Clinical trials: Gastrointestinal Microbiota
Personalized Nutrition, Health Status
Personalized Nutrition Advice for Optimizing Dietary Habits and Metabolic Status
The alteration maintained over time of some metabolic processes, such as oxidative stress, low-grade inflammation, carbohydrate and lipid metabolism, and of the intestinal microbiota activity, can induce some chronic diseases…
- Conditions
- Personalized Nutrition, Health Status, Dietary Habits
- Trial name
- PREVENTOMICS (NCT04641559)
- Testing
- Personalized nutrition group, Personalized Plan group, Control group
- Where
- Spain
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Pancreatic Cancer, Gut Microbiota
The Mechanism of Enhancing the Anti-tumor Effects of CAR-T on PC by Gut Microbiota Regulation
Pancreatic cancer (PC) is one of the deadliest diseases of human digestive malignancies. Despite the recent advances in surgery and chemotherapy, the 5-year survival rate of PC continues to be less than 10%.
- Conditions
- Pancreatic Cancer, Gut Microbiota, CAR-T
- Trial name
- NCT04203459
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Ulcerative Colitis
Restoration of the Microbiome Through Superdonor Selection
The AIM of this study is to investigate whether the FMT success rate in active UC patients can be increased by intensive donor pre-screening, anaerobic preparation of the FMT and by repeated FMT.
- Trial name
- RESTORE-UC (NCT03110289)
- Testing
- superdonor FMT, autologous FMT
- Where
- Belgium
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Ulcerative Colitis
Golimumab Effect in the Modulation of Gut Microbiota in Ulcerative Colitis
This study aims to characterize the changes on intestinal microbiota pattern associated with the use of golimumab in order to determine if intestinal microbiota markers may correlate with golimumab therapeutic effect in patients…
- Trial name
- GOLI2015 (NCT03018925)
- Testing
- Golimumab
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Inflammatory Bowel Diseases
REgulating Pain Through Neurofeedback in infLammatory Bowel diseasE and Musculoskeletal Dysfunction
Clinical trial with a CE-marked medical device. Use as indicated in patients with chronic inflammatory bowel disease and musculoskeletal pain.
- Trial name
- RELIEF (NCT07473076)
- Testing
- Experimental group
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Urinary Tract Infections, Malnutrition
Effect of Hygiene and Menstrual Hygiene Interventions on Learning and Psychosocial Wellbeing in Madagascar
A previous study in schools in rural Madagascar found that a bundle of hygiene-focused interventions substantially improved girls' learning outcomes.
- Conditions
- Urinary Tract Infections, Malnutrition, Inflammation, Stress
- Trial name
- KILONGA2 (NCT07702916)
- Testing
- Peer leadership/sensitization + sanitary pads, School infrastructure
- Where
- Madagascar
- Volunteers
- 3,080 people, healthy volunteers welcome
- Sponsor
- University of California Santa Cruz
Metastatic Breast Cancer
Determinants of Acquired Endocrine Resistance in Metastatic Breast Cancer: A Pilot Study
This is a single-center prospective study involving analysis of circulating tumor DNA (ctDNA) and the gut microbiome in patients with metastatic breast cancer on standard of care endocrine therapy with an aromatase inhibitor in…
- Trial name
- ENDO-RESIST (NCT04579484)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Sunnybrook Health Sciences Centre
Diverticulitis, Uncomplicated Diverticular Disease
FMT in Uncomplicated Diverticulitis
Fecal Microbiota Transplantation (FMT) is an established treatment for Clostridium difficile (C. diff) infection refractory to medical management. As C.
- Trial name
- NCT05373784
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Justin Maykel
Drug Resistant Epilepsy
Role of the Gut Microbiota in Pediatric Epilepsy
Nearly a third of children with epilepsy are refractory to pharmacotherapy. The ketogenic diet (KD) is a highly effective alternative therapy reducing seizure frequency by 50% in more than half of treated children.
- Trial name
- EPBiome (NCT04705298)
- Testing
- Prebiotic
- Where
- 2 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- British Columbia Children's Hospital
Metabolic Syndrome, Sleeping Disorders
Effects of Nattokinase on Cardiovascular Risk, Gut Microbiota, Sleep, and Cognition in Metabolic Syndrome With Sleep Disorders.
Nattokinase has been confirmed by many experiments to have a thrombolytic effect, but there are currently very few studies on nattokinase's effect on gut microbiota, sleeping status, and age-related cognitive function.
