Clinical trials: Gastrointestinal Microbiota
Crohn Disease
FMT for Postop Crohn's Disease
People with Crohn's disease often need surgery. The gut bacteria of people with Crohn's is associated with Crohn's disease coming back after surgery.
- Trial name
- NCT05248191
- Testing
- Capsule fecal microbiota material (cap-FMT), Colonoscopic fecal microbiota material (colo-FMT)
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Minnesota
Cystic Fibrosis
Microbial Community Composition and Metabolism in Cystic Fibrosis
Scientist have begun to realize that many types of bacteria often live together as a complex community, and the investigators wish to apply that idea to the bacteria in the respiratory system of people with Cystic Fibrosis (CF).
- Trial name
- NCT00954018
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Negative Symptom, Schizophrenia
Study on the Gut Microbial Mechanism of Negative Symptoms of Schizophrenia
Negative symptoms are one of the five-dimensional symptoms of patients with schizophrenia, and medications are not effective in treating negative symptoms.
- Conditions
- Negative Symptom, Schizophrenia, Amisulpride, Gut Microbiomes
- Trial name
- NCT04533724
- Testing
- Amisulpride
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Shanghai Mental Health Center
Rectal Cancer
Oral & Faecal Microbiota Analysis in Patients With Rectal Cancer Requiring Pre-operative Therapy Before Surgery, & Correlation With Response
Rectal cancer is a common pathology which is treated by a multimodal approach. Those tumours in the rectum that are locally advanced are treated with neoadjuvant chemoradiotherapy before an operation.
- Trial name
- MICROBRECT (NCT04601727)
- Testing
- 16srRNA pyrosequencing analysis of microbiota of saliva and faeces
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- University of Aberdeen
Crohn Disease
Standardized Microbiota Transplant Therapy in Crohn's Disease
Crohn's disease (CD) develops because of a disruption of homeostasis between the gut microbiota and the host immune system resulting in excessive inflammation in the intestinal tract.
- Trial name
- NCT06631586
- Testing
- MTP-101C, MTP-101S
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Minnesota
Perinatal Depression, PerinatalAnxiety
Perinatal Depression & Anxiety (PDA) and Maternal Gut Microbiome
Perinatal depression and anxiety (PDA) are the leading causes of maternal mortality in developed countries. Women with a history of depression have a 20 fold higher risk of PDA at subsequent pregnancies.
- Trial name
- NCT06074250
- Testing
- Fish oil, Probiotics, Prebiotics
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- The Canadian College of Naturopathic Medicine
Healthy Men and Women
Effects of an Organic Plant-rich Diet on Gut Microbiome and Vascular Function (ORGAMIC Pilot Study)
Previous work have shown that consumption of foods rich in polyphenols, such as berries and cocoa, led to beneficial changes in the gut microbiota composition, as well as improvements in biomarkers of cardiovascular disease risk…
- Trial name
- NCT04276974
- Testing
- Organic diet, Non-organic diet
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- King's College London
Colorectal Cancer, Serrated Polyposis Syndrome
Oral and Gut Microbiota in Individuals With Serrated Polyposis Syndrome.
Background: Serrated polyposis syndrome is the most common colorectal polyposis syndrome. Its pathogenesis is still unknown and its diagnosis is based on clinical criteria.
- Conditions
- Colorectal Cancer, Serrated Polyposis Syndrome, Intestinal Microbiota
- Trial name
- NCT07290023
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Health Adults
The Effect of Increasing Dietary Protein on the Gut Microbiome and Its Metabolites
This study will determine the effect of dietary protein not absorbed in the small intestine on the bacteria in the large intestine and the metabolites those bacteria produce when they break down the protein.
- Trial name
- PSGM (NCT06677333)
- Testing
- Whey Protein, Pea protein
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Microbial Colonization
Gut Microbiome Analysis in Organ Transplant Recipient
The microbiome acts as an antigen and can induce signaling through receptors like TLRs and NODs. Microbial metabolites can directly act on gut cells or reach other organs systemically.
