Clinical trials: Gastrointestinal Reflux
Pancreatic Pseudocyst
Clinical Evaluation of Enteral-extended Anti-reflux Stents for Pancreatic Pseudocyst
At present, endoscopic therapy is the preferred method to solve biliary or pancreatic diseases. And EUS-guided stent implantation and drainage of pancreatic pseudocyst is the main method in Endoscopic treatment of pancreatic…
- Trial name
- NCT05716594
- Testing
- Plant enteral-extended anti-reflux stents, Plant traditional stents
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Peking University Third Hospital
Bile Reflux
Omega Loop Gastric Bypass With And Without Anti-Reflux Sutures
This proposed trial is designed to answer the following questions: First, is biliary reflux to the distal esophagus present before OLGB and does it increase after the procedure? Second, does performing an OLGB with or without…
- Trial name
- NCT03097887
- Testing
- Omega Loop Gastric Bypass, Bilitec 2000™, V-Loc
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Medical University of Vienna
Bariatric Surgery Candidate, GERD
9-Step Magnetic Bariatric Revisional Surgery
RYGB represents one of the best alternatives for weight loss in obese patients achieving a weight loss of up to 60% and a resolution of comorbidities of 70%.
- Conditions
- Bariatric Surgery Candidate, GERD, Revisional Bariatric Surgery
- Trial name
- NCT04945304
- Testing
- magnetic bariatric surgery, Magnetic gastric bypass
- Where
- Venezuela
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Unidad Internacional de Cirugia Bariatrica y Metabolica
Gastroesophageal Reflux
Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers
To investigate the effect of citalopram, a selective serotonin reuptake inhibitor, on esophageal sensitivity.
- Trial name
- NCT04355455
- Testing
- Citalopram
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Gastroesophageal Reflux Disease
Dexlansoprazole in Asian Participants With Gastroesophageal Reflux Disease
The purpose of this study is to evaluate the effectiveness of symptom control in gastroesophageal reflux disease (GERD) participants following treatment with dexlansoprazole.
- Trial name
- NCT02351960
- Testing
- Dexlansoprazole
- Where
- 10 sites in Hong Kong, South Korea and 1 more
- Volunteers
- 296 people
- Sponsor
- Takeda
Laryngopharyngeal Reflux
Study of an Oropharyngeal Aerosolized pH Probe for Diagnosing Laryngopharyngeal Reflux (LPR)
This study is a test of how well a new FDA-approved device is for diagnosing a condition known as laryngopharyngeal reflux (LPR).
- Trial name
- NCT00321503
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Emory University
Obesity, Gastric Reflux
The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass
The objective of this study is to investigate the effect of Esomeprazol administered in tablets (Esomeprazol MUT Sandoz® 40mg) or in solution (Esomeprazol MUT Sandoz® 40mg in 10ml tap water) on acid production in the gastric…
- Conditions
- Obesity, Gastric Reflux, Ulcer, Gastric
- Trial name
- NCT05320796
- Testing
- upper endoscopy
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Prof Urs Zingg
Gastroesophageal Reflux Disease, Heartburn
Rubber Band Ligation and Mucosectomy for Gastroesophageal Reflux Disease (GERD)
The purpose of this study is to determine the safety and effectiveness of two separate procedures to treat gastroesophageal reflux disease (GERD) also known as heartburn.
- Conditions
- Gastroesophageal Reflux Disease, Heartburn, Regurgitation, Dyspepsia
- Trial name
- GERD (NCT01199679)
- Testing
- Mucosectomy, Rubber Band Ligation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Cook Group Incorporated
Sleeve Gastrectomy
Hiatal Interrogation in Sleeve Gastrectomy
The subject will undergo standard pre-operative preparation. Subjects will be evaluated for the presence of bothersome GERD symptoms by GERD questionnaires and use of Proton-Pump Inhibitor (PPI) medications.
- Trial name
- NCT03527810
- Testing
- Sleeve Gastrectomy Without Interrogation of Hiatus, Sleeve Gastrectomy With Interrogation of Hiatus
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Miguel Burch
Laryngopharyngeal Reflux
The Effects of Dexlansoprazole for the Treatment of Throat-Related Reflux
Recent studies have demonstrated that patients with throat-related reflux often require twice daily proton pump inhibitor therapy to attain significant symptomatic improvement, with once daily therapy offering little relief.
- Trial name
- NCT01317472
- Testing
- dexlansoprazole
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gastro Oesophageal Reflux Disease
Influence of Wrap Fixation Technique on the Results of Fundoplication
Patients who underwent anti-reflux surgery were divided into two groups. In the I group Nissen fundoplication was supplemented with suturing wrap to the crura or the body of stomach using two non-absorbable stitches on each side.
