Clinical trials: Gastrointestinal Bleed
Roux-en-y Anastomosis Site, Marginal Ulcer
Marginal Ulcer Healing With Low-Thermal Argon Plasma Endoscopic Treatment
The objective of the study is to investigate the treatment of marginal ulcers with Low Thermal plasma in an endoscopic setting. By a treatment of the ulcerated areas with argon plasma with low power settings (~ 1 W) we…
- Conditions
- Roux-en-y Anastomosis Site, Marginal Ulcer, Marginal Ulcer (Peptic) or Erosion, Ulcer
- Trial name
- AMULET (NCT06543316)
- Testing
- Low Thermal Plasma (LTP) Treatment, Standard of Care Ulcer Treatment (typically PPI Administration)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Bleeding Anal, Pain
Topical Vitamin E Ovules for the Treatment of Hemorrhoids
Patients with hemorrohoids grade II and III were included. Patients were randomized into 2 groups: Experimental group: Patients will receive a treatment with vitamin E ovules, which must be placed inside the annus Control group…
- Conditions
- Bleeding Anal, Pain, Stings
- Trial name
- NCT04362384
- Testing
- Vitamin E ovules, Prednisolone ointment
- Volunteers
- 120 people
- Sponsor
- Hospital General Universitario Elche
Gastrointestinal Hemorrhage, Portal Hypertension
Secondary Prophylaxis After Variceal Bleeding in Non-Responders
Controlled and randomized study comparing combined treatment (nadolol and endoscopic ligation) versus nadolol associated with isosorbide mononitrate or prazosin according to hemodynamic response, in the prevention of esofagic…
- Conditions
- Gastrointestinal Hemorrhage, Portal Hypertension, Cirrhosis
- Trial name
- KT-2000 (NCT00450164)
- Testing
- esofagic varices ligation, Nadolol, Isosorbide mononitrate
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Gastrointestinal Endoscopy, Upper Gastrointestinal Hemorrhage
TEAS for Variceal Bleeding Endoscopy in Cirrhosis
This randomized controlled trial evaluates whether transcutaneous electrical acupoint stimulation (TEAS) improves procedural success and patient tolerance in cirrhotic patients undergoing urgent unsedated endoscopy for suspected…
- Conditions
- Gastrointestinal Endoscopy, Upper Gastrointestinal Hemorrhage, Variceal Bleeding, Cirrhosis
- Trial name
- TEAS-VBE-C (NCT07106658)
- Testing
- TEAS + Urgent Endoscopy, Urgent Endoscopy Only
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Beijing 302 Hospital
Acute Bleeding Esophageal Varices
RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
The mortality rates from Acute Variceal Haemorrhage remain significant and first line therapy may fail in 15-25% of patients. The self-expandable metal stent has been described in case series as having a very high efficacy at…
- Trial name
- SOV (NCT01851564)
- Testing
- Self-expanding mesh-metal oesophageal stent (SEMS), Standard Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College, London
Advanced Hepatocellular Carcinoma, Variceal Bleeding
Early Transjugular Intrahepatic Portosystemic Shunt for Advanced Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) with main trunk portal vein tumor thrombus (PVTT) has poor prognosis. The main lethiferous factor is the upper gastrointestinal hemorrhage by PVTT-related portal hypertension.
- Trial name
- NCT06624098
- Testing
- Early TIPS
- Where
- 2 sites in China
- Volunteers
- 22 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Cardiovascular Disease
Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU
In this study researchers want to learn more about the effect of low-dose Aspirin on cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine…
- Conditions
- Colorectal Cancer, Cardiovascular Disease, Bleeding
- Trial name
- PEACOCS (NCT03904732)
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465)
- Where
- United Kingdom
- Volunteers
- 2,000,000 people
- Sponsor
- Bayer
ERAS, Pancreas Cancer
Compliance With ERAS Protocol in Pancreatic Surgery, Stress Response and Outcomes
The purpose of this study is to evaluate the impact of compliance with enhanced recovery after surgery (ERAS) program on patient reported outcomes (PROs), surgery-specific outcomes and stress response after pancreatic surgery.
- Conditions
- ERAS, Pancreas Cancer, Pancreas; Fistula, Delayed Gastric Emptying
- Trial name
- NCT05518643
- Testing
- ERAS protocol
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- University of Thessaly
Hepatocerebral Encephalopathy, Portal-Systemic Encephalopathy
Lactulose for the Prevention of Hepatic Encephalopathy in Cirrhotic Patients With Upper Gastrointestinal Hemorrhage
To evaluate the role of lactulose in prevention of clinically overt hepatic encephalopathy (HE) in the setting of acute upper gastrointestinal bleeding in cirrhotic patients
- Conditions
- Hepatocerebral Encephalopathy, Portal-Systemic Encephalopathy, Encephalopathy, Hepatic, Encephalopathy, Hepatocerebral
- Trial name
- NCT00553423
- Testing
- Lactulose
- Where
- 2 sites in Pakistan
- Volunteers
- 128 people
- Sponsor
- Aga Khan University
Esophageal Varices Bleeding, Portal Hypertension
Effectiveness of Treatments for Cirrhosis With Varicose Veins
Liver cirrhosis is the fifth leading cause of death among adults, characterized by diffuse fibrous tissue proliferation and the formation of regenerative nodules and false lobules on the basis of widespread hepatocyte necrosis…
- Trial name
- NCT06961474
- Testing
- Endoscopic treatment
- Where
- China
- Volunteers
- 1,900 people
- Sponsor
- Shanghai Zhongshan Hospital
Enteritis, Bleeding
Balloon-assisted Enteroscopy and Bacteria
1. Balloon-assisted enteroscopy (BAE) is a new tool to investigate small intestinal diseases. 2. Deep enteroscopy made possible by balloon expansion and manipulation of small intestines. 3.
- Trial name
- NCT01065324
- Where
- 2 sites in Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Gastro Intestinal Bleeding
Factor XIII Activity in Gastrointestinal Bleedings
The aim of this retrospective study is to investigate the relationship between factor XIII activity and the outcome of gastrointestinal bleedings.
- Trial name
- NCT05933135
- Testing
- Factor XIII Injection
- Where
- Austria
- Volunteers
- 97 people
- Sponsor
- Medical University of Graz
Colonic Diverticula, Angiodysplasia
Study of Hemospray for Lower Gastrointestinal Hemorrhage
This study is to evaluate the performance of Hemospray for the teatment of nonvariceal lower gastrointestinal bleeding.
- Conditions
- Colonic Diverticula, Angiodysplasia, Colonic Polyp
- Trial name
- NCT02099435
- Testing
- Hemospray
- Where
- 4 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Cook Group Incorporated
Venous Thrombosis, Pulmonary Embolism
Study of Rivaroxaban Use and Potential Adverse Outcomes in Routine Clinical Pratice (UK)
This prospective cohort study will provide information about: characteristics of Rivaroxaban use in patients who are prescribed Rivaroxaban for the first time compared to patients who are prescribed Warfarin for the first time…
- Conditions
- Venous Thrombosis, Pulmonary Embolism, Atrial Fibrillation, Acute Coronary Syndrome
- Trial name
- NCT01947998
- Testing
- Rivaroxaban (Xarelto, Bay59-7939), Warfarin, Antiplatelet drugs
- Where
- United Kingdom
- Volunteers
- 50,299 people
- Sponsor
- Bayer
Portal Hypertension, Varice Bleed
Carvedilol vs. Propranolol in Second Prophylaxis of Variceal Bleeding
This randomized controlled trial was conducted to evaluate the efficacy and safety of carvedilol versus propranolol, combined with routine endoscopic treatment, in the secondary prophylaxis of variceal bleeding in patients with…
- Conditions
- Portal Hypertension, Varice Bleed, Cirrhosis, Liver
- Trial name
- NCT05651789
- Testing
- Carvedilol, Propranolol
- Volunteers
- 160 people
- Sponsor
- West China Hospital
Gastrointestinal Hemorrhage
The Risk of Bleeding After Removal of Large Colorectal Polyps in Patients Taking Aspirin
The risk of bleeding after polypectomy of large colorectal polyps in patients taking aspirin is uncertain. This is a randomized, multi-center, placebo-controlled, double-blind study to compare the risk of significant bleeding…
- Trial name
- ASAPOL (NCT01549418)
- Testing
- Aspirin (ASA)
- Volunteers
- 760 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Occult GI Bleeding
A Prospective Evaluation of Same Day Bidirectional Endoscopy for Occult Bleeding
This study is a prospective evaluation of patients with occult (hidden) GI bleeding without iron deficiency. Such patients usually undergo a diagnostic colonoscopy as a standard of care.
- Trial name
- NCT00636597
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- US Department of Veterans Affairs
Peptic Ulcer Hemorrhage
Supplementary Angiographic Embolization for Peptic Ulcer Bleeding
Peptic ulcer bleeding is a common disorder. Despite optimal endoscopic and medical treatment, there is a high risk of rebleeding and high mortality.
- Trial name
- NCT01125852
- Testing
- Angiographic embolization, Therapeutic endoscopy
- Where
- Denmark
- Volunteers
- 105 people
- Sponsor
- Odense University Hospital
End-stage Liver Disease (ESLD), Cirrhosis, Liver
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
The purpose of this study is to assess the safety and efficacy of RTX001 in patients with end-stage liver disease. This study is the first time RTX001, a macrophage cell therapy engineered to have an anti-inflammatory and…
- Conditions
- End-stage Liver Disease (ESLD), Cirrhosis, Liver, Cirrhosis, Decompensated, Liver Diseases
- Trial name
- EMERALD (NCT06823713)
- Testing
- RTX001
- Where
- 15 sites in Spain, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Resolution Therapeutics Limited
Early Gastric Cancer, Gastric Adenoma
Fibrin Glue After ESD for High Risk Patients of Bleeding
It is a prospective randomized controlled study to look for effectiveness of fibrin glue to prevent bleeding in high-risk patients after endoscopic submucosal dissection in gastric neoplasm.
- Trial name
- NCT04602689
- Testing
- Human fibrinogen concentrate
- Where
- South Korea
- Volunteers
- 134 people
- Sponsor
- Seoul National University Hospital