Clinical trials: Gastrointestinal Microbiota
Irritable Bowel Syndrome
SH-DS01 on Fecal Metagenomic Stability
This is a randomized, double blind, Phase 1 study. There will be a 12-week comparison of the safety of DS-01 versus placebo with a secondary outcome measure of the efficacy in a cohort of 100 men or women with IBS with…
- Trial name
- NCT04598295
- Testing
- DS-01
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Beth Israel Deaconess Medical Center
End Stage Renal Disease (ESRD)
Food Preparation Effects on Gut Bacteria in Patients on Peritoneal Dialysis
This is an intervention study of the effects of food preparation on the gut bacteria in patients with end stage renal disease on peritoneal dialysis.
- Trial name
- NCT02467530
- Testing
- AGE
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Metabolic Syndrome, Insulin Resistance
An Antiinflammatory Diet as Modulator of Cardiometabolic Risk and Body Weight in Healthy Subjects
Main scientific question: A previous intervention with an anti-inflammatory multifunctional dietary portfolio (MFD) showed remarkable reductions in cardiometabolic (CM) risk markers compared with a well-designed control diet.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Overweight
- Trial name
- NCT02148653
- Testing
- Multifunctional diet (MFD), Control diet
- Where
- Sweden
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Lund University
Allergic Rhinitis
Probiotic Ameliorates Adult Allergic Rhinitis and Modulates Gut Microbiota
Assessing the clinical efficacy of weizmannia coagulans BC99 in alleviating allergic rhinitis symptoms, improving gut microbiota, and reducing adverse reactions in patients.
- Trial name
- NCT06680102
- Testing
- Probiotic, Maltodextrin
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Attention-Deficit Hyperactivity Disorder, Unspecified Type, Autism Spectrum Disorder
A Multi-dimensional Prospective Study to Discover Gene-microenvironment Interactions in Neurodevelopmental Disorders
This project is the first involving the two most common neurodevelopmental disorders, ASD and ADHD, as well as TDC to establish a multi-dimensional database (clinic, behavior, neurocognitive function, brain imaging, metabolomics…
- Trial name
- NCT04878575
- Testing
- ASD diagnosis, Psychiatric diagnosis
- Where
- Taiwan
- Volunteers
- 360 people
- Sponsor
- National Taiwan University Hospital
Quality of Life
Effect of Colon Delivered Vitamin B2 on Gut Microbiota and Related Health Biomarkers in Healthy Older Adults
The goal of this intervention study (clinical trial) is to investigate the effect of colon-delivered Riboflavin (vitamin B2) on the faecal microbial composition and diversity in older healthy subjects (50 -70 years of age)
- Trial name
- NCT05803811
- Testing
- Riboflavin
- Where
- Ireland
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- dsm-firmenich Switzerland AG
Allergic Disease, Obesity
Pre-, Peri- and Postnatal Programming and Origins of Disease: Early Targeting the Epidemics of Allergy and Overweight
Combined programme: Nutrition, Allergy, Mucosal immunology and Intestinal microbiota (NAMI) was created with the objective to reverse the rising trend of chronic inflammatory diseases, such as allergic disease and obesity, by…
- Conditions
- Allergic Disease, Obesity, Immunology
- Trial name
- NAMI (NCT00167700)
- Testing
- Dietary counselling and probiotics, Probiotics, Prebiotics
- Where
- Finland
- Volunteers
- 800 people
- Sponsor
- University of Turku
Diabetic Kidney Disease
Gut Microbiota and Serum Metabolites as Predictors of Glycemic Variability and Outcomes in Diabetic Kidney Disease
Diabetic kidney disease (DKD) is one of the main complications of diabetes and a leading cause of end-stage kidney disease. Blood glucose variability is closely associated with disease progression in individuals with DKD.
