Clinical trials: Gastrointestinal Microbiota
IBS - Irritable Bowel Syndrome, Gut Microbiota
Effects of Continuous Treatment With Rifaximin and Probiotics on the Gut Microbiota of Patients With IBS-D
We will use the latest Rome IV criteria to recruit IBS-D patients and evaluate the effects of repeated treatment with rifaximin and sequential treatment with rifaximin and probiotics on different symptoms and quality of life.
- Trial name
- NCT04074421
- Testing
- Rifaximin, Probiotic Formula
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Multidrug Resistant Bacterial Infection
Antibiotics Resistance Gene in Healthcare Workers
Multidrug resistant bacteria (MDR) pose a threat to the safety of patients worldwide. Drug resistant bacteria are commonly present in hospital environments and can cause infections, often leading to outbreaks within hospitals.
- Trial name
- ARGH (NCT06228248)
- Testing
- metagenomics
- Where
- 8 sites in China
- Volunteers
- 250 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Antibiotic-associated Diarrhea
Antibiotic-Associated Diarrhea and the Role of Microorganisms in the Gut
Amoxicillin-clavulanate is an antibiotic commonly prescribed to treat a myriad of community-acquired infections. One of the most common adverse effects of amoxicillin-clavulanate is antibiotic-associated diarrhea (AAD).
- Trial name
- NCT04156555
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet
- Where
- Singapore
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Discrimination, Racial, Social Isolation
Discrimination and the Brain-Gut-Microbiome (BGM) Axis
Obesity is a major public health problem related to a variety of illnesses such as heart disease and diabetes. Prior research indicates that social stressors contribute to risk for obesity, possibly through alterations in diet…
- Conditions
- Discrimination, Racial, Social Isolation, Stress
- Trial name
- NCT05120908
- Where
- United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Gut Microbiome
Rescuing the Microbiome Effectively With Different Doses of B. Infantis in Infants
The REMEDI Study is a single-center, prospective, double-blind, randomized, placebo-controlled trial of multiple doses of B. infantis EVC001 supplementation in healthy term breastfed infants.
- Trial name
- REMEDI (NCT03476447)
- Testing
- B. infantis EVC001, Lactose
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Evolve BioSystems, Inc.
HIV, Lipodystrophy
Factors Mediating Gut Microbiota Dysbiosis and Metabolic Disease in HIV Patients.
This study plans to learn more about immune responses in intestinal (gut) tissue in people with human immunodeficiency virus (HIV) infection.
- Trial name
- NCT02258685
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy
Influence of Food Matrix on Prebiotic Efficacy in Inulin Type Fructans
The aim of the study is to investigate whether the food matrix has an influence on the prebiotic efficacy (bifidobacteria growth) of chicory-derived Orafti® inulin in healthy adult volunteers.
- Trial name
- NCT05581615
- Testing
- Inulin
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Inflammation
Effects of Adding Chickpeas to the American Diet on Fecal Microbiota Composition and Markers of Inflammation
This prospective study will assess the effects of adding legumes, especially chick peas, to the diet of healthy adults on the commensal bacteria from feces of human subjects and resulting self-reported GI symptoms as well as…
- Trial name
- NCT02375347
- Testing
- Chickpea Enhanced Diet (Short term)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cardiovascular Risk Factor
Effects of Freeze Dried Strawberry Powder Supplementation on Cardiovascular Risk Factors and Gut Microbiome
Dietary interventions designed to promote health by increasing the consumption of particular health-promoting foods (e.g., strawberries) generally target blood pressure and LDL-C; however, CVD risk reduction may also be achieved…
- Trial name
- NCT03522974
- Testing
- Strawberry powder
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Irritable Bowel Syndrome
Effect of Two Different Rye Bread Types in Irritable Bowel Syndrome
The purpose of this study is to evaluate if low-FODMAP (Fermented Oligo-, Di-, Monosaccharides And Polyols) rye bread is better tolerated in irritable bowel syndrome than commonly available traditional rye bread higher in FODMAP…
- Trial name
- NCT02161120
- Testing
- Traditional Finnish rye bread, Low FODMAP rye bread
- Where
- Finland
- Volunteers
- 87 people
- Sponsor
- Oy Karl Fazer Ab
Autism Spectrum Disorder
Effects of Probiotic Consumption in Children With Autism Spectrum Disorder (ASD)
The goal of this clinical trial is to determine the effects of Saccharomyces boulardii (Sb) consumption on Ecuadorian children with a diagnosis of autism spectrum disorder (ASD) and digestive symptoms.
