Clinical trials: Gastrointestinal Lesions
Pancreas Neoplasm
Multicentered Prospective Randomized Controlled Trial For Solid Pancreatic Lesions
Endoscopic ultrasound (EUS) is an indispensable tool for tissue acquisition for pancreatic lesions. Fine needle aspiration (FNA) is once considered as the first line diagnostic method especially when rapid on-site evaluation…
- Trial name
- NCT04841616
- Testing
- Endoscopic Ultrasound -Guided Fine Needle Biopsy, Contrast-Enhanced Harmonic Endoscopic Ultrasound
- Where
- Hong Kong
- Volunteers
- 128 people
- Sponsor
- Chinese University of Hong Kong
Early Gastric Cancer, Colon Neoplasia
Magnetic Guided Counetrtraction During Endoscopic Submucosal Dissection
Endoscopic submucosal dissection (ESD) is a technique that allows curative treatment of early gastrointestinal neoplasia with organ preservation. However, it is a technically demanding procedure.
- Trial name
- NCT06962293
- Testing
- MAG-ESD assisted ESD
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Benign Breast Disease
REGENERA Implant in Excised Non-Malignant Breast Lesions
The purpose of this First-in-Human pilot study is to evaluate the safety and performance of REGENERA breast implant in a selected cohort of patients with non- malignant breast lesions treated with excision or lumpectomy in whom…
- Trial name
- NCT04131972
- Testing
- REGENERA
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Tensive SRL
Early Detection of Cancer
Sedation Versus No Sedation for Detection Rates of Precancerous Lesions and Cancer
The influence of sedation on the endoscopic detection rate of the precancerous lesions and cancer of upper digestive system has not been assessed.
- Trial name
- NCT04069975
- Testing
- Sedation
- Where
- China
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
Colon Cancer, Rectum Cancer
Phase I of SGM-101 in Patients With Cancer of the Colon, Rectum or Pancreas
This study evaluates the safety and performance of SGM-101, a Carcinoembryonic Antigen (CEA)-specific chimeric antibody conjugated with a NIR emitting fluorochrome, for the visualization of CEA-expressing cancers during surgery.
- Conditions
- Colon Cancer, Rectum Cancer, Pancreas Cancer, Metastatic Colorectal Cancer
- Trial name
- NCT02973672
- Testing
- SGM-101
- Where
- 3 sites in Netherlands
- Volunteers
- 75 people
- Sponsor
- Surgimab
Pancreatic Cancer, Pancreatic Cyst
Using Radiogenomics to Predict Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas
The Florida Pancreas Collaborative wants to partner with individuals who are known to have, or are suspected to have a pancreatic lesion, tumor, cyst, mass, cancer, or pancreatitis and are undergoing diagnosis and treatment at a…
- Trial name
- NCT04275557
- Testing
- Blood Sample collection, Tissue sample collection, Data collection
- Where
- 3 sites in United States
- Volunteers
- 1,274 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Pancreatic Cancer, Pancreatic Cystic Lesions
Trial Assessing Roux-en-Y Anastomosis of the Pancreatic Stump to Prevent Pancreatic Fistula Following Distal Pancreatectomy
The objective is to clarify Roux-en-Y anastomosis of the pancreatic stump decreases pancreatic fistula following distal pancreatectomy, compared with stapling closure of the pancreatic stump.
- Conditions
- Pancreatic Cancer, Pancreatic Cystic Lesions, Chronic Pancreatitis, Pancreatic Neuroendocrine Tumors
- Trial name
- NCT01384617
- Testing
- Stapling closure of the pancreatic stump, Roux-en-Y anastomosis of the pancreatic stump
- Where
- Japan
- Volunteers
- 136 people
- Sponsor
- Wakayama Medical University
Colorectal Neoplasm, Sessile Serrated Lesion
Detection and Characterization of Sessile Serrated Lesions (SSL) of the Right Colon
There are a few studies regarding Sessile Serrated Lesions (SSL). They are recently identified as precancerous lesions. Yet, digestive tract serrated lesions would be part of a new colic carcinogenesis way : the serrated tumor…
- Conditions
- Colorectal Neoplasm, Sessile Serrated Lesion, Neoplasms
- Trial name
- Lesion SSL (NCT02861885)
- Testing
- Chromoendoscopy
- Where
- 6 sites in France
- Volunteers
- 71 people
- Sponsor
- Hospices Civils de Lyon
Colorectal Neoplasms
Full Thickness Resection or Endoscopic Submucosal Dissection for Difficult Colorectal Lesions.
Compare the efficacy and safety of endoscopic resection a full thickness (EFTR) with Full Thickness Resection Device (FTRD) System versus endoscopic submucosal dissection (ESD) in the treatment of Laterally Spreading Tumor Non…
- Trial name
- NCT05502276
- Testing
- Endoscopic Full-Thickness Resection (EFTR), Endoscopic Submucosal Dissection (ESD)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Roma La Sapienza
Colorectal Cancer, Non Resectable Metastasis
Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate Synthase
The aim of the study was to evaluate the feasibility of TS determination in a multicenter trial setting using a central facility for measurement and confirm its role as predictive factor for 5-FU treatment in MCRC.
