Clinical trials: Gastrointestinal Bleed
Thrombocytopenia
Managed Access Programs for ETB115, Eltrombopag
The purpose of this registration is to list Managed Access Programs (MAPs) related to ETB115, Eltrombopag
- Trial name
- NCT04837703
- Testing
- Eltrombopag
- Sponsor
- Novartis Pharmaceuticals
Healthy Volunteer
Assess Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban in Healthy Adult Participants
The primary objective of the study is to determine whether aspirin alone or aspirin combined with various doses of rivaroxaban causes subclinical GI blood loss as determined by the HemoQuant assay.
- Trial name
- NCT05546957
- Testing
- Aspirin, rivaroxaban low dose, rivaroxaban high dose
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Regeneron Pharmaceuticals
Upper Gastrointestinal Bleeding
Risk Stratification of Patients Presenting With Upper Gastrointestinal Bleeding to the Emergency Department Using AIMS65 Score and Red Cell Distribution Width
The rationale of this study in UGIB patients is to assess whether the prediction of mortality and morbidity using AIMS65 score improves when used in combination with RDW in the emergency department setting.
- Trial name
- RUGBE (NCT04825977)
- Testing
- RISK STRATIFICATION USING AIMS65 SCORE AND RDW
- Where
- India
- Volunteers
- 348 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Portal Hypertension, Cirrhosis
The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed
Terlipressin and Octreotide are two common agents used as adjuvants in the management of variceal bleeding. Both agents have been claimed equivalent to endoscopic therapy in randomized studies.
- Conditions
- Portal Hypertension, Cirrhosis, Hematemesis, Melena
- Trial name
- NCT00534677
- Testing
- Terlipressin, Octreotide
- Where
- Pakistan
- Volunteers
- 320 people
- Sponsor
- Aga Khan University
Bowel Cancer, Bowel Diseases, Inflammatory
LuCID - Investigating the Use of a Novel Digital Rectoscope for Community Examinations During COVID-19
The LumenEye scope and CHiP platform will be piloted in a number of clinical settings including remote colorectal clinics. The rationale is to perform an initial pilot study to determine the clinical utility of the LumenEye…
- Conditions
- Bowel Cancer, Bowel Diseases, Inflammatory, Rectal Bleeding
- Trial name
- LuCID (NCT05043363)
- Testing
- LumenEye X1 digital rectoscope
- Where
- United Kingdom
- Volunteers
- 114 people
- Sponsor
- Imperial College London
Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding
Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients
The goal of this randomized controlled clinical trial is to evaluate the efficacy of Tranexamic acid and vitamin K injection versus placebo in control of upper gastrointestinal bleeding (UGIB) in Egyptian cirrhotic patients.
- Conditions
- Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding, Cirrhosis
- Trial name
- NCT06881628
- Testing
- Tranexamic Acid and vitamin K
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Tanta University
Acute Upper Gastrointestinal Hemorrhage
Endoscopic Treatment of Recurrent Upper GI Bleeding: OTSC [Over the Scope Clip] Versus Standard Therapy
Prospective-randomized trial. Patients with recurrent bleeding from gastroduodenal ulcers are randomized into either endoscopic treatment with the OTSC [Over The Scope Clip] or endoscopic standard therapy.
- Trial name
- STING (NCT01836900)
- Testing
- Endoscopic hemostasis
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Kliniken Ludwigsburg-Bietigheim gGmbH
Pancreaticoduodenectomy
Impact of External Drainage of the Main Pancreatic Duct and Common Bile Duct on Pancreatic Fistula Following Pancreaticoduodenectomy
Pancreaticoduodenectomy (PD) is the standard treatment for tumors of the pancreatic head, distal bile duct, duodenum, and ampulla of Vater.
- Trial name
- NCT06322680
- Testing
- Main pancreatic duct and biliary duct external drainage, Main pancreatic duct and biliary duct internal drainage
- Where
- China
- Volunteers
- 322 people
- Sponsor
- Shanghai Zhongshan Hospital
Peptic Ulcer, Hemorrhage
Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot
The investigators will include those patients with adherent clot on gastric or duodenal ulcers after endoscopic confirmation After receiving well explanation and giving written consent, they are enrolled and will be allocated to…
- Trial name
- NCT02536989
- Testing
- omeprazole
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Far Eastern Memorial Hospital
Acute Coronary Syndrome or B Cerebral Infarction Requiring DAPT(Clopidogrel + Aspirin) for at Least 6 Months
An Observational Study to Evaluate the Incidence of MACCE According to Time Interval of Taking Medication in Patients With Acute Coronary Syndrome or Cerebral Infarction Who Received DAPT for the Secondary Prevention and Esomezol Cap for the Prevention of Gastrointestinal Bleeding
This study is to evaluate the incidence rate of Major Adverse CardioCerebrovascular Events(MACCE) in Patients with Acute Coronary Syndrome or Cerebral Infarction Who Received DAPT for the secondary prevention and Esomezol Cap for…
- Trial name
- NCT05487560
- Testing
- Esomezol Cap
- Where
- South Korea
- Volunteers
- 4,133 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Gastro Intestinal Bleeding
Factor XIII Activity in Gastrointestinal Bleedings
The aim of this retrospective study is to investigate the relationship between factor XIII activity and the outcome of gastrointestinal bleedings.
