Clinical trials: Gastrointestinal Neoplasm Malignant
Gastrointestinal Cancer
Nutritional and Functional Assessment of Patients Undergoing Surgery Due to Gastrointestinal Cancer (NUFAGI).
Several patients that suffer from gastrointestinal (GI) cancer are characterized by malnutrition and impairment of their functional status.
- Trial name
- NUFAGI (NCT05795374)
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- Maximos Frountzas
Stomach Neoplasm
ICG-NIR Guided Lymph Node Dissection in Gastric Cancer
As the survival rate of patients with gastric cancer has increased, there has been a growing interest in interventions that improve postoperative quality of life.
- Trial name
- NCT04056260
- Testing
- ICG-NIR guided surgery
- Volunteers
- 219 people
- Sponsor
- Ho Seok Seo
Colonic Neoplasms, Neoplasm Metastasis
A Study to See Whether Stereotactic Body RadioTherapy (SBRT) Can Shrink Tumours Within the Liver Safely
The proposed study will evaluate if "curative intent" SBRT can provide high response rates and clinically meaningful cancer control with acceptable toxicity specifically in patient with metastatic colorectal cancer (mCRC) who do…
- Trial name
- NCT03175146
- Testing
- Stereotactic Body Radiation Therapy
- Volunteers
- 30 people
- Sponsor
- AHS Cancer Control Alberta
Lymph Node Metastasis, Colorectal Cancer
Clinical Trial Comparing Carnoy's and GEWF Solutions
Regional lymph node metastasis is a major determinant of local recurrence and overall survival rates in patients with colorectal cancer.
- Trial name
- NCT02704988
- Testing
- Carnoy Solution, GEWF Solution
- Where
- Brazil
- Volunteers
- 181 people
- Sponsor
- Hospital Moinhos de Vento
Gastric Cancer, Metastasis
Genomic Evolution of Metastasis in Gastric Cancer
The aim of this study is to track tumor evolution of regional and distant metastases in gastric cancer using the Next Generation Sequencing technologies.
- Trial name
- NCT05061082
- Where
- Vietnam
- Volunteers
- 20 people
- Sponsor
- University Medical Center Ho Chi Minh City (UMC)
Colonic Cancer, Metastasis to Lymph Node
EMI-137 in Laparoscopic Colonic Resections
EMI-137 in laparoscopic colonic resections is a single-centre stage IIa developmental study. Ten adult participants with a diagnosis of colon adenocarcinoma undergoing laparoscopic colonic will be recruited to the trial.
- Trial name
- NCT03360461
- Testing
- EMI-137
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Leeds
Stomach Cancer, Gastric (Stomach) Cancer
Ph II of Capecitabine, Carboplatin & Bevacizumab for Gastroesophageal Junction & Gastric Carcinoma
To investigate bevacizumab in combination with carboplatin and capecitabine for patients with unresectable or metastatic GEJ or gastric cancers.
- Conditions
- Stomach Cancer, Gastric (Stomach) Cancer, Neoplasm of Cardioesophageal Junction, Gastrointestinal Stromal Tumor (GIST)
- Trial name
- NCT00780494
- Testing
- bevacizumab, carboplatin, capecitabine
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Stanford University
Pancreas Cancer, Biliary Tract Cancer
Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers
The primary objective of this study is to evaluate the ability to recruit and retain participants, and to successfully conduct a psilocybin-based protocol, for a study of the treatment of distress related to stage IV or…
- Conditions
- Pancreas Cancer, Biliary Tract Cancer, Psychological Distress, Gastrointestinal Cancer
- Trial name
- NCT05220046
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Nebraska
Stomach Neoplasm
ILF With/Without Cisplatin for Advanced Gastric Cancer
To compare the combination of irinotecan, leucovorin and 5-FU (ILF) with ILF plus cisplatin (PILF) as first-line chemotherapy in patients with measurable metastatic gastric cancer.
- Trial name
- NCT00320294
- Testing
- irinotecan, cisplatin
- Where
- South Korea
- Volunteers
- 86 people
- Sponsor
- Gachon University Gil Medical Center
Gastric Cancer, Locally Advanced Malignant Neoplasm
Pre-Operative Or Peri-Operative Dox Regimen In Patients With Locally Advanced Resectable Gastric Cancer
Study design: Multicenter, randomized, open label phase II study Arm A: DOX 4 cycles - Surgery - Follow-up Arm B: DOX 2 cycles - Surgery - DOX 2 cycles - Follow-up Population: Male or female, 18-75 years of age, with a diagnosis…
- Trial name
- GastroDOC (NCT01876927)
- Testing
- DOX 4 cycles - Surgery, DOX 2 cycles - Surgery - DOX 2 cycles
- Where
- 20 sites in Italy
- Volunteers
- 106 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Hepatocellular Carcinoma, Metastasis
Efficacy and Safety of Concurrent TACE and Sorafenib in Patients With HCC and Extrahepatic Metastasis (COTSOM Study)
This study is a phase II, prospective, open-label, single arm, single center study of the efficacy and safety of concurrent conventional transarterial chemoembolization (TACE) and sorafenib in patients with hepatocellular…
- Trial name
- COTSOM (NCT02311205)
- Testing
- Conventional Transarterial Chemoembolization (TACE), sorafenib
- Where
- South Korea
- Volunteers
- 55 people
- Sponsor
- Asan Medical Center
Malignant Bowel Obstruction, Cancer Pain
Lidocaine Infusions for Pain in Patients With Malignant Bowel Obstruction
Malignant bowel obstruction is a frequent complication of advanced cancer, particularly of abdominal and pelvic origin, and most affected patients experience pain.