- Conditions
- Colorectal Cancer, Non Resectable Metastasis, Reference Lesion, Biopsy
- Trial name
- FOGT5 (NCT01212718)
- Testing
- FUFA, systemic chemotherapy
- Where
- Germany
- Volunteers
- 168 people
- Sponsor
- University of Ulm
Liver Cancer
High Dose Rate Brachyablation of Primary Liver Lesions
The objectives of this study are to demonstrate feasibility of an optimized, image-guided pre-planned workflow to deliver at least 25 Gy to the periphery of the target lesion while maintaining established dose constraints to…
- Trial name
- NCT02893982
- Testing
- brachytherapy
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Texas Southwestern Medical Center
Kidney or Liver Tumors
Registration and Fusion of Real-Time Ultrasound With CT for Lesion Localization and Characterization
Acquire CT data and US and transducer position data (magnetic sensor system) of focal hepatic or renal lesions to serve as sample data sets for fusion algorithm development and subsequent optimization.
- Trial name
- NCT00586235
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Gastric Cancer, Gastric Intestinal Metaplasia
Cytosponge for Gastric Intestinal Metaplasia
Gastric cancer has a very poor prognosis. The disease is often diagnosed at a late stage, when curative treatment options are limited or ineffective.
- Conditions
- Gastric Cancer, Gastric Intestinal Metaplasia, Gastric Atrophy
- Trial name
- CyGIM (NCT05657080)
- Testing
- Cytosponge-TFF3
- Where
- United Kingdom
- Volunteers
- 226 people
- Sponsor
- University of Cambridge
Pancreatic Fistula, Distal Pancreatectomy Complications
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
The purpose of this trial is to determine whether the use of an autologous falciform ligament patch combined with fibrin glue will reduce the rate of pancreatic fistula in patients completing distal pancreatectomy.
- Conditions
- Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
- Trial name
- NCT00889213
- Testing
- Falciform patch and fibrin glue application, standard pancreatic closure
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC)
Narrow Band Imaging Versus Artificial Intelligence for Colonic Surveillance in Inflammatory Bowel Disease
Patients with inflammatory bowel disease (IBD) - ulcerative colitis or Crohn's disease - have a higher risk of developing colorectal cancer than the general population.
- Conditions
- Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Ulcerative Colitis (UC), Crohn's Disease Colon, Colonic Dysplasia/Adenomata
- Trial name
- CLEAR-IBD (NCT07694362)
- Testing
- ENDO-AID CADe System (Olympus, Tokyo, Japan) (AI device)
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Vall d'Hebron Institute Research
Laryngeal Disease, Laryngeal Tumor
CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal Lesions
The study will take place at Rambam medical center, department of Otolaryngology Head and Neck Surgery, for two years. Patients suspected of LPR or laryngeal l tumor and are candidate for laryngeal or hypopharyngeal biopsies will…
- Conditions
- Laryngeal Disease, Laryngeal Tumor, Laryngopharyngeal Reflux
- Trial name
- NCT03214835
- Testing
- Endo CDx Brush biopsy
- Sponsor
- CDx Diagnostics
Colorectal Cancer, Liver Metastasis
Feasibility Study of Neoadjuvant Chemotherapy Modified FOLFOX6 for Resectable Liver Metastases of Colorectal Cancers
The purpose of this study is to evaluate the safety of liver resection for metastatic, resectable lesions from colorectal cancers after systemic chemotherapy.
- Trial name
- NCT00594529
- Testing
- Surgery
- Where
- Japan
- Volunteers
- 27 people
- Sponsor
- Kyoto University
Anal Cancer, Neoplasm of Uncertain Malignant Potential
Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia
RATIONALE: Infrared coagulator ablation may be effective in preventing the development of anal cancer in patients with anal neoplasia PURPOSE: This randomized phase III trial is studying infrared coagulator ablation to see how…
- Conditions
- Anal Cancer, Neoplasm of Uncertain Malignant Potential, Nonneoplastic Condition, Precancerous Condition
- Trial name
- NCT01164722
- Testing
- clinical observation, infrared photocoagulation therapy
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- AIDS Malignancy Consortium
Lung Cancer (Diagnosis), Osteochondroma
Clonal Hematopoiesis Chemotherapy and Radiation Effects Study
The goal of the Clonal Hematopoiesis Chemotherapy and Radiation Effects (CH CARE) Study is to understand how the presence or absence of clonal hematopoiesis (CH) influences outcomes in people receiving chemotherapy and radiation…
- Conditions
- Lung Cancer (Diagnosis), Osteochondroma, Spitz Nevus, Solid Cancers
- Trial name
- CH CARE (NCT07675967)
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Dana-Farber Cancer Institute
Cancer, Lung, Perfusion Computed Tomography Target Lesion
DCE-CT of Thoracic Tumors as an Early Biomarker for Treatment Monitoring in Comparison With Morphologic Criteria
DCE-CT of thoracic tumors as an early biomarker for treatment monitoring in comparison with morphologic criteria. 1. Rationale of the clinical investigation For the evaluation of response to anti-tumoral therapy in thoracic…
- Conditions
- Cancer, Lung, Perfusion Computed Tomography Target Lesion, Cancer Liver, Metastatic Lung Cancer
- Trial name
- NCT04708483
- Testing
- Extra DCE-CT scan
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Hyperfusion