Clinical trials: Gastrointestinal Bleed
Bleeding Peptic Ulcer
The Use of OTSC in LBGDU to Standard Endoscopic Hemostatic Methods
In managing bleeding gastroduodenal ulcers, endoscopic control of bleeding is the first line treatment-further bleeding after endoscopic hemostasis is associated with a 3-fold increase in mortality.
- Trial name
- OTSC-LBGDU (NCT06196710)
- Testing
- Over-the-scope Clips, Hemo-clipping
- Sponsor
- Chinese University of Hong Kong
Gastroesophageal Varices Hemorrhage, Colorectal Cancer
Oxaliplatin-induced Portal Hypertension
Oxaliplatin has been used as the first choice for the adjuvant chemotherapy of colorectal cancer and it has significantly improved the outcomes in patients with colorectal cancer.
- Conditions
- Gastroesophageal Varices Hemorrhage, Colorectal Cancer, Received Oxaliplatin-based Chemotherapy
- Trial name
- NCT04524676
- Testing
- Individualized Treatment
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shanghai Zhongshan Hospital
Hypertension, Portal, Liver Cirrhosis
Outcome After TIPS
This clinical trial is a retrospective single-centre study. Research data will be acquired via patient histories stored in the hospital data system.
- Conditions
- Hypertension, Portal, Liver Cirrhosis, Variceal Hemorrhage, Ascites Hepatic
- Trial name
- NCT03459378
- Testing
- no intervention - retrospective analyses
- Where
- Austria
- Volunteers
- 158 people
- Sponsor
- Medical University of Graz
Angiodysplasia, Vascular Malformations
Efficacy of Octreotide on Blood and Iron Requirements in Patients With Anemia Due to Angiodysplasias
The purpose of this study is to determine whether 40 mg octreotide long-acting release intramuscular every 28 days is effective in the treatment of patients with refractory anemia due to gastrointestinal angiodysplasias.
- Conditions
- Angiodysplasia, Vascular Malformations, Gastrointestinal Hemorrhage, Anemia
- Trial name
- OCEAN (NCT02384122)
- Testing
- Octreotide
- Where
- 12 sites in Netherlands
- Volunteers
- 62 people
- Sponsor
- Radboud University Medical Center
Gastrointestinal Bleeding
Occult Obscure Gastrointestinal Bleeding
To test the activity of a polyglucosamine (PG) together with a Standard Management protocol (SM) on the occult and obscure gastrointestinal bleeding (OGIB) and the clinical symptoms in patients suffering from colonic…
- Trial name
- OGIB (NCT03464539)
- Testing
- PG low molecular weight chitosan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Blymum Srl
Pancreatitis, Cholangitis
The Patency Period of the New Plastic Anti-reflux Biliary Stent
The aim of this study is to determine the average patency period of the new anti-reflux biliary stent on patients with malignant bile duct strictures and to determine if this stent remains patent for a longer period of time…
- Trial name
- NCT01142921
- Testing
- Anti-reflux Tannenbaum biliary stent, Ordinary Tannenbaum biliary stent
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Chinese University of Hong Kong
Portal Hypertension, Variceal Hemorrhage
Vonoprazan Efficacy to Prevent Post Variceal Band Ligation Ulcer
Endoscopic variceal ligation (EVL) is used to control and prevent variceal bleeding in patients with liver cirrhosis, but it can be complicated by bleeding from post-EVL ulcers.
- Conditions
- Portal Hypertension, Variceal Hemorrhage, Ulcer Hemorrhage
- Trial name
- NCT05227833
- Testing
- Vonoprazan fumarate (Vonaspire), Pantoprazole 40mg
- Where
- Egypt
- Volunteers
- 284 people
- Sponsor
- Alexandria University
Type 3 Von Willebrand's Disease
Type 3 Von Willebrand International Registries Inhibitor Prospective Study
International Registries and Prospective Study on Type 3 Von Willebrand's Disease (VWD3), aimed to assess number, types and risk factors for bleeding and the efficacy and safety of plasma-derived and/or recombinant Von Willebrand…
- Trial name
- 3WINTERS-IPS (NCT02460458)
- Testing
- Von Willebrand Factor
- Where
- 25 sites in Finland, France and 8 more
- Volunteers
- 265 people
- Sponsor
- Fondazione Angelo Bianchi Bonomi
Myocardial Infarction, Helicobacter Pylori Infection
HELicobacter Pylori Screening to Prevent Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction
Background: Potent antithrombotic therapy has improved prognosis for patients with acute myocardial infarction (MI) significantly, however, at a price of increased bleeding risk. Helicobacter pylori (H.
- Conditions
- Myocardial Infarction, Helicobacter Pylori Infection, GastroIntestinal Bleeding, Cardiovascular Diseases
- Trial name
- HELP-MI (NCT05024864)
- Testing
- Urea breath test (UBT)
- Where
- 35 sites in Sweden
- Volunteers
- 20,000 people
- Sponsor
- Karolinska Institutet
Liver Failure, Acute on Chronic, Hemostatic Disorder
A Prospective Study of Evaluation of Minor Bleeding and Utility of Bleeding Criteria in Acute-on-chronic Liver Failure Patients in China
Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. However, the minor and major bleeding events has not been described yet.
- Trial name
- NCT03281252
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Anemia, Chronic Liver Disease
Etiopathogenesis of Anemia in Chronic Liver Disease
Anemia is the most common complication of liver cirrhosis and is seen in 75% of cases. The etiology of anemia in liver disease is diverse and often multi-factorial.
- Trial name
- NCT04622449
- Where
- India
- Volunteers
- 125 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis
TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
To date, there is no treatment strategies for these patients according to American Association of the Study of Liver Disease (AASLD) practice guidelines and Baveno V consensus.
- Conditions
- Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis, Liver Cirrhosis, Bleeding Esophageal Varices
- Trial name
- NCT02853526
- Testing
- TIPS, Propranolol, Endoscopic therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zaibo Jiang
Hepatic Vein Thromboses, Hepatic Venous Outflow Obstruction
Global Coagulation Assessment in Portal Vein Thrombosis and Budd-Chiari Syndrome
Portal vein thrombosis is defined as partial or complete occlusion of the portal vein lumen by the blood clot or its replacement by multiple collateral vessels with the hepato-petal flow, known as 'portal cavernoma'.
- Conditions
- Hepatic Vein Thromboses, Hepatic Venous Outflow Obstruction, Portal Vein Thrombosis, Portal Hypertension, Noncirrhotic
- Trial name
- Liv-Thrombus (NCT05123326)
- Testing
- Rotational thromboelastometry, Genetic tests for Thrombophilia, ELISA tests/ Functional assays
- Where
- India
- Volunteers
- 300 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Anemia, Neonatal, Intracranial Hemorrhages
Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates
The purpose of this study is to test the safety and effectiveness of a whole own (autologous) umbilical cord blood transfusion in the first 5 days after birth if the baby is born premature <34 weeks and developed anemia of…
- Conditions
- Anemia, Neonatal, Intracranial Hemorrhages, Necrotizing Enterocolitis, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT02050971
- Testing
- Umbilical Cord Blood Infusion, Intravenous Infusion of Peripheral Blood or its Components
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Pomeranian Medical University Szczecin
Hematemesis, Melena
Point of Care Testing of Platelet Function in Patients With Acute Upper Gastrointestinal Bleeding
Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency. In an ageing population, antiplatelet drugs are increasingly being prescribed for treatment and prophylaxis against cardiovascular thrombo-embolic…
- Conditions
- Hematemesis, Melena, Gastrointestinal Hemorrhage, Platelet Dysfunction
- Trial name
- POCGIB (NCT03028064)
- Testing
- blood taking
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Chinese University of Hong Kong
Liver Cancer, Surgery
Pre- Vs Postoperative Thromboprophylaxis for Liver Resection
Thromboprophylaxis for liver surgery can be commenced either preoperatively or postoperatively. Despite a clear trade-off between thrombosis and bleeding in liver surgery patients, there is no international consensus when…
- Conditions
- Liver Cancer, Surgery, Thrombosis, Deep Vein, Embolism, Pulmonary
- Trial name
- PREPOSTEROUS (NCT04731558)
- Testing
- enoxaparin or tinzaparin or dalteparin, No intervention
- Where
- 7 sites in Finland, Norway
- Volunteers
- 1,012 people
- Sponsor
- Helsinki University Central Hospital
Peptic Ulcer Hemorrhage
Precise Delivery of Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding
Peptic ulcer bleeding is a common emergency for patients who need therapeutic endoscopy. According to international guidelines and Taiwan consensus, the standard therapy included proton pump inhibitor (PPI) and endoscopic…
- Trial name
- NCT05248321
- Testing
- Tranexamic Acid Powder
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Cheng-Kung University Hospital
Upper Gastrointestinal Bleeding
Patients With Upper Gastrointestinal Bleeding in Emergency Department
More than 80% of patients with upper gastrointestinal bleeding (UGIB) are hospitalized after their visit to the emergency department (ED). However, some of these hospitalizations do not seem justified.
- Trial name
- UGIB-ED (NCT05927493)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hyperthermic Intraperitoneal Chemotherapy, Hepatocellular Carcinoma
Surgical Resection Combined With Intraperitoneal Hyperthermic Chemotherapy
Patients with ruptured liver cancer and bleeding after surgical resection were included according to the criteria of admission, and the patients were divided into experimental and control groups.
- Conditions
- Hyperthermic Intraperitoneal Chemotherapy, Hepatocellular Carcinoma, Ruptured Liver
- Trial name
- NCT06247293
- Testing
- intraperitoneal hyperthermic perfusion chemotherapy
- Volunteers
- 100 people
- Sponsor
- Zhujiang Hospital
Esophageal and Gastric Varices
Validation of Esophageal Variceal Grading: A Comparative Study of Upper Gastrointestinal (GI) Endoscopy and Capsule Endoscopy
The purpose of this study is to develop a grading system for esophageal varices using capsule endoscopy in patients with portal hypertension and cirrhosis.
- Trial name
- NCT00475592
- Testing
- Esophageal Capsule Endoscopy, Upper Gastrointestinal Endoscopy
- Where
- United States
- Sponsor
- Johns Hopkins University