Clinical trials: Gastrointestinal Motility Disorder
Laryngopharyngeal Reflux, Zenker's Diverticulum
Laryngopharyngeal Reflux Before and After Cricopharyngeal Myotomy
The purpose of this study is to see if people with reflux with a Zenker's diverticulum have increased reflux into the throat following a cricopharyngeal myotomy.
- Trial name
- NCT01880892
- Testing
- Cricopharyngeal myotomy, PH probe Testing
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mayo Clinic
Gastroesophageal Reflux Disease
An Explorative Trial to Evaluate the Pharmacodynamic Effect of SPD557 on Reflux Parameters in Refractory GERD Patients
The purpose of this trial is to investigate the pharmacodynamic effect on reflux parameters of SPD557 tablets (0.5 mg t.i.d., on top of PPI treatment) in patients with Gastroesophageal Reflux Disease (GERD) with persistent…
- Trial name
- NCT01370863
- Testing
- SPD557
- Where
- 15 sites in Belgium, France and 4 more
- Volunteers
- 67 people
- Sponsor
- Shire
Esophagus Disorder, Esophageal Achalasia
Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders
No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM).
- Trial name
- NCT03944863
- Testing
- Antibiotics
- Volunteers
- 252 people
- Sponsor
- Société Française d'Endoscopie Digestive
GERD
Pre- and Post-Therapy Evaluation of Air-Associated Symptoms in Patients With Gastro-esophageal Reflux Disease (GERD): Assessing the Role of Speech and Language Therapy
Patients with gastroesophageal reflux disease (GERD) may present with concomitant gas-related symptom (GRS) such as supragastric or gastric belching, and aerophagia.
- Trial name
- LAS (NCT07634614)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Prof Urs Zingg
Gastro-esophageal Reflux
Safety & Initial Efficacy of the LunGuard PFT Sys. on Enteral-Fed, Sedated and Mechanically Ventilated Patients Peristaltic Feeding Tube
This study is designated to test the safety and initial efficacy of the LunGuard's PFT device for reduction of GER. Enterally-Fed, Sedated and Mechanically Ventilated Critically Ill Patients in the ICU will have the PFT…
- Trial name
- PFT (NCT02609620)
- Testing
- Peristaltic Feeding Tube, ConvaTec Levin Duodenal Tube
- Volunteers
- 20 people
- Sponsor
- LunGuard Ltd.
Gastroesophageal Reflux Disease
The Difference of Reflux Pattern Between the Patients Who Have Postprandial Reflux Symptoms
Gastroesophageal reflux disease is increasing worldwide. The causes of reflux symptoms are not found exactly. especially, the postprandial reflux symptoms are more common than the all day reflux symptoms.
- Trial name
- NCT02154659
- Testing
- 24hr pH monitoring
- Where
- South Korea
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Gastro Esophageal Reflux Disease
Endoscopic Treatment of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD) occurs when stomach acid repeatedly flows back into the tube connecting your mouth and stomach (esophagus). This backwash (acid reflux) can irritate the inner lining of the esophagus.
- Trial name
- NCT05678491
- Testing
- Endoscopic mucosal band ligation
- Where
- Norway
- Volunteers
- 12 people
- Sponsor
- St. Olavs Hospital
Gastroesophageal Reflux Disease (GERD)
Endoscopic Fundoplication Versus Proton Pump Inhibitors for GERD Treatment
The study objective is to evaluate the relative merits, safety and effectiveness of Transoral Incisionless Fundoplication (TIF) in GERD patients currently treated with daily Proton Pump Inhibitors (PPIs).
- Trial name
- TvP (NCT00857597)
- Testing
- Transoral Incisionless Fundoplication, Proton Pump Inhibitors; active control
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Achalasia
Short Vs Standard Length Myotomy in Achalasia
The objective of this randomized controlled trial (non-inferiority study) is to evaluate the outcomes of 4 cm short myotomy compared to the 8 cm standard length myotomy in Per-Oral Endoscopic Myotomy (POEM) for patients with…
- Trial name
- NCT04798547
- Testing
- Short Myotomy, Standard Length Myotomy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
GERD
A Study to Compare PK, PD and Safety of CKD-381 in Healthy Subjects
A Study to compare Pharmacokinetics, Pharmacodynamics and safety of CKD-381 and D027 in healty subjects
- Trial name
- NCT03211143
- Testing
- CKD-381, Nexium
- Where
- South Korea
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Reflux Disease, Microbiome
Development of a Preparation for Supportive Supplementation of Probiotics in Patients With Reflux
A two-arm, double-blind, randomized, placebo-controlled study investigating the efficacy of a probiotic preparation developed as supportive supplementation of probiotics in patients with reflux.
