Clinical trials: Gastrointestinal Microbiota
Infection Due to Resistant Organism
FMT for MDRO Colonization After Infection in Renal Transplant Recipients
Transplant patients are at increased risk of colonization and infection with Multidrug Resistant Organisms (MDROs) due to medications that modify their immune systems, increased healthcare and antibiotic exposure, and surgical…
- Trial name
- PREMIX (NCT02922816)
- Testing
- Fecal Microbiota Transplant (FMT), Bowel preparation, Stool or perirectal swab sampling
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Emory University
Oral Mucositis, Microbiota
Microbiota and Symptom Distress in Head and Neck Cancer Patients Receiving Radiotherapy
The investigators plan to conduct a 3-year pioneering care research project for mucositis in cancer patients. These include: (1) an analysis of the incidence and severity of mucositis, severity, treatment methods, and treatment…
- Conditions
- Oral Mucositis, Microbiota, Symptoms and Signs
- Trial name
- NCT04843644
- Testing
- honey, propolis, Control
- Volunteers
- 250 people
- Sponsor
- Taipei Medical University
Transgender Persons
Effect of Testosterone Treatment on Drug Metabolism and Transport
This project will evaluate the effect of gender-affirming testosterone treatment on how other medications are processed by the body.
- Trial name
- NCT05116293
- Testing
- Midazolam oral solution, Digoxin Oral Tablet, Acetaminophen Oral Tablet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Washington
Gut Microbiome, Skin Microbiome
The Influence of Oral Probiotics on the Microbiome and Lipidome
The purpose of this study is to measure oil production of the face, facial properties, and gut bacteria in people being given oral probiotics.
- Conditions
- Gut Microbiome, Skin Microbiome, Gut Lipidome, Skin Lipidome
- Trial name
- NCT03605108
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Lymphoma, B-Cell, Multiple Myeloma
Microbiome Intervention for CAR-T Optimization and Response (MICRO-CART)
Chimeric Antigen Receptor T-Cell (CAR-T) therapy has transformed the management of large B-cell lymphoma, and multiple myeloma by achieving remarkable responses, yet inconsistent durability and severe toxicities remain major…
- Trial name
- (MICRO-CART) (NCT07871747)
- Testing
- Live Biotherapeutic Product (LBP)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Chicago
Colorectal Cancer
Microbiome, Exercise Tracking Study: Among Individuals at High Risk for Colorectal Cancer
The purpose of this study has 2 aims: Aim 1: To demonstrate the feasibility of recruiting and retaining adults at high risk of colorectal cancer to a physical activity intervention trial.
- Trial name
- METS (NCT02780284)
- Testing
- Physical activity intervention
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Columbia University
Liver Disease Chronic
Gut Microbiota Metagenomics for Chronic Liver Disease
Gut microbiota modulation has effect on chronic liver disease
- Trial name
- NCT04339725
- Testing
- DNA extraction
- Where
- South Korea
- Volunteers
- 3,240 people, healthy volunteers welcome
- Sponsor
- Chuncheon Sacred Heart Hospital
Effects of Bacillus Coagulans TCI711 Supplementation on Liver and Gut Microbiota Function in Non-alcoholic Fatty Liver Disease Patients
Effects of Bacillus Coagulans on Liver and Gut Microbiota Function in NAFLD
According to the 2018 statistics of the American Association of Liver Diseases, about 25% of the world's population has non-alcoholic fatty liver disease, and about 10 to 20% of patients with simple fatty liver will develop…
- Trial name
- NCT05635474
- Testing
- Bacillus Coagulans
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University
Endothelial Dysfunction, High Blood Pressure
Inulin and Nitrate's Effects on Vascular Health and Gut Microbiome
Previous research has revealed that adults with pre-hypertensive and hypertensive blood pressure levels typically exhibit impaired vasodilation, which is a crucial aspect of blood vessel function, due to decreased nitric oxide…
- Conditions
- Endothelial Dysfunction, High Blood Pressure, Gut Microbiota Dysbiosis and Nutrition
- Trial name
- NCT06502535
- Testing
- Inulin, Potassium nitrate and inulin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Exeter
Healthy Women, Diet Habit
Diets, Metabolic Profile and Gut Microbiota Among Indonesian Women in Minangkabau and Sundanese-ethnic Community
Many provinces in Indonesia have some well known traditional foods that are widely consumed, but it remains unknown whether traditional ethnic dietary patterns can confirm healthy diets.
