Clinical trials: Gastrointestinal Disorders, Functional
Irritable Bowel Syndrome, Digestive System Diseases
Efficacy of a Multi-strain Probiotic in the Treatment of Irritable Bowel Syndrome (IBS)
The Canadian College of Naturopathic Medicine is conducting a research study on Irritable Bowel Syndrome (IBS), a common condition in North America.
- Conditions
- Irritable Bowel Syndrome, Digestive System Diseases, Colonic Diseases, Functional, Colitis, Mucous
- Trial name
- NCT01176227
- Testing
- Kyodophilus multi-strain probiotic capsules
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Functional Gastrointestinal Disorders
Behavioral Therapy in Patients With Rumination
The study aim is to diagnose patients with the rumination syndrome defined by the Rome IV criteria and to treat them with behavioral therapy consisting of diaphragmatic breathing exercises and physiotherapy to relax tensed…
- Trial name
- NCT05232097
- Testing
- Behavioral therapy, Physiotherapy
- Where
- 2 sites in Finland
- Volunteers
- 11 people
- Sponsor
- Helsinki University Central Hospital
IBS - Irritable Bowel Syndrome, IBS
Ebastine Versus Mebeverine in IBS Patients
Multicenter randomized controlled clinical trial comparing ebastine and mebeverine as treatment of irritable bowel syndrome Trial rationale 1.
- Trial name
- NCT05815602
- Testing
- Ebastine, Duspatalin
- Where
- 5 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Guy Boeckxstaens
Gastroparesis, Functional Dyspepsia
Effects of Liraglutide on Body Surface Gastric Mapping
Aim 1: To investigate, in healthy participants, the effect of liraglutide injection on gastric electrophysiology (as measured by body surface gastric mapping using the Gastric Alimetry device) during an 13-dayramping dose of…
- Conditions
- Gastroparesis, Functional Dyspepsia, Chronic Nausea and Vomiting Syndrome, Healthy
- Trial name
- NCT06500130
- Testing
- Body Surface Gastric Mapping
- Where
- New Zealand
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Alimetry
Ulcerative Colitis
Scintigraphic Evaluation of IPAA Function in Patients With Ulcerative Colitis
The aim of this study is to evaluate scintigraphic methods as objective factors for functional outcome in patients treated with ileal-pouch-anal anastomosis (IPAA).
- Trial name
- SKIPO (NCT02110862)
- Testing
- Transittime. Defecography
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Odense University Hospital
Stroke, Dysphagia
Taste Stimulation for Post-stroke Dysphagia
The goal of this clinical study is to compare the effect of favourate taste stimulation of oral cavity and tounge, with sour and traditional single thermal stimulation in post-stroke patients with dysphagia.
- Trial name
- NCT05989100
- Testing
- Favourate taste stimulation, Sour taste stimulation, Thermal stimulation group
- Where
- 2 sites in China
- Volunteers
- 87 people
- Sponsor
- Qilu Hospital of Shandong University
Genito Urinary Function Evaluation
Genito Urinary Function With High or Low Inferior Mesenteric Artery Ligation in Laparoscopic Anterior Rectal Resection
The aim of this study is to compare the incidence of genito-urinary function depression and anastomotic leak in Laparoscopic Anterior Rectal Resection (LAR) with Total Mesorectal Excision with Ligation if the Inferior Mesenteric…
- Trial name
- NCT02153801
- Testing
- During the surgical procedure of Laparoscopic Low Anterior Resection with Total mesorectal Excision .
- Where
- Italy
- Volunteers
- 212 people
- Sponsor
- Niguarda Hospital
Celiac Disease
A Low FODMAPs Diet in Celiac Patients With Persistent Gastrointestinal Symptoms
FODMAPS (fructose, oligosaccharides, monosaccharides, disaccharides and polyols) are characterised as fermentable but poorly absorbed carbohydrates which enter the colon and are utilised by colonic bacteria.
- Trial name
- NCT02946827
- Testing
- Balanced low FODMAPs /gluten free diet, Balanced gluten free diet
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Tumor, Colorectal, Organoids
Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)
COSENSE-1 is an unblinded, phase II, single-armed, single center feasibility study for using a functional precision medicine platform to select oxaliplatin-based versus irinotecan-based chemotherapy regimens, for male and female…
- Conditions
- Tumor, Colorectal, Organoids, Tumoroid, Metastatic Colorectal Cancer
- Trial name
- COSENSE-1 (NCT06907342)
- Testing
- FOLFOX or FOLFIRI
- Where
- Norway
- Volunteers
- 148 people
- Sponsor
- St. Olavs Hospital
Irritable Bowel Syndrome
Ileocecal Sphincter Reflex by Cecal Distension During Colonoscopy
The aim of the current study is to test the hypothesis that patients with IBS may have a defective ICV pressures and may have small bowel bacterial overgrowth.