- Trial name
- NCT06568588
- Testing
- S. boulardii CNCM (National Collection of Cultures of Microorganisms) I-745
- Where
- Ecuador
- Volunteers
- 66 people
- Sponsor
- Universidad San Francisco de Quito
Coronary Artery Disease, Arterial Stiffness, Blood Pressure
Expanded Studies on the SCAPIS Stockholm Reexamination Cohort
The Swedish CArdioPulmonary bioImage Study (SCAPIS) is a unique, large-scale national research initiative involving 30,000 randomly selected individuals aged 50-64, recruited between 2014 and 2018.
- Conditions
- Coronary Artery Disease, Arterial Stiffness, Blood Pressure, AORTIC VALVE DISEASES, Mitral Valve Stenosis and/or Insufficiency
- Trial name
- SCAPIS-ReEx (NCT07476703)
- Testing
- Coronary computer tomography (CCTA), Echocardiograhy and aortic ultrasound, Liver elastography
- Where
- Sweden
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Danderyd Hospital
Obesity, Obesity & Overweight
Interaction of Sleep, Diurnal Eating Pattern, Gut Microbiota, and Obesity
The goals of the proposed study are 1) to provide scientific basis for the relationship between subjective sleep quality, diurnal eating pattern, gut microbiome, and obesity, 2) to develop and test a pragmatic, cost-effective new…
- Trial name
- ObeApp (NCT04850391)
- Testing
- Mobile app
- Where
- Finland
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
GDM, Blood Glucose
Diet-glucose-gut Microbiome Net in Women With GDM
A prospective cohort study was conducted to :1. explore the effective of diet intervention on blood glucose control; 2. observe the changeable composition of microbiota; 3. seek the possible microbiome intervened to prevent GDM.
- Conditions
- GDM, Blood Glucose, Pregnancy Outcome, Microbiota
- Trial name
- NCT04930276
- Testing
- Diet intervention
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking Union Medical College Hospital
Cognitive Decline, Cognitive Dysfunction
Microbiota Mediated Flavonoid Metabolites for Cognitive Health
Globally, populations are ageing increasing the prevalence of Alzheimer's disease (AD), due to lack of effective treatments. The traditional Mediterranean diet, rich in fibre and polyphenols (PPs) can help prevent or delay…
- Trial name
- MAEVE (NCT07226674)
- Testing
- Polyphenol Supplement
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Fat Burn, Diabetes Mellitus, Type 2
Physical Exercise, Diet, and Health in People With Type 2 Diabetes: Longitudinal Design of the EDUGUTION Study
This longitudinal design study is a continuation of the EDUGUTION project (Ref: PID2019-110063RA-I00; Clinical Trial: NCT05261373), a randomized controlled trial that was approved by the Clinical Research Ethics Committee of…
- Conditions
- Fat Burn, Diabetes Mellitus, Type 2, Cardiovascular Diseases, Metabolism Disorder
- Trial name
- NCT06219850
- Testing
- No intervention
- Volunteers
- 120 people
- Sponsor
- University of Cadiz
Ulcerative Colitis
The Effect of Diet on Disease Activity and Symptoms in Patients With Ulcerative Colitis
The Mediterranean Diet Pattern (MDP) has been shown to have beneficial effects on the intestinal bacteria and the immune system in diseases like cancer and diabetes.
- Trial name
- NCT03053713
- Testing
- Mediterranean diet pattern, Habitual diet (control)
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of British Columbia
Psoriasis, Psoriasis Vulgaris
A Pilot Study to Explore the Role of Gut Flora in Psoriasis
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding Psoriasis.
- Conditions
- Psoriasis, Psoriasis Vulgaris, Psoriasis Universalis, Psoriasis Face
- Trial name
- NCT04099979
- Testing
- No Intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Infectious Diarrhea, Acute Gastroenteritis
Lactobacillus Acidophilus and Limosilactobacillus Reuteri for Acute Diarrhea in Children
This randomized controlled trial evaluated the effect of a combination of Lactobacillus acidophilus DSMZ 26280 and Limosilactobacillus reuteri DSMZ 25441 on the duration of diarrhea and gut microbiota composition in children aged…
- Trial name
- NCT07342088
- Testing
- Probiotic, Standard therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Eskisehir Osmangazi University
Preterm, Neurodevelopmental Disorders
Dietary Pattern Intervention for Neurodevelopment in Preterm Infants
The purpose of this randomized controlled trial is to evaluate the effect of a structured, high-prebiotic dietary pattern on the neurodevelopmental outcomes of preterm infants.
- Conditions
- Preterm, Neurodevelopmental Disorders, Dysbiosis
- Trial name
- NCT07702734
- Testing
- Structured High-Prebiotic Dietary Pattern
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Fudan University
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