Clinical trials: Gastrointestinal Bleed
Gastrointestinal Hemorrhage
Effectiveness Study of the BioVac Direct Suction Device in Upper Gastrointestinal Bleeding
Upper endoscopy is performed for upper gastrointestinal bleeding (bleeding in the esophagus, stomach, or part of the duodenum) to identify and potentially treat the cause of bleeding.
- Trial name
- NCT02150941
- Testing
- BioVac Direct Suction Device, Standard Endoscopy Suction
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Calcium Electroporation for Hemostasis in Gastric Neoplasms
Endoscopic Calcium Electroporation in Gastric Tumors
Brief Summary Background Gastric cancer (GC) remains a major global public health challenge, ranking as the fifth most common malignancy worldwide and the third leading cause of cancer-related mortality.
- Trial name
- GASTRIC-CaEP (NCT07647731)
- Testing
- Endoscopy Calcium Electroporation
- Volunteers
- 28 people
- Sponsor
- Hospital del Rio Hortega
Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB)
FENOX Trial (Comparative Effectiveness of Fexuprazan Co-therapy in Patients Receiving Non-Vitamin K Antagonist Oral Anticoagulants)
Background Non-vitamin K antagonist oral anticoagulants (NOACs) are recommended for stroke prevention in non-valvular atrial fibrillation (AF).
- Conditions
- Atrial Fibrillation (AF), Upper Gastrointestinal Bleeding (UGIB), Gastrointestinal Hemorrhage (Clinically Important, Upper), Drug-Related Side Effects and Adverse Reactions
- Trial name
- FENOX (NCT07497893)
- Testing
- Fexuprazan, NOAC therapy
- Where
- South Korea
- Volunteers
- 1,000 people
- Sponsor
- Ewha Womans University Mokdong Hospital
Gastrointestinal Injury, Gastrointestinal Hemorrhage
Gastrointestinal Emergency Surgery: Evaluation of Morbidity and Mortality
Gastrointestinal Emergency Surgery: Evaluation of Morbidity and Mortality
- Conditions
- Gastrointestinal Injury, Gastrointestinal Hemorrhage, Gastrointestinal Lesions, Gastrointestinal Ulcer
- Trial name
- GESEMM (NCT05226221)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Campus Bio-Medico University
Gastrointestinal Bleeding, Stress Ulcers
Stress Ulcer Prophylaxis in the Intensive Care Unit
Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported.
- Trial name
- SUP-ICU (NCT02467621)
- Testing
- Pantoprazole, Saline (0.9%)
- Where
- 33 sites in Denmark, Finland and 4 more
- Volunteers
- 3,350 people
- Sponsor
- Dr. Morten Hylander Møller
Internal Hemorrhoid
Outcomes and Quality of Life Following Rectal Artery Embolization for Bleeding Internal Hemorrhoids
This study will assess how effective and safe rectal artery embolization works to treat symptomatic bleeding predominant internal hemorrhoids.
- Trial name
- HEMBO-1 (NCT06106269)
- Testing
- Rectal Artery Embolization
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Gastrointestinal Hemorrhage, Colon Cancer
Bowel Preparation for Inpatient Colonoscopy
This study will compare two strategies for bowel cleansing prior to inpatient colonoscopy: the entire preparation taken the night before the procedure versus half the preparation taken the night before the procedure, and the…
- Conditions
- Gastrointestinal Hemorrhage, Colon Cancer, Diverticulosis
- Trial name
- NCT01169220
- Testing
- Go-Lytely, Go Lytely
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Santa Clara Valley Health & Hospital System
Lower Gastrointestinal Bleeding, Hemostatic Disorder
Clinical and Urgent Colonoscopy Outcomes Using the Pure-Vu® Cleansing System
The Pure-Vu® System can be effectively used as a cleansing device in patients admitted with acute LGIB to the intensive care unit and the regular nurse floor (RNF) bypassing the need to administer an oral bowel preparation for…
- Trial name
- NCT04729946
- Testing
- Pure-Vu Cleansing Device
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- The Cleveland Clinic
Dyspepsia, Hematemesis
Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing Gastroduodenoscopy
The purpose of this study is to examine in prospective, double-blinded randomised manner the ability of novel articaine-containing lozenge to enhance the procedure related compliance (compared to placebo) of the adult patients…
- Conditions
- Dyspepsia, Hematemesis, Abdominal Pain, Heartburn
- Trial name
- NCT02105090
- Testing
- Anesthetics, Local, Sodium Chloride 0.9%
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- Helsinki University Central Hospital
Acute Gastrointestinal Bleeding
Compare VKA vs LMWH in Patients With Anticoagulation Criteria and Episode of Gastrointestinal Bleeding.