- Conditions
- Healthy Women, Diet Habit, Bifidobacterium, Inflammation
- Trial name
- NCT03412617
- Volunteers
- 360 people
- Sponsor
- Rina Agustina
Healthy
Effects of a Diet Based on Inulin-rich Vegetables on Gut Health and Nutritional Behaviour in Healthy Humans
Inulin-type fructans (ITF) are fermentable dietary fibres that can confer beneficial health effects through changes in the gut microbiota. However, their effect on gut sensitivity and nutritional behaviour is a matter of debate.
- Trial name
- NCT03540550
- Testing
- Diet based on inulin-rich vegetables
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Menopause
Milk on Gut Microbiome and Bone Remodeling CTX in Postmenopausal Women
Milk consumption drives beneficial effect on Bone Mass Density and on Gut Microbiome. Altered Gut Microbiome is associated with postmenopausal status, reduced Bone Mass Density, abnormal serum levels of Bone Turnover Markers…
- Trial name
- Milk-CTX-GM (NCT06050018)
- Testing
- YesMilkdiet, NoMilkdiet
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Gut Microbiome
Gut Microbiome and Metabolic Pathways Changes in Vitiligo
Vitiligo is a chronic depigmenting autoimmune-associated skin disease and a growing psychological health concern because of its low quality of life.
- Trial name
- NCT03797417
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
HIV
Diet / Gut Microbiome Interaction and Influence on Inflammatory Disease in HIV Patients
The primary objective is to assess the effect of short-term diet modification on the microbiome composition, and inflammatory/metabolic disease markers in Antiretroviral therapy (ART)-treated HIV-infected participants and Human…
- Trial name
- NCT02610374
- Testing
- Agrarian Diet, Western-type Diet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Necrotising Enterocolitis, Late-Onset Neonatal Sepsis
Characterization of Intestinal Microbiota Stability in Preterm Born Neonates
Study around very-low birthweight preterm infants at high risk of developing necrotizing enterocolitis (NEC) or late-onset sepsis (LOS).
- Trial name
- NEC (NCT04792918)
- Where
- 2 sites in Switzerland
- Volunteers
- 81 people
- Sponsor
- Emma Marie Caroline Slack
Gastrointestinal Dysfunction
Phage 3Determination of Phage/Probiotic Synergistic Effects on Gastrointestinal Health
The goal of this double blinded clinical trial is to determine whether consumption of the PreforPro product, when co-consumed with Bacillus subtilis DE111 probiotic, synergistically improves bowel regularity, perceived physical…
- Trial name
- NCT05750433
- Testing
- PreforPro+B. subtilis DE111 probiotics, B. subtilis DE111
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Bowel Function Dissatisfaction
Impact of a Dried Vegetable on Bowel Function and Gut Microbiota
A randomized, placebo-controlled, parallel, double-blind trial with three intervention arms and a period of four intervention-weeks that assesses the intake of different dosages of a complex fiber product on bowel function via…
- Trial name
- HappYFiber (NCT05473793)
- Testing
- Dried chicory root particles
- Where
- Netherlands
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on Gut Microbiota Composition and Clinical Effectiveness in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- TEMPO (NCT03067714)
- Testing
- Infant formula with added synbiotics, Standard infant formula
- Where
- 59 sites in Belgium, Czechia and 11 more
- Volunteers
- 855 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Burn Injuries, Skin Disease
Dynamics of Dysbiosis in the Skin and Gut Microbiome of Burn Patients
This prospective observational cohort study aims to investigate the longitudinal changes in the skin and gut microbiome of burn patients after injury and compare them with healthy controls.
- Conditions
- Burn Injuries, Skin Disease, Microbiome, Microbiome Dysbiosis
- Trial name
- BURN-MICRO (NCT07209007)
- Testing
- No Intervention: Observational Cohort
- Where
- South Korea
- Volunteers
- 600 people
- Sponsor
- Cho Yoon soo
Pancreatic Cancer, Adult, Cephalic Duodenopancreatectomy
Effects of Peptamen 1.6 in Malnourished Patients (or at Risk) With Pancreatic Neoplasia Undergoing Cephalic Pancreaticoduodenectomy (CPD): A Mechanistic Study
Malnutrition is a common challenge in patients with pancreatic cancer undergoing cephalic pancreaticoduodenectomy (CPD), impacting postoperative recovery and overall prognosis.
- Trial name
- NCT06852014
- Testing
- Dietary Supplement: Experimental Treatment with nutritional suplement A + nutritional suplement B, Dietary Supplement: Dietary Supplement: Experimental Treatment with nutritional suplement B + nutritional suplement A
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.