- Trial name
- NCT01413945
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Fibromyalgia, Irritable Bowel Syndrome
Efficacy of Transcranial Magnetic Stimulation (TMS) in Chronic Idiopathic Pain Disorders
Objectives : To investigate the analgesic effects of repeated sessions of unilateral rTMS in patients with chronic pain syndrome due to fibromyalgia, IBS or burning mouth syndrome. Primary outcome will be numerical pain scores.
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Burning Mouth Syndrome
- Trial name
- NCT00374673
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospital Ambroise Paré Paris
Irritable Bowel Syndrome, GI Disorders
GUT LINK: A Study of a Care Pathway Across Primary and GI Specialty Care
It can be challenging for Primary Healthcare Providers (PHCPs) to differentiate between IBS and more serious illnesses involving the GI tract, such as Crohn's disease, ulcerative colitis, or cancer.
- Trial name
- NCT05725954
- Testing
- GUT LINK SmartPath
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Michael Stewart
Irritable Bowel Syndrome
A Study of the Safety and Effectiveness of DDP733 in Treating IBS With Constipation in Females
This study will evaluate the safety and effectiveness of the investigational drug DDP733 in treating female patients with IBS-c. A placebo control will be utilized.
- Trial name
- NCT00547469
- Testing
- DDP733
- Where
- 69 sites in United States, Canada
- Volunteers
- 360 people
- Sponsor
- Dynogen Pharmaceuticals
Irritable Bowel
Effect of Rate Of Delivery on Colonic Fermentation of inuliN (EON)
To test whether slowing the rate of delivery of inulin with either psyllium or divided dosing of inulin, will reduce colonic gas production as compared to inulin combined with placebo.
- Trial name
- EON (NCT05619341)
- Testing
- psyllium, inulin
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Obesity, Diabetes Mellitus, Type 2
School-Based Program On Metabolic Disease
Mexico occupies the first place worldwide in childhood obesity. Its urban and indigenous communities present different levels of westernization which have triggered different epidemiological diseases.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Cardiovascular Function, Kidney Diseases
- Trial name
- NCT03768245
- Testing
- Health Education and Physical activity program, Nutrition Program
- Where
- Mexico
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
Hepatitis B, Chronic
A Cross-sectional Study for Renal Function of Patients With Chronic Hepatitis B in China
1. To acknowledge the prevalence of renal insufficiency and kidney-related diseases in patients with chronic hepatitis B in China through epidemiological surveys in outpatient clinics of about 150 hospitals across the country; 2.
- Trial name
- NCT04538651
- Where
- China
- Volunteers
- 11,453 people
- Sponsor
- Sun Yat-sen University
Irritable Bowel Syndrome, Abdominal Pain
Percutaneous Electrical Nerve Field Stimulation for Adults With Irritable Bowel Syndrome
This is a prospective, double-blind, randomized, sham-controlled pilot study evaluating the efficacy of percutaneous electrical nerve field stimulation for the treatment of adult patients with irritable bowel syndrome (IBS).
- Conditions
- Irritable Bowel Syndrome, Abdominal Pain, Autonomic Nervous System Imbalance
- Trial name
- NCT04428619
- Testing
- Peripheral Electrical Nerve Field Stimulation (PENFS) Device
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Los Angeles
Cholelithiasis
Effect of Erector Spinae Plane Block on Postoperative Respiratory Function After Laparoscopic Cholecystectomy
Postoperative pulmonary dysfunction is frequently observed after laparoscopic abdominal surgery due to the combined effects of general anesthesia, pneumoperitoneum, diaphragmatic dysfunction, and postoperative pain.
- Trial name
- ESP-LC (NCT07478601)
- Testing
- Erector Spinae Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Uludag University
Irritable Bowel Syndrome (IBS)
Synbiotic Supplement With Botanical Extracts for Gut Microbiota Balance in Irritable Bowel Syndrome
The goal of this clinical trial is to evaluate whether a synbiotic dietary supplement containing botanical extracts and multiple probiotic strains can improve gastrointestinal symptoms and modulate gut microbiota composition in…
- Trial name
- NCT07475299
- Testing
- Synbiotic supplement containing probiotic strains, botanical extracts, magnesium, vitamin B1, and L-theanine designed to support gut microbiota balance.
- Where
- Romania
- Volunteers
- 8 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Irritable Bowel Syndrome
Caecal pH as a Biomarker for Irritable Bowel Syndrome
Irritable bowel syndrome is common. Currently, it is a diagnosis of exclusion. There is increasing evidence of the importance of the microbiota in the pathophysiology of this disorder.
- Trial name
- NCT02360384
- Testing
- Linaclotide, FODMAP diet
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Wingate Institute of Neurogastroenterology