Clinical trials: Gastrointestinal Reflux
Food Allergy in Infants, Proctocolitis
Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution
Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive...
- Conditions
- Food Allergy in Infants, Proctocolitis, Atopic Dermatitis, Reflux, Gastroesophageal
- Trial name
- NCT04651829
- Testing
- oral food challenge 1, oral food challenge 2
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Armand Trousseau
Mitral Prosthetic Valve Stenosis and Regurgitation
Redo Surgery or Transcatheter Valve-in-Valve for Mitral Bioprosthetic Dysfunction (SURViV)
Transcatheter valve-in-valve implantation has emerged as a valid alternative to redo surgery for patients with surgical bioprosthetic dysfunction.
- Trial name
- SURVIV (NCT04402931)
- Testing
- Transcatheter Valve-in-Valve Intervention, Redo Mitral valve surgery
- Where
- 7 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
GERD
Gatekeeper European 005
Evaluation of the Gatekeeper System in the treatment of patients with Gastroesophageal Reflux Disease (GERD) who already have been treated under study protocols Endo 2000-03 and Endo 2000-04
- Trial name
- NCT00229086
- Testing
- Gatekeeper Reflux Repari System (Device)
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 55 people
- Sponsor
- MedtronicNeuro
Gastroesophageal Reflux Disease, Dyspepsia
Evaluation of Efficiency of Esophageal Capsule Endoscopy in the Screening of Patients With Gastroesophageal Reflux Disease or Dyspepsia as Compared to Upper Endoscopy
The exploration of evocative symptoms of esophageal reflux disease or dyspepsia is based on a relatively invasive endoscopic examination, often badly tolerated, and which, in France, is carried out in 50% of the cases under…
- Trial name
- NCT00217347
- Testing
- Esophageal Capsule Endoscopy
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Nantes University Hospital
Pulmonary Aspiration of Gastric Contents
Body Position and Ultrasound Examination of the Gastric Antrum
Pulmonary aspiration of gastric contents is a complication causing significant morbidity and mortality related to anesthesia. Ultrasound examination of the gastric antrum allows the detection of preoperative gastric contents…
- Trial name
- POSIGAST (NCT04097236)
- Testing
- Qualitative and quantitative assessment of gastric content volume with bed elevation, Qualitative and quantitative assessment of gastric content volume without bed elevation
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Obesity, Morbid, Gastroesophageal Reflux Disease
Impact of Crural Repair and Gastropexy During Laparoscopic Sleeve Gastrectomy
This prospective, randomized comparative controlled study evaluated the impact of concomitant posterior crural repair and posterior gastropexy on postoperative reflux outcomes in patients undergoing laparoscopic sleeve…
- Trial name
- NCT07560787
- Testing
- Laparoscopic Sleeve Gastrectomy with Crural Repair and Gastropexy, Standard Laparoscopic Sleeve Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Van Training and Research Hospital
GERD
Clinical Trial to Assess the PK/PD of YYD601 20mg After Oral Administration if Healthy Adult Subjects (Phase1)
Clinical Trial to Assess the PK/PD of YYD601 20mg After Oral Administration if Healthy Adult Subjects (Phase1)
- Trial name
- NCT03985319
- Testing
- YYD601 20mg, Nexium tab 20mg
- Where
- South Korea
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Paraesophageal Hernia, Gastro Esophageal Reflux
Partial Versus Total Fundoplication in the Surgical Repair of Para-esophageal Hernia.
Short-term follow up after surgery of para-esophageal hernia comparing two different types of fundoplication
- Trial name
- NCT04436159
- Testing
- Addition of 360 fundoplication after crural closure, Addition of 180 posterior fundoplication after crural closure
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Karolinska University Hospital
Stomach Ulcer, Gastroesophageal Reflux
Pharmacodynamics and Safety of CDFR0209
This is a randomized, open-label, two-way crossover study to investigate the pharmacodynamics(24 hour gastric pH) and the safety between repeated doses of CDFR0209 and Losec in Healthy Male Volunteers
- Trial name
- NCT02710994
- Testing
- CDFR0209, Losec
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Pregnancy, Respiratory Aspiration of Gastric Contents
Gastric Emptying Following an Oral Carbohydrate Load in Women Admitted for Elective Cesarean Delivery
Because of the risk of pulmonary aspiration, patients are asked to comply with the fasting guidelines when they are scheduled for an elective cesarean section.
- Trial name
- NCT03593980
- Testing
- Cranberry juice
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Gastroesophageal Reflux Disease
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of Pumosetrag in Patients With Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to determine if pumosetrag is effective in treating Gastroesophageal Reflux Disease (GERD) symptoms in patients who have a history of GERD symptoms and are currently taking an acid suppression…
- Trial name
- NCT01161602
- Testing
- Pumosetrag
- Where
- 5 sites in United States
- Sponsor
- Edusa Pharmaceuticals, Inc.