- Conditions
- Malignant Bowel Obstruction, Cancer Pain, Intestinal Obstruction
- Trial name
- NCT07856251
- Testing
- Lidocaine
- Volunteers
- 50 people
- Sponsor
- Fundación Santa Fe de Bogota
Colorectal Cancer, Stomach Cancer
Study of CEA Targeting CAR-T (PTC13) in the Treatment of CEA-Positive Advanced Malignant Solid Tumors
This is a phase I clinical study to evaluate the safety and tolerability of FAST targeted chimeric antigen receptor (CAR)-T cells (PTC13) in patients with carcinoembryonic antigen (CEA)-positive advanced malignant solid tumors…
- Conditions
- Colorectal Cancer, Stomach Cancer, Pancreatic Cancer, Metastatic Cancer
- Trial name
- NCT06821048
- Testing
- Intraperitoneal infusion of FAST CEA-targeted CAR-T
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Weijia Fang, MD
Cancer of Rectum, Cancer of Pancreas
LIQUID BIOPSY FOCUSING ON CIRCULATING TUMOR CELLS AND CIRCULATING TUMOR DNA AS PRECISION MEDICINE IN GASTROINTESTINAL TUMORS
This is a prospective, observational, multicenter cohort study. Our main objective is to to evaluate the use of CTCs and ctDNA with prognostic factors in locally advanced rectal tumors treated with total neoadjuvant therapy…
- Conditions
- Cancer of Rectum, Cancer of Pancreas, Cancer of Stomach
- Trial name
- BLENTI (NCT06940778)
- Testing
- No Interventions
- Where
- Brazil
- Volunteers
- 273 people
- Sponsor
- Hospital do Coracao
Cancer of Rectum, Cancer of the Rectum
Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum
The purpose of this research study is to look at how tumors responds to a short course of radiation (5 days) followed by 8 cycles of chemotherapy.
- Conditions
- Cancer of Rectum, Cancer of the Rectum, Neoplasm, Rectum, Rectal Cancer
- Trial name
- NORMAL-R (NCT02641691)
- Testing
- Radiation, Oxaliplatin, Leucovorin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC)
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
Evaluate the safety and tolerability of RMC-6236 in adults with specific RAS mutant advanced solid tumors.
- Conditions
- Non-small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Pancreatic Ductal Adenocarcinoma (PDAC), Advanced Solid Tumors
- Trial name
- NCT05379985
- Testing
- RMC-6236
- Where
- 21 sites in United States
- Volunteers
- 754 people
- Sponsor
- Revolution Medicines, Inc.
Liver Neoplasms
TheraSphere Japan Pre-Market Study
To investigate the safety and effectiveness of BSJ019T in Japanese patients with primary or secondary liver who are not candidate for standard treatment.
- Trial name
- INDIGO (NCT07377487)
- Testing
- TheraSphere Y-90 glass microsphere
- Where
- 5 sites in Japan
- Volunteers
- 51 people
- Sponsor
- Boston Scientific Corporation
Colorectal Neoplasms, Precancerous Conditions
Liquid Biopsy in Early Colorectal Lesions
Early colorectal cancer screening increasingly detects small superficial colonic lesions, but current diagnostic tools still struggle to distinguish benign from malignant lesions and to assess lymph node risk.
- Conditions
- Colorectal Neoplasms, Precancerous Conditions, Adenocarcinoma of the Colon
- Trial name
- FECCO-BioBank (NCT07319104)
- Testing
- Venous blood sampling
- Where
- 12 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Montpellier
Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.
- Trial name
- STELLAR-311 (NCT06943755)
- Testing
- Zanzalintinib, Everolimus
- Where
- 135 sites in United States, Australia and 16 more
- Volunteers
- 440 people
- Sponsor
- Exelixis
Radiotherapy Side Effect, NSCLC
CPAP or BiPAP for Motion Mitigation During Radiotherapy
When using highly conformal radiotherapy techniques, such as proton therapy, a controlled breathing pattern and a minimal breathing amplitude could greatly benefit the treatment of mobile tumors.
- Conditions
- Radiotherapy Side Effect, NSCLC, Esophageal Cancer, Malignant Lymphoma
- Trial name
- SISTER (NCT04986293)
- Testing
- CPAP
- Where
- Netherlands
- Volunteers
- 31 people
- Sponsor
- University Medical Center Groningen
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.