Clinical trials: Gastrointestinal Reflux
Gastroesophageal Reflux
Efficacy of Pantoprazole in Patients Older Than 18 Years Who Have Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/M3-339)
Gastroesophageal reflux disease (GERD) is a medical condition affecting the stomach and esophagus. GERD occurs when the lower esophageal sphincter does not close properly and stomach contents leaks back (refluxes) into the…
- Trial name
- NCT00163306
- Testing
- Pantoprazole
- Where
- 79 sites in Austria, Germany and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease (GERD)
The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity
It is planned to investigate the effect of dexrabeprazole on gastric acid primarily, and then gastroesophageal reflux disease (GERD) symptoms, intraesophageal acidity (reflux) and impedance kinetics.
- Trial name
- NCT02689999
- Testing
- Dexrabeprazole 10 mg Enteric-Coated Tablets
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Neutec Ar-Ge San ve Tic A.Ş
Gastroesophageal Reflux
A Study of Dexlansoprazole Modified Release Formulation to Treat Night Heartburn
The purpose of this study is to determine whether Dexlansoprazole once daily (QD) is effective in treating patients with night heartburn.
- Trial name
- NCT00627016
- Testing
- Dexlansoprazole
- Where
- 43 sites in United States
- Volunteers
- 305 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease
Symptom Assessment for Patients With Gastro-esophageal Reflux Disease Receiving Helicobacter Pylori Eradication
Background: Rebound acid hypersecretion and acid-related symptoms after discontinuation of proton-pump inhibitor has been reported in previous studies.
- Trial name
- NCT02934152
- Testing
- H pylori eradication, H pylori eradication timing
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Gastroesophageal Reflux Disease, GERD
Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD?
Purpose: 1. Determine if oral quercetin increases the expression of claudin-4 in the lining of the esophagus of patients with a diagnosis of gastroesophageal reflux disease (GERD); and 2.
- Conditions
- Gastroesophageal Reflux Disease, GERD, Acid Reflux, Reflux
- Trial name
- NCT02226484
- Testing
- Quercetin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of North Carolina, Chapel Hill
Gastroesophageal Reflux Disease
An Evaluation of the Medtronic Gatekeeper System in the Treatment of SUBJECTS With Gastroesophageal Reflux Disease (GERD)
The purpose of the study is to demonstrate the intended use of the Gatekeeper Reflux Repair System to provide symptomatic relief is subjects with gastroesophageal reflux disease.
- Trial name
- NCT00200044
- Testing
- Gatekeeper Reflux Repair System
- Where
- 11 sites in United States, Netherlands
- Volunteers
- 143 people
- Sponsor
- MedtronicNeuro
Reflux
Study to Investigate the Pharmacodynamic Effect of a Single Dose of AZD2516 in Healthy Male Subjects
The purpose of this study is to investigate the pharmacodynamic effect of AZD2516 in healthy male subjects.
- Trial name
- NCT01154634
- Testing
- AZD2516, 5 mg, AZD2516, 16 mg, AZD2516, 40 mg
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Vasomotor Rhinitis
Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled Trial
The purpose of this study was to see if high dose esomeprazole (40mg bid) was effective in treating non-allergic rhinitis
- Trial name
- NCT00745849
- Testing
- esomeprazole
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Texas Southwestern Medical Center
Gastroesophageal Reflux
Study Evaluating Pantoprazole in Adolescents With GERD
The purpose of this study is characterize the PK profile of single and multiple doses of pantoprazole in adolescents aged 12 to 16 years with Gastroesophageal Reflux Disease (GERD).
- Trial name
- NCT00367614
- Testing
- pantoprazole
- Volunteers
- 20 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Mitral Valve (MV) Regurgitation
ACCESS-Europe A Two-Phase Observational Study of the MitraClip® System in Europe
The MitraClip System enables the European physicians an alternative therapeutic option for patients with mitral regurgitation (MR).
