Clinical trials: Gastrointestinal Bleed
Morbid Obesity, Anastomotic Leak
Stratafix vs. Vicryl OAGB / MGB Suture Study
To compare shorttime (6 months) results of two competitive suture materials with regard to time demanded to perform the concerned surgical step and secondary to study anastomotic site safety and complications like leakage and…
- Conditions
- Morbid Obesity, Anastomotic Leak, Anastomotic Stenosis, Hemorrhage Postoperative
- Trial name
- NCT04613635
- Testing
- Stratafix, Vicryl
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- St. Franziskus Hospital
Anemia, Small Bowel Bleeding
Tranexamic Acid for The Management of Bleeding Gastrointestinal Angioectasias
The goal of this clinical trial is to learn if oral tranexamic acid works to treat gastrointestinal angioectasias. It will also learn about the safety of tranexamic acid.
- Conditions
- Anemia, Small Bowel Bleeding, Angioectasias
- Trial name
- TAMBA (NCT07125508)
- Testing
- Tranexamic Acid (TXA) treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Cirrhosis, Portal Hypertension
The Feasibility, Safety, and Efficacy of EUS-Guided PSE: A Cohort Study
Bleeding from esophagogastric varices in patients with liver cirrhosis is often life-threatening. Thrombocytopenia caused by hypersplenism secondary to portal hypertension is an independent risk factor for such gastrointestinal…
- Conditions
- Cirrhosis, Portal Hypertension, Bleeding
- Trial name
- EUS; PSE (NCT07354789)
- Testing
- EUS guided PSE
- Volunteers
- 50 people
- Sponsor
- Qilu Hospital of Shandong University
Surgery, Liver Metastases
Improved Recovery by Iron Following Surgery With Blood Loss, the IRIS-trial
The aim of the study is to investigate if iv iron formulation improve recovery after surgery with blood loss. Post-operative anaemia is a common debilitating condition after major surgery due to a combination of preoperative iron…
- Conditions
- Surgery, Liver Metastases, Liver Cancer, Pancreas Cancer
- Trial name
- IRIS (NCT05744219)
- Testing
- Ferric carboxymaltose
- Where
- Sweden
- Volunteers
- 338 people
- Sponsor
- Jon Unosson
Obscure Gastrointestinal Bleeding
Preparation Regimens to Improve Capsule Endoscopy Visualization and Diagnostic Yield
Small bowel capsule endoscopy (SBCE) has become an important tool in clinical practice since its introduction in 2000. This non-invasive method allows the visualization of small bowel mucosa, being essential in the management of…
- Trial name
- PrepRICE (NCT05140057)
- Testing
- Moviprep
- Where
- Portugal
- Volunteers
- 210 people
- Sponsor
- Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
Liver Disease
Randomised Prospective Study of CUSA Versus Radiofrequency Ablation Technique in Liver Resections
The purpose of this study is to determine whether a particular method of operating on the liver is superior to the "gold" standard commonest technique.
- Trial name
- NCT06980571
- Testing
- radiofrequency ablation
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Barts & The London NHS Trust
Liver Cancer, Surgery
Pre- Vs Postoperative Thromboprophylaxis for Liver Resection
Thromboprophylaxis for liver surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in liver surgery patients, there is no international consensus when…
- Conditions
- Liver Cancer, Surgery, Thrombosis, Deep Vein, Embolism, Pulmonary
- Trial name
- PREPOSTEROUS (NCT04731558)
- Testing
- enoxaparin or tinzaparin or dalteparin, No intervention
- Where
- 7 sites in Finland, Norway
- Volunteers
- 1,012 people
- Sponsor
- Helsinki University Central Hospital
Pilot Study, Clips
Clinical Trial of Metal-Reinforced Teeth Designed for Endoscopic Clips
Postoperative gastrointestinal complications following ESD, EMR, and EFTR procedures, such as gastrointestinal bleeding, diverticula, fistulas, perforations, and stent fixation, can be effectively treated through gradual…
- Trial name
- NCT06285955
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Beijing 302 Hospital
Von Willebrand Disease (VWD)
Algorithm-based Management to Reduce the Recurrence of GI Bleeding and Severe Epistaxis in Von Willebrand Disease
WILL MANAGE is a prospective multicenter controlled open label randomized trial comparing an algorithm-based multidisciplinary management to a standard of care to reduce the incidence of bleeding (GI bleeding or severe epistaxis)…
- Trial name
- WILL MANAGE (NCT06651255)
- Testing
- Optimized management, Standard of care management
- Where
- 17 sites in France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Lille
Heart Failure
Prevention of Hemorrhage After Implantation of Mechanical Circulatory Support
Main objective of the study is to demonstrate that a prophylactic treatment with VWF factor concentrate after implantation of continuous-flow left ventricular assist device (CF-LVAD) reduces the frequency of clinically…
- Trial name
- PHAM (NCT02488525)
- Testing
- Prophylactic treatment with Wilfactin
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Lille
Colorectal Cancer
Community Based Screening for Colorectal Cancer in an Underserved High Risk Population in Nigeria
Patient age 45 year old and above who presented with rectal bleeding at three tertiary hospitals in South West Nigeria were invited for colonoscopy. The clinical information of the patients and the colonoscopy data were analyzed
- Trial name
- NCT03032874
- Testing
- Colonoscopy
- Where
- Nigeria
- Volunteers
- 100 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Non-variceal Upper Gastrointestinal Bleeding
Surgicel® (Fibrillar) in Non-variceal UGI Bleeding
The aim of this study is to assess of effect of Surgicel® (Fibrillar) for preventing delayed bleeding after endoscopic hemostasis in non-variceal upper gastrointestinal bleeding
- Trial name
- NCT02054260
- Testing
- Surgicel
- Where
- South Korea
- Sponsor
- Soonchunhyang University Hospital
Portal Hypertension, Variceal Hemorrhage
Vonoprazan Efficacy to Prevent Post Variceal Band Ligation Ulcer
Endoscopic variceal ligation (EVL) is used to control and prevent variceal bleeding in patients with liver cirrhosis, but it can be complicated by bleeding from post-EVL ulcers.