- Trial name
- NCT04335734
- Testing
- Nissen Fundoplication with wrap fixation, Nissen Fundoplication without wrap fixation
- Volunteers
- 138 people
- Sponsor
- Grubnik Volodymyr
Barrett Esophagus, Gastroesophageal Reflux
Novel Imaging Techniques in Barrett's Esophagus
Primary Aim: In patients with endoscopically suspected BE, compared to standard endoscopy, novel techniques (NBI and AFI) with target biopsies will Detect more patients with intestinal metaplasia Detect more areas of high grade…
- Trial name
- NCT00576498
- Testing
- NBI-AFI imaging, Standard Endoscopy
- Where
- 3 sites in United States, Netherlands
- Volunteers
- 130 people
- Sponsor
- Midwest Biomedical Research
Gastroesophageal Reflux Disease
Neonatal Gastro-Esophageal Reflux Disease (GERD) Management Trial
The overall purpose of the investigator's study is to evaluate the causes of and treatment for feeding difficulty in infants with Gastro-esophageal Reflux Disease (GERD). New treatments can be possible only if the cause is known.
- Trial name
- GMT (NCT02486263)
- Testing
- Study Arm - acid suppression plus feeding bundle, Conventional arm - acid suppression only
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Sudarshan Jadcherla
Reflux Esophagitis
Study to Investigate the Safety, Tolerability and Efficacy of YH4808 in Patients With Reflux Esophagitis
This study is to investigate the optimal clinical dose and administration methods of YH4808 in patients with reflux esophagitis by evaluating the safety and efficacy after YH4808 oral administration.
- Trial name
- NCT01538849
- Testing
- Esomeprazole 40mg, YH4808 A mg, YH4808 B mg
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Yuhan Corporation
Esophagitis, Reflux
Efficiency Study of S-Tenatoprazole-Na to Treat Erosive or Ulcerative Esophagitis
STU-Na belongs to the proton pump inhibitors (PPI), a group of drugs that reduce gastric acidity. PPI are used to treat acid related diseases like erosive or ulcerative esophagitis.
- Trial name
- NCT00282555
- Testing
- S-Tenatoprazole-Na (STU-Na)
- Where
- 17 sites in Canada
- Volunteers
- 450 people
- Sponsor
- STEBA France
Gastroesophageal Reflux Disease (GERD)
Effect of Pantoprazole on the Symptoms of Acid Reflux Disease in Adult Patients (BY1023/M3-341)
The aim of the present study is to identify factors (such as symptom patterns and symptom scores) that influence the response to treatment with pantoprazole using different evaluation methods (e.g., ReQuest™ questionnaire…
- Trial name
- NCT00312806
- Testing
- Pantoprazole
- Where
- 186 sites in Argentina, Australia and 20 more
- Volunteers
- 2,000 people
- Sponsor
- Takeda
Gastroesophageal Reflux Disease, Obesity
The Effect of PPI Therapy on Weight, Gut Microbiome, and Expression of GPR41 and GPR43
The investigators long-term goal is to understand how PPIs influence energy balance in both obese and normal-weight individuals.
- Trial name
- NCT02457104
- Testing
- Colonoscopy, Weight and diet questionnaire
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Reflux, Gastroesophageal
Comparison of Total and Partial Fundoplication During Surgery of Patients With Gastroesophageal Reflux Disease
460 patients who are scheduled for surgical treatment of gastroesophageal reflux disease (GERD) participate in the study following the usual preoperative Clinical routines (Medical history, endoscopy with biopsies, esophageal…
- Trial name
- RefluxII (NCT03659487)
- Testing
- Nissen, Toupét
- Volunteers
- 460 people
- Sponsor
- Karolinska Institutet
Pediatric Obesity, NAFLD
Effect of Obesity on Proton Pump Inhibitors
This longitudinal study tests the hypothesis that obesity affects drug pharmacology of acid suppression medications in children.
- Conditions
- Pediatric Obesity, NAFLD, GERD
- Trial name
- LiverLabPPI (NCT04248335)
- Testing
- Lansoprazole, Pantoprazole, Midazolam
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Proximal Gastric Adenocarcinoma, Gastrectomy
Protocol for Comparing the Efficacy of Three Reconstruction Methods of the Digestive Tract After Proximal Gastrectomy
The efficacy of three different reconstruction methods after proximal gastrectomy will be investigated in this study through a prospective, multicenter, randomized controlled trial.
- Conditions
- Proximal Gastric Adenocarcinoma, Gastrectomy, Anastomosis, Reflux Esophagitis
- Trial name
- NCT06062225
- Testing
- Kamikawa, STJI, SOFY
- Volunteers
- 180 people
- Sponsor
- Changzhi People's Hospital Affiliated to Changzhi Medical College
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