- Conditions
- Reflux Disease, Microbiome, Probiotics Supplement
- Trial name
- NCT07600008
- Testing
- A probiotic dietary supplement
- Where
- Czechia
- Volunteers
- 50 people
- Sponsor
- University Hospital Olomouc
Gastroesophageal Reflux Disease
SThe Effects of Melatonin on GERD Symptoms
We hypothesize that melatonin as compared to PPI and to placebo, improves GERD symptoms by decreasing esophageal acid exposure and esophageal acid sensitivity in GERD.
- Trial name
- NCT00564590
- Testing
- Melatonin, omeprazole
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Rabin Medical Center
Gastro-oesophageal Reflux Disease
Osteopathic Manipulative Treatment for Gastro-oesophageal Reflux Disease
To evaluate the effects of osteopathic manipulative treatment in patients affected by symptoms related to gastro-oesophageal reflux disease (GERD)
- Trial name
- NCT06317675
- Testing
- Osteopathic manipulative treatment (OMT)
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Studio Osteopatico Busto Arsizio
Gastroesophageal Reflux Disease (GERD), Reflux, Gastroesophageal
An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Reflux
The purpose of this investigation is to demonstrate the safety and effectiveness of Lower Esophageal Sphincter (LES) Stimulation System in treating gastroesophageal reflux disease (GERD).
- Conditions
- Gastroesophageal Reflux Disease (GERD), Reflux, Gastroesophageal, Gastroesophageal Reflux, Acid Reflux
- Trial name
- NCT02749071
- Testing
- Laparoscopic implantation surgery with or without crural repair, EndoStim stimulation for first six months of study, EndoStim stimulation from Month 6 thru end of study
- Where
- 21 sites in United States, Belgium and 2 more
- Volunteers
- 161 people
- Sponsor
- EndoStim Inc.
Gastroesophageal Reflux in Children
Study on the Efficacy and Tolerance of a New Anti-regurgitation Infant Formula (STELLAR)
The aim of the study is to assess the effectiveness of this new formula on regurgitations and secondarily its effect on digestive tolerance through a randomized, controlled, double-blind trial against a comparator.
- Trial name
- STELLAR (NCT04358146)
- Testing
- Experimental Infant formula, Infant formula thickened with locust bean gum
- Where
- 12 sites in Belgium, France and 2 more
- Volunteers
- 346 people
- Sponsor
- United Pharmaceuticals
GERD (Heartburn, Regurgitation, and Dyspepsia) Frequency, GERD (Heartburn, Regurgitation, and Dyspepsia) Severity
The Anti-gastroesophageal Reflux Effect of Anvitra Gastric Suspension on Outpatients With Gastroesophageal Reflux Disease
This is an open-label, single-center clinical trial evaluating the efficacy and safety of Anvitra Gastric Suspension health supplements in adult patients with gastroesophageal reflux.
- Trial name
- ANVITRA (NCT06889246)
- Testing
- Anvitra Gastric Suspension
- Where
- 2 sites in Vietnam
- Volunteers
- 27 people
- Sponsor
- Haiphong University of Medicine and Pharmacy
GERD
Study of the NDO Endoscopic Plication System For the Treatment of Symptomatic Gastroesophageal Reflux Disease
The purpose of this prospective, multicenter study was to evaluate the safety and efficacy of endoscopic full-thickness plication for the treatment of symptomatic gastroesophageal reflux.
- Trial name
- NCT00587522
- Testing
- NDO Full-thickness Plicator
- Where
- 7 sites in United States, Canada
- Volunteers
- 64 people
- Sponsor
- NDO Surgical, Inc.
Constipation, Analgesia
Enteral Naloxone Versus a Traditional Bowel Regimen for the Prevention of Opioid Induced Constipation in Trauma Patients
The purpose of this study is to determine if enteral naloxone is more effective than a traditional bowel regimen in the prevention and treatment of constipation and impaired gastric motility in critically ill trauma patients.
- Trial name
- NCT00799201
- Testing
- Naloxone and Docusate
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- CAMC Health System
Gastroesophageal Reflux Disease
A Study to Evaluate the Effect of Lansoprazole on Hospitalized Neonates With Gastroesophageal Reflux Disease
The purpose of this study is to understand how quickly lansoprazole, once daily (QD), improves feeding in premature babies or babies less than 28 days of age.
- Trial name
- NCT00174928
- Testing
- Lansoprazole
- Volunteers
- 24 people
- Sponsor
- Takeda
GERD, Acid Reflux Disease
Validation of Patient-reported Outcomes Measures for the Assessment of Gastroesophageal Reflux Disease (GERD) Symptoms
This research study is being done to gather information about how to do further clinical studies using AZD3355 as an add-on treatment to proton pump inhibitors (PPI).
- Conditions
- GERD, Acid Reflux Disease, Heartburn, Regurgitation
- Trial name
- C27 (NCT00703534)
- Testing
- AZD3355, Gelusil®
- Where
- 84 sites in United States
- Volunteers
- 478 people
- Sponsor
- AstraZeneca