Clinical trials: Gastrointestinal Microbiota
Hypercholesterolemia
Red Yeast Rice for Primary Prevention of Hypercholesterolemia
This two-year observational study will be conducted at the outpatient clinic of the Department of Traditional Chinese Medicine of Taoyuan Chang Gung Hospital from February 26, 2024 to December 31, 2025.
- Trial name
- NCT06301906
- Testing
- LipoCol Forte Capsule 600mg twice a day
- Where
- Taiwan
- Volunteers
- 41 people
- Sponsor
- Chang Gung Memorial Hospital
Diet Modification
Effects of Consuming Red Meat on the Gut Microbiota in Young Adults
The purpose of this study is to assess the impact of consuming unprocessed and processed red meat on gut microbiota in young healthy adults in a cross-over, randomized controlled feeding trial.
- Trial name
- S51 (NCT03885544)
- Testing
- Controlled Lacto-ovo vegetarian diet, Controlled Unprocessed red meat diet, Controlled processed red meat diet
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Purdue University
Hepatocellular Carcinoma, Liver Cancer
Gut Microbiota in People With Hepatocellular Carcinoma (HCC)
Background: There are about 100 trillion microbial cells in a person s gut. This is called the human gut microbiota. When this is disrupted, it can lead to many diseases.
- Conditions
- Hepatocellular Carcinoma, Liver Cancer, Liver Cell Caricinoma, Liver Neoplasm
- Trial name
- NCT02599909
- Sponsor
- National Cancer Institute (NCI)
Postmenopausal Osteoporosis, Gut Microbiome
Blackcurrants Modify Gut Microbiota and Reduce Osteoporosis Risk in Postmenopausal Females
The goal of this clinical trial is to evaluate the effects of blackcurrant (BC) supplementation on changes in bone density and gut microbiome composition in postmenopausal females.
- Conditions
- Postmenopausal Osteoporosis, Gut Microbiome, Menopause
- Trial name
- NCT07365514
- Testing
- Blackcurrant (BC) extract
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Healthy Infants
Probiotic for Infants
The BABIES II study is a single-center, randomized, double-blinded, placebo-controlled study in newborns with an 8½ months intervention period from 14 days of age to 9 months of age followed by a 3-months short-term follow-up…
- Trial name
- BABIES II (NCT07054216)
- Testing
- Probiotic
- Where
- 2 sites in Denmark
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Colitis, Ulcerative
Fecal Microbiota Alterations in Steroid Refractory Active Colitis Ulcerosa
Alterations in the intestinal microbiota have been associated to disease pathogenesis in ulcerative colitis. Refractory disease to standard medical therapy as corticosteroids often leads to an unfavourable course in patients…
- Trial name
- NCT03460847
- Testing
- Steroids
- Where
- Austria
- Volunteers
- 114 people
- Sponsor
- Medical University of Graz
Gastrointestinal Lymphoma
A Metagenome-wide Association Study of Gut Microbiota in Gastrointestinal Non-Hodgkin's Lymphoma Patients
This is a observational study on the fecal microbiota in primary/secondary gastrointestinal lymphoma patients.
- Trial name
- NCT03930043
- Testing
- Metagenomic shotgun sequencing
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Mental Health Wellness
Study of Probiotic Use After Childbirth in Relation to Emotional Well-Being
Researchers at Massachusetts General Hospital are interested in learning more about the neurobiology of well-being in new mothers and novel ways to support them during their transition to parenthood.