- Conditions
- Portal Hypertension, Variceal Hemorrhage, Ulcer Hemorrhage
- Trial name
- NCT05227833
- Testing
- Vonoprazan fumarate (Vonaspire), Pantoprazole 40mg
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Alexandria University
Peptic Ulcer
Esomeprazole Versus Pantoprazole to Prevent Peptic Ulcer Rebleeding
The aim of this study is to compare the clinical effectiveness of intravenous esomeprazole and pantoprazole in preventing recurrent bleeding in the patients with high-risk bleeding peptic ulcers after successful standard…
- Trial name
- NCT00881413
- Testing
- Esomeprazole, Pantoprazole
- Sponsor
- Lotung Poh-Ai Hospital
Gastrointestinal Hemorrhage, Vascular Malformation
Efficacy Study of Thalidomide in Gastrointestinal Vascular Malformation Related Bleeding
Background: Repeated bleeding from gastrointestinal vascular malformations remains to be a major therapeutic challenge. Methods: The investigators performed a randomised, double-blind, placebo-controlled, single centre study to…
- Trial name
- NCT02754960
- Testing
- Thalidomide
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
MALIGNANT GASTROINTESTINAL BLEEDING
TC-325 (HEMOSPRAY™) VS. CURRENT STANDARD OF CARE IN MANAGING MALIGNANT GASTROINTESTINAL BLEEDING: A PILOT STUDY TO INFORM A RANDOMIZED CONTROLLED TRIAL.
Introduction: Gastrointestinal (GI) bleeding arising from malignant tumors is increasingly recognized as a result of oncological advances and improved detection methods, and stems from local vessel damage and tumor invasion with…
- Trial name
- NCT02135627
- Testing
- TC-325 monotherapy on initial endoscopy ± radiation therapy, angioembolization, and/or surgery., Current standard therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Acute Upper Gastrointestinal Hemorrhage
The Weekend Effect and Its Possible Influence on the Prognosis of Patients With Non-varicose Upper Gastrointestinal Bleeding
The hypothesis is that the mortality of patients with non-varicose upper gastrointestinal bleeding after performing early gastroscopy who are admitted on weekends and night hours is higher than those admitted on weekdays or…
- Trial name
- NCT04296435
- Where
- Spain
- Volunteers
- 1,320 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Bloody Stool, Necrotizing Enterocolitis
a Clinical Risk Score to Predict Bloody Stool in Neonates
Bloody stool is a main focus in non-neonatal intensive care unit ward, and it is one of the risk factors in neonates with subsequent necrotizing enterocolitis(NEC) and usually lead to longed duration of hospitalization.
- Trial name
- NCT05055817
- Testing
- bloody stool group, non-bloody stool group
- Where
- China
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Upper Gastrointestinal Bleeding
Randomized Control Trial Comparing Prokinetics and Their Influence on Endoscopy Outcomes for Upper GI Bleed.
This is a study comparing the effect of erythromycin or metoclopramide, 2 prokinetic drugs (Drugs which are known to speed up the emptying of the stomach or in other words to move the blood out of the stomach faster) given before…
- Trial name
- NCT02017379
- Testing
- Erythromycin, Metoclopromide
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Ischemic Hepatitis
To Compare The Efficacy Of N -Acetylcysteine and Standard Therapy Versus Standard Therapy In The Prevention Of Ischemic Hepatitis And Survival Post Upper GI Bleed
Patient presenting with upper GI bleed in ILBS (Institute of Liver and Biliary Sciences) emergency admitted to ICU (Intensive Care Unit) or shifted from ward to ICU (Intensive Care Unit) in view of upper GI bleed randomized to…
- Trial name
- NCT02015403
- Testing
- Standard Care + NAC (N -ACETYLCYSTEINE), Standard Care (in control arm)
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Institute of Liver and Biliary Sciences, India