- Trial name
- NCT05933135
- Testing
- Factor XIII Injection
- Where
- Austria
- Volunteers
- 97 people
- Sponsor
- Medical University of Graz
Head Injury
Effect of Intrathoracic Pressure Regulation on Traumatic Brain Injury
The purpose of this study is to demonstrate proof of clinical concept that application of the Intrathoracic Pressure Regulator (ITPR) will result in an increase in Cerebral Perfusion Pressure (CPP) and a decrease in Intracranial…
- Trial name
- NCT01824589
- Testing
- -7 cm H2O ITPR, -12cm H2O ITPR
- Volunteers
- 1 people
- Sponsor
- Advanced Circulatory Systems
Gastroduodenal Ulcer, Marginal Ulcer
Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding
Evaluate the efficacy of Two different regimens of proton pump inhibitors High against Low in the management of acute peptic ulcer bleeding
- Conditions
- Gastroduodenal Ulcer, Marginal Ulcer, Peptic Ulcer Hemorrhage
- Trial name
- NCT02724150
- Testing
- Omeprazole High dose, Omeprazole Low dose
- Where
- Syria
- Sponsor
- Damascus Hospital
Hemorrhoid, Internal Hemorrhoids
Prospective HemorrhoIdaL EmboliSation (PILES) Registry
The goal of this observational study (prospective registry) is to collect long-term real-world data on the effectiveness and safety of hemorrhoid artery embolization (HAE) for symptomatic bleeding internal hemorrhoids in adults…
- Conditions
- Hemorrhoid, Internal Hemorrhoids, Hemorrhoid Bleeding, Hemorrhoidal Bleeding
- Trial name
- PILES (NCT07635784)
- Testing
- Hemorrhoid Artery Embolization
- Where
- United States
- Volunteers
- 1,200 people
- Sponsor
- Joint & Vascular Institute
Gastrointestinal Hemorrhage, Postoperative Hemorrhage
The Major Bleeding Risk Following Hepatectomy
This study examined long-term incidence rates of major bleeding associated with hepatectomy. The investigators used data from Taiwan's National Health Insurance Research Database.
- Conditions
- Gastrointestinal Hemorrhage, Postoperative Hemorrhage, Surgery--Complications
- Trial name
- NCT04748081
- Testing
- hepatectomy
- Where
- Taiwan
- Volunteers
- 5,265 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Esophageal and/or Gastric Varices
Efficacy and Safety of Endoscopic Injection of Fibrin Sealant Versus Endoscopic Ligature for Bleeding Esophageal Varices
The purpose of this study was to assess whether endoscopic sclerotherapy with Fibrin Sealant was superior to ligature, with or without Polidocanol, in achieving hemostasis in bleeding esophageal varices and preventing rebleeding.
- Trial name
- NCT00161915
- Testing
- Fibrin Sealant
- Where
- 12 sites in Germany
- Sponsor
- Baxter Healthcare Corporation
Chronic Diarrhea, Persistent Vomitting
Pediatric GI Endoscopy at Assiut University
1. To evaluate the diagnostic role, and outcomes of upper and lower gastrointestinal (GI) endoscopy in identifying gastrointestinal disorders among infants and pediatric patients attending Assiut University Children Hospital. 2.
- Conditions
- Chronic Diarrhea, Persistent Vomitting, Gastrointestinal Bleeding, Dysphagia
- Trial name
- NCT07239934
- Testing
- Gastrointestinal Endoscopy
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Assiut University
Portal Hypertension, Biliary Atresia
Primary Prophylaxis for Variceal Bleed in Biliary Atresia
Biliary atresia is the commonest etiology of neonatal cholestasis and is the most common indication for pediatric liver transplantation world-wide.
- Trial name
- BA-BB (NCT04494763)
- Testing
- Propanolol
- Where
- India
- Volunteers
- 92 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis and Hepatoma., Gastric Variceal Bleeding
Endoscopic Cyanoacrylate Obliteration vs. Nadolol Treatment in the Prevention of Gastric Variceal Rebleeding
Gastric variceal bleeding has a very high rebleeding rate even after endoscopic variceal injection of cyanoacrylate (GVO) which is considered the first choice of endoscopic treatment.
- Trial name
- GVO-nadolol (NCT00567216)
- Testing
- Nadolol
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Peptic Ulcer Bleeding
Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy
The investigators used two different doses of esomeprazole (40 mg IV q.d. and 40 mg IV q6h for three days followed by esomeprazole 40 mg q.d.
- Trial name
- lowdosePPI (NCT04407832)
- Testing
- heat probe or hemoclip
- Where
- Taiwan
- Sponsor
- Changhua Christian Hospital