- Trial name
- NCT07229521
- Testing
- Nattokinase
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taipei Medical University
GLP-1, Weight Loss Trajectory
Evaluation of a Nutritional Intervention With Dietary Supplements in People Who Have Recently Lost Weight: Effects on Body Composition, Emotional Health, and Gut Microbiota
This study aims to evaluate the effects of a 12-week nutritional intervention with dietary supplements on individuals who have experienced significant weight loss following the use of GLP-1 receptor agonists or similar…
- Conditions
- GLP-1, Weight Loss Trajectory, Emotional Disorder, Microbiota Balance
- Trial name
- NCT07269821
- Testing
- Metabolaid®-based nutraceutical formulation
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- University of Alicante
Chronic Kidney Diseases, Healthy
Identification of P-cresyl Sulfate Producer Phenotype by Oral Tyrosine Challenge Test: Interactions Among Diet, Gut Microbiota, and Host Genome
Patients with chronic kidney disease (CKD) display a substantial increase in cardiovascular disease (CVD). Moreover, the prognosis of CVD in CKD is extremely poor.
- Trial name
- NCT04204174
- Testing
- Tyrosine, brand name: myprotein
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Irritable Bowel Syndrome (IBS)
IBS-Oriented CDED Versus Low FODMAP Diet for Irritable Bowel Syndrome
Background: Irritable Bowel Syndrome (IBS) affects approximately 4.1% of the global population and imposes a significant personal and healthcare burden.
- Trial name
- IBS-CDED (NCT07707635)
- Testing
- Modified Crohn's Disease Exclusion Diet (CDED), Low FODMAP Diet
- Volunteers
- 150 people
- Sponsor
- Ariel University
Endometriosis, Bacterial Vaginosis
Effects of a Multi-strain Oral Probiotic on the Vaginal Microbiota Composition in Healthy Women and Women with Endometriosis
Endometriosis is a chronic inflammatory disease affecting approximately 10-15% of reproductive age women, and, in recent years, an association between this pathology and dysbiosis, either involving the gut or the genital…
- Conditions
- Endometriosis, Bacterial Vaginosis, Healthy Volunteer
- Trial name
- NCT06592976
- Testing
- Multi-strain Oral Probiotic (CDS22-formula)
- Where
- Italy
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Helicobacter Pylori Infection, Intestinal Bacteria Flora Disturbance
Fucoidan Assisted Eradication of Helicobacter Pylori
The purpose of this study is to investigate whether the eradication rate of H.pylori will be improved when adding fucoidan to the duplex scheme combination of amoxicillin and vonoprazan, and to explore the effect of fucoidan on…
- Trial name
- NCT05461508
- Testing
- Amoxicillin combined with vonoprazan and fucoidan, Amoxicillin combined with vonoprazan
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Urinary Tract Infection(UTI)
Antibiotic Therapies for Urinary Tract Infections and Their Impact on the Gut Microbiota
A urinary tract infection requires antibiotic treatment. While this treatment is intended to eliminate bacteria from the urine, it may also facilitate the development of resistant strains in the digestive tract.
- Trial name
- ABIME (NCT07424989)
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Rouen
Obesity
Effect of Diet Versus Sleeve Gastrectomy and Gastric Bypass on Appetite
The biggest challenge in obesity management is maintaining weight loss in the long-term. Currently, bariatric surgery is the most effective treatment, leading to sustained weight loss that is not yet achievable with lifestyle…
- Trial name
- DISGAP (NCT04051190)
- Testing
- VLED group, Sleeve Gastrectomy group, Gastric Bypass group
- Where
- 2 sites in Norway
- Volunteers
- 54 people
- Sponsor
- Norwegian University of Science and Technology
Microscopic Colitis
Faecal Microbiota Transplantation for Microscopic Colitis
A pilot study investigating if orally administrated faecal microbiota transplantation capsules have the potential to treat active microscopic colitis.
- Trial name
- NCT05998174
- Testing
- Faecal Microbiota Transplantation
- Volunteers
- 20 people
- Sponsor
- Hvidovre University Hospital
Healthy Volunteers
Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis
Background: Human intestines are home to a complex gut flora, also called microbiome; this is a natural occurring community of bacteria, fungi, yeast, and viruses.
- Trial name
- NCT06615986
- Testing
- Cardiosyn
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Menopause
The Influence of the "Washoku" Diet on the Gut Microbiota in Postmenopausal Women
Menopause is a special period in a woman's life, when a sudden drop in estrogen levels leads to the cessation of menstrual cycles.
- Trial name
- NCT06673199
- Testing
- Washoku diet
- Where
- Poland
- Volunteers
- 35 people
- Sponsor
- Joanna Bajerska
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