- Trial name
- NCT07352436
- Volunteers
- 270 people
- Sponsor
- Eighth Affiliated Hospital, Sun Yat-sen University
Healthy
Chronic Cardiovascular and Gut-bacteria Effects of Phenolic Rich Oats in Adults With Above Average Blood Pressure
In this proposed human trial, the investigators aim to establish whether 4 weeks of daily consumption of beta-glucan matched meals providing either a high dose or a moderate dose of oat avenanthramides and phenolic acids leads to…
- Trial name
- NCT02847312
- Testing
- High avenanthramide, phenolic acid, Low avenanthramide, medium phenolic acid, Control
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Reading
Depression
Personalized Diet-driven Microbiota Alterations as a Tool for Improving Mood Status in Elderly
The propose of the study is a multi-disciplinary project connecting nutritional and health sciences with social and behavioral sciences, and aimed at understanding the microbiota changes related to the third age and their effects…
- Trial name
- NCT03256929
- Testing
- Personalized Diet-driven microbiota, General information on nutrition and health
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel Hai College
Type 1 Diabetes
The Effect of Gluten-free Diet on New Onset Type 1 Diabetes (T1D)
The primary aim of this pilot study is to test whether gluten-free diet (GFD) instituted in children shortly after onset of Type 1 Diabetes (T1D) can decelerate the decline in beta cell function as compared to age matched…
- Trial name
- NCT02867436
- Testing
- Gluten-free diet
- Where
- 2 sites in Czechia
- Volunteers
- 45 people
- Sponsor
- University Hospital, Motol
Parkinson Disease
Effects of Resistant Starch on Bowel Habits, Fecal Short Chain Fatty Acids and Gut Microbiota in Parkinson Disease
The investigators will investigate the effects of an 8-week resistant starch (RS) supplementation (5 g twice a day) in patients with Parkinson Disease and matched controls on: 1.
- Trial name
- RESISTA-PD (NCT02784145)
- Testing
- Resistant starch, Recommendation with regard to nutrition
- Where
- Germany
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Universität des Saarlandes
HBV, HBV Coinfection
Changes in Bile Acids and Microbiota in Patients With Hepatitis D Treated With Bulvertide
HDV is an RNA virus that infects only in the presence of HBV, affecting about 13% of HBsAg carriers. In Italy, prevalence ranges from 3.2% to 9.3%.
- Conditions
- HBV, HBV Coinfection, HCV, HIV Infections
- Trial name
- Bio-Delta (NCT07429864)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Gut Microbiota
Characterization of the Gastrointestinal Microbiota in Term Newborn Infants After 4 Weeks Supplementation of Probiotics
A mono center, open label, pilot study in term newborn infants. The study will investigate the effect of supplementation with probiotics on the presence of total Bifidobacterium in the infant feces.
- Trial name
- NCT04994834
- Testing
- Probiotics
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
Ulcerative Colitis
Effects of Eicosapentaenoic Acid on Subjects at High Risk for Colorectal Cancer
The aim of this study is to test Eicosapentaenoic acid's effects on markers relevant to colorectal carcinogenesis, RNA and DNA profiles, and the possibility that Eicosapentaenoic Acid treatment might be associated with changes of…
- Trial name
- EPAUC (NCT02069561)
- Testing
- Eicosapentaenoic Acid
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Fecal Microbiota Transplantation, Bowel Obstruction
Methodology and Clinical Value of RIT in Intestinal Obstructive Diseases Mediated by Colonic TET
The etiology of bowel obstruction is usually diagnosed by imaging techniques such as MSCTE,MRE, et al, which have some disadvantages.
- Trial name
- RIT;TET (NCT05253222)
- Testing
- retrograde image by colonic TET
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Breast Cancer Females
Synergic Effects of Physical Activity and Probiotic on Gut Immune System and Quality of Life of Breast Cancer Survivors.
Physical exercise along with gut microbiota improvement -because of probiotic intake- can improve the quality of life and immune system in breast cancer survivors.
- Trial name
- ESICA (NCT03760653)
- Testing
- Physical Exercise and probiotic group, Probiotic group
- Where
- Spain
- Sponsor
- Universidad Europea de Madrid
Autism
Prebiotic Intervention for Autism Spectrum Disorders
The purpose of this study is to determine the effect of a prebiotic (BGOS) on gut microbiota and metabolites in children with autism spectrum disorders.
- Trial name
- NCT02720900
- Testing
- B-GOS, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Clasado Limited
Necrotizing Enterocolitis, Premature Birth
Cohort of Premature Newborns for Charaterization of the Digestive Microbiota in Ulcerative Necrotizing Enterocolitis in Premature Infants
Compare the bacterial digestive microbiota during the stay in neonatal intensive care between a group of premature newborns developing a NEC (necrotizing enterocolitis) and a group of newborns free from NEC.
- Trial name
- CortECS (NCT04972734)
- Testing
- premature newborns developing a NEC, premature newborns without NEC
- Where
- France
- Volunteers
- 297 people
- Sponsor
- University Hospital, Clermont-Ferrand
Obsessive-Compulsive Disorder
The Gut Microbiota in Obsessive-Compulsive Disorder
This study will examine the gut microbiota and serum inflammatory markers in patients with Obsessive-Compulsive Disorder vs. healthy controls.
- Trial name
- NCT02285699
- Testing
- SSRIs
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- McMaster University
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