Clinical trials: Gastrointestinal Microbiota
Aging, Healthy, Aging and Cognitive Health
Fecal Microbiota Transplantation (FMT) to Slow Biological Aging
The goal of this clinical trial is to evaluate if multi-dose fecal microbiota transplantation (FMT) capsules can safely and effectively slow down biological aging and reduce chronic low-grade inflammation in adults aged 45 to 80…
- Conditions
- Aging, Healthy, Aging and Cognitive Health, Inflammation, Metabolic Syndrome
- Trial name
- LONGEVIBIOME (NCT07912164)
- Testing
- Fecal microbiota transplantation delivery through oral capsules (HBI MBiotix Caps)
- Volunteers
- 68 people
- Sponsor
- Human Biome S.A.
Irritable Bowel Syndrome
Fecal Microbial Transplantation in Treatment of Irritable Bowel Syndrome; a Double Blinded Placebo Controlled Trial.
Fecal Microbial Transplantation in Treatment of Irritable Bowel Syndrome; a Double Blinded Placebo Controlled Trial - the REFIT project Irritable bowel syndrome (IBS) is a condition characterized by variable complaints like…
- Trial name
- REFIT (NCT02154867)
- Testing
- Fecal transplantation
- Where
- Norway
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital of North Norway
Gut Microbiota, NSCLC
Analysis of Gut Microbiota in Patients With Brain Metastasis of Non-small Cell Lung Cancer Treated by Pembrolizumab Combined With Chemotherapy
Analysis of Gut Microbiota in Patients With Brain Metastasis of Non-small Cell Lung Cancer Treated by Pembrolizumab Combined With Chemotherapy
- Conditions
- Gut Microbiota, NSCLC, Pembrolizumab, Chemotherapy
- Trial name
- NCT04333004
- Testing
- Pembrolizumab Combined With Chemotherapy
- Volunteers
- 40 people
- Sponsor
- Xiaorong Dong
Ulcerative Colitis
Optimal Fecal Microbiota Transplant Dosing for Mild to Moderate Ulcerative Colitis
This is a prospective unblinded, randomized trial for the use of Fecal Microbiota Transplantation (FMT) for the treatment of Ulcerative Colitis (UC), in combination with or without antibiotic pretreatment.
- Trial name
- NCT03006809
- Testing
- Fecal Microbiota Transplantation (FMT), OpenBiome, pretreatment antibiotics
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Najwa Elnachef
Obesity
Metabolic Impact on the Mitochondria-gut Microbiota Axis of Failure to Follow Restrictive Dietary Interventions in Subjects Living With Obesity
Nutritional interventions with dietary restrictions have become highly popular for promoting weight and body fat loss; In addition, they are largely associated with the improvement and preservation of mitochondrial function as…
- Trial name
- NCT06782009
- Testing
- Calorie restriction, Intermittent fasting 16/8, Ketogenic diet
- Where
- 2 sites in Mexico
- Volunteers
- 84 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Rhinitis, Allergic
Washed Microbiota Transplantation for Allergic Rhinitis
Allergic rhinitis (AR) is characterized by sneezing, nasal congestion, nasal itching and nasal leakage and is caused by immunoglobulin E (IgE)-mediated reactions to inhaled allergens.
- Trial name
- NCT06372184
- Testing
- Washed Microbiota Transplantation
- Where
- China
- Volunteers
- 32 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Gut Dysbiosis for TMAO Production From L-carnitine Consumption
Using Gut Microbial Gbu Gene Testing to Estimate Host TMAO Production Capacity
The risk of cardiovascular diseases from red meat consumption varies among individuals due to variations in gut microbiota. L-carnitine in red meat can be converted to TMAO in the body by certain bacteria.
- Trial name
- NCT05980884
- Testing
- L-carnitine
- Where
- Taiwan
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pulmonary Disease, Chronic Obstructive (COPD), Pulmonary Diseases
Effect of Dietary Fiber Supplementation on Systemic Inflammation and Clinical Parameters in COPD
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent respiratory symptoms and systemic inflammation. Dietary fiber intake has been associated with beneficial effects on gut microbiota composition and…
- Conditions
- Pulmonary Disease, Chronic Obstructive (COPD), Pulmonary Diseases, Pulmonary Diseases, Obstructive
- Trial name
- NCT07868211
- Testing
- Dietary Fiber Supplementation
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Júnea Regina Pires Drews
Pouchitis
the Prophylaxis of Recurrent Pouchitis After Fecal Microbiota Transplant in UC With Ileo-anal Anastomosis
Ulcerative colitis (UC) is a chronic inflammatory digestive (IBD) disease medically treated with corticosteroids, aminosalicylates, immunomodulators, and biologics.
