Clinical trials: Gastrointestinal Microbiota
Myopia Progressing
Clinical Efficacy and Mechanism Exploration of MR-61 in Delaying the Progression of Myopia
To investigate whether probiotic MR-61 can assist in slowing down the progression rate of myopia (a prospective randomized controlled study).
- Trial name
- NCT07298824
- Testing
- Investigational Bifidobacterium Preparation MR-61
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Second Affiliated Hospital of Nanchang University
Obesity, Morbid
BASUN - Risks for Malnutrition, Metabolic Bone Disease and Impaired Oral Health After Obesity Treatment
Weight-reducing obesity surgery (OS) generally gives good results but complications are common; e.g. impaired weight loss, weight regain, bowel pain, diarrhea, vitamin/mineral deficiency, osteoporosis and impaired dental health.
- Trial name
- BASUN (NCT03152617)
- Where
- Sweden
- Volunteers
- 1,400 people
- Sponsor
- Göteborg University
Crohn Disease
A Study to Evaluate the Effect of Fecal Transplant and Dietary Changes on Disease Activity in Patients With Newly Diagnosed Active Crohn Disease
Dysbiosis can be rectified by several methods: antibiotics, prebiotics, probiotics, dietary modulation, and fecal microbiota transplantation.
- Trial name
- ALTER-CD (NCT06890650)
- Testing
- Fecal Microbial Transplantation, Crohns disease exclusion diet
- Where
- 6 sites in India
- Volunteers
- 168 people
- Sponsor
- All India Institute of Medical Sciences
Irritable Bowel Syndrome
Donor Selection for Faecal Microbiota Transplantation in Irritable Bowel Syndrome
Five hundred patients are randomized 1:1:1:1 into placebo (own feces), or receiving 90 g fecal transplant from donor A, donor B or donor C.
- Trial name
- NCT06171126
- Testing
- Faeces from donor A, Faeces from donor B, Faeces from donor C
- Where
- 3 sites in Norway
- Volunteers
- 500 people
- Sponsor
- Haukeland University Hospital
Melanoma, Skin, Melanoma Stage Iii
MelPRO-0322 (CRISTINA Trial) [miCrobiome pRedIctS aPD1 effecTivnes In melaNoma pAtietns]
The goal of this observational study is to learn about if new biomarkers such as gut microbiota and molecular genetics melanoma features could predict clinical radiological and pathological response to neoadjuvant monotherapy…
- Trial name
- CRISTINA (NCT06299878)
- Testing
- Gut microbiota analysis
- Where
- Russia
- Volunteers
- 72 people
- Sponsor
- Russian Academy of Medical Sciences
MASLD
Effect of Ancestry Supplementation in Subjects With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
The goal of this clinical trial is to evaluate the effect of Ancestry, a supplement made from Mexican-origin foods (nopal, cacao, and cricket) in adults with Metabolic dysfunction-associated steatotic liver disease (MASLD).
- Trial name
- Ancestry (NCT07592013)
- Testing
- Ancestry
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- University of Guadalajara
Stunting
Gut Microbiota Stunted Children NTT
NTT Province is on the list of priority areas of high prevalence of stunting, Southwest Sumba, South Middle East, and Kupang district have a stunting prevalence of 36.2%, 34.5% and 48.1% respectively in 2020.
- Trial name
- NCT05119218
- Testing
- No Intervention
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Bina Nusantara University
Cardiometabolic Health, Healthy Aging
Impacts of Fruit on the Gut Health and Human Health
The objectives of this study are to investigate the effect of fruit consumption on the gut microbiota and their collective fecal and plasma metabolomes, vascular and cardiometabolic functions, cognition, and motor control.
- Conditions
- Cardiometabolic Health, Healthy Aging, Cognition
- Trial name
- NCT05063929
- Testing
- Fruit (2 cup eq), Fruit restriction (1/2 cup eq)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- San Diego State University
Bariatric Surgery Candidate
Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery
This is a single-center study that aims to better understand how diet and sex affect the risk of kidney stones in people who have had gastric bypass surgery.
