Clinical trials: Gastrointestinal Hemorrhage
Portal Hypertension
Standard Therapy and TIPS for Moderate to High-risk Esophageal and Gastric Variceal Bleeding
Comparison of endoscopic therapy combined with non-selective therapy β Receptor blockers (NSBBs) and TIPS in the treatment of liver cirrhosis The impact of reducing bleeding on the survival of critically ill patients.
- Trial name
- NCT06013670
- Testing
- Endoscopy+NSBBs, Transjugular intrahepatic portosystemic shunt
- Where
- China
- Volunteers
- 86 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Peptic Ulcer Hemorrhage
Study Evaluating Pantoprazole in Peptic Ulcer Hemorrhage
This is a multicenter, randomized, double-blind, parallel-group, dose-ranging, comparator-controlled study of the effect of pantoprazole on intragastric pH after successful endoscopic hemostasis in hospitalized patients.
- Trial name
- NCT00037570
- Testing
- Pantoprazole
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Gastrointestinal Bleeding
Efficacy of Wireless Capsule Endoscopy and CT Enterography in Obscure Gastrointestinal Bleeding
The purpose of this study is to compare the efficacy between video capsule endoscopy and CT enterography in diagnosis of obscure gastrointestinal bleeding.
- Trial name
- NCT02219568
- Testing
- CT enterography, video capsule endoscopy
- Where
- Thailand
- Volunteers
- 52 people
- Sponsor
- Mahidol University
Gastrointestinal Bleeding, Antiplatelet Therapy
MCE Identifying Bleeding Lesions in Patients with Antiplatelet Drugs-Related Acute Non-Hematochezia Gastrointestinal Bleeding
The goal of this clinical trial is to explore the diagnostic efficacy of detachable string magnetically controlled capsule endoscopy (ds-MCE) for identification of bleeding lesions in patients with antiplatelet drugs-related…
- Trial name
- MCE (NCT06698874)
- Testing
- ds-MCE and EGD examinations
- Where
- 4 sites in China
- Volunteers
- 204 people
- Sponsor
- Changhai Hospital
Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis
TIPS for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis and CTPV
To date, there is no treatment strategies for these patients according to American Association of the Study of Liver Disease (AASLD) practice guidelines and Baveno V consensus.
- Conditions
- Portal Vein, Cavernous Transformation of, Portal Vein Thrombosis, Liver Cirrhosis, Bleeding Esophageal Varices
- Trial name
- NCT02853526
- Testing
- TIPS, Propranolol, Endoscopic therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zaibo Jiang
Acute Non-variceal Upper Gastrointestinal Bleeding
Clinical Prediction Model for In-Hospital Rebleeding in Acute Non-Variceal Upper Gastrointestinal Bleeding
ANVUGIB is a serious condition that can cause symptoms like vomiting blood or passing black stools. Although treatments have improved, about 10% to 30% of patients experience rebleeding shortly after their initial treatment…
- Trial name
- NCT06697691
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Junwei Yan
Precancerous Condition
Risk Factors for Barrett's Esophagus in Patients With BE, Gastroesophageal Reflux, or Gastrointestinal Bleeding
RATIONALE: A study that evaluates DNA changes and other disease-related health information in patients with Barrett's esophagus, gastroesophageal reflux, or gastrointestinal bleeding may help doctors learn more about the risk…
- Trial name
- NCT00445653
- Where
- 2 sites in United States
- Volunteers
- 170 people
- Sponsor
- Massachusetts General Hospital
Liver Cancer, Hemorrhage Liver
Standard of Care Versus Hemopatch® During Liver Resection
This multicentre prospective and randomized study aims to compare the sealant effect after surgical liver resection of a new collagen - polyethylene glycol hemostatic / sealant patch (Hemopatch) vs standard of care.
- Conditions
- Liver Cancer, Hemorrhage Liver, Bile Leak, Surgery
- Trial name
- IBERLIVER (NCT03166683)
- Testing
- Hemopatch, Standard of care
- Volunteers
- 284 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
GastroIntestinal Bleeding
Effectiveness and Safety of Nexpowder as an Endoscopic Hemostatic Treatment
In patients who show signs of bleeding and bleeding after polypectomy such as EMR and ESD for polyps with a diameter of 2 cm or more in the lower gastrointestinal tract, the effectiveness and safety of Nexpowder as an endoscopic…
- Trial name
- NCT05884931
- Testing
- Nexpowder, Conventional Treatment
- Where
- 3 sites in South Korea
- Volunteers
- 66 people
- Sponsor
- Next Biomedical Co., Ltd.
Gastrointestinal Bleeding
Yiwei Jiaohuang Ointment for Gastrointestinal Bleeding Associated With Oral Antithrombotic Agents
The goal of this clinical trial is to evaluate the clinical efficacy and safety of YiWei Jiaohuang Ointment in treating gastrointestinal bleeding associated with oral antithrombotic therapy.
