Clinical trials: Gastrointestinal Microbiota
Obesity (Disorder), Bariatric Surgery
Impact of a Pro-diversity Gut Microbiota Diet After a Bariatric Surgery on Gut Microbiota, Eating Behaviour and Sensory Function
Bariatric surgery is the most effective treatment for long-term weight loss and reducing obesity-related health risks. It alters the gastrointestinal tract as well as metabolic and hormonal functions, influencing eating…
- Trial name
- BariaGut Taste (NCT07268508)
- Testing
- Nutritional counseling
- Where
- 3 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Graft vs Host Disease, Graft Versus Host Disease
Comparison of Gut Microbiota, Inflammation and Symptoms Following Allogeneic HSCT
The purpose of this study is to examine the gut bacteria, levels of peripheral blood inflammation markers, and symptoms in patients with and without chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic…
- Conditions
- Graft vs Host Disease, Graft Versus Host Disease, Hematopoietic Stem Cell Transplantation, Peripheral Blood Stem Cell Transplantation
- Trial name
- NCT02398708
- Testing
- Questionnaires, Blood Sample, Stool Sample
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Florida
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass
Up to approximately 205 (dependent on drop-out rate) healthy elderly individuals (at least 65 years old) are recruited as subjects.
- Trial name
- CALM (NCT02034760)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Radiation Enteritis
Associations of Fecal Bile Acid Profile and Intestinal Flora With Chronic Radiation Enteritis
To explore the fecal bile acid profile of patients with radiation enteritis, to clarify the types of bile acids that are closely related to the occurrence of radiation enteritis; to explore the interaction between fecal bile…
- Trial name
- NCT05728060
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Probiotics
Use of a Selected Mixture of Probiotic Strains for Degrading Gluten During Digestion
Gluten intake spreads worldwide, being the major food protein consumed in the Western diets (up to 20 g gluten/d). But gluten has unique and unusual features.
- Trial name
- NCT05798689
- Testing
- Probiotic administration and gluten
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Free University of Bozen-Bolzano
Ulcerative Colitis, Fecal Microbiota Transplantation
Fecal Microbiota Transplantation for Ulcerative Colitis
Fecal microbiota transplantation (FMT) is a strategy that infuses a fecal suspension containing a healthy donor's microbiota into a patient's gut to restore his/her intestinal microbiome.
- Trial name
- NCT03804931
- Testing
- Fecal microbiota transplantation, Infusion of Saline, 5-Aminosalicylic acid(5-ASA) and/or Prednisone
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Guangzhou First People's Hospital
Severely Burned Patients, Gut Microbiota Diversity and Composition
Monitoring the Clinical and Immunological Effects of Microbiome Changes Following Severe Burn Injury
The aim of this study is to longitudinally monitor dynamic changes in the gut microbiome following severe burn injury using fecal samples.
- Conditions
- Severely Burned Patients, Gut Microbiota Diversity and Composition, Inflammatory Responses
- Trial name
- microbiome (NCT07329595)
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Tamas Vegh, MD
Constipation, Inflammation
Constipation, Gut Microbiome, and Microbial-derived Uremic Toxins From the Gut Microbiota in HD Patients
Chronic constipation is a prevalent, multifactorial gastrointestinal disorder, and its etiology and pathophysiology remain poorly understood.
- Trial name
- NCT04309019
- Where
- Taiwan
- Volunteers
- 61 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Inflammatory Bowel Diseases, Clostridium Difficile Infections
Research on Gut Microbiome and Metabolomics Alterations in C.Difficile Infected IBD Patients
The goal of this research is to compare alterations of gut microbiota and fecal metabolomics alterations between inflammatory bowel disease patients infected with or without Clostridioides difficile.
- Conditions
- Inflammatory Bowel Diseases, Clostridium Difficile Infections, Microtia
- Trial name
- NCT05714566
- Testing
- Clostridioides difficile toxin detection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
Dietary Behaviors, Sustainable Diets
Community-Based Nutritional Intervention Based on the Planetary Health Diet and Its Impact on Gut Microbiota in Rural Women in Mexico
This study aims to evaluate the impact of a community-based nutritional intervention based on the Planetary Health Diet on dietary patterns, gut microbiota composition, and health indicators in adult women living in rural…
- Conditions
- Dietary Behaviors, Sustainable Diets, Gut Microbiota, Nutrition Intervention
- Trial name
- PHD-RURAL (NCT07597811)
- Testing
- Community-Based Planetary Health Diet Intervention
- Where
- Mexico
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Edgar Leon
Ulcerative Colitis
Multi-Strain Probiotics Supplementation With Standard Care in Mild to Moderate Ulcerative Colitis
Probiotics are one of the adjunctive treatments that have been extensively explored for Ulcerative colitis (UC) disease management.
