Clinical trials: Gastrointestinal Microbiota
Gut Microbiota
Effects of Riboflavin on Faecalibacterium Prausnitzii and the Gut Microbiota
The purpose of this trial is to investigate comprehensively the effect of riboflavin supplementation on the abundance of F. prausnitzii and on other members of the gut microbiota in faeces of healthy volunteers.
- Trial name
- NCT02929459
- Testing
- Riboflavin Dose 1, Riboflavin Dose 2
- Where
- Netherlands
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Human Microbiome
Oral Pomegranate Extract on the Microbiome and Skin Biophysical Properties
Pomegranate extract (Pomella) is well known for its antioxidant properties due to its phenolic compounds. It has also been shown to increase the amount of short chain fatty acid producing Lactobacillus and Bifidobacteria genera.
- Trial name
- NCT04596722
- Testing
- Pomella
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Renal Failure Chronic
Probiotics and Low Protein Diet in Advanced Chronic Kidney Disease
Here the investigators will perform a double-blinded randomized placebo-controlled clinical trial to evaluate the synergic effect of low protein diet and prebiotics in reducing the microbial inflammatory uremic toxins.
- Trial name
- ProLowCKD (NCT04204005)
- Testing
- Probiotics
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Probiotical S.p.A.
A03 - Digestive System, B03 - Bacteria
Fermented Dairy Product and Bifidobacterium Diversity (ThreeBees)
Bifidobacterium strains with potential health benefits can contribute to the gastrointestinal wellbeing. However, the ability of these strains to survive gastro-intestinal tract stress and their impact on gut microbiome remains…
- Trial name
- ThreeB (TB) (NCT06799364)
- Testing
- 28-days consumption of Product A in 45 to 60-year-old healthy subjects., 28-days consumption of Product B in 45 to 60-year-old healthy subjects., 28-days consumption of Control product in 45 to 60-year-old healthy subjects.
- Where
- 3 sites in France
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Healthy
Pilot Study on the Effect of a XOS95 on the Human Gut Microbiome
The purpose of this clinical trial is to assess the efficacy of a novel prebiotic, XOS95, at two different dosages, in comparison to a placebo by assessing shifts in microbial populations after 8 weeks of supplementation…
- Trial name
- NCT03074019
- Testing
- Xylooligosaccacharide, Maltodextrin
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Prenexus Health
Dysbiosis, Prophylaxis
Lactobacillus Reuteri DSM 17938 in Gut Microbiota Development in Infant Born by Caesarean Section
The aim of this study is to assess influence of probiotic Lactobacillus reuteri DSM 17938 on formation of gut microbiota in infant born by Caesarean section.
- Trial name
- NCT03675048
- Testing
- BioGaia Protectis drops
- Where
- Russia
- Volunteers
- 97 people
- Sponsor
- BioGaia AB
Type 2 Diabetes, Chronic Obstructive Pulmonary Disease
Probiotic on Type 2 Diabetes and Chronic Obstruction Pulmonary Disease
This trial is a randomized, double-blind, parallel placebo clinical trial, the purpose of which is to investigate whether the adjuvant therapy of using probiotics during the treatment of diabetic patients can decrease blood sugar…
- Trial name
- NCT05492448
- Testing
- L. salivarius AP-32 and L. reuteri GL-104, L. reuteri GL-104
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Glac Biotech Co., Ltd
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on Gut Microbiota Composition and Clinical Effectiveness in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- TEMPO (NCT03067714)
- Testing
- Infant formula with added synbiotics, Standard infant formula
- Where
- 59 sites in Belgium, Czechia and 11 more
- Volunteers
- 855 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Intestinal Flora
A Probiotic That Improve Intestinal Flora
Purpose: to verify the physiological properties of Lactobacillus rhamnosus LRa05. Bacterial count:100 billion Test Objective: to test and collect the changes of intestinal flora before and after the daily use of LRa05 product.
- Trial name
- NCT06103240
- Testing
- Lacticaseibacillus rhamnosus LRa05
- Where
- China
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD)
AIM-IBD: A Microbiome-Targeted Supplement in Mild-to-Moderate Ulcerative Colitis
This Phase 2b randomized, double-blind, placebo-controlled, multicenter trial will evaluate the efficacy and safety of a once-daily oral microbiome-targeted food supplement compared with matching placebo in adults with…
- Conditions
- Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD), Colitis
- Trial name
- AIM-IBD (NCT07619638)
- Testing
- Microbiome-Targeting Nutraceutical
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- ENBIOSIS BIOTECHNOLOGIES
Infant Development, Gut Microbiome
Characterisation of the Gut Microbiota in Term Infants After Maternal Supplementation of Probiotics
A monocenter, open label pilot study in pregnant women and their offspring with at least four weeks prenatal and four weeks postnatal maternal intervention with a study product consisting of four different food constituents.