- Trial name
- PACE (NCT04472065)
- Testing
- Lactobacillus reuteri
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Elizabeth Austen Lawson
Cognition, Gut Microbiome
The Path Study: Cognitive and Inflammation Targeted Gut-brain Interventions in Alcohol; Probiotics, Alcohol, Transcutaneous Vagus Nerve Stimulation, and HIV Study
This project uses a hybrid trial design to evaluate two biomedical interventions targeting the gut-brain axis. One intervention is portable Transcutaneous Vagus Nerve Stimulator, tVNS, that is hypothesized to stimulate the…
- Trial name
- NCT05090267
- Testing
- Probiotic Supplement, Transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Florida
Overweight or Obesity, Healthy
Berries, Inflammation, and Gut Microbiome
The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations…
- Trial name
- NCT04100200
- Testing
- Mixed berries, FOS, Control
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Lifestyle-related Condition
Effects of Pulses Through the Gut Microbiome and Bioavailability of Bioactive Compounds
The goal of this clinical trial is to investigate the effects of replacing red meat with pulses, on cardiometabolic health and gut microbiome in individuals with unhealthy habits and sedentary lifestyles at high risk for…
- Trial name
- LEGUMINIBUS (NCT05999136)
- Testing
- Pulses diet, Plant proteins diet, Habitual diet
- Where
- Italy
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Paola Vitaglione
Colon Cancer, Colitis
Novel Listeria Vectors Secreting Gut Flora-Altering Agents to Prevent Colon Cancer and Treat Colitis
This is a simple tissue collection study with no therapeutic intent. Colon tissues will be taken from standard of care procedures.
- Trial name
- NCT03014284
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Gut Microbiome
Effects of Mango or Low-Fat Cookie Consumption on Gut Health, and Its Relationship With Mental, Sexual and Skin Health
The objective of the proposed research is to determine the effects of fresh mango consumption on gut microbiome, and its relationship with skin health, sexual and mental health in relatively healthy adults.
- Trial name
- NCT06800833
- Testing
- Low fat cookies, Mango
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Critical Illness
Precision Modulation of Gut Microbiome Enteropathogen Colonization in Critical Illness
Patients requiring life support therapies in intensive care units are at very high risk of hospital-acquired infections. An important source of these infections is the accumulation of pathogenic bacteria in the microbiome of…
- Trial name
- MicroMod (NCT07813507)
- Testing
- Synbiotic, Standard of Care (SOC)
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of Calgary
Mild Cognitive Impairment, Alzheimer Disease
Effects of 24-week Computerized Cognitive Training in Patients With MCI and AD
This study aims to testify multi-domain effects of computerized cognitive training in patients with mild cognitive impairment and mild Alzheimer's disease through multi-dimensional evaluation.
- Trial name
- NCT06094452
- Testing
- Computerized Cognitive Training, Treatment As Usual
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Chongqing Medical University
Crohn Disease
Corporal Composition and Gut Microbiome Modification Through Exclusion Dietary Intervention in Crohn's Disease
Crohn's disease (CD) is an inflammatory bowel disease in which there is an alteration of the homeostasis and functionality of the intestinal mucosa accompanied by a dysbiosis of the commensal microbiota.
- Trial name
- NCT06933264
- Testing
- Exclusion diet
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Universitario Virgen de la Arrixaca
Gut Microbiome, Mother to Child Transmission
Mother-infant Microbiota Transmission and Its Link to the Health of the Baby
The human intestinal tract harbors a diverse and complex microbial community, known as gut microbiota, which is critical in sustaining physiology, metabolism, nutrition and immune function.
- Trial name
- NCT04117321
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation
Fungal Fiber for Gut Health
This study compares effects of plant based fiber vs fungi based fiber on clinical outcomes related to gut function (immunity, emotions, stress) and explores the role of gut microbiome structure and function on individual…
- Conditions
- Mild Gastrointestinal Symptoms in Healthy Adults, Low-grade Chronic Inflammation, Stress, Gut Health
- Trial name
- FUN4GUT (NCT06404749)
- Testing
- fungal fiber, inulin
- Where
- Argentina
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Future Biome SA
Microbiota, SIBO
Capillary Endoscopy Aspiration Catheter
The small intestine is an understudied frontier of microbiome research. While aspiration during endoscopy is considered the gold standard to assess small bowel bacteria, the tools for sterile retrieval are primitive and poorly…
- Trial name
- NCT04418258
- Testing
- Capillary Endoscopy Aspiration Catheter, Endoscopy Aspiration Catheter
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer, Colorectal Neoplasms
A Pilot Study to Explore the Role of Gut Flora in Colorectal Cancer
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Carcinoma, Colorectal Adenocarcinoma
- Trial name
- NCT04148378
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.