- Trial name
- NCT04590690
- Testing
- Special diet
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Chicago
Intestinal Microbiota and Barrier Function
Use of a Novel Synbiotic to Change Human Gut Bacteria and Improve Health in Obese Adults
This study evaluates the effect of a dietary supplement to improve gut health. The participants will take one of six dietary treatments for three weeks, and the gut bacteria and the gut intestinal barrier will be assessed to…
- Trial name
- NCT02355210
- Testing
- Bifidobacteria adolescentis BD1, Bifidobacteria animalis subsp. lactis BB-12, Bifidobacteria adolescentis BD1 and galactooligosaccharide
- Where
- United States
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Preterm Birth, Neurodevelopmental Disorders
Guangzhou Preterm and Term Birth Cohort Study
The Guangzhou Preterm-Term Birth Cohort (GPTBC) is a prospective observational study of how early-life nutrition, environmental exposures, and family factors relate to the health and development of preterm and term infants and…
- Conditions
- Preterm Birth, Neurodevelopmental Disorders, Overweight, Obesity
- Trial name
- GPTBC (NCT07756177)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Digestive Health, Quality of Life
Protein-Prebiotic Wellbeing Study
Healthy participants with self-reported GI complaints will consume the protein supplement that they normally use for recovery purposes after exercise during a 3-week baseline period, followed by a 3-week intervention period in…
- Trial name
- NCT05303753
- Testing
- fermented dairy protein with prebiotic fiber
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Hepatic Encephalopathy, Dysbiosis
Fecal Microbiota Transplantation by Oral Capsules for Hepatic Encephalopathy Treatment
This interventional study aims to evaluate the safety and efficacy of oral capsule fecal microbiota transplantation (FMT) for treating hepatic encephalopathy refractory to conventional rifaximin and lactulose therapy in patients…
- Trial name
- NCT06368895
- Testing
- Fecal microbiota transplantation delivery through colonoscopy, Fecal microbiota transplantation delivery through oral capsules
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Taking Sialic Acid to Regulate the Gut Microbiota, Healthy
A Study on the Modulation of Gut Microbiota by Oral Sialic Acid in Healthy Subjects
This is a single-center prospective cohort study conducted by the Department of General Surgery at the Second Affiliated Hospital of Army Medical University (Xinqiao Hospital).
- Trial name
- MFMOSA (NCT07162662)
- Testing
- Oral Sialic acid
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Xiaolong Li
Metabolic Syndrome X
Effect of Meat and Egg on TMAO in Plasma and Urine in Subjects with and Metabolic Subjects
The purpose of this clinical trial is to investigate in subjects with and without metabolic syndrome how meals of choline- and carnitine-rich foods (eggs and meat) affect the trimethylamine-N-oxide (TMAO) concentration in blood…
- Trial name
- NCT06660251
- Testing
- Egg intervention, Meatball intervention
- Where
- Sweden
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Linnaeus University
Pain, Postoperative, Gastrointestinal Microbiome
Characterization of Rebound Pain Following Peripheral Nerve Block and Its Association With Gut Microbiome Diversity
The objective of this study is to determine the association between gut microbiome diversity and the characteristics of rebound pain at offset of peripheral nerve block in patients who have undergone upper limb surgery.
- Trial name
- NCT02998177
- Where
- 2 sites in Ireland
- Volunteers
- 20 people
- Sponsor
- Cork University Hospital
Nonalcoholic Fatty Liver Disease, NAFLD
Rifaximin in Fatty Liver Disease
TITLE Rifaximin in Fatty Liver Disease (RiFL) DESIGN Open-label pilot study HYPOTHESIS Reduction in gut flora by the antibiotic Rifaximin reduces hepatic inflammation in Non-Alcoholic Steatohepatitis (NASH).
- Conditions
- Nonalcoholic Fatty Liver Disease, NAFLD, Nonalcoholic Steatohepatitis
- Trial name
- RiFL (NCT01355575)
- Testing
- Rifaximin
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Imperial College London
Irritable Bowel Syndrome
Frequency of Sleep Abnormalities in Patients With Irritable Bowel Syndrome and Effect of Pharmacological Intervention
Irritable bowel syndrome (IBS), a common gastrointestinal (GI) disorder in India and in the rest of the World, is enigmatic in its pathogenesis.
- Trial name
- NCT04193501
- Testing
- Melatonin 3 mg
- Where
- 2 sites in India
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Type 2 Diabetes Mellitus (T2DM)
Study of AI-based Prediction Models for Exercise-Induced Gut Microbiota Alterations in Patients With Type 2 Diabetes
This study is a randomized controlled clinical trial. The participants will be randomized into two groups in a 1:1 ratio: exercise intervention and sedentary control group.
- Trial name
- NCT06931210
- Testing
- Sedentary behavior, Exercise intervention
- Where
- China
- Volunteers
- 79 people
- Sponsor
- Shanghai 6th People's Hospital
Healthy
Xanthohumol Metabolism and Signature
A pilot study to assess the safety and tolerability of oral xanthohumol in humans, to identify a biological signature of xanthohumol exposure, and to characterize the role of xanthohumol metabolism by intestinal microorganisms in…
- Trial name
- XMaS (NCT03735420)
- Testing
- Xanthohumol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
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