- Trial name
- ACCESS-EU (NCT01288976)
- Testing
- MitraClip, Medical Management, Mitral Valve Surgery
- Where
- Germany
- Volunteers
- 721 people
- Sponsor
- Abbott Medical Devices
Erosive Esophagitis
Proton Pump Inhibitor (PPI) Responsive Eosinophilic Esophagitis EoE: Gastroesophageal Reflux Disease (GERD) or Eosinophilic Esophagitis (EoE)?
The investigators would like to determine if there are patients with PPI responsive Eosinophilic Esophagitis Infiltration that have significant loss of esophageal distensibility suggestive of esophageal fibrosis typical of…
- Trial name
- NCT01865825
- Testing
- Esophageal Barium Xray
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Gastric Reflux
Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients
A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.
- Trial name
- Gastric (NCT06687187)
- Testing
- Neostigmine
- Where
- Egypt
- Volunteers
- 3 people
- Sponsor
- Zulekha Hospitals
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Upper GIT Symptoms
Prevalence of Gastroesophageal Reflux Disease (GERD) in Patients With Upper Gastrointestinal Track (GIT) Symptoms in Thailand
This is a prospective , epidemiological, multi-centre, phase IV study, approximately 5,000 patients who suffer with upper gastrointestinal tract symptoms. Each patient will be assessed for GERD with GerdQ Thai Version.
- Trial name
- GerdQ (NCT00999063)
- Where
- 25 sites in Thailand
- Volunteers
- 4,108 people
- Sponsor
- AstraZeneca
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
Gastric Cancer (GC), Double-tract Reconstruction
Comparison of Double-tract and Tubular Gastric Anastomosis in Proximal Gastric Cancer
This study includes patients diagnosed with proximal gastric cancer (Siewert type II/III, cT1-3N0-1M0) across six tertiary hospitals, who underwent either double-tract reconstruction (DTR) or tubular gastric anastomosis (TGA).
- Conditions
- Gastric Cancer (GC), Double-tract Reconstruction, Tubular Gastric Anastomosis
- Trial name
- NCT07635836
- Testing
- Double-tract reconstruction
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Qilu Hospital of Shandong University
Varicose Veins, Chronic Venous Insufficiency
The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression
Technically successful laser crossectomy will reduce the risk of reflux recurrence at the sapheno-femoral junction without increasing the risk of endovenous heat-induced thrombosis, which may positively impact the likelihood of…
- Trial name
- LACROSS-VVP (NCT07449728)
- Testing
- Laser crossectomy on 1470 nm, Laser crossectomy on 1940 nm, Standard EVLT with a stump
- Where
- Russia
- Volunteers
- 400 people
- Sponsor
- Pirogov Russian National Research Medical University
Gastroesophageal Reflux Disease
The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease
Gastro-Esophageal Reflux Disease was defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications.
- Trial name
- NCT00915616
- Testing
- Melatonin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mansoura University
Gastro Esophageal Reflux Disease, Dyspepsia
Spirulina Platensis for PPI Withdrawal
Background: Rebound acid hypersecretion after proton pump inhibitors (PPIs) discontinuation may be accompanied by dyspepsia. Aim: To assess whether Spirulina platensis, by its anti-inflammatory properties, could minimize rebound…
- Conditions
- Gastro Esophageal Reflux Disease, Dyspepsia, Rebound Acid Hypersecretion
- Trial name
- SpAReDPPI (NCT04988347)
- Testing
- Spirulina platensis
- Volunteers
- 45 people
- Sponsor
- Universidade de Passo Fundo
Nutritional Insufficiency
Food Energy Density in Eating Disorders
Nutritional insufficiency is defined as an inadequate amount of nutrition due to decreased food/caloric intake, often due to an eating disorder, such as anorexia nervosa or bulimia.
- Trial name
- NCT01095107
- Testing
- Low fat intake, Increased fat intake
- Sponsor
- The Cleveland Clinic
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