Clinical trials: Gastrointestinal Lesions
Colorectal Dysplasia, Colorectal Neoplasms
CAD EYE Detection of Remaining Lesions After EMR
In the last decade, many innovative systems have been developed to support and improve the diagnosis accuracy during endoscopic studies.
- Trial name
- NCT05542030
- Testing
- EMR with CAD-Eye™, EMR without CAD-Eye™, Follow-up colonoscopy with CAD-Eye™
- Where
- Ecuador
- Volunteers
- 60 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Polyp of Colon, Colorectal Polyp
Artificial Intelligence Development for Colorectal Polyp Diagnosis
Accurate classification of growths in the large bowel (polyps) identified during colonoscopy is imperative to inform the risk of colorectal cancer.
- Trial name
- NCT06447012
- Testing
- Colonoscopy
- Where
- United Kingdom
- Volunteers
- 4,000 people
- Sponsor
- King's College Hospital NHS Trust
Screening for Colon Cancer, Blood Samples
Evaluation of PreveCol's Efficiency As a Second Line Method for the Early Colorectal Cancer Detection
The objective of this low-risk interventional study is to evaluate whether the PreveCol® test has sufficient efficiency to be considered as a second-line method for the detection of both colorectal cancer and advanced adenomas…
- Conditions
- Screening for Colon Cancer, Blood Samples, Survey and Questionnaire, Colorectal Carcinoma
- Trial name
- MS-Prevecol (NCT06703632)
- Testing
- blood sampling, Survey using a questionnaire.
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 4,538 people, healthy volunteers welcome
- Sponsor
- ADVANCED MARKER DISCOVERY S.L.
Postoperative Gastric Distension, Postoperative Gastrointestinal Dysfunction
Anti-Bloating Patch for Postoperative Gastric Distension After Cardiac Surgery
Postoperative gastric distension is a common gastrointestinal complication after cardiac surgery and may delay recovery, prolong intensive care unit (ICU) stay, and reduce patient comfort.
- Conditions
- Postoperative Gastric Distension, Postoperative Gastrointestinal Dysfunction, Cardiac Surgery
- Trial name
- ABP-CS (NCT07677423)
- Testing
- Anti-Bloating Patch, Standard Perioperative Care
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Southeast University, China
Esophageal Cancer
Prospective Evaluation of a New Covered Metal Stent for Malignant Lesions of the Esophagus
In this study, a newly designed and FDA approved fully covered metal stents will be used to palliate 20 patients with malignant lesion of the esophagus.
- Trial name
- NCT01301495
- Testing
- HANAROSTENT TM covered Esophageal Stent
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Pancreatic Neoplasms
Diagnostic Yield of 20-gauge Procore Needle for EUS-guided FNA Biopsy in Solid Pancreatic Lesions
This study aims to examine technical feasibility and diagnostic yield of new 20-gauge Procore needle for EUS-guided fine needle biopsy in solid lesions by comparing with 22-gauge Procore needle.
- Trial name
- NCT02920944
- Testing
- EUS-FNB with 20 gauge ProCore needle, EUS-FNB with 22 gauge ProCore needle
- Where
- South Korea
- Volunteers
- 35 people
- Sponsor
- Seung Bae Yoon
Lesion; Gastrointestinal, Liver, Biliary, Pancreas and Gastrointestinal Disease, Nos
CO2 vs. Air Insufflation for Endoscopic Ultrasound
The insufflation of air in the viscera is indispensable during endoscopy. However, the distension of the bowel that follows is often the cause of abdominal discomfort.
- Trial name
- NCT02773563
- Testing
- EUS with air insufflation, EUS with CO2 insufflation
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Bologna
Barrett's Esophagus
pCLE in the Detection of Esophageal and Gastric Lesions and Intestinal Metaplasia or Dysplasia in Patients After Endoscopic Treatment of BORN
To assess diagnostic accuracy and clinical effectiveness including cost-effectiveness analysis of pCLE in patients after finishing the endoscopic treatment of BORN in detecting persistent/recurrent IM, recurrent neoplasia and…
- Trial name
- NCT02922049
- Testing
- Biopsies with histopathology
- Where
- Czechia
- Volunteers
- 67 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Adenoma Colon, Serrated Polyp
Cold EMR Vs Standard EMR for the Treatment of Large Nonpedunculated Homogeneous Colorectal Lesions
This study compares the effectiveness in complete resection (absence of recurrence at 6 months) the two different techniques for performing endoscopic mucosal resection (EMR) of nonpedunculated homogeneous colorectal lesions >20mm
- Conditions
- Adenoma Colon, Serrated Polyp, Serrated Adenoma, Colorectal Neoplasms
- Trial name
- NCT04418843
- Testing
- Standard Endoscopic Mucosal Resection, Cold Snare Endoscopic Mucosal Resection
- Where
- Spain
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- Oscar Nogales
Leiomyoma, GIST
Detective Flow Imaging Endoscopic Ultrasonography in Subepithelial Lesions
Gastrointestinal stromal tumors (GIST) are the most common malignant subepithelial lesions (SELs) found in the gastrointestinal tract.