SUMMARY 1.0. Type of Application: Clinical trial comparing two treatments in terms of authorized use. 1.1. Promoter: Institute of Research, Hospital de la Santa Creu i Sant Pau. Avgda. Sant Antoni M.Claret, 167. 08025 Barcelona.
- Trial name
- HEPACO (NCT01727453)
- Testing
- warfarin, Bemiparina
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Gastric Varix, Cirrhosis
EUS-guided Combined Therapy Versus Beta Blocker Therapy in Primary Prophylaxis o GOV II and IGV I
The EUS-guided combined therapy of coilingand 2-octyl-cyanoacrylate in patients with gastric varices reduced rebleeding and need for reintervention in comparison to EUS-guided coiling alone.The purpose of this study is to…
- Conditions
- Gastric Varix, Cirrhosis, GastroIntestinal Bleeding
- Trial name
- NCT04075760
- Testing
- Coils + Cyanoacrylate Group + beta-blocker, beta blocker therapy
- Where
- Ecuador
- Volunteers
- 26 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Feeding Intolerance, Abdominal Distention
SAFEstart Feeding Intolerance Study Phase II
Feeding intolerance is a common problem in the NICU. Feeding intolerance complicates the hospitalization, lengthens the hospital stay, and adds substantially to the cost of care.
- Conditions
- Feeding Intolerance, Abdominal Distention, Gastric Residual, Emesis and Diarrhea
- Trial name
- NCT00331201
- Testing
- SAFEstart
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Intermountain Health Care, Inc.
Upper Gastrointestinal Bleeding (UGIB)
Study of Patients With Drug-induced Non-variceal Upper Gastrointestinal Bleeding
To study the association between non-variceal UGIB and the use of NSAIDs, VKAs, DOACs and antiplatelet therapy. To compare the severity of bleeding related to specified drugs.
- Trial name
- NCT06945328
- Testing
- Upper endoscopy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hepatic Encephalopathy
Diet Management on Hepatic Encephalopathy of Patients With Variceal Bleeding After Intrahepatic Portosystemic Shunt Creation
Hepatic encephalopathy is a severe complication of transjugular intrahepatic portosystemic shunt (TIPS) treatment in patients with cirrhosis and variceal bleeding.
- Trial name
- DM-PTHE (NCT03372499)
- Testing
- diet management strategy for encephalopathy
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Li Yang
Postpartum Period
Evaluation of Blood Loss After Cesarean Delivery Via US Compared to Standard Care
Postpartum hemorrhage and anemia are considered a major health concern due to their impact on maternal morbidity and mortality, quality of life, and maternal cognitive and emotional functioning after delivery, which are…
- Trial name
- NCT06963047
- Testing
- Ultrasound, Standard care
- Where
- Israel
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- Holy Family Hospital, Nazareth, Israel
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
COVID-19, GastroIntestinal Bleeding
Re-EValuating the Inhibition of Stress Erosions (REVISE) - COVID-19 Cohort Study
Commonly employed medications used in critically ill patients requiring life support include proton pump inhibitors (PPIs). These medications are thought to prevent gastrointestinal (GI) bleeding from stress-induced ulceration.
- Trial name
- NCT05715567
- Testing
- Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial (NCT03374800)
- Where
- Canada
- Volunteers
- 600 people
- Sponsor
- McMaster University
Coronary Heart Disease, GI Bleeding
Platelet Inhibitory Effect of Clopidogrel in Patients Treated With Omeprazole, Pantoprazole, or Famotidine
Current guidelines recommend the addition of proton pump inhibitors (PPI) to patients taking double anti-platelet therapy (Aspirin and Clopidogrel) to prevent upper GI bleeding1.
- Trial name
- NCT00950339
- Testing
- omeprazole, 20mg twice daily, famotidine 40mg twice daily, pantoprazole 40mg once daily
- Where
- Israel
- Volunteers
- 63 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Death
Prognostic Factors in Malignant GI Bleeding Treated With Hemostatic Powder
This is a retrospective study to identify the prognostic factors of the good outcomes in patients who presented with upper GI bleeding from tumor and received Hemospray via endoscopy for hemostatic control.
- Trial name
- NCT03066700
- Testing
- Hemostatic powder
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Acute Myocardial Infarction (AMI), Gastrointestinal Bleeding
Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute Myocardial Infarction
This study aims to compare the clinical outcomes between routine use of potassium competitive acid blocker (P-CAB) and guideline-directed gastrointestinal (GI) protection strategy in patients with acute myocardial infarction…
- Trial name
- PCAB-AMI (NCT07467213)
- Testing
- Zastaprazan, Proton Pump Inhibitors (PPI)
- Where
- South Korea
- Volunteers
- 5,000 people
- Sponsor
- Samsung Medical Center