- Trial name
- NCT06595719
- Testing
- Multi-Strain Probiotics
- Where
- Malaysia
- Volunteers
- 124 people
- Sponsor
- National University of Malaysia
Diet, Healthy, Systemic Inflammatory Response
Effect Dietary Fibre Supplementation on Gut Microbiota Composition
The study involves taking pectin fibre at increasing doses ranging from 5g, 10g and 15g for a total period of 6 weeks with the increase every 2 weeks.
- Trial name
- NCT06758570
- Testing
- Pectin dosages
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Elizabeth Simpson
Ulcerative Colitis Associated Pouchitis
FMT in Ulcerative Colitis-Associated Pouchitis
The purpose of this study is to test whether Fecal Microbiota Transplant (FMT) is a safe and effective treatment for people who have Ulcerative Colitis and have had an ileal pouch anastomosis.
- Trial name
- NCT02049502
- Testing
- biologically active human fecal microbiota, sigmoidoscopy
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Virginia O. Shaffer
Microbiota
Effect of Intrapartum Antibiotic Prophylaxis (IAP) on the Development of the Neonatal Gut Microbiota.
The colonization of the neonatal gastro-intestinal (GI) tract begins at birth and is influenced by several factors, such as mode of delivery, gestational age, maternal intestinal and vaginal microbiota, type of feeding…
- Trial name
- MICROBIOTA-SO (NCT02212002)
- Testing
- IAP
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Irritable Bowel Syndrome
Influence of Ear Vagus Nerve Stimulator on Patients With IBS
Irritable bowel syndrome (IBS) is a very common functional digestive disorder characterized by chronic abdominal pain and altered bowel habits in the absence of biological or structural abnormalities.
- Trial name
- NCT06321237
- Testing
- Vagus nerve stimulation for 8 weeks, Vagus nerve stimulation for the first 4 weeks, Vagus nerve stimulation for the last 4 weeks
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huaping Xie
Celiac Disease
Impact of a Low-FODMAP Gluten-free Diet on Gut Microbiota and Circulating miRNAs in Celiac Disease Patients
15 patients with refractory celiac disease (RCD) and 15 patients with CD responsive to the GFD between the ages of 21 and 60 will be enrolled.
- Trial name
- FODMAP2019 (NCT04655495)
- Testing
- Low FODMAPs /balanced gluten free diet
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Obesity & Overweight, Perimenopausal Women
Prebiotic Inulin for Late-Reproductive Individuals
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are: 1.
- Conditions
- Obesity & Overweight, Perimenopausal Women, Prebiotics, Inulin
- Trial name
- PILI (NCT07724522)
- Testing
- Inulin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- George Washington University
Healthy, Obesity
Open Label Randomized Clinical Study to Promote a Healthy Lifestyle in Medical Students
The main medical and social purpose of the project "It's trendy to be healthy!" is the promotion of healthy lifestyles and healthy eating among student youth.
- Conditions
- Healthy, Obesity, Nutrition, Healthy, Vitamin D Deficiency
- Trial name
- NCT05073029
- Testing
- nutrition program and modification of physical activity, synbiotic (Fructooligosaccharides+Lactobacillus rhamnosus GG ATCC 53103, 4.0х109 colony forming units - CFU), vitamin D3
- Where
- 2 sites in Ukraine
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bogomolets National Medical University
H.Pylori Gastrointestinal Disease
Second Line Bismuth Containing Quadruple Therapy With Supplementary Probiotic
This study is designed to evaluate the clinical outcome of second line Bismuth containing quadruple therapy with supplementary probiotic for Helicobacter pylori eradication
- Trial name
- NCT05577572
- Testing
- Probiotics packets
- Where
- 4 sites in Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Ulcerative Colitis
Dynamic Changes of Gut Microbiota in UC After FMT
A prospective study to investigate the dynamic changes of gut microbiota through colonic transendoscopic enteral tubing in patients with ulcerative colitis after fecal microbiota transplantation.
- Trial name
- NCT03949257
- Testing
- colonic transendoscopic enteral tubing
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Second Hospital of Nanjing Medical University
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