- Trial name
- NCT04987593
- Testing
- Probiotics
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Irritable Bowel Syndrome
Fructo-oligosaccharides and Irritable Bowel Syndrome
Fructo-oligosaccharides are known as prebiotic ingredients to modulate the composition of the intestinal microbiota and particularly to stimulate the growth of Bifidobacteria.
- Trial name
- NCT00806104
- Testing
- Fructo-oligosaccharides, Maltodextrins
- Where
- 2 sites in France, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Beghin-Meiji
Photoaging
Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women
Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins.
- Trial name
- NCT04869852
- Testing
- Food
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Occasional Constipation, Gastrointestinal Health
A Clinical Trial to Investigate the Efficacy of Acacia Fiber on Gastrointestinal Health and Microbiota Composition in Healthy Adults With Occasional Constipation
The goal of this randomized blinded placebo-controlled clinical trial is to investigate the effect of low- and high-dose supplementation of Acacia fiber on gut health and microbiota composition in adults with occasional…
- Conditions
- Occasional Constipation, Gastrointestinal Health, Gut Microbiota Composition
- Trial name
- NCT07703254
- Testing
- Low-dose Acacia fiber, High-dose Acacia fiber
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Nexira
Clostridium Difficile Infection
A Novel Faecal Microbiota Transplantation System for Treatment of Primary and Recurrent Clostridium Difficile Infection
This study is a two-arm, interventional, prospective, open-label, multi-center clinical trial with randomized and non-randomized study groups to evaluate the safety and effectiveness of faecal microbiota transplantation (FMT) for…
- Trial name
- FMTREAT (NCT03053505)
- Testing
- faecal human microbiota transplant (FMT), Vancomycin or Fidaxomicin
- Where
- 3 sites in Hungary
- Volunteers
- 150 people
- Sponsor
- Sejtterapia Kozpont Kft.
Autism Spectrum Disorder, Autism
Autism Spectrum Disorder (ASD) Neurodevelopmental Disorder With Issues Social Behavior, Communication Issues, GI Dysfunction. Study is Multimodal Interventions Targeting These Pathways With cSVF, Stored MSCs, FMT and Diet Modification. Role of Autoimmunity, Gut-brain Issues, & Issues Examined.
Autism spectrum disorder (ASD) is a neurodevelopmental condition with core deficits in social communication and behavior, often accompanied by gastrointestinal (GI) and metabolic dysfunction.
- Conditions
- Autism Spectrum Disorder, Autism, Autism Spectral Disorder
- Trial name
- GARM-Autism (NCT07546942)
- Testing
- Autologous MSC isolation, concentration, and cryopreservation of adult mesenchymal stem cells, Fecal Biomicrome Transplantation (FMT), Ketogenic RESET Diet Protocol
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Black Tie Medical, Inc.
Allergic Rhinitis
Probiotic Ameliorates Adult Allergic Rhinitis and Modulates Gut Microbiota
Assessing the clinical efficacy of weizmannia coagulans BC99 in alleviating allergic rhinitis symptoms, improving gut microbiota, and reducing adverse reactions in patients.
- Trial name
- NCT06680102
- Testing
- Probiotic, Maltodextrin
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Quality of Life
Effect of Colon Delivered Vitamin B2 on Gut Microbiota and Related Health Biomarkers in Healthy Older Adults
The goal of this intervention study (clinical trial) is to investigate the effect of colon-delivered Riboflavin (vitamin B2) on the faecal microbial composition and diversity in older healthy subjects (50 -70 years of age)
- Trial name
- NCT05803811
- Testing
- Riboflavin
- Where
- Ireland
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Gut Microbiota
Characterization of the Gastrointestinal Microbiota in Term Newborn Infants After 4 Weeks Supplementation of Probiotics
A mono center, open label, pilot study in term newborn infants. The study will investigate the effect of supplementation with probiotics on the presence of total Bifidobacterium in the infant feces.
- Trial name
- NCT04994834
- Testing
- Probiotics
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Autism
Prebiotic Intervention for Autism Spectrum Disorders
The purpose of this study is to determine the effect of a prebiotic (BGOS) on gut microbiota and metabolites in children with autism spectrum disorders.
- Trial name
- NCT02720900
- Testing
- B-GOS, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Clasado Limited