- Trial name
- NCT07339956
- Testing
- A Chinese herb formula--Yiwei Jiaohuang Onitment, Rabeprazole Enteric-Coated Tablets
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China-Japan Friendship Hospital
Gastro Intestinal Bleeding
The Role of Hypertonic Dextrose Spray as Endoscopic Topical Hemostatic Agent for Acute Non-Variceal Upper GI Bleeding
This study is conducted to evaluate the effectivity of hypertonic dextrose spray as an endoscopic topical hemostatic agent, compared to conventional agent (adrenaline injection, followed by hemoclip or thermocoagulation), in…
- Trial name
- NCT04979273
- Testing
- Dextrose 40 % in Water, Adrenaline 1 Mg/mL Solution for Injection, argon plasma coagulation
- Where
- Indonesia
- Volunteers
- 66 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Cirrhosis, Liver, Acute Upper Gastrointestinal Hemorrhage
Risk Assessment After Acute Upper Gastrointestinal Haemorrhage in Cirrhosis
In previous studies, the investigators used retrospective analysis of cases of acute upper gastrointestinal bleeding in patients with liver cirrhosis from the Fifth Medical Center of the General Hospital of Beijing PLA, China…
- Trial name
- NCT04235166
- Testing
- Current risk scores, New risk scores
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Portal Hypertension
Endoscopic Variceal Ligation (EVL)+ Drugs Versus Endoscopic Variceal Ligation (EVL) Alone For Secondary Prophylaxis
Background: Both endoscopic variceal ligation (EVL) and propranolol are valuable methods for secondary prophylaxis of variceal bleeding. Addition of ISMN to propranolol improves the efficacy of drug therapy.
- Trial name
- Secondary (NCT00766805)
- Testing
- EVL + Propranolol + Isosorbide 5 mononitrate, EVL alone
- Where
- India
- Volunteers
- 177 people
- Sponsor
- Govind Ballabh Pant Hospital
Gastric Cancer
Palliative Radiotherapy for Symptomatic Locally Advanced Gastric Cancer: A Phase II Trial
The hypothesis of this study is that a radiotherapy dose of 36Gy in 12 fractions, which equates to a BED of 48.6Gy, increases the response rates of symptom relief compared to historical controls.
- Trial name
- NCT01341756
- Testing
- Palliative Radiotherapy
- Where
- Singapore
- Volunteers
- 63 people
- Sponsor
- National University Hospital, Singapore
Acute Gastrointestinal Bleeding
Randomized Trial of UI-EWD vs. Conventional Endoscopic Therapy for Nonvariceal Upper Gastrointestinal Bleeding
A prospective, multi-center, noninferiority randomized controlled trial designed to compare the efficacy of UI-EWD (Nexpowder™) hemostatic powder versus conventional endoscopic hemostatic therapy in patients presenting with acute…
- Trial name
- TREET (NCT06188585)
- Testing
- UI-EWD, Conventional therapy
- Where
- 14 sites in United States, Canada and 4 more
- Volunteers
- 278 people
- Sponsor
- Medtronic - MITG
Peptic Ulcer
Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy
To evaluate if intravenous PPI infusion, when administered prior to endoscopy, hastens resolution of bleeding stigmata and thereby facilitates endoscopic examinations and reduces the need for endoscopic treatment.
- Trial name
- NCT00164866
- Testing
- Omeprazole
- Where
- China
- Volunteers
- 638 people
- Sponsor
- Chinese University of Hong Kong
Obscure Gastrointestinal Bleeding, Anemia, Iron Deficiency
Depth of Maximal Ileal Insertion During Retrograde Enteroscopy With TTS Balloon
Diagnostic modalities for the evaluation of small bowel pathology include video capsule endoscopy (VCE), antegrade and retrograde device-assisted enteroscopy, CT and MR enterography (1).
- Trial name
- NaviAid2 (NCT04646083)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Texas Tech University Health Sciences Center, El Paso
Upper GI Bleeding
Inhalation of Sevoflurane Versus Intravenous Midazolam,Ketamine,Propofol For Pediatrics Undergoing Upper GI Endoscopy
In the field of pediatric gastroenterology, upper gastrointestinal endoscopy has established itself as a diagnostic and therapeutic tool. In order to increase patient tolerance during this procedure, deep sedation is essential.
- Trial name
- NCT05474937
- Testing
- Sevoflurane Inhalation Solution, Midazolam, Ketamine and Propofol
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Zagazig University
Peptic Ulcer Bleeding, Hypoalbuminemia
The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia
To test whether intravenous albumin can decrease the rebleeding rate or shorten the duration of hospitalization in patients with peptic ulcer bleeding and hypoalbuminemia.
- Trial name
- NCT01822600
- Testing
- Human albumin, Omeprazole
- Where
- Taiwan
- Volunteers
- 91 people
- Sponsor
- National Cheng-Kung University Hospital
Portal Hypertension
RCT of Carvedilol Versus Variceal Band Ligation in the Primary Prophylaxis of Oesophageal Variceal Haemorrhage
Aim To compare Carvedilol with variceal band ligation in the prevention of first variceal bleed. End points of trial Primary: Variceal hemorrhage Secondary: Death Study design Randomised controlled clinical trial.
- Trial name
- NCT01070641
- Testing
- Carvedilol, Esophageal variceal band ligation
- Where
- Pakistan
- Volunteers
- 148 people
- Sponsor
- Aga Khan University