Clinical trials: Gastroesophageal Reflux
Barrett Esophagus, Esophageal Adenocarcinoma
Barrett's Esophagus Patient Registry
The ultimate goal of the Barrett's Esophagus Patient Registry is to help develop more effective targeted screening strategies and treatment options for Barrett's esophagus and esophageal adenocarcinoma (EAC).
- Conditions
- Barrett Esophagus, Esophageal Adenocarcinoma, Gastroesophageal Reflux
- Trial name
- BPR (NCT01776346)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastroesophageal Reflux Disease
Effects of AFQ056 and Baclofen on Meal-Induced Gastroesophageal Reflux
This study will assess the safety and tolerability of oral single dose applications of AFQ056 in GERD patients.
- Trial name
- NCT00414856
- Testing
- AFQ056
- Where
- 4 sites in Belgium, France and 2 more
- Volunteers
- 34 people
- Sponsor
- Novartis
GERD (Gastroesophageal Reflux Disease), NERD
New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)
The goal of this randomized, double-blind, single-center clinical trial RELEIF is to learn if medical devices work to decrease symptoms of gastroesophageal reflux disease (GERD) in adults' patients.
- Conditions
- GERD (Gastroesophageal Reflux Disease), NERD, Heartburn, Regurgitation, Gastric
- Trial name
- RELIEF (NCT07624383)
- Testing
- Esophageal barrier medical device
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Cellmedis
Gastroesophageal Reflux Disease and Position
Car Safety Seat and Gastroesophageal Reflux Disease
What's known? Prone position is no longer a treatment option for GERD because of the association with SIDS. Originally, positioning in an infant seat was recommended for infants with GERD.
- Trial name
- NCT01266551
- Testing
- car safety seat
- Where
- Belgium
- Sponsor
- University Hospital, Antwerp
Endogenous and Esophageal Sensitivity
The Effect of Naloxone and Methylnaltrexone on Esophageal Sensitivity in Health
The aim of this study was to investigate the effect of naloxone (IV or IM administration) and methylnaltrexone (subcutaneous administration) on esophageal sensitivity, in a group of healthy volunteers in order to evaluate the…
- Trial name
- NCT03014843
- Testing
- Naloxone, Methylnaltrexone Bromide
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastro Esophageal Reflux
The Effect of Inspiratory Muscle Training in People With Gastroesophageal Reflux Disease
The present Randomized Control Trial will be a single centric, two arm parallel equivalence randomized controlled. Participants will be assigned to either the Inspiratory MuscleTraining (IMT) group (investigation) or to Sham IMT…
- Trial name
- NCT07131397
- Testing
- Inspiratory Muscle Traing
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of West Attica
Gastroesophageal Reflux
LINX Reflux Management System Clinical Study Protocol
The purpose of the study is to evaluate the safety and effectiveness of the LINX Reflux Management System in the treatment of Gastroesophageal Reflux Disease (GERD).
- Trial name
- NCT00776997
- Testing
- Magnetic Sphincter Augmentation
- Where
- 14 sites in United States, Netherlands
- Volunteers
- 100 people
- Sponsor
- Torax Medical Incorporated
Gastroesophageal Reflux
Medical and Surgical Treatment of Esophageal Reflux
The purpose of this project is to lay the groundwork for a proposed clinical trial to compare the effectiveness of two approaches to gastroesophageal reflux disease: treatment with medications and treatment with anti-reflux…
- Trial name
- NCT00061724
- Where
- 3 sites in United States
- Volunteers
- 175 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Esophagitis, Reflux
Assessment of GERD Knowledge Level Among Patients With it in Korea
1. Research topic: How much do patients with GERD know about their own disease in Korea? (multicenter survey) 2. Questionnaires for multicenter survey: 1.
- Trial name
- GERD (NCT02049723)
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Chuncheon Sacred Heart Hospital
Gastroesophageal Reflux, Heartburn
A Study of the Safety of Rabeprazole Administered to Adults With Gastroesophageal Reflux Disease (GERD)
The purpose of the study is to confirm the safety and effectiveness of rabeprazole in the treatment of patients with erosive or ulcerative gastroesophageal reflux disease (GERD) in routine primary health care.
- Trial name
- NCT00216489
- Testing
- rabeprazole sodium
- Volunteers
- 191 people
- Sponsor
- Janssen Cilag Pharmaceutica S.A.C.I., Greece
Gastroesophageal Reflux Disease
Compound Sodium Alginate Double Action Chewable Tablets 4-hour Esophageal pH Study in GERD Patients
This study is being conducted to assess the effectiveness of the Compound Sodium Alginate Double Action Chewable Tablets compared to placebo on acidic reflux events into the esophagus in patients diagnosed with Gastroesophageal…
- Trial name
- NCT01872897
- Testing
- Sodium Alginate Double Action Chewable Tablets
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Asthma, Gastroesophageal Reflux
Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma
This study will evaluate the effect of CYP2C19 and ABCB1 genes on pharmacokinetics of lansoprazole in children with mild gastroesophageal reflux (GER) and uncontrolled asthma.