- Trial name
- NCT05474794
- Testing
- DFI-EUS, CE-EUS
- Where
- Ecuador
- Volunteers
- 30 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Pancreatic Cancer, Pancreatic Adenocarcinoma
Pancreatic Cancer Models Developed From EUS Guided Biopsy Tissue
Pancreatic cancer is a very aggressive cancer. Over the past 40 years there has not been much progress made in reducing deaths from this cancer.
- Conditions
- Pancreatic Cancer, Pancreatic Adenocarcinoma, Pancreatic Cyst
- Trial name
- NCT03140592
- Testing
- Biopsy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Stony Brook University
Colonic Polyp, Colonic Neoplasms
Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract
The investigators want to verify in a randomised trial, the effectiveness of EndoClotTM in preventing post-procedural bleeding after EMR (Endoscopic Mucosal Resection) or ESD (Endoscopic Submucosal Dissection) for sessile lesions…
- Conditions
- Colonic Polyp, Colonic Neoplasms, Colonic Dysplasia
- Trial name
- NCT02688699
- Testing
- EndoClot
- Volunteers
- 288 people
- Sponsor
- University of Turin, Italy
Colorectal Cancer (Diagnosis)
Colorectal Lesion Evaluation and Appropriate Resolution (CLEAR) Study
The primary objective of this study is to evaluate a blood-based screening test for Colorectal Cancer (CRC).
- Trial name
- CLEAR (NCT07479381)
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Harbinger Health
Early Detection of Cancer
Sedation Versus No Sedation for Detection Rates of Precancerous Lesions and Cancer
The influence of sedation on the endoscopic detection rate of the precancerous lesions and cancer of upper digestive system has not been assessed.
- Trial name
- NCT04069975
- Testing
- Sedation
- Where
- China
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
Liver Cancer, Neoplasms, Liver
Study of New Software Used During Ablations
Background: Ablation is a procedure that heats tumor tissue to a high temperature to destroy it. Doctors perform this procedure by putting a probe in the tumor. This delivers heat to the site.
- Conditions
- Liver Cancer, Neoplasms, Liver, Hepatic Neoplasms, Hepatic Cancer
- Trial name
- NCT01906021
- Testing
- CT/CBCT thermometry method, Ablation Probe
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Colonic Neoplasms
Retroview™ Colonoscope and Lesion Detection Rate
Colonoscopy is considered the gold standard for colorectal polyp and cancer detection. However, even meticulous colonoscopy substantial numbers of colorectal polyps may be missed and carcinomas may not be prevented.
- Trial name
- NCT03155165
- Testing
- Retroview™ colonoscope
- Where
- Ecuador
- Volunteers
- 100 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Upper Gastrointestinal Lesions, Crohn's Disease
Upper Gastrointestinal Lesions in Crohn's Disease
A cross-sectional study was performed from 2017 to 2018. Consecutive Crohn's disease patients diagnosed in the Inflammatory bowel disease center of the Sixth Affiliated Hospital of Sun Yat-sen University were recruited.
- Trial name
- NCT03524144
- Testing
- gastroscopy
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Pancreatic Cancer, Pancreatitis
TOF-18F-FDG-PET/CT in Patients With Suspected Pancreatic Cancer
Aim of the prospective study is a better differentiation of benign and malignant lesions in the pancreas in patients with suspected pancreatic cancer using images 30 and 90 min p.i.
- Conditions
- Pancreatic Cancer, Pancreatitis, IPMN
- Trial name
- TOF-P (NCT03914950)
- Testing
- PET/CT results with TOF/without TOF
- Volunteers
- 174 people
- Sponsor
- Medical University of Graz
Crohn's Disease, Mucosal Inflammation
Assessment of Mucosal Activity to Improve the Prognosis of Patients With Crohn's Disease Treated With Immunosuppressants
This study will test that individualized treatment in patients with Crohn's Disease in remission or mild clinical activity under immunosuppressants may improve prognosis, rather than just treating flares.
- Trial name
- ADACAL (NCT01562951)
- Testing
- ADALIMUMAB
- Where
- 30 sites in Belgium, France and 1 more
- Volunteers
- 15 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Inflammatory Bowel Diseases, Psoriasis
Response to Ustekinumab for Anti-tnf Induced Psoriasiform Skin Lesions
Using transcriptomics and proteomics to gain insights in the development of psoriasiform skin lesions under anti-tumor necrosis factor (TNF) therapy, and predicting response to ustekinumab.
- Trial name
- STRAUSS (NCT03629379)
- Testing
- Ustekinumab, Vedolizumab
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven