Clinical trials: Gastrointestinal Microbiota
T2D
Peanut Consumption and Cardiovascular Disease Risk in a Chinese Population
This is a 2 parallel-arm randomized controlled study with free-living subjects on self-selected diets. The objective of this study is to compare the effects of two servings of peanuts with an isocaloric matched refined…
- Trial name
- NCT03194152
- Testing
- Peanut, Control
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Harvard School of Public Health (HSPH)
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Role of Gut Microbiome in Cancer Therapy
This study examines how gut microbiome can affect cancer therapy in cancer patients undergoing cancer therapy or stem cell transplant. The human microbiome affects the way some cancer drugs are metabolized in the human body.
- Trial name
- NCT05112614
- Testing
- Biospecimen Collection, Electronic Health Record Review
- Where
- 3 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome
Probiotics and Irritable Bowel Syndrome
This clinical trial was conducted on 90 IBS patients, who fulfill ROME IV criteria and the IBS diagnostic questionnaire (Arabic version licensed by Rome Foundation) in Egyptair hospital outpatient clinic, Cairo, Egypt between May…
- Trial name
- NCT04572932
- Testing
- lactobacillus delbruekii
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Ulcerative Colitis
Fecal Microbiota Transplantation (FMT) in the Management of Ulcerative Colitis (UC)
Inflammatory bowel disease is a condition caused by gastrointestinal immune system dysregulation and affected by both genetic and environmental factors.
- Trial name
- NCT02516384
- Testing
- Fecal Microbiota Transplantation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Non-alcoholic Fatty Liver Disease (NAFLD), NASH - Nonalcoholic Steatohepatitis
Integrated Phenotyping of the Gut-plAtelet-Liver AXIS in the Progression of Chronic Liver Disease (iGAL-AXIS)
Objective of the study Our working hypothesis is that platelets activated by gut-derived metabolites dock in the liver of NAFLD patients and amplify the inflammatory state by releasing pro-inflammatory cytokines/chemokines, which…
- Conditions
- Non-alcoholic Fatty Liver Disease (NAFLD), NASH - Nonalcoholic Steatohepatitis, Cirrhosis, Control Condition
- Trial name
- NCT06623084
- Testing
- Platelets characterization
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Stefania Basili
Pregnancy
The Effect of Under-nutrition on the Human Microbiota
The purpose of this study is to determine whether a difference exists in the gut, oral, vaginal and human milk microbiome of under-nourished pregnant women as compared to healthy and obese pregnant women.
- Trial name
- NCT02021799
- Testing
- Moringa and Lactobacillus rhamnosus GR-1
- Where
- Tanzania
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Blood Glucose, High
A Personal Microbiome-dependent Glucose Response in Healthy Young Volunteers
Individuals eating identical meals present high variability in post-meal blood glucose response making comparisons challenging. This study evaluates in 40 healthy and fasted participants whether the postprandial glucose response…
- Trial name
- MIGLUCOSE (NCT03686293)
- Testing
- Standardized breakfast
- Where
- Denmark
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Prader-Willi Syndrome
Targeting the Gut Microbiome for Prader-Willi Syndrome Treatment
The gut microbiome has recently emerged as a major contributor to obesity, systemic inflammation, and metabolic disease. Furthermore, intestinal bacteria are crucial players in the gut-brain axis, regulating a broad range of…
- Trial name
- BALPWS (NCT03548480)
- Testing
- Probiotic
- Where
- Spain
- Volunteers
- 39 people
- Sponsor
- Fundació Sant Joan de Déu
Gut Microbiota, Constipation
Fecal Microbiota Transplantation for Constipation
Difficult defecation is a common symptom involving with patients'life quality. The stool pattern of these patients might be related to the contribution of gut microbiota.
- Trial name
- NCT03308461
- Testing
- Fecal Microbiota suspension
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Intermittent Fasting, Non-Alcoholic Fatty Liver Disease
Intermittent Fasting in Nonalcoholic Fatty Liver Disease
Although preliminary evidence suggests that intermittent fasting mimic-diet (IFD) exerts stronger effects on body weight and metabolic parameters, which may link obesity, non-alcoholic fatty liver disease (NAFLD) and major…
- Conditions
- Intermittent Fasting, Non-Alcoholic Fatty Liver Disease, Insulin Resistance, Obesity
- Trial name
- NCT04355910
- Testing
- Calorie restriction
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shaoguan University
Spinal Cord Injuries, Gut Microbiome
Impact of Gut Microbiome on Metabolic and Bowel Function During the First Year After Spinal Cord Injury
The Investigators will recruit 35 participants with acute SCI (within 6 weeks of injury) Fasting blood collection and bowel function survey will be conducted 3 times: at baseline [within 6 weeks of injury], 6, and 12 months after…
- Trial name
- NCT05670288
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Alabama at Birmingham
Symbiotic, Uremic Toxins
Alterations of Gut Derived Uremic Toxins and Microbiome Metabolites by Multispecies Synbiotic
Patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis frequently exhibit significant gut microbiota dysbiosis and increased intestinal permeability.
- Conditions
- Symbiotic, Uremic Toxins, Gut -Microbiota
- Trial name
- NCT07443280
- Testing
- Multispecies Synbiotic Supplementation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Healthy
ProAliFun_6.5_Health Effects of a Functional Pasta Enriched With Barley Beta-glucans on Healthy Subjects
The purpose of this study is to evaluate the healthy properties of a dietary intervention based on an innovative pasta enriched with prebiotic fibers (barley beta-glucans).
- Trial name
- ProAliFun65 (NCT02710513)
- Testing
- Beta-glucans
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome
Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota.
The Role of Gut Microbiota in the Mechanism of Helicobacter pylori Eradication-Induced Amelioration of Metabolic Syndrome-Related Parameters Study Sponsor: Nanjing First Hospital Principal Investigator: Dr.
- Trial name
- NCT07306988
- Testing
- Vonoprazan-Amoxicillin Dual Therapy, Vonoprazan-Amoxicillin with Bifidobacterium tetravaccae, Vonoprazan-Amoxicillin with Berberine
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Colorectal Cancer
Psychological Evaluation According Colonic Colonization by Escherichia Coli of Patients After Colorectal Surgery
The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.
- Trial name
- MicrobioPSY (NCT02970513)
- Testing
- Psychiatric evaluation
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Clermont-Ferrand
Gut Microbiota, Metachronous Adenoma
Gut Microbiota Prediction of Metachronous Colorectal Neoplasms
Patients with colorectal cancer are known to be at high risk of developing metachronous adenoma, however, participation in colonoscopy are low.
- Trial name
- NCT03383159
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Dietary Quality, Feasibility Studies
Feasibility and Potential Efficacy of Herbs and Spices for Improving Dietary Quality in College Students: A Pilot Study
The goal of this single-arm feasibility, pilot study is to assess the feasibility, acceptability, and potential effectiveness of the Herbs and Spices Nutrition Education Program (HSNP-focusing on incorporating herbs and spices…
- Conditions
- Dietary Quality, Feasibility Studies, College Student, Dietary Guidelines for Americans
- Trial name
- HerbSpicesDiet (NCT07082348)
- Testing
- Herbs and Spices Nutrition Education Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Nevada, Las Vegas
IBS - Irritable Bowel Syndrome
Microbiota, Metabolome and Nutrition: an 'Artificially Intelligent' Way to Personalized Nutrition
Intervention: (Weeks 1-2, Visit 3-4) - Starting from the second week after the date of consent, patients with IBS will be randomized 1:1 into two groups.
- Trial name
- PN-AI-21 (NCT06420843)
- Testing
- FOODMAP
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Istituto Clinico Humanitas
Lung Cancer (NSCLC)
Association Between Microbiome and the Efficacy and Safety of PD-1/PD-L1 Blockade in Resectable NSCLC
This study will investigate the relationship between respiratory and gut microbiome and PD-1/PD-L1 immune checkpoint inhibitor efficacy and immune-related adverse events (irAE) in patients with non-small cell lung cancer (Stage…
- Trial name
- NCT06613308
- Testing
- Neoadjuvant immunotherapy combined with chemotherapy, Neoadjuvant chemotherapy
- Volunteers
- 20 people
- Sponsor
- Capital Medical University
Inflammatory Bowel Disease, Crohn's Disease
The Role of Gut Microbiome in Predicting Comorbidities and Complications in Children With Inflammatory Bowel Disease
Background: Bacteria and other microorganisms that live in the intestines (the gut microbiome) play an important role in a person s health. The gut microbiome helps to regulate the immune system and control inflammation.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT05652491
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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