- Trial name
- GenARA (NCT03015610)
- Testing
- commercially available lansoprazole
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Jason Lang, M.D., M.P.H.
Laryngeal Disease, Laryngeal Tumor
CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal Lesions
The study will take place at Rambam medical center, department of Otolaryngology Head and Neck Surgery, for two years. Patients suspected of LPR or laryngeal l tumor and are candidate for laryngeal or hypopharyngeal biopsies will…
- Conditions
- Laryngeal Disease, Laryngeal Tumor, Laryngopharyngeal Reflux
- Trial name
- NCT03214835
- Testing
- Endo CDx Brush biopsy
- Sponsor
- CDx Diagnostics
Dyspepsia, GERD
Sensitivity and Specificity of the Modified Helicobacter Test INFAI
Study to confirm the sensitivity of the C^13-UBT using the new test meal for H. Pylori in patients with dyspepsia and GERD taking PPI Secondary objectives : to compare the sensitivity and specificity of the C^13-UBT using the new…
- Trial name
- NCT04294823
- Testing
- Helicobacter Pylori Diagnostic, Vital signs measurments, endoscopy
- Where
- France
- Sponsor
- International Pharmaceutical Consultancy
Erosive Gastroesophageal Reflux Disease
Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 2, Therapeutic Exploratory Study)
The purpose of this study is to determine the efficacy and safety of DWP14012 compared to esomeprazole in the treatment of erosive gastroesophageal reflux disease classified as Los Angeles(LA) classification grades A to D.
- Trial name
- NCT03184324
- Testing
- DWP14012, Esomeprazole
- Where
- South Korea
- Volunteers
- 211 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Obesity, Bariatric Surgery Candidate
Crural Repair During Laparoscopic Sleeve Gastrectomy in Patients With a Lax Gastroesophageal Junction
Background: Laparoscopic sleeve gastrectomy (LSG) is one of the commonest bariatric procedures. However, it is associated with postoperative gastroesophageal reflux disease (GERD) and erosive esophagitis (EE).
- Conditions
- Obesity, Bariatric Surgery Candidate, Esophagus Injury, Gastroesophageal Reflux
- Trial name
- REPAIR (NCT05330910)
- Testing
- Laparoscopic sleeve gastrectomy with concomitant hiatal hernia repair arm, Laparoscopic sleeve gastrectomy arm
- Where
- 2 sites in Singapore
- Volunteers
- 96 people
- Sponsor
- Sengkang General Hospital
Gastroesophageal Reflux
Efficacy and Safety of Thread Embedding Acupuncture in Treating Gastroesophageal Reflux Disease
Gastroesophageal reflux disease is a very common disease nowadays. Proton-pump inhibitors (PPIs) are the first-line treatment for this disease. However, the effectiveness of treatment with PPIs is still limited.
- Trial name
- NCT05353933
- Testing
- Thread embedding acupuncture, Pantoprazole 40mg
- Where
- Vietnam
- Volunteers
- 66 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD)
Epidemiology of Barrett's Esophagus: A Population Based Study
To assess attitudes toward screening for esophageal adenocarcinoma (EAC) and Barrett's esophagus (BE) in the community. To develop a population based clinical risk factor prediction model for the diagnosis of BE and identify…
- Conditions
- Barrett's Esophagus, Gastroesophageal Reflux Disease (GERD), Olmsted County Resident
- Trial name
- NCT01286155
- Where
- United States
- Volunteers
- 534 people
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux Disease
A Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of YPI 011 to Rabeprazole in Healthy Adult Subjects
A study to compare the safety, pharmacokinetics and pharmacodynamics of YPI 011 to Rabeprazole in healthy adult subjects
- Trial name
- NCT04703868
- Testing
- Rabeprazole Sodium 10mg, Rabeprazole Sodium 20mg
- Where
- South Korea
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Yungjin Pharm. Co., Ltd.
Gastroesophageal Reflux
Sleeve-pex: A Randomized Trial to Reduce Reflux After Sleeve Gastrectomy
The goal of this clinical trial is to test gastropexy as a measure to reduce reflux in morbidly obese patients being submitted to sleeve gastrectomy.
- Trial name
- NCT05704348
- Testing
- Sleeve gastrectomy with gastropexy, Sleeve gastrectomy without gastropexy
- Where
- 4 sites in Norway
- Volunteers
- 550 people
- Sponsor
- Helse Forde
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