Laryngopharyngeal Reflux, Throat Pain
Anti-reflux Control to Decrease Post Tonsillectomy Pain
The study aims to determine if treating pediatric patients (age 7-17) for four weeks with omeprazole prior to tonsillectomy will decrease post tonsillectomy pain.
- Trial name
- NCT01777854
- Testing
- Omeprazole
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Ascension Health
Gastroesophageal Reflux Disease and Position
Car Safety Seat and Gastroesophageal Reflux Disease
What's known? Prone position is no longer a treatment option for GERD because of the association with SIDS. Originally, positioning in an infant seat was recommended for infants with GERD.
- Trial name
- NCT01266551
- Testing
- car safety seat
- Where
- Belgium
- Sponsor
- University Hospital, Antwerp
Barrett Esophagus, Proton Pump Inhibitor
On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett's Esophagus.
On-demand PPI therapy is feasible for the long-term treatment of patients with Barrett's esophagus.
- Conditions
- Barrett Esophagus, Proton Pump Inhibitor, Symptom, Reflux
- Trial name
- NCT04329000
- Testing
- Esomeprazole 40mg, Esomeprazole
- Volunteers
- 218 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Gastric Ulcer, Duodenal Ulcer
BE Study Between a Capsule and a Sachet Formulation of D961H by Pharmacodynamics in Japanese Healthy Male Subjects
The purpose of this study is; To investigate whether a D961H sachet 20 mg is bioequivalent to a D961H HPMC capsule 20 mg by the assessment of percentage of time with intragastric pH>4.
- Conditions
- Gastric Ulcer, Duodenal Ulcer, Anastomotic Ulcer, Reflux Esophagitis
- Trial name
- NCT01964131
- Testing
- D961H sachet 20 mg, D961H HPMC capsule 20 mg
- Where
- 2 sites in Japan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Gastroesophageal Reflux Disease
Minimal Change Esophagitis by i-Scan Endoscopy in Dyspeptic Patients
The purpose of this study to assess efficacy of SE endoscopy in the detection of MCE in dyspeptic patients with or without GERD diagnosed by GerdQ or by endoscopy + PHM and in normal volunteers.
- Trial name
- MCE (NCT01742377)
- Testing
- Patients with GerdQ positive, Patients with GerdQ negative, Normal volunteers
- Where
- Thailand
- Volunteers
- 174 people
- Sponsor
- Prince of Songkla University
GERD, Barrett Esophagus
The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample With 3-Dimensional Computer-Assisted Analysis) vs. 4-Quadrant Forceps Biopsy
Patients scheduled to undergo routine upper endoscopy for foregut or esophageal symptoms or undergoing surveillance for Barrett's esophagus with no dysplasia or low-grade dysplasia are candidates for participation, but patients…
- Conditions
- GERD, Barrett Esophagus, Low Grade Esophageal Glandular Dysplasia, Esophageal Diseases
- Trial name
- NCT03859557
- Where
- United States
- Volunteers
- 1,032 people
- Sponsor
- CDx Diagnostics
GERD
Prospective Evaluation of PH-impedance Tracings According to the Wingate Consensus, and Influence on GERD Classification According to the Lyon Consensus
Commonly, in clinical practice an automated analysis of pH-MII tracings is obtained.
- Trial name
- WinPro (NCT06084572)
- Testing
- Questionnaires
- Where
- 3 sites in Belgium, Germany
- Volunteers
- 120 people
- Sponsor
- Universitair Ziekenhuis Brussel
Gastric Adenocarcinoma, Adenocarcinoma of the Esophagogastric Junction
Sino-Russian Comparison of Outcomes After Proximal Gastrectomy With Double-Tract Reconstruction
This two-center retrospective observational cohort study compares Chinese and Russian patients who underwent curative proximal gastrectomy with double-tract reconstruction for proximal gastric adenocarcinoma or Siewert type…
- Trial name
- RUSCHI-DTR (NCT07800819)
- Testing
- Proximal gastrectomy with double-tract reconstruction
- Where
- 2 sites in China, Russia
- Volunteers
- 250 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Dysphagia
Impact of Glossopharyngeal Nerve Block on Swallowing Difficulties Caused by Gastroesophageal Reflux Disease
The goal of this clinical trial is to explore Clinical Effect of Glossopharyngeal Nerve Block on Pharyngeal Dysphagia Induced by Gastroesophageal Reflux Disease.
- Trial name
- NCT06328205
- Testing
- Rehabilitation therapy, Glossopharyngeal Nerve Block, Lidocaine Hydrochloride
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
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