- Trial name
- POCA (NCT03524352)
- Testing
- fecal microbiota
- Where
- 13 sites in France
- Volunteers
- 42 people
- Sponsor
- Nantes University Hospital
Sepsis, Nutrition
Personalized Nutritional Formula for ICU Patients: A Study on Prognosis and Multidimensional Health Markers
This study aims to evaluate the effects of an individualized enteral nutrition formula on clinical outcomes in critically ill adult patients in the intensive care unit (ICU).
- Conditions
- Sepsis, Nutrition, Gut -Microbiota
- Trial name
- NCT07755033
- Testing
- Individualized Enteral Nutrition Formula, Standard Enteral Nutrition Formula
- Volunteers
- 1,200 people
- Sponsor
- Chinese Medical Association
Type 2 Diabetes Mellitus
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly
Cognitive disorders increase with age and in the presence of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). In addition, digestive disorders, changes in dietary pattern and decreased activity negatively influence the…
- Trial name
- SmartAge (NCT04841668)
- Testing
- Metformin
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Gastrointestinal Microbiome, Nutrition, Healthy
The Effects of a Novel Nutritional Product on Nutrient Gaps and Gut Health in Adults With Occasional Gastrointestinal Issues
This study is a randomized, double-blind, placebo-controlled study of N=40 adult men and women with occasional GI issues. This study to assess the effect of a novel dietary supplement on the gut microbiome, nutrient gaps, and…
- Trial name
- NCT06564285
- Testing
- AG1 - Nutritional Supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Athletic Greens International
Ulcerative Colitis
LFMT vs Placebo in New Biologic Start for Ulcerative Colitis
To compare the safety and efficacy of concomitant LFMT versus placebo in UC patients who are starting vedolizumab or ustekinumab.
- Trial name
- NCT05327790
- Testing
- Lyophilized fecal microbiota (LFMT)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Hepatocellular Carcinoma (HCC)
PULSAR Combined With Fecal Microbiota Transplantation for Advanced Hepatocellular Carcinoma Progressing After First-Line Targeted-Immunotherapy
This is an open-label, multicenter, randomized controlled Phase II trial. Patients with advanced hepatocellular carcinoma (HCC) who developed secondary resistance to first-line targeted-immunotherapy were randomly assigned to…
- Trial name
- NCT07463248
- Testing
- Tislelizumab Combined With TKI, Fecal Microbiota Transplantation, PULSAR
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Wang Xin
Colorectal Adenoma
Ginger and Gut Microbiome (GINGER)
Estimate the impact of a 6-week daily intake of 2000 mg of ginger extract on the composition of the gut microbiome using a randomized placebo-controlled double-blinded design, i.e.
- Trial name
- NCT03268655
- Testing
- Ginger extract
- Where
- 13 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of Minnesota
Healthy
An Intervention on Healthy Adults of Probiotics on Gut Flora Metabolisms of Choline
The aim of the study is to examine the effects of probiotics intervention on choline metabolites and intestinal microbiota composition using a randomized double blind clinical trial.
- Trial name
- NCT03292978
- Testing
- probiotics intervention, non-probiotic control
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Huilian Zhu
Allergic Rhinitis
Traditional Chinese Medicine on Gut Microbiota and Allergic Diseases
Allergic rhinitis is an importance disease in Taiwan with its high incidence about 20-30% and gradually increased annually. However, symptom relapse still bothered the majority of patients though there were certain advances in…
- Trial name
- NCT03033290
- Testing
- Bu-Zhong-Yi-Qi-Tang
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Obesity, Weight Loss
Pilot Project on Interdisciplinary Therapy of Obesity
Obese individuals that undergo major intervention such as a low-calorie formula diet program or bariatric surgery with the result of substantial weight loss (> 10%) are included and followed-up for at least 3 years.
- Trial name
- NCT01344525
- Testing
- Laparoscopic gastric sleeve, Gastric Banding, Multidisciplinary lifstyle intervention
- Where
- 3 sites in Germany
- Volunteers
- 480 people
- Sponsor
- University of Hohenheim
Infant Colic, Atopic Dermatitis
Use of Bifidobacterium Bifidum in Formula-Fed Infants With Colic, With or Without Atopic Dermatitis
The goal of this clinical trial is to evaluate whether daily probiotic supplementation with Bifidobacterium bifidum (Bifipral® drops) can reduce crying time in formula-fed infants aged 5 months or younger diagnosed with infant…
- Trial name
- NCT07754968
- Testing
- Bifidobacterium bifidum BFP19® and BFP29® (Bifipral®)
- Where
- Italy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Kidney Calculi, Ureteral Calculi
Impact of Humid-Heat on Gut-Tryptophan-Stone Pathway
Investigating the differences in gut microbiota composition and tryptophan metabolite levels between kidney stone patients and healthy individuals, with special focus on: 1.
- Trial name
- NCT07043374
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
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