- Trial name
- NCT06405958
- Testing
- gut microbiome
- Volunteers
- 200 people
- Sponsor
- Asan Medical Center
Head and Neck Cancer (H&N)
Fecal Microbiota And Metabolites In Head And Neck Cancer Patients Receiving (Chemo)Radiotherapy
This clinical study investigates whether the composition of the fecal microbiome and selected bacterial metabolites are associated with the efficacy and acute toxicity of radiotherapy in patients with locally advanced head and…
- Trial name
- NCT07407218
- Testing
- Radical (Chemo)Radiotherapy
- Where
- Slovenia
- Volunteers
- 58 people
- Sponsor
- Institute of Oncology Ljubljana
Obesity, Metabolic Syndrome
Socioecological Factors Associated With Ethnic Disparities in Bariatric Surgery Utilization and Post-WLS
The goal of this cross-sectional observational study is to examine potential relationships between the blood and gut microbiota of patients with obesity before and after weight loss surgery (WLS) and evaluate potential ethnic…
- Trial name
- NCT06342050
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Texas Southwestern Medical Center
CKD, PAD - Peripheral Arterial Disease
Oral Absorbent and Probiotics in CKD Patients With PAD on Gut Microbiota, IncRNA, Metabolome, and Vascular Function
Taiwan has more chronic kidney disease (CKD) per capita than anywhere in the world, leading to the highest expense of National Health Insurance.
- Trial name
- NCT04792320
- Testing
- Active bamboo charcoal, probiotics
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- National Taiwan University Hospital
Irritable Bowel Syndrome
Edible Insects: Good for the Gut and the Globe
Edible insects have been eaten by people throughout human history and are consumed today across the globe. Insects are also currently being incorporated into a number of food products in the United States, Canada, and Europe due…
- Trial name
- GGG (NCT06397924)
- Testing
- Chitin Fiber
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Colorado State University
Multiple Sclerosis, Relapsing-Remitting
Tecfidera and the Gut Microbiota
The primary objective of the study is to determine if dimethyl fumarate (DMF) causes changes in the abundance and diversity of commensal microbiota.
- Trial name
- TECONGUT (NCT02471560)
- Testing
- dimethyl fumarate, injectable MS DMT
- Where
- 7 sites in Norway
- Volunteers
- 36 people
- Sponsor
- Biogen
Gastrointestinal Tolerance
A Double Blind Study on the Gastrointestinal Effects of Arabinoxylan (Leaf Fiber Extract).
The objective of this study is to investigate the effect on Arabinoxylan on gastrointestinal (GI) tolerance, bowel habits, and microbiota in adults.
- Trial name
- NCT04100460
- Testing
- 7.25 grams of Arabinoxylan leaf fiber extract, 14.5 grams of Arabinoxylan leaf fiber extract, Control - No Arabinoxylan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Comet Bio Inc.
Healthy
Lacticaseibacillus Rhamnosus GG Pili Study
The aim of this study was to investigate the host-microbe interaction effects of various Lacticaseibacillus rhamnosus GG strains, with different binding capacities to the mucus in the small intestine, in healthy individuals
- Trial name
- NCT05461443
- Testing
- Probiotic
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Parkinson Disease (PD), Gut Microbiota
Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
Preclinical human trials will be utilized to validate the research direction, followed by clinical trials to assess the impact of a cocktail formula product containing the optimal probiotic Y7 combined metabolites on motor…
- Conditions
- Parkinson Disease (PD), Gut Microbiota, Probiotic
- Trial name
- NCT07619560
- Testing
- Y7
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University
Overweight, Insulin Resistance
Wheat Germ Supplementation Will Improve Markers of Gut Health, Inflammation, and Insulin Resistance in Overweight Adults
The objective of this pilot study is to determine the effects of wheat germ (WG) supplementation on gut health and subsequent effects on markers of inflammation and insulin resistance in overweight individuals.
- Conditions
- Overweight, Insulin Resistance, Inflammation
- Trial name
- NCT03989882
- Testing
- Wheat germ energy ball, Control
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Allergic Rhinitis
Probiotics Improve Adult Allergic Rhinitis and Regulate Gut Microbiota
Assessing the clinical efficacy of weizmannia coagulans BC99 in alleviating allergic rhinitis symptoms, improving gut microbiota, and reducing adverse reactions in patients.
- Trial name
- NCT06885346
- Testing
- Probiotic
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
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