- 50 people
- Sponsor
- Assiut University
Patient Satisfaction, Relapse
Long-term Follow-up After Surgical Treatment for GERD (Gastroesophageal Reflux Disease)
10 years of follow-up with SF-36 global (Quality of Life issues), GSRS (Gastrointestinal Symptom Rating Scale) and two reflux specific questionnaires.
- Conditions
- Patient Satisfaction, Relapse, Dysphagia, Bloating
- Trial name
- NCT04182178
- Testing
- 10 years follow up
- Where
- Sweden
- Volunteers
- 307 people
- Sponsor
- Karolinska Institutet
Venous Leg Ulcer
A Prospective Randomized, Double-Blind, Placebo-Controlled Trial Comparing VitroGro® ECM to Placebo in Patients With Venous Leg Ulcers
The objective of this study is to assess the efficacy and safety of VitroGro® combined with standard care in the treatment of Venous Leg Ulcers (VLUs) compared to Placebo with standard care over the course of the 8-week treatment…
- Trial name
- NCT01982318
- Testing
- VitroGro® ECM, Dulbecco's Phosphate Buffered Saline
- Sponsor
- Tissue Therapies Ltd.
GERD
Melanole, a Dietary Supplement, for the Treatment of Gastroesophageal Reflux Disease
Melanole, a Nigella sativa (Black Seed) extract , is studied for the treatment of GERD. Participants, who meet the inclusion criteria, will be divided into two arms.
- Trial name
- GERDMeDS (NCT02587910)
- Testing
- Melanole for GERD treatment
- Where
- 2 sites in Lebanon
- Volunteers
- 170 people
- Sponsor
- Lebanese American University
Gastroesophageal Reflux
Fexofenadine Use in Gastroesophageal Reflux Symptoms
The investigators wish to study the effectiveness of Fexofenadine (an over the counter allergy pill) for the treatment of gastroesophageal reflux symptoms in patients who still have symptoms despite being on a proton pump…
- Trial name
- NCT03425097
- Testing
- Fexofenadine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Stanford University
Barrett Esophagus, Gastroesophageal Reflux
Assessment of Zegerid on Esophageal pH in Patients With Barrett's Esophagus
The purpose of this research study is to assess how safe, effective (how well it works), and tolerable (to put up with) the drug Zegerid is in reducing reflux episodes in patients who have both gastroesophageal reflux disease…
- Trial name
- NCT01129778
- Testing
- Zegerid (proton pump inhibitor), Bravo pH monitoring
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Stanford University
Refractory Gastroesophageal Reflux Disease
Anti-reflux Mucosectomy (ARMS) is a Useful Therapy for Refractory Gastroesophageal Reflux Disease (RGERD)
Anti-reflux mucosectomy (ARMS) may be a new therapy for refractory gastroesophageal reflux disease (RGERD). The aim of the present study is to explore the safety and efficacy of ARMS.
- Trial name
- NCT03259191
- Testing
- anti-reflux mucosectomy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Ruihua Shi
Gastroesophageal Reflux Disease, Obesity
Waist Circumference Versus Body Mass Index to Predict Severity of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) is a common and important disorder. Previous studies have demonstrated the association of obesity with GERD, and now obesity is regarded as a risk factor for GERD.
- Trial name
- NCT00698178
- Testing
- Anthropometric measurements
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Lotung Poh-Ai Hospital
Gastroesophageal Reflux Disease
Laparoscopic Antireflux Surgery Versus Endoscopic Full-thickness Gastroplication for Gastroesophageal Reflux Disease (GERD)
Endoscopic full thickness gastroplication (Plicator-Procedure) has the potential to be a safe and effective alternative to laparoscopic antireflux surgery (LARS)to improve symptoms of GERD.
- Trial name
- NCT01324791
- Testing
- anti-reflux surgery
- Where
- Austria
- Sponsor
- General Public Hospital Zell am See
Regurgitation, Gastric
Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant Formula
A randomised, controlled, double-blind trial to evaluate the tolerance and safety of a new partly fermented anti-regurgitation infant formula containing prebiotics and locust bean gum in infants with regurgitation.
- Trial name
- Leopard (NCT03371615)
- Testing
- Anti-regurgitation infant formula
- Where
- 2 sites in Poland
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Sleeve Gastrectomy, Obesity
Clip Ascent and Sleeve Gastrectomy
This is a single institution study. All patients, one year after sleeve gastrectomy will be included. All will have a CT scan looking for clip ascent.
- Trial name
- POST-SLEEVE (NCT03932968)
- Testing
- pH-metry during 24 hours
- Where
- France
- Volunteers
- 223 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, GERD
Pharmacokinetics of Pantoprazole and CYP2C19 Activity in Children and Adolescents With GERD: A Pilot Study
The World Health Organization has declared childhood obesity to be "one of the most serious public health challenges of the 21st century," (http://www.who.int/dietphysicalactivity/childhood).
- Trial name
- NCT01887743
- Testing
- Pantoprazole
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
GERD
A Study to Compare PK, PD and Safety of UI058 and UIC202004 in Healthy Subjects
A Study to compare pharmacokinetics, pharmacodynamics and safety of UI058 and UIC202004 in healthy subjects
- Trial name
- NCT05282914
- Testing
- administration of UI058, administration of UIC202004
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Korea United Pharm. Inc.
Symptomatic Gastroesophageal Reflux Disease (sGERD)
A Multicenter, Randomized, Double-Blind Parallel-Group, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg Once Daily to Placebo qd for the Resolution of Upper Abdominal Pain in Patients With Symptomatic Gastroesophageal Reflux Disease (sGERD)
This study compares 4 weeks of treatment with Esomeprazole 20 mg once daily to Placebo in the treatment of Upper Abdominal Pain in patients with Symptomatic Gastroesophageal Reflux Disease (sGERD)
- Trial name
- NCT00626535
- Testing
- Esomeprazole
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies.
- Trial name
- NCT02934152
- Testing
- H pylori eradication, H pylori eradication timing
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
GERD
Gastric Neuromuscular Function in GERD
Bodysurface gastric mapping (BSGM) will be used to assess gastric neuromuscular function in healthy controls and patients with medical refractory gastroesophageal reflux disease (GERD).
- Trial name
- NCT05719168
- Testing
- Body Surface Gastric Mapping
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Functional Gut Clinic
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